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Article ; Online: Comparative whole-genome sequence analysis of a BoNT/B5-producing Clostridium botulinum isolate from an infant botulism case of unknown source in Osaka, Japan.

Umeda, Kaoru / Hirai, Yuji / Nakamura, Hiromi / Amo, Kiyoko

2022 Volume 369, Issue 1

Abstract: A case of infant botulism of unknown origin, not involved in honey consumption, occurred in Osaka, Japan in 2020. A Clostridium botulinum type B strain named Osaka2020 was isolated from a stool sample of the patient. To clarify the epidemiology of the ... ...

Abstract	A case of infant botulism of unknown origin, not involved in honey consumption, occurred in Osaka, Japan in 2020. A Clostridium botulinum type B strain named Osaka2020 was isolated from a stool sample of the patient. To clarify the epidemiology of the case, we performed whole-genome sequencing (WGS) of the isolate and compared it with strains from other sources. WGS analysis revealed that isolate Osaka2020 was classified into ST133 of a new sequence type, B5 subtype, and its toxin gene was encoded in a ∼274 kb plasmid. This plasmid was closely related to the pCLJ plasmid from strain 657Ba in the USA, reported to be conjugatively transferable to other strains. Moreover, isolate Osaka2020 also possesses another smaller plasmid that was common with some type A(B) infant botulism isolates in Japan. The phylogenetic tree from whole-genome SNP analysis showed that isolate Osaka2020 was the most closely related to a type B infant botulism isolate that occurred in Japan 10 years ago. Although no epidemiological connection among the two cases was confirmed, there is possibility that the cases are attributed to common causes such as some environmental substance.
MeSH term(s)	Botulism/diagnosis ; Botulism/epidemiology ; Clostridium botulinum/genetics ; Humans ; Infant ; Japan ; Phylogeny ; Sequence Analysis
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1093/femsle/fnac069
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Zs.A 1372: Show issues

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Article ; Online: Osmotically evoked PLCδ1-dependent translocation of ΔN-TRPV1 channels in rat supraoptic neurons.

Haan, Kirk D / Park, Sung Jin / Nakamura, Yoshikazu / Fukami, Kiyoko / Fisher, Thomas E

iScience

2023 Volume 26, Issue 3, Page(s) 106258

Abstract: Osmoregulation is an essential homeostatic process that requires constant release of vasopressin during sustained increases in plasma osmolality. The magnocellular neurosecretory cells (MNCs) respond to increases in external osmolality through increases ... ...

Abstract	Osmoregulation is an essential homeostatic process that requires constant release of vasopressin during sustained increases in plasma osmolality. The magnocellular neurosecretory cells (MNCs) respond to increases in external osmolality through increases in the activity of ΔN-TRPV1 channels, which leads to increased action potential firing and vasopressin release. We show that sustained exposure of acutely isolated rat and mouse MNCs to hypertonic solutions (90 min) causes a reversible translocation of ΔN-TRPV1 channels from internal stores to the plasma membrane that depends on the activation of phospholipase C and on SNARE-dependent exocytosis. ΔN-TRPV1 channel translocation is absent in MNCs isolated from transgenic mice lacking the PLCδ1 isoform, suggesting that PLCδ1 is essential for triggering this process. The translocation of ΔN-TRPV1 channels to the cell surface could contribute to the maintenance of MNC excitability during sustained increases in osmolality. Our data therefore have important implications for the mechanisms underlying mammalian osmoregulation.
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106258
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Article ; Online: Osmotically evoked PLCδ1-dependent translocation of ΔN-TRPV1 channels in rat supraoptic neurons

Kirk D. Haan / Sung Jin Park / Yoshikazu Nakamura / Kiyoko Fukami / Thomas E. Fisher

iScience, Vol 26, Iss 3, Pp 106258- (2023)

2023

Abstract: Summary: Osmoregulation is an essential homeostatic process that requires constant release of vasopressin during sustained increases in plasma osmolality. The magnocellular neurosecretory cells (MNCs) respond to increases in external osmolality through ... ...

