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  1. Article ; Online: B-cell prolymphocytic leukemia after COVID-19 infection.

    Falini, Brunangelo / Lazzi, Stefano

    Blood

    2023  Volume 141, Issue 14, Page(s) 1777

    MeSH term(s) Humans ; Leukemia, Prolymphocytic, B-Cell ; COVID-19/complications
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023019816
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  2. Article ; Online: Pre-B acute lymphoblastic leukemia presenting with NPM1 and FLT3 mutations.

    Khan, Alesia A / James, Daniel / Andresen, Vibeke / Atkey, Julie / Bradbury, Rachel / Cargo, Catherine / Dillon, Richard / Gjertsen, Bjørn Tore / Goldstone, Antony R / Leach, Richard / Lock, Daniel / Narayanan, Mayanka / Russell, Nigel / Verigou, Eleni-Anna / Green, Simone / Fielding, Adele K / Falini, Brunangelo

    American journal of hematology

    2024  

    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27301
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  3. Article ; Online: Pediatric large B-cell lymphoma with 11q aberration.

    Falini, Brunangelo / Lazzi, Stefano

    Blood

    2022  Volume 140, Issue 24, Page(s) 2644

    MeSH term(s) Humans ; Child ; Chromosome Aberrations ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017409
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  4. Article ; Online: Diffuse large B-cell lymphoma of the testis.

    Falini, Brunangelo / Lazzi, Stefano

    Blood

    2022  Volume 140, Issue 24, Page(s) 2645

    MeSH term(s) Male ; Humans ; Testis/pathology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Testicular Neoplasms/pathology
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018344
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  5. Article ; Online: How I treat refractory/relapsed diffuse large B-cell lymphomas with CD19-directed chimeric antigen receptor T cells.

    Nagler, Arnon / Perriello, Vincenzo Maria / Falini, Lorenza / Falini, Brunangelo

    British journal of haematology

    2023  Volume 201, Issue 3, Page(s) 396–410

    Abstract: ... for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), offering ~40% of long-term responses ...

    Abstract Chimeric antigen receptor (CAR) T cells targeting CD19 represent a promising salvage immunotherapy for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), offering ~40% of long-term responses. In everyday clinical practice, haematologists involved in CAR T cell treatment of patients with R/R DLBCL have to deal with diagnostically complex cases and difficult therapeutic choices. The availability of novel immunotherapeutic agents for R/R DLBCL and recent advances in understanding CAR T-cell failure mechanisms demand a rational approach to identify the best choice for bridging therapy and managing post-CAR T-cell therapy relapses. Moreover, positron emission tomography/computerised tomography may result in false-positive interpretation, highlighting the importance of post-treatment biopsy. In this review, we discuss all above issues, presenting four instructive cases, with the aim to provide criteria and new perspectives for CAR T-cell treatment of DLBCL.
    MeSH term(s) Humans ; Receptors, Chimeric Antigen/therapeutic use ; Receptors, Antigen, T-Cell/therapeutic use ; Neoplasm Recurrence, Local/etiology ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; T-Lymphocytes ; Immunotherapy, Adoptive/methods ; Antigens, CD19
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell ; Antigens, CD19
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18724
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  6. Article ; Online: A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas.

    Falini, Brunangelo / Martino, Giovanni / Lazzi, Stefano

    Leukemia

    2022  Volume 37, Issue 1, Page(s) 18–34

    Abstract: ... on mature B-cell neoplasms. The main aim is to provide a tool to facilitate the work of pathologists ...

    Abstract Several editions of the World Health Organization (WHO) classifications of lympho-hemopoietic neoplasms in 2001, 2008 and 2017 served as the international standard for diagnosis. Since the 4th WHO edition, here referred as WHO-HAEM4, significant clinico-pathological, immunophenotypic and molecular advances have been made in the field of lymphomas, contributing to refining diagnostic criteria of several diseases, to upgrade entities previously defined as provisional and to identify new entities. This process has resulted in two recent classifying proposals of lymphoid neoplasms, the International Consensus Classification (ICC) and the 5th edition of the WHO classification (WHO-HAEM5). In this paper, we review and compare the two classifications in terms of diagnostic criteria and entity definition, with focus on mature B-cell neoplasms. The main aim is to provide a tool to facilitate the work of pathologists, hematologists and researchers involved in the diagnosis and treatment of lymphomas.
    MeSH term(s) Humans ; Consensus ; Lymphoma, B-Cell/diagnosis ; Lymphoma/pathology ; World Health Organization ; Hematologic Neoplasms
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-022-01764-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Microenvironmental immune cell alterations across the spectrum of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B-cell lymphoma.

