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Article ; Online: Modulation of SUR1 K

Luu, Wing / Bjork, James / Salo, Erin / Entenmann, Nicole / Jurgenson, Taylor / Fisher, Cole / Klein, Amanda H

International journal of molecular sciences

2019 Volume 20, Issue 9

Abstract: The ATP-sensitive K ...

Abstract	The ATP-sensitive K
MeSH term(s)	Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Diazoxide/pharmacology ; Diazoxide/therapeutic use ; Evoked Potentials ; Female ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Potassium Channels, Inwardly Rectifying/metabolism ; Spinal Nerves/drug effects ; Spinal Nerves/metabolism ; Spinal Nerves/physiopathology ; Sulfonylurea Receptors/agonists ; Sulfonylurea Receptors/genetics ; Sulfonylurea Receptors/metabolism ; Touch
Chemical Substances	Abcc8 protein, mouse ; Analgesics ; Kir6.2 channel ; Potassium Channels, Inwardly Rectifying ; Sulfonylurea Receptors ; Diazoxide (O5CB12L4FN)
Language	English
Publishing date	2019-05-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20092251
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Article ; Online: KNNENS: A k-Nearest Neighbor Ensemble-Based Method for Incremental Learning Under Data Stream With Emerging New Classes.

Zhang, Jianjun / Wang, Ting / Ng, Wing W Y / Pedrycz, Witold

IEEE transactions on neural networks and learning systems

2023 Volume 34, Issue 11, Page(s) 9520–9527

Abstract: ... Therefore, we propose the k -Nearest Neighbor ENSemble-based method (KNNENS) to handle these problems. The KNNENS is ...

Abstract	In this brief, we investigate the problem of incremental learning under data stream with emerging new classes (SENC). In the literature, existing approaches encounter the following problems: 1) yielding high false positive for the new class; i) having long prediction time; and 3) having access to true labels for all instances, which is unrealistic and unacceptable in real-life streaming tasks. Therefore, we propose the k -Nearest Neighbor ENSemble-based method (KNNENS) to handle these problems. The KNNENS is effective to detect the new class and maintains high classification performance for known classes. It is also efficient in terms of run time and does not require true labels of new class instances for model update, which is desired in real-life streaming classification tasks. Experimental results show that the KNNENS achieves the best performance on four benchmark datasets and three real-world data streams in terms of accuracy and F1-measure and has a relatively fast run time compared to four reference methods. Codes are available at https://github.com/Ntriver/KNNENS.
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3149991
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Book ; Online: A Fully Dynamic Algorithm for k-Regret Minimizing Sets

Wang, Yanhao / Li, Yuchen / Wong, Raymond Chi-Wing / Tan, Kian-Lee

2020

Abstract: ... such as multi-criteria decision making, web search, and recommendation. The $k$-regret minimizing set ($k$-RMS ... of tuples with multiple numerical attributes, the $k$-RMS problem returns a size-$r$ subset $Q$ of $P$ ... of the $k$\textsuperscript{th}-ranked tuple in $P$. Although the $k$-RMS problem has been extensively studied ...

Abstract	Selecting a small set of representatives from a large database is important in many applications such as multi-criteria decision making, web search, and recommendation. The $k$-regret minimizing set ($k$-RMS) problem was recently proposed for representative tuple discovery. Specifically, for a large database $P$ of tuples with multiple numerical attributes, the $k$-RMS problem returns a size-$r$ subset $Q$ of $P$ such that, for any possible ranking function, the score of the top-ranked tuple in $Q$ is not much worse than the score of the $k$\textsuperscript{th}-ranked tuple in $P$. Although the $k$-RMS problem has been extensively studied in the literature, existing methods are designed for the static setting and cannot maintain the result efficiently when the database is updated. To address this issue, we propose the first fully-dynamic algorithm for the $k$-RMS problem that can efficiently provide the up-to-date result w.r.t.~any insertion and deletion in the database with a provable guarantee. Experimental results on several real-world and synthetic datasets demonstrate that our algorithm runs up to four orders of magnitude faster than existing $k$-RMS algorithms while returning results of nearly equal quality. Comment: 15 pages, 11 figures; to appear in ICDE 2021
Keywords	Computer Science - Databases ; Computer Science - Data Structures and Algorithms
Subject code	006
Publishing date	2020-05-29
Publishing country	us
Document type	Book ; Online
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Article ; Online: Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K