Abstract	Summary: Osmoregulation is an essential homeostatic process that requires constant release of vasopressin during sustained increases in plasma osmolality. The magnocellular neurosecretory cells (MNCs) respond to increases in external osmolality through increases in the activity of ΔN-TRPV1 channels, which leads to increased action potential firing and vasopressin release. We show that sustained exposure of acutely isolated rat and mouse MNCs to hypertonic solutions (90 min) causes a reversible translocation of ΔN-TRPV1 channels from internal stores to the plasma membrane that depends on the activation of phospholipase C and on SNARE-dependent exocytosis. ΔN-TRPV1 channel translocation is absent in MNCs isolated from transgenic mice lacking the PLCδ1 isoform, suggesting that PLCδ1 is essential for triggering this process. The translocation of ΔN-TRPV1 channels to the cell surface could contribute to the maintenance of MNC excitability during sustained increases in osmolality. Our data therefore have important implications for the mechanisms underlying mammalian osmoregulation.
Keywords	Cellular neuroscience ; Cell biology ; Science ; Q
Subject code	571 ; 500
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Hemophagocytic Lymphohistiocytosis and Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Possibly Caused by Enterococcus faecalis Infective Endocarditis.

Nakamura, Gen / Matsuo, Saki / Hosaka, Kiyoko / Abe, Takashi / Kato, Kaori / Yabe, Masahiro / Murakami, Shuichi / Hashidate, Hideki / Kondo, Daisuke

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 24, Page(s) 3691–3697

Abstract: Infection can induce hemophagocytic lymphohistiocytosis (HLH) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We herein report a 52-year-old man who had HLH and AAV simultaneously, possibly caused by Enterococcus faecalis ... ...

Abstract	Infection can induce hemophagocytic lymphohistiocytosis (HLH) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We herein report a 52-year-old man who had HLH and AAV simultaneously, possibly caused by Enterococcus faecalis infective endocarditis. The HLH diagnosis was based on the HLH-2004 criteria. AAV was diagnosed based on a positive result for proteinase-3 ANCA and necrotizing vasculitis of the small vessels on a skin biopsy. He eventually died and was sent for autopsy after combination treatment of valve replacement, antibiotics, and immunosuppressants, including corticosteroids. This case involved a challenging diagnosis and treatment of HLH with various complications in an adult.
MeSH term(s)	Male ; Adult ; Humans ; Middle Aged ; Enterococcus faecalis ; Antibodies, Antineutrophil Cytoplasmic ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Bacterial Infections/complications ; Heart Diseases/complications ; Endocarditis/complications
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2023-04-28
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1518-22
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Article ; Online: Complete reduction surgery of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy.

Tokui, Hiroha / Yahata, Hideaki / Okabe, Yasuhiro / Magarifuchi, Naomi / Maenohara, Shoji / Hachisuga, Kazuhisa / Tomonobe, Hiroshi / Kodama, Keisuke / Yagi, Hiroshi / Yasunaga, Masafumi / Onoyama, Ichiro / Asanoma, Kazuo / Oda, Yoshinao / Nakamura, Masafumi / Kato, Kiyoko

International cancer conference journal

2024 Volume 13, Issue 2, Page(s) 162–166

Abstract: Adult granulosa cell tumors are rare, accounting for only 3-5% of all ovarian tumors. Adult granulosa cell tumors have late recurrences, for which complete resection is an effective option. We report a patient who underwent complete resection of a huge ... ...

Abstract	Adult granulosa cell tumors are rare, accounting for only 3-5% of all ovarian tumors. Adult granulosa cell tumors have late recurrences, for which complete resection is an effective option. We report a patient who underwent complete resection of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy. A 72-year-old woman underwent primary surgery for an adult granulosa cell tumor 19 years earlier. A huge recurrent tumor, 11 × 10 cm in size, was noted to elevate the hepatic hilum, inferior vena cava, and right renal vein. The recurrent tumor was too large to resect, thus paclitaxel and carboplatin were administered as neoadjuvant chemotherapy. The tumor shrank to 6 × 5 cm after 6 cycles of chemotherapy, then complete tumor extirpation with resection of the right kidney and temporary scission of inferior vena cava was performed. The patient was alive and well without evidence of a recurrence 1 y postoperatively. Paclitaxel and carboplatin, as neoadjuvant chemotherapy, might be an effective treatment option to achieve complete reduction surgery. This is the first report demonstrating the effectiveness of paclitaxel and carboplatin for huge recurrent adult granulosa cell tumor.
Language	English
Publishing date	2024-02-14
Publishing country	Singapore
Document type	Journal Article
ISSN	2192-3183
ISSN (online)	2192-3183
DOI	10.1007/s13691-024-00659-5
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Article ; Online: Fabrication of gold-calcium phosphate composite nanoparticles through coprecipitation mediated by amino-terminated polyethylene glycol.

