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Article ; Online: Integrating education for clinical practice change.

Chawla, Elizabeth M / Schuler, Christine L / Barnhardt, Elizabeth W / Herbst, Lori A / Sarkissian, Aliese / McNeal-Trice, Kenya / Newmeyer, Amy / Perry, Martha / Poynter, Sue E / Lannon, Carole

The clinical teacher

2024 , Page(s) e13753

Abstract: Background: Children with chronic medical conditions and their families have significant emotional health concerns, yet paediatricians are often ill-equipped to address these needs. The American Board of Pediatrics launched the Roadmap Project to better ...

Abstract	Background: Children with chronic medical conditions and their families have significant emotional health concerns, yet paediatricians are often ill-equipped to address these needs. The American Board of Pediatrics launched the Roadmap Project to better support emotional health as part of routine care. We present pilot work in paediatric training programmes to test educational approaches and explore lessons learned. Approach: Four institutions implemented Roadmap tools into their paediatric training programmes, either incorporating them into existing educational structures or embedding them into the clinical workplace. One programme utilised an existing longitudinal curriculum, and another incorporated into a block rotation. Two programmes embedded training for residents into a larger programme for the healthcare team within the clinical space, one in outpatient clinics and one in an inpatient service. Evaluation: Evaluation strategies at each site matched the intended outcomes. Sites working within education programmes evaluated learners, demonstrating increases in resident skills and confidence on pre-/post-self-assessments. Sites embedding tools into the practice context measured changes in the clinical practice of the healthcare team. Despite variability in implementation, all approaches improved trainee skills; sites embedding education into a clinical setting saw greater changes in clinical practice. Implications: Our pilot provided structure yet allowed for flexibility, and all sites improved trainee skills. Engaging the entire healthcare team within practice settings appears advantageous, thus embedding education into clinical practice may be preferable to a separate education programme. Similar to outcomes found in interprofessional education (IPE), educating clinical teams together may be more impactful for cultural shifts needed for changing clinical practice.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2151518-9
ISSN	1743-498X ; 1743-4971
ISSN (online)	1743-498X
ISSN	1743-4971
DOI	10.1111/tct.13753
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Article ; Online: Survey of confidence and knowledge to manage patellofemoral pain in readers versus nonreaders of the physical therapy clinical practice guideline.

Willy, Richard W / Hoglund, Lisa T / Glaviano, Neal R / Bolgla, Lori A / Bazett-Jones, David M

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

2022 Volume 55, Page(s) 218–228

Abstract: Objectives: To compare beliefs of physical therapists (PTs) who read the clinical practice guideline (CPG) for the management of individuals with patellofemoral pain (PFP) to those who have not read the CPG.: Design: Cross-sectional study.: Setting! ...

Abstract	Objectives: To compare beliefs of physical therapists (PTs) who read the clinical practice guideline (CPG) for the management of individuals with patellofemoral pain (PFP) to those who have not read the CPG. Design: Cross-sectional study. Setting: Online survey. Participants: 494 currently licensed/registered PTs or physiotherapists. Main outcome measures: Respondents answered Likert-based or open-ended questions regarding the diagnosis, prognosis, risk factors, and management of individuals with PFP, as well as confidence for managing individuals with PFP, especially the ability to identify beneficial and non-beneficial interventions. We dichotomized responses into participants who read (READERS) and did not read (NonREADERS) the CPG. Results: Most respondents held inaccurate beliefs about risk factors and prognosis; however, READERS' beliefs better aligned with the CPG than NonREADERS (P < 0.01). Most respondents correctly agreed that hip and knee exercise was the recommended treatment strategy; yet NonREADERS believed in implementing unsupported passive treatments (P < 0.01). READERS reported greater confidence in managing individuals with PFP, delivering evidence-based interventions, identifying less beneficial treatments, and locating evidence-based resources than NonREADERS (P < 0.01). Conclusion: While READERS and NonREADERS held accurate beliefs for exercise-based treatment for PFP, greater knowledge translation is needed to counter inaccurate beliefs regarding risk factors, prognostic factors, and passive treatments.
MeSH term(s)	Cross-Sectional Studies ; Humans ; Patellofemoral Pain Syndrome/rehabilitation ; Physical Therapists ; Physical Therapy Modalities ; Surveys and Questionnaires
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2008604-0
ISSN	1873-1600 ; 1466-853X
ISSN (online)	1873-1600
ISSN	1466-853X
DOI	10.1016/j.ptsp.2022.04.009
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Article ; Online: COVID-19 SeroHub, an online repository of SARS-CoV-2 seroprevalence studies in the United States

