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  1. Article: [PATHOGENIC MEMORY THE2 CELLS INDUCE CONJUNCTIVAL ITCH VIA IL-33-ST2-CGRP AXIS].

    Onoue, Miki / Hirahara, Kiyoshi

    Arerugi = [Allergy

    2024  Volume 73, Issue 2, Page(s) 160–164

    MeSH term(s) Humans ; Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; Calcitonin Gene-Related Peptide ; Th2 Cells
    Chemical Substances Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language Japanese
    Publishing date 2024-02-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.73.160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 245: Show issues Location:
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  2. Article ; Online: Pathogenicity of acquired immunity in human diseases.

    Hirahara, Kiyoshi

    Seminars in immunopathology

    2019  Volume 41, Issue 3, Page(s) 279–281

    MeSH term(s) Adaptive Immunity ; Animals ; Disease Susceptibility/immunology ; Host-Pathogen Interactions/immunology ; Humans ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
    Language English
    Publishing date 2019-05-07
    Publishing country Germany
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-019-00739-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [THE DIVERSE ROLES OF MEMORY-TYPE PATHOGENIC Th2 CELLS IN CHRONIC ALLERGIC INFLAMMATION].

    Hirahara, Kiyoshi / Onoue, Miki / Yokoyama, Mikiko / Nakayama, Toshinori

    Arerugi = [Allergy

    2022  Volume 71, Issue 4, Page(s) 297–300

    MeSH term(s) Cytokines ; Humans ; Hypersensitivity ; Immunologic Memory ; Inflammation ; Th2 Cells
    Chemical Substances Cytokines
    Language Japanese
    Publishing date 2022-06-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.71.297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Memory-type pathogenic T

    Hirahara, Kiyoshi / Aoki, Ami / Kiuchi, Masahiro / Nakayama, Toshinori

    The Journal of allergy and clinical immunology

    2021  Volume 147, Issue 6, Page(s) 2063–2066

    MeSH term(s) Animals ; Biomarkers ; Cytokines/metabolism ; Disease Susceptibility/immunology ; Humans ; Hypersensitivity/etiology ; Hypersensitivity/metabolism ; Hypersensitivity/pathology ; Immunity, Innate ; Immunologic Memory ; Organ Specificity ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th2 Cells/immunology ; Th2 Cells/metabolism
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hepatic ketone body regulation of renal gluconeogenesis.

    Hatano, Ryo / Lee, Eunyoung / Sato, Hiromi / Kiuchi, Masahiro / Hirahara, Kiyoshi / Nakagawa, Yoshimi / Shimano, Hitoshi / Nakayama, Toshinori / Tanaka, Tomoaki / Miki, Takashi

    Molecular metabolism

    2024  Volume 84, Page(s) 101934

    Abstract: Objectives: During fasting, liver pivotally regulates blood glucose levels through glycogenolysis and gluconeogenesis. Kidney also produces glucose through gluconeogenesis. Gluconeogenic genes are transactivated by fasting, but their expression patterns ...

    Abstract Objectives: During fasting, liver pivotally regulates blood glucose levels through glycogenolysis and gluconeogenesis. Kidney also produces glucose through gluconeogenesis. Gluconeogenic genes are transactivated by fasting, but their expression patterns are chronologically different between the two organs. We find that renal gluconeogenic gene expressions are positively correlated with the blood β-hydroxybutyrate concentration. Thus, we herein aim to investigate the regulatory mechanism and its physiological implications.
    Methods: Gluconeogenic gene expressions in liver and kidney were examined in hyperketogenic mice such as high-fat diet (HFD)-fed and ketogenic diet-fed mice, and in hypoketogenic PPARα knockout (PPARα
    Results: Renal gluconeogenic genes were transactivated concurrently with blood β-hydroxybutyrate uprise under ketogenic states, but the increase was blunted in hypoketogenic PPARα
    Conclusions: Our findings demonstrate that β-hydroxybutyrate mediates hepato-renal interaction to maintain homeostatic regulation of blood glucose and systemic acid-base balance through renal gluconeogenesis regulation.
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2024.101934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The roles of tertiary lymphoid structures in chronic diseases.

    Sato, Yuki / Silina, Karina / van den Broek, Maries / Hirahara, Kiyoshi / Yanagita, Motoko

    Nature reviews. Nephrology

    2023  Volume 19, Issue 8, Page(s) 525–537

    Abstract: Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique ... ...