Nakamura, Maki / Oyane, Ayako / Kuroiwa, Kiyoko / Kosuge, Hisanori

Colloids and surfaces. B, Biointerfaces

2020 Volume 194, Page(s) 111169

Abstract: Calcium phosphate (CaP) nanoparticles immobilizing gold (Au) nanocrystals (Au-CaP composite nanoparticles) would be useful in diagnoses and/or treatments with Au nanocrystals. In this study, we achieved the rapid one-pot fabrication of such nanoparticles ...

Abstract	Calcium phosphate (CaP) nanoparticles immobilizing gold (Au) nanocrystals (Au-CaP composite nanoparticles) would be useful in diagnoses and/or treatments with Au nanocrystals. In this study, we achieved the rapid one-pot fabrication of such nanoparticles via coprecipitation in labile supersaturated CaP solutions by using appropriate Au sources, namely, Au nanocrystals coated with amino-terminated polyethylene glycol (PEG). In this process, amino groups at the PEG terminal played a crucial role in the coprecipitation with CaP through affinity interactions, and thus in the formation of Au-CaP composite nanoparticles; however, the molecular weight of the PEG chain was not a controlling factor in the coprecipitation. The important role of the functional groups at the PEG terminal was suggested by comparison with Au nanocrystals coated with carboxyl- and methoxy-terminated PEG, both of which barely coprecipitated with CaP and failed to form Au-CaP composite nanoparticles. Au nanocrystals coated with amino-terminated PEG were immobilized on the CaP nanoparticles, thereby regulating their size (∼140 nm in hydrodynamic diameter) and their dispersion in water. This coprecipitation process and the resulting Au-CaP composite nanoparticles have great potential in biomedical applications.
MeSH term(s)	Calcium Phosphates ; Gold ; Metal Nanoparticles ; Nanoparticles ; Polyethylene Glycols
Chemical Substances	Calcium Phosphates ; Polyethylene Glycols (3WJQ0SDW1A) ; Gold (7440-57-5)
Language	English
Publishing date	2020-06-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2020.111169
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Article ; Online: A novel near-infrared ray catheter fluorescent ureteral catheter for preventing ureteral injury in gynecologic laparoscopic surgery.

Kisu, Iori / Shiraishi, Tetsuro / Iijima, Moito / Nakamura, Kanako / Matsuda, Kiyoko / Hirao, Nobumaru

Archives of gynecology and obstetrics

2021 Volume 304, Issue 2, Page(s) 283–284

MeSH term(s)	Female ; Fluorescence ; Fluorescent Dyes ; Gynecologic Surgical Procedures/adverse effects ; Gynecologic Surgical Procedures/methods ; Gynecology/instrumentation ; Gynecology/methods ; Humans ; Hysterectomy/adverse effects ; Infrared Rays ; Laparoscopy ; Ureter ; Urinary Catheterization/adverse effects ; Urinary Catheterization/instrumentation ; Urinary Catheters
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2021-05-29
Publishing country	Germany
Document type	News
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-021-06103-w
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Article ; Online: Inappropriate surgery in a patient with misdiagnosed Robert's uterus.

Kisu, Iori / Nakamura, Kanako / Shiraishi, Tetsuro / Iijima, Tomoko / Iijima, Moito / Matsuda, Kiyoko / Hirao, Nobumaru

BMC women's health

2021 Volume 21, Issue 1, Page(s) 264

Abstract: Background: Robert's uterus is a rare Mullerian anomaly, which can be described as an asymmetric, septate uterus with a non-communicating hemicavity. Herein, we present the case of a misdiagnosed Robert's uterus, resulting in an invasive and ... ...