Neal D. Freedman / Liliana Brown / Lori M. Newman / Jefferson M. Jones / Tina J. Benoit / Francisco Averhoff / Xiangning Bu / Konuralp Bayrak / Anna Lu / Brent Coffey / Latifa Jackson / Stephen J. Chanock / Anthony R. Kerlavage

Scientific Data, Vol 9, Iss 1, Pp 1-

2022 Volume 11

Abstract: Measurement(s) SARS-CoV-2 seroprevalence Technology Type(s) serology assay Factor Type(s) geography • age • sex • race/ethnicity • Collection date Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment spatiotemporal region ... ...

Abstract	Measurement(s) SARS-CoV-2 seroprevalence Technology Type(s) serology assay Factor Type(s) geography • age • sex • race/ethnicity • Collection date Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment spatiotemporal region Sample Characteristic - Location United States of America
Keywords	Science ; Q
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acute Effects of Ketamine on Intracranial Pressure in Children With Severe Traumatic Brain Injury.

Laws, Jennifer C / Vance, E Haley / Betters, Kristina A / Anderson, Jessica J / Fleishman, Sydney / Bonfield, Christopher M / Wellons, John C / Xu, Meng / Slaughter, James C / Giuse, Dario A / Patel, Neal / Jordan, Lori C / Wolf, Michael S

Critical care medicine

2023 Volume 51, Issue 5, Page(s) 563–572

Abstract: Objectives: The acute cerebral physiologic effects of ketamine in children have been incompletely described. We assessed the acute effects of ketamine on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in children with severe traumatic ...

Abstract	Objectives: The acute cerebral physiologic effects of ketamine in children have been incompletely described. We assessed the acute effects of ketamine on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in children with severe traumatic brain injury (TBI). Design: In this retrospective observational study, patients received bolus doses of ketamine for sedation or as a treatment for ICP crisis (ICP > 20 mm Hg for > 5 min). Administration times were synchronized with ICP and CPP recordings at 1-minute intervals logged in an automated database within the electronic health record. ICP and CPP were each averaged in epochs following drug administration and compared with baseline values. Age-based CPP thresholds were subtracted from CPP recordings and compared with baseline values. Trends in ICP and CPP over time were assessed using generalized least squares regression. Setting: A 30-bed tertiary care children's hospital PICU. Patients: Children with severe TBI who underwent ICP monitoring. Interventions: None. Measurements and main results: We analyzed data from 33 patients, ages 1 month to 16 years, 22 of whom received bolus doses of ketamine, with 127 doses analyzed. Demographics, patient, and injury characteristics were similar between patients who did versus did not receive ketamine boluses. In analysis of the subset of ketamine doses used only for sedation, there was no significant difference in ICP or CPP from baseline. Eighteen ketamine doses were given during ICP crises in 11 patients. ICP decreased following these doses and threshold-subtracted CPP rose. Conclusions: In this retrospective, exploratory study, ICP did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during ICP crises. If these findings are reproduced in a larger study, ketamine may warrant consideration as a treatment for intracranial hypertension in children with severe TBI.
MeSH term(s)	Humans ; Child ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Retrospective Studies ; Intracranial Pressure/physiology ; Cerebrovascular Circulation ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/drug therapy ; Intracranial Hypertension/drug therapy ; Intracranial Hypertension/etiology
Chemical Substances	Ketamine (690G0D6V8H)
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000005806
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Article ; Online: Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.

Neal, Lori M / Knoll, Laura J

PLoS pathogens

2014 Volume 10, Issue 6, Page(s) e1004203

Abstract: Ly6C+ inflammatory monocytes are essential to host defense against Toxoplasma gondii, Listeria monocytogenes and other infections. During T. gondii infection impaired inflammatory monocyte emigration results in severe inflammation and failure to control ... ...