Li, Jiexin / Lam, Wendy Wai-Ling / Lai, Tsz-Wah / Au, Shannon Wing-Ngor

Biochemical and biophysical research communications

2017 Volume 493, Issue 2, Page(s) 1115–1121

Abstract: ... exerts its effects primarily on nuclear Ubc9 and this process is mediated by K ...

Abstract	Listeriolysin O (LLO) is a pore-forming toxin produced by L. monocytogenes, and is belonged to a protein family of cholesterol-dependent cytolysins (CDCs). Previous studies have demonstrated that LLO triggers Ubc9 degradation and disrupts host SUMOylation to facilitate bacterial infection. However, the underlying mechanism of Ubc9 degradation is unclear. Here we show that LLO-induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling. Additionally, LLO exerts its effects primarily on nuclear Ubc9 and this process is mediated by K
MeSH term(s)	Bacterial Toxins/metabolism ; Cations, Monovalent/metabolism ; HeLa Cells ; Heat-Shock Proteins/metabolism ; Hemolysin Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Listeria monocytogenes/physiology ; Listeriosis/metabolism ; Listeriosis/microbiology ; Phosphorylation ; Potassium/metabolism ; Proteolysis ; Sumoylation ; Ubiquitin-Conjugating Enzymes/metabolism
Chemical Substances	Bacterial Toxins ; Cations, Monovalent ; Heat-Shock Proteins ; Hemolysin Proteins ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; ubiquitin-conjugating enzyme UBC9 (EC 6.3.2.-) ; hlyA protein, Listeria monocytogenes (R06ZRQ1YX9) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2017-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.09.051
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Article ; Online: Vitamin K intake and mortality in people with chronic kidney disease from NHANES III.

Cheung, Ching-Lung / Sahni, Shivani / Cheung, Bernard M Y / Sing, Chor-Wing / Wong, Ian C K

Clinical nutrition (Edinburgh, Scotland)

2015 Volume 34, Issue 2, Page(s) 235–240

Abstract: ... with chronic kidney disease (CKD), partly due to increased vascular calcification. Vitamin K plays a role in preventing ... vascular calcification in CKD yet the relationship between vitamin K intake and mortality in CKD patients remains unclear ... Health and Nutrition Examination Survey. Vitamin K intake was estimated from 24-h dietary recalls (1988 ...

Abstract	Background & aims: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD), partly due to increased vascular calcification. Vitamin K plays a role in preventing vascular calcification in CKD yet the relationship between vitamin K intake and mortality in CKD patients remains unclear. Methods: This observational cohort study included 3401 participants with CKD from the Third National Health and Nutrition Examination Survey. Vitamin K intake was estimated from 24-h dietary recalls (1988-94). Mortality was determined from the National Death Index records through 2006. Cox-proportional hazards regression was used to estimate Hazard Ratios (HR) by comparing those with adequate intake of vitamin K to those with low intake, adjusting for advanced CKD covariates. For sensitivity analysis, these associations were also examined among those with different renal status. Results: During a median follow-up of 13.3 years (37,408 person-years), 1815 and 876 participants died from all-cause and CVD causes, respectively. 72% of the participants had vitamin K intake lower than the recommended adequate intake. Participants with vitamin K intake higher than recommended adequate intake for vitamin K were associated with lower risk of all-cause (HR = 0.85; 95%: 0.72-1; P = 0.047) and CVD mortality (HR = 0.78; 95%: 0.64-95; P = 0.016). Sensitivity analyses in subgroups with advanced CKD revealed similar findings. Conclusions: This observational study suggests that adequate intake of vitamin K may be associated with reduced all-cause and CVD mortality in CKD patients. However, vitamin K may be a marker of a healthy diet; therefore clinical trials may help in clarifying the effect of vitamin K independent of a healthy diet.
MeSH term(s)	Adult ; Aged ; Antifibrinolytic Agents/administration & dosage ; Antifibrinolytic Agents/blood ; Antifibrinolytic Agents/therapeutic use ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cohort Studies ; Data Collection/methods ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Observation ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/mortality ; Vitamin K/administration & dosage ; Vitamin K/blood ; Vitamin K/therapeutic use ; Vitamins/administration & dosage ; Vitamins/blood ; Vitamins/therapeutic use
Chemical Substances	Antifibrinolytic Agents ; Vitamins ; Vitamin K (12001-79-5)
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2014.03.011
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Article ; Online: BatMis: a fast algorithm for k-mismatch mapping.