    Abstract Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions. The presumed influence of TLSs on the disease course has led to widespread interest in obtaining a better understanding of their biology and function. Studies using single-cell analyses have suggested heterogeneity in TLS composition and phenotype, and consequently, functional correlates with disease progression are sometimes conflicting. The presence of TLSs correlates with a favourable disease course in cancer and infection. Conversely, in autoimmune diseases and chronic age-related inflammatory diseases including chronic kidney disease, the presence of TLSs is associated with a more severe disease course. However, the detailed mechanisms that underlie these clinical associations are not fully understood. To what extent the mechanisms of TLS development and maturation are shared across organs and diseases is also still obscure. Improved understanding of TLS development and function at the cellular and molecular levels may enable the exploitation of these structures to improve therapies for chronic diseases, including chronic kidney disease.
    MeSH term(s) Humans ; Tertiary Lymphoid Structures/genetics ; Tertiary Lymphoid Structures/pathology ; Neoplasms ; Disease Progression ; Chronic Disease ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00706-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
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  7. Article ; Online: Pathogenic helper T cells.

    Hirahara, Kiyoshi / Aoki, Ami / Nakayama, Toshinori

    Allergology international : official journal of the Japanese Society of Allergology

    2021  Volume 70, Issue 2, Page(s) 169–173

    Abstract: Intractable chronic inflammatory diseases, including autoimmune diseases, autoinflammatory diseases and allergic diseases, are caused by disruption or failure of the immune system. Pathogenic immune cells are presumed to be closely related to the ... ...

    Abstract Intractable chronic inflammatory diseases, including autoimmune diseases, autoinflammatory diseases and allergic diseases, are caused by disruption or failure of the immune system. Pathogenic immune cells are presumed to be closely related to the pathogenesis of intractable diseases, but the precise cellular and molecular mechanisms underlying the pathogenesis of these diseases remain unclear. The balance between the T helper type 1 (Th1) and Th2 cell fractions has been believed to be responsible for the differences among inflammatory diseases. However, an analysis of the cells infiltrating inflammatory lesions in mice and humans revealed the generation of pathogenic Th cells with different characteristics at the memory T-cell stage in the peripheral tissues in various inflammatory diseases. In this review, we will summarize and discuss recent progress regarding the characteristics of pathogenic Th cells, their mode of action, and the molecular mechanisms that regulate the pathology of intractable chronic inflammatory diseases, particularly those with tissue fibrosis. We hope this article will help clarify the pathogenesis of these diseases and propose a future direction for research.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Fibrosis ; Humans ; Hypersensitivity/immunology ; Immunologic Memory ; Inflammation/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5248: Show issues Location:
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  8. Article: [THE CRUCIAL ROLES OF ST2-POSITIVE PATHOGENIC CD4 T CELLS IN THE IMPAIRMENT OF THE LUNG BARRIER FUNCTION].

    Hirahara, Kiyoshi / Nakayama, Toshinori

    Arerugi = [Allergy

    2018  Volume 67, Issue 3, Page(s) 179–186

    MeSH term(s) CD4-Positive T-Lymphocytes ; Cytokines ; Interleukin-33 ; Lung ; Receptors, Interleukin
    Chemical Substances Cytokines ; Interleukin-33 ; Receptors, Interleukin
    Language Japanese
    Publishing date 2018-02-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.67.179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab.

    Suga, Kensuke / Kiuchi, Masahiro / Kageyama, Takahiro / Kokubo, Kota / Tanaka, Shigeru / Iwata, Arifumi / Suzuki, Kotaro / Hirahara, Kiyoshi / Nakajima, Hiroshi

    Allergology international : official journal of the Japanese Society of Allergology

    2023  Volume 72, Issue 4, Page(s) 610–613

    MeSH term(s) Humans ; Leukocytes, Mononuclear ; Kimura Disease ; Antibodies, Monoclonal, Humanized/therapeutic use ; Sequence Analysis, RNA
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Letter
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis.

    Kokubo, Kota / Onodera, Atsushi / Kiuchi, Masahiro / Tsuji, Kaori / Hirahara, Kiyoshi / Nakayama, Toshinori

    Frontiers in immunology

    2022  Volume 13, Page(s) 945063

    Abstract: Type 2 helper T (Th2) cells, a subset of ... ...

    Abstract Type 2 helper T (Th2) cells, a subset of CD4
    MeSH term(s) Allergens ; Cytokines ; Fibrosis ; Humans ; Inflammation ; Th2 Cells
    Chemical Substances Allergens ; Cytokines
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.945063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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