    Panayi, Christos / Akarca, Ayse U / Ramsay, Alan D / Shankar, Ananth G / Falini, Brunangelo / Piris, Miguel A / Linch, David / Marafioti, Teresa

    Frontiers in oncology

    2023  Volume 13, Page(s) 1267604

    Abstract: ... NLPHL), also known as nodular lymphocyte predominant B-cell lymphoma, partially overlaps with T-cell ... histiocyte-rich large B-cell lymphoma (THRLCBL). NLPHL histology may vary in architecture and B-cell/T-cell ... progressive expansions of cytotoxic granzyme-B-expressing natural killer and CD8-positive T-cells, PD1 ...

    Abstract Background: The clinicopathological spectrum of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), also known as nodular lymphocyte predominant B-cell lymphoma, partially overlaps with T-cell/histiocyte-rich large B-cell lymphoma (THRLCBL). NLPHL histology may vary in architecture and B-cell/T-cell composition of the tumour microenvironment. However, the immune cell phenotypes accompanying different histological patterns remain poorly characterised.
    Methods: We applied a multiplexed immunofluorescence workflow to identify differential expansion/depletion of multiple microenvironmental immune cell phenotypes between cases of NLPHL showing different histological patterns (as described by Fan et al, 2003) and cases of THRLBCL.
    Results: FOXP3-expressing T-regulatory cells were conspicuously depleted across all NLPHL cases. As histology progressed to variant Fan patterns C and E of NLPHL and to THRLBCL, there were progressive expansions of cytotoxic granzyme-B-expressing natural killer and CD8-positive T-cells, PD1-expressing CD8-positive T-cells, and CD163-positive macrophages including a PDL1-expressing subset. These occurred in parallel to depletion of NKG2A-expressing natural killer and CD8-positive T-cells.
    Discussion: These findings provide new insights on the immunoregulatory mechanisms involved in NLPHL and THLRBCL pathogenesis, and are supportive of an increasingly proposed biological continuum between these two lymphomas. Additionally, the findings may help establish new biomarkers of high-risk disease, which could support a novel therapeutic program of immune checkpoint interruption targeting the PD1:PDL1 and/or NKG2A:HLA-E axes in the management of high-risk NLPHL and THRLBCL.
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1267604
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  8. Article ; Online: Acute myeloid leukemia development soon after anti-CD19 chimeric antigen receptor T-cell infusion in a patient with refractory diffuse large B-cell lymphoma and pre-existing clonal hematopoiesis.

    Falini, Lorenza / Venanzi, Alessandra / Tini, Valentina / Innocente, Alessandra / Ballanti, Stelvio / Saldi, Simonetta / Sivolella, Silvio / Pierini, Antonio / Aristei, Cynthia / Tiacci, Enrico / Perriello, Vincenzo Maria / Falini, Brunangelo

    Haematologica

    2023  Volume 108, Issue 1, Page(s) 290–294

    MeSH term(s) Humans ; Receptors, Chimeric Antigen/genetics ; Clonal Hematopoiesis ; Immunotherapy, Adoptive/adverse effects ; Receptors, Antigen, T-Cell/genetics ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/therapy ; T-Lymphocytes ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Antigens, CD19
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell ; Antigens, CD19
    Language English
    Publishing date 2023-01-01
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281351
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  9. Article ; Online: The first human acute myeloid leukemia genome ever fully sequenced.

    Falini, Brunangelo

    Haematologica

    2024  Volume 109, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Base Sequence ; Leukemia, Myeloid, Acute/genetics
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.282118
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  10. Article ; Online: NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions.

    Falini, Brunangelo

    American journal of hematology

    2023  Volume 98, Issue 9, Page(s) 1452–1464

    Abstract: The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm. NPM1 mutations occur in about one-third of AML, are AML-specific, usually ... ...

    Abstract The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm. NPM1 mutations occur in about one-third of AML, are AML-specific, usually involve exon 12 and are frequently associated with FLT3-ITD, DNMT3A, TET2, and IDH1/2 mutations. Because of its unique molecular and clinico-pathological features, NPM1-mutated AML is regarded as a distinct leukemia entity in both the International Consensus Classification (ICC) and the 5th edition of the World Health Organization (WHO) classification of myeloid neoplasms. All NPM1 mutations generate leukemic mutants that are aberrantly exported in the cytoplasm of the leukemic cells and are relevant to the pathogenesis of the disease. Here, we focus on recently identified functions of the NPM1 mutant at chromatin level and its relevance in driving HOX/MEIS gene expression. We also discuss yet controversial issues of the ICC/WHO classifications, including the biological and clinical significance of therapy-related NPM1-mutated AML and the relevance of blasts percentage in defining NPM1-mutated AML. Finally, we address the impact of new targeted therapies in NPM1-mutated AML with focus on CAR T cells directed against NPM1/HLA neoepitopes, as well as XPO1 and menin inhibitors.
    MeSH term(s) Humans ; Nucleophosmin ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Leukemia, Myeloid, Acute/pathology ; Mutation ; Cytoplasm
    Chemical Substances Nucleophosmin (117896-08-9) ; Nuclear Proteins
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26989
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