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Article ; Online: CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.

Février, Michèle / Dorgham, Karim / Rebollo, Angelita

2011 Volume 3, Issue 5, Page(s) 586–612

Abstract: Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and systemic immune hyperactivation are the hallmarks of HIV infection. The end ... ...

Abstract	Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and systemic immune hyperactivation are the hallmarks of HIV infection. The end of acute infection is associated with the emergence of specific CD4+ and CD8+ T cell responses and the establishment of a chronic phase of infection. Abnormal levels of immune activation and inflammation persist despite a low steady state level of viremia. Although the causes of persistent immune hyperactivation remain incompletely characterized, physiological alterations of gastrointestinal tract probably play a major role. Failure to restore Th17 cells in gut-associated lymphoid tissues (GALT) might impair the recovery of the gut mucosal barrier. This review discusses recent advances on understanding the contribution of CD4+ T cell depletion to HIV pathogenesis.
MeSH term(s)	Animals ; Apoptosis ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/immunology ; HIV Infections/physiopathology ; HIV Infections/virology ; HIV-1/immunology ; HIV-1/physiology ; Humans
Language	English
Publishing date	2011-05-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v3050586
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Efficiency of dihydroxamic and trihydroxamic siderochelates to extract uranium and plutonium from contaminated soils

Février, Laureline / Coppin, Frédéric / Pierrisnard, Sylvie / Bourdillon, Mélanie / Nguyen, Lé Vi / Zaiter, Nissrine / Brandès, Stéphane / Sladkov, Vladimir / Chambron, Jean-Claude / Meyer, Michel

Journal of environmental radioactivity. 2021 Sept., v. 235-236

2021

Abstract: Actinide-based mineral phases occurring in contaminated soils can be solubilized by organic chelators excreted by plants, such as citrate. Herein, the efficiency of citrate towards U and Pu extraction is compared to that of siderophores, whose primary ... ...

Abstract	Actinide-based mineral phases occurring in contaminated soils can be solubilized by organic chelators excreted by plants, such as citrate. Herein, the efficiency of citrate towards U and Pu extraction is compared to that of siderophores, whose primary function is the acquisition of iron(III) as an essential nutrient and growth factor for many soil microorganisms. To that end, we selected desferrioxamine B (DFB) as an emblematic bacterial trishydroxamic siderophore and a synthetic analog, abbreviated (LCʸ,ᴾʳ)H₂, of the tetradentate rhodotorulic acid (RA) produced by yeasts. Firstly, the uranyl speciation with both ligands was assessed in the pH range 2–11 by potentiometry and visible absorption spectrophotometry. Equilibrium constants and absorption spectra for three [UO₂(DFB)Hₕ]⁽ʰ⁻¹⁾⁺ (h = 1–3) and five [UO₂(LCʸ,ᴾʳ)ₗHₕ]⁽²⁺ʰ⁻²ˡ⁾⁺ (−1 ≤ h ≤ 1 for l = 1 and h = 0–1 for l = 2) solution complexes were determined at 25.0 °C and I = 0.1 M KNO₃. Similar studies for the Fe³⁺/(LCʸ,ᴾʳ)²– system revealed the formation of five species having [Fe(LCʸ,ᴾʳ)]⁺, [Fe(LCʸ,ᴾʳ)OH], [Fe(LCʸ,ᴾʳ)(OH)₂]–, [Fe(LCʸ,ᴾʳ)₂H], and [Fe₂(LCʸ,ᴾʳ)₃] compositions. Then, the ability of DFB, (LCʸ,ᴾʳ)H₂, and citrate to solubilize either U or Pu from pitchblende-rich soils (soils 1 and 2) or freshly plutonium-contaminated soils (LBS and PG) was evaluated by performing batch extraction tests. U was extracted significantly only by citrate after a day. After one week, the amount of U complexed by citrate only slightly exceeded that measured for the siderochelates, following the order citrate > (LCʸ,ᴾʳ)H₂ ≥ DFB ≈ H₂O, and were comparatively very low. Pu was also more efficiently extracted by citrate than by DFB after a day, but only by a factor of ~2–3 for the PG soil, while the Pu concentration in the supernatant after one week was approximately the same for both natural chelators. It remained nearly constant for DFB between the 1st and 7th day, but drastically decreased in the case of citrate, suggesting chemical decomposition in the latter case. For the Fe-rich soils 1 and 2, the efficiencies of the three chelators to solubilize Fe after a day were of the same order of magnitude, decreasing in the order DFB > citrate > (LCʸ,ᴾʳ)H₂. However, after a week DFB had extracted ~1.5 times more Fe, whereas the amount extracted by the other chelators stayed constant. For the less Fe-rich LBS and PG soils contaminated by Pu, the amounts of extracted Fe were higher, especially after 7 days, and the DFB outperformed citrate by a factor of nearly 3. The higher capacity of the hexadentate DFB to extract Pu in the presence of Fe and its lower ability to mobilize U qualitatively agree with the respective complexation constant ratios, keeping in mind that both Pu-containing soils had a lower iron loading. Noticeably, (LCʸ,ᴾʳ)H₂ has roughly the same capacity as DFB to solubilize U, but it mobilizes less Fe than the hexadentate siderophore. Similarly, citrate has the highest capacity to extract Pu, but the lowest to extract Fe. Therefore, compared to DFB, (LCʸ,ᴾʳ)H₂ shows a better U/Fe extraction selectivity and citrate shows a better Pu/Fe selectivity.
Keywords	absorption ; chemical degradation ; citrates ; deferoxamine ; iron ; ligands ; pH ; plutonium ; radioactivity ; siderophores ; solubilization ; spectroscopy ; uranium ; uranyl ions
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1483112-0
ISSN	1879-1700 ; 0265-931X
ISSN (online)	1879-1700
ISSN	0265-931X
DOI	10.1016/j.jenvrad.2021.106645
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Article ; Online: Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein.