Abstract	Ly6C+ inflammatory monocytes are essential to host defense against Toxoplasma gondii, Listeria monocytogenes and other infections. During T. gondii infection impaired inflammatory monocyte emigration results in severe inflammation and failure to control parasite replication. However, the T. gondii factors that elicit these monocytes are unknown. Early studies from the Remington laboratory showed that mice with a chronic T. gondii infection survive lethal co-infections with unrelated pathogens, including L. monocytogenes, but a mechanistic analysis was not performed. Here we report that this enhanced survival against L. monocytogenes is due to early reduction of bacterial burdens and elicitation of Ly6C+ inflammatory monocytes. We demonstrate that a single TLR11/TLR12 ligand profilin (TgPRF) was sufficient to reduce bacterial burdens similar to T. gondii chronic infection. Stimulation with TgPRF was also sufficient to enhance animal survival when administered either pre- or post-Listeria infection. The ability of TgPRF to reduce L. monocytogenes burdens was dependent on TLR11 and required IFN-γ but was not dependent on IL-12 signaling. TgPRF induced rapid production of MCP-1 and resulted in trafficking of Ly6Chi CCR2+ inflammatory monocytes and Ly6G+ neutrophils into the blood and spleen. Stimulation with TgPRF reduced L. monocytogenes burdens in mice depleted with the Ly6G specific MAb 1A8, but not in Ly6C/Ly6G specific RB6-8C5 depleted or CCR2-/- mice, indicating that only inflammatory monocytes are required for TgPRF-induced reduction in bacterial burdens. These results demonstrate that stimulation of TLR11 by TgPRF is a mechanism to promote the emigration of Ly6Chi CCR2+ monocytes, and that TgPRF recruited inflammatory monocytes can provide an immunological benefit against an unrelated pathogen.
MeSH term(s)	Animals ; Antigens, Ly/immunology ; Chemokine CCL2/biosynthesis ; Coinfection/immunology ; Coinfection/microbiology ; Coinfection/parasitology ; Inflammation/immunology ; Interferon-gamma/biosynthesis ; Interleukin-12/biosynthesis ; Listeria monocytogenes/immunology ; Listeriosis/immunology ; Listeriosis/microbiology ; Mice ; Mice, Inbred A ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/immunology ; Neutrophils/immunology ; Profilins/genetics ; Receptors, CCR2/immunology ; Receptors, Interleukin-12/immunology ; Recombinant Proteins ; Signal Transduction/immunology ; Toll-Like Receptors/immunology ; Toxoplasma/immunology ; Toxoplasmosis, Animal/immunology ; Toxoplasmosis, Animal/parasitology ; Tumor Necrosis Factor-alpha/biosynthesis
Chemical Substances	Antigens, Ly ; Ccl2 protein, mouse ; Ccr2 protein, mouse ; Chemokine CCL2 ; Ly-6C antigen, mouse ; Profilins ; Receptors, CCR2 ; Receptors, Interleukin-12 ; Recombinant Proteins ; Tlr11 protein, mouse ; Tlr12 protein, mouse ; Toll-Like Receptors ; Tumor Necrosis Factor-alpha ; Interleukin-12 (187348-17-0) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2014-06-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1004203
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 SeroHub, an online repository of SARS-CoV-2 seroprevalence studies in the United States.

Freedman, Neal D / Brown, Liliana / Newman, Lori M / Jones, Jefferson M / Benoit, Tina J / Averhoff, Francisco / Bu, Xiangning / Bayrak, Konuralp / Lu, Anna / Coffey, Brent / Jackson, Latifa / Chanock, Stephen J / Kerlavage, Anthony R

Scientific data

2022 Volume 9, Issue 1, Page(s) 727

Abstract: Seroprevalence studies provide useful information about the proportion of the population either vaccinated against SARS-CoV-2, previously infected with the virus, or both. Numerous studies have been conducted in the United States, but differ ... ...

Abstract	Seroprevalence studies provide useful information about the proportion of the population either vaccinated against SARS-CoV-2, previously infected with the virus, or both. Numerous studies have been conducted in the United States, but differ substantially by dates of enrollment, target population, geographic location, age distribution, and assays used. This can make it challenging to identify and synthesize available seroprevalence data by geographic region or to compare infection-induced versus combined infection- and vaccination-induced seroprevalence. To facilitate public access and understanding, the National Institutes of Health and the Centers for Disease Control and Prevention developed the COVID-19 Seroprevalence Studies Hub (COVID-19 SeroHub, https://covid19serohub.nih.gov/ ), a data repository in which seroprevalence studies are systematically identified, extracted using a standard format, and summarized through an interactive interface. Within COVID-19 SeroHub, users can explore and download data from 178 studies as of September 1, 2022. Tools allow users to filter results and visualize trends over time, geography, population, age, and antigen target. Because COVID-19 remains an ongoing pandemic, we will continue to identify and include future studies.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Seroepidemiologic Studies ; United States ; Vaccination
Language	English
Publishing date	2022-11-26
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-022-01830-4
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Article ; Online: Site-level variability in the processes of care and outcomes over time among patients with COVID-19 and myocardial injury: Insights from the American Heart Association's COVID-19 Cardiovascular Disease Registry.