Abstract	Background: Robert's uterus is a rare Mullerian anomaly, which can be described as an asymmetric, septate uterus with a non-communicating hemicavity. Herein, we present the case of a misdiagnosed Robert's uterus, resulting in an invasive and disadvantageous surgery. Case presentation: A 16-year-old woman was referred to our department because of dysmenorrhea and suspicion of uterine malformation. We misdiagnosed Robert's uterus as a unicornuate uterus with a non-communicating rudimentary horn and hematometra, and performed laparoscopic hemi-hysterectomy. Although the patient's symptoms were relieved, our surgical procedure left the lateral uterine wall weak, making the patient's uterus susceptible to uterine rupture in any future pregnancy. Conclusions: Although the early diagnosis of Robert's uterus is challenging, it is important in order to determine appropriate surgical interventions and management for maintaining the quality of life and ensuring safety in future pregnancies.
Language	English
Publishing date	2021-07-03
Publishing country	England
Document type	Journal Article
ISSN	1472-6874
ISSN (online)	1472-6874
DOI	10.1186/s12905-021-01404-3
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Article ; Online: PLCδ1 Plays Central Roles in the Osmotic Activation of ΔN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine Osmoregulation.

Park, Sung Jin / Haan, Kirk D / Nakamura, Yoshikazu / Fukami, Kiyoko / Fisher, Thomas E

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 16, Page(s) 3579–3587

Abstract: The magnocellular neurosecretory cells (MNCs) of the hypothalamus play a vital role in osmoregulation, but the mechanisms underlying MNC osmosensitivity are not fully understood. We showed previously that high osmolality activates phospholipase C (PLC) ... ...

Abstract	The magnocellular neurosecretory cells (MNCs) of the hypothalamus play a vital role in osmoregulation, but the mechanisms underlying MNC osmosensitivity are not fully understood. We showed previously that high osmolality activates phospholipase C (PLC) in rat MNCs in a Ca
MeSH term(s)	Actins/metabolism ; Action Potentials/physiology ; Angiotensin II/pharmacology ; Animals ; Electrophysiological Phenomena ; Hypertonic Solutions ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/metabolism ; Neurosecretory Systems/metabolism ; Osmoregulation/physiology ; Osmosis ; Phospholipase C delta/genetics ; Phospholipase C delta/physiology ; Supraoptic Nucleus/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Water Deprivation
Chemical Substances	Actins ; Hypertonic Solutions ; TRPV Cation Channels ; TRPV1 protein, mouse ; Angiotensin II (11128-99-7) ; Phospholipase C delta (EC 3.1.4.11) ; Plcd1 protein, mouse (EC 3.1.4.11)
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2892-20.2021
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Zs.A 1668: Show issues

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Article ; Online: Regulation and physiological functions of mammalian phospholipase C.

Nakamura, Yoshikazu / Fukami, Kiyoko

Journal of biochemistry

2017 Volume 161, Issue 4, Page(s) 315–321

Abstract: Phospholipase C (PLC) is a key enzyme in phosphoinositide metabolism. PLC hydrolyses phosphatidylinositol 4,5-bis-phosphate to generate two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol, that generate diverse cellular responses. PLC ... ...

Abstract	Phospholipase C (PLC) is a key enzyme in phosphoinositide metabolism. PLC hydrolyses phosphatidylinositol 4,5-bis-phosphate to generate two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol, that generate diverse cellular responses. PLC is activated by various signalling molecules, including Ca2+, heterometric G proteins, small G proteins, and receptor/non-receptor tyrosine kinases. In addition to their enzymatic activity, some PLC subtypes also function as a guanine nucleotide exchange factor, GTPase-activating protein, and adaptor protein, independent of their lipase activity. There are 13 PLC isozymes in mammals, and they are categorized into six classes based on structure. Generation and analysis of genetically modified mice has revealed the unexpectedly diverse physiological functions of PLC isozymes. Although all PLC isozymes catalyze the same reaction, each PLC isozyme has unique physiological functions. This review focuses on the regulation and physiological functions of PLCs.
MeSH term(s)	Animals ; Diglycerides/metabolism ; GTPase-Activating Proteins/metabolism ; Gene Expression Regulation, Enzymologic ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Type C Phospholipases/genetics ; Type C Phospholipases/metabolism
Chemical Substances	Diglycerides ; GTPase-Activating Proteins ; Guanine Nucleotide Exchange Factors ; Isoenzymes ; Phosphatidylinositol 4,5-Diphosphate ; Inositol 1,4,5-Trisphosphate (85166-31-0) ; Type C Phospholipases (EC 3.1.4.-)
Language	English
Publishing date	2017-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/jb/mvw094
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