Escriou, Nicolas / Callendret, Benoît / Lorin, Valérie / Combredet, Chantal / Marianneau, Philippe / Février, Michèle / Tangy, Frédéric

Virology

2014 Volume 452-453, Page(s) 32–41

Abstract: The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. ... ...

Abstract	The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the respiratory tract, a vaccine inducing mucosal long-term protection would be an asset to control new epidemics. To this aim, we generated live attenuated recombinant measles vaccine (MV) candidates expressing either the membrane-anchored SARS-CoV spike (S) protein or its secreted soluble ectodomain (Ssol). In mice susceptible to measles virus, recombinant MV expressing the anchored full-length S induced the highest titers of neutralizing antibodies and fully protected immunized animals from intranasal infectious challenge with SARS-CoV. As compared to immunization with adjuvanted recombinant Ssol protein, recombinant MV induced stronger and Th1-biased responses, a hallmark of live attenuated viruses and a highly desirable feature for an antiviral vaccine.
MeSH term(s)	Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Genetic Vectors/genetics ; Genetic Vectors/immunology ; Humans ; Male ; Measles Vaccine/genetics ; Measles Vaccine/immunology ; Measles virus/genetics ; Measles virus/immunology ; Mice ; SARS Virus/genetics ; SARS Virus/immunology ; SARS Virus/physiology ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/virology ; Spike Glycoprotein, Coronavirus/administration & dosage ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Th1 Cells/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Measles Vaccine ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike glycoprotein, SARS-CoV
Keywords	covid19
Language	English
Publishing date	2014-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2014.01.002
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Article ; Online: CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection

Angelita Rebollo / Karim Dorgham / Michèle Février

Viruses, Vol 3, Iss 5, Pp 586-

Role of Apoptosis

2011 Volume 612

Abstract	Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and systemic immune hyperactivation are the hallmarks of HIV infection. The end of acute infection is associated with the emergence of specific CD4+ and CD8+ T cell responses and the establishment of a chronic phase of infection. Abnormal levels of immune activation and inflammation persist despite a low steady state level of viremia. Although the causes of persistent immune hyperactivation remain incompletely characterized, physiological alterations of gastrointestinal tract probably play a major role. Failure to restore Th17 cells in gut-associated lymphoid tissues (GALT) might impair the recovery of the gut mucosal barrier. This review discusses recent advances on understanding the contribution of CD4+ T cell depletion to HIV pathogenesis.
Keywords	apoptosis ; HIV ; viral proteins ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	570
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Urine toxicological screening method using an immunoenzymatic assay based on a biochip array technology: comparative study with immunochromatography and Liquid chromatography–mass spectrometry

Metsu, David / Nouhaud, Malika / El-Balkhi, Souleiman / Lavit, Michel / Paillard, Hélène / Berthomès, Pierre / Martinez, Chantal / Gicquel-Bordelongue, Nathalie / Blonstein, Benjamin / Latier, Julien / Billoré, Sabine / Chassagne, Claire / Lanot, Thomas / Février, Frédéric

Annales de biologie clinique

2022 Volume 80, Issue 4, Page(s) 369–384

Abstract: Multiparametric toxicology research is mainly based on immunochromatography [IC] and chromatography methods. A new automated method using an immunoenzymatic (IE) assay based on a biochip array technology combines short turning around time and analytical ... ...