Sammour, Yasser M / Spertus, John A / Kennedy, Kevin / Morrow, David A / Daniels, Lori B / Jones, Phil / Alger, Heather / Stevens, Laura / Shah, Alpesh / Goel, Sachin S / de Lemos, James A / Hayek, Salim S / Sutton, Nadia R / Kleiman, Neal S

American heart journal plus : cardiology research and practice

2023 Volume 27, Page(s) 100265

Abstract: Background: Elevated cardiac troponin (cTn) levels in patients with COVID-19 has been associated with worse outcomes. Guidelines on best practices of those patients remain uncertain.: Methods: We included patients with COVID-19 and cTn above the ... ...

Abstract	Background: Elevated cardiac troponin (cTn) levels in patients with COVID-19 has been associated with worse outcomes. Guidelines on best practices of those patients remain uncertain. Methods: We included patients with COVID-19 and cTn above the assay-specific upper limit of normal (ULN) enrolled in the American Heart Association's COVID-19 registry between March 2020-January 2021. Site-level variability in invasive coronary angiography, LVEF assessment, ICU utilization, and inpatient mortality were determined by calculating adjusted median odds ratio (MOR) using hierarchical logistic regression models. Temporal trends were assessed with Cochran-Armitage trend test. Results: Among 32,636 patients, we included 6234 (19.4 %) with cTn above ULN (age 68.7 ± 16.0 years, 56.5 % male, 51.5 % Caucasian), of whom 1365 (21.6 %) had ≥5-fold elevations. Across 55 sites, the median rate of invasive coronary angiography was 0.1 % with adjusted MOR 1.5(1.0,2.3), median LVEF assessment was 25.5 %, MOR 3.0(2.2,3.9), ICU utilization was 41.7 %, MOR 2.2(1.8,2.6), and mortality was 20.9 %, MOR 1.7(1.5,2.0). Over time, we noted a significant increase in invasive coronary angiography (p-trend = 0.001), and LVEF assessment (p-trend<0.001), and reduction in mortality (p-trend<0.001), without significant change in ICU admissions (p-trend = 0.08). Similar variability and temporal trends were seen among patients with ≥5-fold cTn elevation. Conclusions: The use of invasive coronary angiography among patients with COVID-19 and myocardial injury was very low during the early pandemic. We found moderate institutional variability in processes of care with an uptrend in invasive catheterization and LVEF assessment, and downtrend in mortality. Comparative effectiveness studies are needed to examine whether variability in care is associated with differences in outcomes.
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2023.100265
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Article ; Online: Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype.

Tan, Xiaohong / Jain, Era / Barcellona, Marcos N / Morris, Evan / Neal, Sydney / Gupta, Munish C / Buchowski, Jacob M / Kelly, Michael / Setton, Lori A / Huebsch, Nathaniel

Biomaterials

2021 Volume 277, Page(s) 121113

Abstract: Biomaterial based strategies have been widely explored to preserve and restore the juvenile phenotype of cells of the nucleus pulposus (NP) in degenerated intervertebral discs (IVD). With aging and maturation, NP cells lose their ability to produce ... ...

Abstract	Biomaterial based strategies have been widely explored to preserve and restore the juvenile phenotype of cells of the nucleus pulposus (NP) in degenerated intervertebral discs (IVD). With aging and maturation, NP cells lose their ability to produce necessary extracellular matrix and proteoglycans, accelerating disc degeneration. Previous studies have shown that integrin or syndecan binding peptide motifs from laminin can induce NP cells from degenerative human discs to re-express juvenile NP-specific cell phenotype and biosynthetic activity. Here, we engineered alginate hydrogels to present integrin- and syndecan-binding peptides alone or in combination (cyclic RGD and AG73, respectively) to introduce bioactive features into the alginate gels. We demonstrated human NP cells cultured upon and within alginate hydrogels presented with cRGD and AG73 peptides exhibited higher cell viability, biosynthetic activity, and NP-specific protein expression over alginate alone. Moreover, the combination of the two peptide motifs elicited markers of the NP-specific cell phenotype, including N-Cadherin, despite differences in cell morphology and multicellular cluster formation between 2D and 3D cultures. These results represent a promising step toward understanding how distinct adhesive peptides can be combined to guide NP cell fate. In the future, these insights may be useful to rationally design hydrogels for NP cell-transplantation based therapies for IVD degeneration.
MeSH term(s)	Alginates ; Humans ; Hydrogels ; Integrins ; Intervertebral Disc ; Intervertebral Disc Degeneration ; Nucleus Pulposus ; Peptides ; Phenotype ; Syndecans
Chemical Substances	Alginates ; Hydrogels ; Integrins ; Peptides ; Syndecans
Language	English
Publishing date	2021-09-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.121113
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Article: Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype

Tan, Xiaohong / Jain, Era / Barcellona, Marcos N. / Morris, Evan / Neal, Sydney / Gupta, Munish C. / Buchowski, Jacob M. / Kelly, Michael / Setton, Lori A. / Huebsch, Nathaniel

Biomaterials. 2021 Oct., v. 277

2021

Abstract	Biomaterial based strategies have been widely explored to preserve and restore the juvenile phenotype of cells of the nucleus pulposus (NP) in degenerated intervertebral discs (IVD). With aging and maturation, NP cells lose their ability to produce necessary extracellular matrix and proteoglycans, accelerating disc degeneration. Previous studies have shown that integrin or syndecan binding peptide motifs from laminin can induce NP cells from degenerative human discs to re-express juvenile NP-specific cell phenotype and biosynthetic activity. Here, we engineered alginate hydrogels to present integrin- and syndecan-binding peptides alone or in combination (cyclic RGD and AG73, respectively) to introduce bioactive features into the alginate gels. We demonstrated human NP cells cultured upon and within alginate hydrogels presented with cRGD and AG73 peptides exhibited higher cell viability, biosynthetic activity, and NP-specific protein expression over alginate alone. Moreover, the combination of the two peptide motifs elicited markers of the NP-specific cell phenotype, including N-Cadherin, despite differences in cell morphology and multicellular cluster formation between 2D and 3D cultures. These results represent a promising step toward understanding how distinct adhesive peptides can be combined to guide NP cell fate. In the future, these insights may be useful to rationally design hydrogels for NP cell-transplantation based therapies for IVD degeneration.
Keywords	alginates ; biocompatible materials ; biosynthesis ; cadherins ; cell structures ; cell transplantation ; cell viability ; extracellular matrix ; humans ; hydrogels ; integrins ; juveniles ; laminin ; peptides ; phenotype ; protein synthesis ; proteoglycans ; syndecans
Language	English
Dates of publication	2021-10
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.121113
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Article ; Online: Chemokine receptor CXCR3 is required for lethal brain pathology but not pathogen clearance during cryptococcal meningoencephalitis.

Xu, Jintao / Neal, Lori M / Ganguly, Anutosh / Kolbe, Jessica L / Hargarten, Jessica C / Elsegeiny, Waleed / Hollingsworth, Christopher / He, Xiumiao / Ivey, Mike / Lopez, Rafael / Zhao, Jessica / Segal, Benjamin / Williamson, Peter R / Olszewski, Michal A

Science advances

2020 Volume 6, Issue 25, Page(s) eaba2502

Abstract: Cryptococcal meningoencephalitis (CM) is the major cause of infection-related neurological death, typically seen in immunocompromised patients. However, T cell-driven inflammatory response has been increasingly implicated in lethal central nervous system ...

Abstract	Cryptococcal meningoencephalitis (CM) is the major cause of infection-related neurological death, typically seen in immunocompromised patients. However, T cell-driven inflammatory response has been increasingly implicated in lethal central nervous system (CNS) immunopathology in human patients and murine models. Here, we report marked up-regulation of the chemokine receptor CXCR3 axis in human patients and mice with CM. CXCR3 deletion in mice improves survival, diminishes neurological deficits, and limits neuronal damage without suppressing fungal clearance. CD4
MeSH term(s)	Adoptive Transfer ; Animals ; Brain/pathology ; Central Nervous System ; Cryptococcosis/pathology ; Cryptococcus ; Humans ; Meningoencephalitis/microbiology ; Meningoencephalitis/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, CXCR3/genetics
Chemical Substances	CXCR3 protein, human ; Cxcr3 protein, mouse ; Receptors, CXCR3
Keywords	covid19
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aba2502
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