Tennakoon, Chandana / Purbojati, Rikky W / Sung, Wing-Kin

Bioinformatics (Oxford, England)

2012 Volume 28, Issue 16, Page(s) 2122–2128

Abstract: ... to align short reads to a reference allowing k mismatches. BatMis is a Burrows-Wheeler transformation based ... that BatMis performs better than competing aligners in solving the k-mismatch problem. Furthermore ... alternative for applications where fast k-mismatch mappings, unique mappings or multiple mappings of SGS data ...

Abstract	Motivation: Second-generation sequencing (SGS) generates millions of reads that need to be aligned to a reference genome allowing errors. Although current aligners can efficiently map reads allowing a small number of mismatches, they are not well suited for handling a large number of mismatches. The efficiency of aligners can be improved using various heuristics, but the sensitivity and accuracy of the alignments are sacrificed. In this article, we introduce Basic Alignment tool for Mismatches (BatMis)--an efficient method to align short reads to a reference allowing k mismatches. BatMis is a Burrows-Wheeler transformation based aligner that uses a seed and extend approach, and it is an exact method. Results: Benchmark tests show that BatMis performs better than competing aligners in solving the k-mismatch problem. Furthermore, it can compete favorably even when compared with the heuristic modes of the other aligners. BatMis is a useful alternative for applications where fast k-mismatch mappings, unique mappings or multiple mappings of SGS data are required. Availability and implementation: BatMis is written in C/C++ and is freely available from http://code.google.com/p/batmis/
MeSH term(s)	Algorithms ; Computational Biology/methods ; Genomics/methods ; Sequence Alignment/methods ; Sequence Analysis, DNA/methods ; Software
Language	English
Publishing date	2012-08-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/bts339
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Article: Inclusive K(S);(0)K(S);(0) resonance production in ep collisions at HERA.

Chekanov, S / Derrick, M / Magill, S / Musgrave, B / Nicholass, D / Repond, J / Yoshida, R / Mattingly, M C K / Antonioli, P / Bari, G / Bellagamba, L / Boscherini, D / Bruni, A / Bruni, G / Cindolo, F / Corradi, M / Iacobucci, G / Margotti, A / Nania, R /