Title translation	Criblage toxicologique urinaire par une méthode automatisée immunoenzymatique multiparamétrique basée sur une technique de biopuce : comparaison à de l'immunochromatographie et de la chromatographie liquide couplée à de la spectrométrie de masse
Abstract	Multiparametric toxicology research is mainly based on immunochromatography [IC] and chromatography methods. A new automated method using an immunoenzymatic (IE) assay based on a biochip array technology combines short turning around time and analytical performances close to chromatography in terms of positivity cut-off. The aim of our study was to compare IE versus IC and chromatography methods using urines samples from clinical cases. Seventy-two samples were analyzed by IC (amphetamines, opiates, benzodiazepines, THC, methadone, cocaine), IE and chromatography (previous classes plus opioids and cathinone). Immunochromatography results were read by at least 7 operators to assess reading subjectivity. Immunoenzymatic, IC, and chromatrography results were compared with each other. Chromatographic quantification was analyzed to understand discrepancies. Significant discrepancies (29-64%) were observed between IC and IE for most of the drug families investigated except for benzodiazepines, methadone and opiates. These discrepancies were not identified between IE and chromatography, except for some substances (28% to 67% discrepancies for buprenorphine, tramadol and oxycodone, 100% for cathinone). In contrast to IC, the performance of IE approached those of chromatography, except for some substances for which cross-reactions must be investigated. Reading discrepancies were frequent with IC (33% of samples) and made robust result output challenging. In conclusion, the Multistat® is an interesting method for first-line toxicological screening for laboratories without chromatography method.
MeSH term(s)	Analgesics, Opioid ; Benzodiazepines ; Chromatography, Affinity ; Chromatography, Liquid/methods ; Humans ; Mass Spectrometry/methods ; Methadone ; Opiate Alkaloids
Chemical Substances	Analgesics, Opioid ; Opiate Alkaloids ; Benzodiazepines (12794-10-4) ; Methadone (UC6VBE7V1Z)
Language	French
Publishing date	2022-09-13
Publishing country	France
Document type	Journal Article
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2022.1744
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Article: Polyphenol profile, PPO activity and pH variation in relation to colour changes in a series of red-fleshed apple juices

Février, Hélène / Gildas Le Bail / Jean-Michel Le Quéré / Sylvain Guyot

Lebensmittel-Wissenschaft + [i.e. und] Technologie. 2017 Nov., v. 85

2017

Abstract: Recently, rosé ciders and pink apple juices, appeared as a real opportunity to diversify the offer. Juices obtained from red-fleshed apple varieties were used to study the impact of raw material on colour intensity and stability. Juices prevented from ... ...

Abstract	Recently, rosé ciders and pink apple juices, appeared as a real opportunity to diversify the offer. Juices obtained from red-fleshed apple varieties were used to study the impact of raw material on colour intensity and stability. Juices prevented from oxidation were compared to the corresponding oxidised juices. Juice colours were measured in the CIE Lab space. Polyphenoloxidase activity and pH were measured. Detailed phenolic composition, including anthocyanins, was characterised by reversed phase HPLC coupled to UV-visible and MS detection. Red-fleshed apple varieties revealed great variation regarding red colour intensity of the juice and its enzymatic oxidative degradation. Statistical classification of juices highlighted three behaviours regarding colour and colour degradation; (i) highly coloured juices resistant to colour degradation, (ii) red juices that shifted to orange-yellow colour and (iii) red juices that became pale. No factor could explain alone, nor the classification of juices, nor the oxidation of anthocyanin. Colour degradation must be considered as a multifactorial evolution. Results suggested that PPO activity, pH, concentration of PPO favourite substrates are among the main factors involved, but the amount of the other polyphenols (dihydrochalcones, catechins and procyanindins) must also be taken into account.
Keywords	anthocyanins ; apple juice ; apples ; catechol oxidase ; ciders ; color ; enzyme activity ; flavanols ; oxidation ; pH ; polyphenols ; raw materials ; reversed-phase high performance liquid chromatography
Language	English
Dates of publication	2017-11
Size	p. 353-362.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2016.11.006
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficiency of dihydroxamic and trihydroxamic siderochelates to extract uranium and plutonium from contaminated soils.