Polini, A / Antonelli, S / Basile, M / Bindi, M / Cifarelli, L / Contin, A / De Pasquale, S / Sartorelli, G / Zichichi, A / Bartsch, D / Brock, I / Hartmann, H / Hilger, E / Jakob, H-P / Jüngst, M / Nuncio-Quiroz, A E / Paul, E / Samson, U / Schönberg, V / Shehzadi, R / Wlasenko, M / Brook, N H / Heath, G P / Morris, J D / Capua, M / Fazio, S / Mastroberardino, A / Schioppa, M / Susinno, G / Tassi, E / Kim, J Y / Ibrahim, Z A / Kamaluddin, B / Wan Abdullah, W A T / Ning, Y / Ren, Z / Sciulli, F / Chwastowski, J / Eskreys, A / Figiel, J / Galas, A / Gil, M / Olkiewicz, K / Stopa, P / Zawiejski, L / Adamczyk, L / Bołd, T / Grabowska-Bołd, I / Kisielewska, D / Lukasik, J / Przybycień, M / Suszycki, L / Kotański, A / Słomiński, W / Behrens, U / Blohm, C / Bonato, A / Borras, K / Ciesielski, R / Coppola, N / Fang, S / Fourletova, J / Geiser, A / Göttlicher, P / Grebenyuk, J / Gregor, I / Haas, T / Hain, W / Hüttmann, A / Januschek, F / Kahle, B / Katkov, I I / Klein, U / Kötz, U / Kowalski, H / Lobodzinska, E / Löhr, B / Mankel, R / Melzer-Pellmann, I-A / Miglioranzi, S / Montanari, A / Namsoo, T / Notz, D / Parenti, A / Rinaldi, L / Roloff, P / Rubinsky, I / Santamarta, R / Schneekloth, U / Spiridonov, A / Szuba, D / Szuba, J / Theedt, T / Wolf, G / Wrona, K / Yagües Molina, A G / Youngman, C / Zeuner, W / Drugakov, V / Lohmann, W / Schlenstedt, S / Barbagli, G / Gallo, E / Pelfer, P G / Bamberger, A / Dobur, D / Karstens, F / Vlasov, N N / Bussey, P J / Doyle, A T / Dunne, W / Forrest, M / Rosin, M / Saxon, D H / Skillicorn, I O / Gialas, I / Papageorgiu, K / Holm, U / Klanner, R / Lohrmann, E / Schleper, P / Schörner-Sadenius, T / Sztuk, J / Stadie, H / Turcato, M / Foudas, C / Fry, C / Long, K R / Tapper, A D / Matsumoto, T / Nagano, K / Tokushuku, K / Yamada, S / Yamazaki, Y / Barakbaev, A N / Boos, E G / Pokrovskiy, N S / Zhautykov, B O / Aushev, V / Borodin, M / Kadenko, I / Kozulia, A / Libov, V / Lisovyi, M / Lontkovskyi, D / Makarenko, I / Sorokin, Iu / Verbytskyi, A / Volynets, O / Son, D / de Favereau, J / Piotrzkowski, K / Barreiro, F / Glasman, C / Jimenez, M / Labarga, L / Del Peso, J / Ron, E / Soares, M / Terrón, J / Zambrana, M / Corriveau, F / Liu, C / Schwartz, J / Walsh, R / Zhou, C / Tsurugai, T / Antonov, A / Dolgoshein, B A / Gladkov, D / Sosnovtsev, V / Stifutkin, A / Suchkov, S / Dementiev, R K / Ermolov, P F / Gladilin, L K / Golubkov, Yu A / Khein, L A / Korzhavina, I A / Kuzmin, V A / Levchenko, B B / Lukina, O Yu / Proskuryakov, A S / Shcheglova, L M / Zotkin, D S / Abt, I / Caldwell, A / Kollar, D / Reisert, B / Schmidke, W B / Grigorescu, G / Keramidas, A / Koffeman, E / Kooijman, P / Pellegrino, A / Tiecke, H / Vázquez, M / Wiggers, L / Brümmer, N / Bylsma, B / Durkin, L S / Lee, A / Ling, T Y / Allfrey, P D / Bell, M A / Cooper-Sarkar, A M / Devenish, R C E / Ferrando, J / Foster, B / Korcsak-Gorzo, K / Oliver, K / Robertson, A / Uribe-Estrada, C / Walczak, R / Bertolin, A / Dal Corso, F / Dusini, S / Longhin, A / Stanco, L / Bellan, P / Brugnera, R / Carlin, R / Garfagnini, A / Limentani, S / Oh, B Y / Raval, A / Ukleja, J / Whitmore, J J / Iga, Y / D'Agostini, G / Marini, G / Nigro, A / Cole, J E / Hart, J C / Abramowicz, H / Ingbir, R / Kananov, S / Levy, A / Stern, A / Kuze, M / Maeda, J / Hori, R / Kagawa, S / Okazaki, N / Shimizu, S / Tawara, T / Hamatsu, R / Kaji, H / Kitamura, S / Ota, O / Ri, Y D / Costa, M / Ferrero, M I / Monaco, V / Sacchi, R / Solano, A / Arneodo, M / Ruspa, M / Fourletov, S / Martin, J F / Stewart, T P / Boutle, S K / Butterworth, J M / Gwenlan, C / Jones, T W / Loizides, J H / Wing, M / Brzozowska, B / Ciborowski, J / Grzelak, G / Kulinski, P / Luzniak, P / Malka, J / Nowak, R J / Pawlak, J M / Tymieniecka, T / Ukleja, A / Zarnecki, A F / Adamus, M / Plucinski, P / Eisenberg, Y / Hochman, D / Karshon, U / Brownson, E / Danielson, T / Everett, A / Kçira, D / Reeder, D D / Ryan, P / Savin, A A / Smith, W H / Wolfe, H / Bhadra, S / Catterall, C D / Cui, Y / Hartner, G / Menary, S / Noor, U / Standage, J / Whyte, J