Journal of environmental radioactivity

2021 Volume 235-236, Page(s) 106645

Abstract	Actinide-based mineral phases occurring in contaminated soils can be solubilized by organic chelators excreted by plants, such as citrate. Herein, the efficiency of citrate towards U and Pu extraction is compared to that of siderophores, whose primary function is the acquisition of iron(III) as an essential nutrient and growth factor for many soil microorganisms. To that end, we selected desferrioxamine B (DFB) as an emblematic bacterial trishydroxamic siderophore and a synthetic analog, abbreviated (L
MeSH term(s)	Ferric Compounds ; Plutonium ; Radiation Monitoring ; Soil ; Uranium
Chemical Substances	Ferric Compounds ; Soil ; Uranium (4OC371KSTK) ; Plutonium (53023GN24M)
Language	English
Publishing date	2021-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1483112-0
ISSN	1879-1700 ; 0265-931X
ISSN (online)	1879-1700
ISSN	0265-931X
DOI	10.1016/j.jenvrad.2021.106645
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Article ; Online: Metallic nanoparticle chains on dielectric waveguides: coupled and uncoupled situations compared.

Février, Mickaël / Gogol, Philippe / Lourtioz, Jean-Michel / Dagens, Béatrice

Optics express

2013 Volume 21, Issue 21, Page(s) 24504–24513

Abstract: We investigate the optical behaviors of metallic nanoparticle (MNP) chains supporting localized surface plasmon (LSP) for different distances between particles. MNPs are excited through the fundamental TE mode of a silicon waveguide. Finite difference ... ...

Abstract	We investigate the optical behaviors of metallic nanoparticle (MNP) chains supporting localized surface plasmon (LSP) for different distances between particles. MNPs are excited through the fundamental TE mode of a silicon waveguide. Finite difference time domain (FDTD) calculations and optical power transmission measurements reveal three different behaviors. For short distances between particles, dipolar coupling occurs, and the MNP chain behaves as a waveguide. For the longest distances, nanoparticles are uncoupled, and the MNP chain acts as a LSP Bragg grating. Finally, for intermediate distances, we observe one behavior at a time, i.e. dipolar coupling or LSP Bragg reflection. There is only a small range of wavelengths within which both behaviors can coexist.
Language	English
Publishing date	2013-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.21.024504
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Article: La sclérose latérale amyotrophique, une maladie au diagnostic complexe.

Catteau, Aurélie / Février, Michelle / Khoumri, Katia / Rabec, Claudio / Giroud, Maurice

Revue de l'infirmiere

2013 , Issue 188, Page(s) 14–16

Abstract: Amyotrophic lateral sclerosis is a degenerative disease with no known cause, no specific presenting symptoms and which results in incapacity and disability. Diagnosis is often delayed. Multi-disciplinary care is essential. ...

Title translation	Amyotrophic lateral sclerosis, a disease with a complex diagnosis.
Abstract	Amyotrophic lateral sclerosis is a degenerative disease with no known cause, no specific presenting symptoms and which results in incapacity and disability. Diagnosis is often delayed. Multi-disciplinary care is essential.
MeSH term(s)	Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/genetics ; Diagnosis, Differential ; Electromyography ; Humans
Language	French
Publishing date	2013-02
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	632538-5
ISSN	1293-8505 ; 0397-7900
ISSN	1293-8505 ; 0397-7900
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Article: Réflexion sur les soins infirmiers aux patients souffrant de sclérose latérale amyotrophique.

Patte, Adeline / Personnier, Blandine / Février, Michelle

Revue de l'infirmiere

2010 , Issue 159, Page(s) 38–40

Title translation	Reflections on the nursing care of patients with amyotrophic lateral sclerosis.
MeSH term(s)	Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/nursing ; Amyotrophic Lateral Sclerosis/psychology ; Baths ; Communication ; Humans ; Nurse's Role ; Nutritional Support ; Oxygen Inhalation Therapy ; Patient Care Planning/organization & administration ; Patient Care Team/organization & administration ; Patient Participation ; Quality Assurance, Health Care
Language	French
Publishing date	2010-04
Publishing country	France
Document type	Journal Article
ZDB-ID	632538-5
ISSN	1293-8505 ; 0397-7900
ISSN	1293-8505 ; 0397-7900
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