Physical review letters

2008 Volume 101, Issue 11, Page(s) 112003

Abstract: Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied ... significance of 5 standard deviations. However, if this state is the same as that seen in gammagamma-->K_{S};{0 ... K_{S};{0}, it is unlikely to be a pure glueball state. ...

Abstract	Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied with the ZEUS detector using an integrated luminosity of 0.5 fb;{-1}. Enhancements in the mass spectrum were observed and are attributed to the production of f_{2}(1270)/a_{2};{0}(1320), f_{2};{'}(1525) and f_{0}(1710). Masses and widths were obtained using a fit which takes into account theoretical predictions based on SU(3) symmetry arguments, and are consistent with the Particle Data Group values. The f_{0}(1710) state, which has a mass consistent with a glueball candidate, was observed with a statistical significance of 5 standard deviations. However, if this state is the same as that seen in gammagamma-->K_{S};{0}K_{S};{0}, it is unlikely to be a pure glueball state.
Language	English
Publishing date	2008-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.101.112003
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Article: Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K+ efflux

Li, Jiexin / Shannon Wing-ngor Au / Tsz-wah Lai / Wendy Wai-ling Lam

Biochemical and biophysical research communications. 2017,

2017

Abstract: ... exerts its effects primarily on nuclear Ubc9 and this process is mediated by K+ efflux. Interestingly ... for intracellular CDCs such as pneumolysin and suilysin, blockage of K+ efflux enhances degradation of nuclear Ubc9 ...

Abstract	Listeriolysin O (LLO) is a pore-forming toxin produced by L. monocytogenes, and is belonged to a protein family of cholesterol-dependent cytolysins (CDCs). Previous studies have demonstrated that LLO triggers Ubc9 degradation and disrupts host SUMOylation to facilitate bacterial infection. However, the underlying mechanism of Ubc9 degradation is unclear. Here we show that LLO-induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling. Additionally, LLO exerts its effects primarily on nuclear Ubc9 and this process is mediated by K+ efflux. Interestingly, for intracellular CDCs such as pneumolysin and suilysin, blockage of K+ efflux enhances degradation of nuclear Ubc9, suggesting that extracellular and intracellular pathogens may exploit different mechanisms to modulate host SUMOylation system. Furthermore, up-regulation of SUMOylation by stable expression of SUMO-1 or SUMO-2 shows a delay in membrane perforation by LLO, indicating that SUMO modification of host proteins may act at the frontline for the defense response against LLO. Taken together, our study provides insights to the understanding of host-pathogen interactions.
Keywords	bacterial infections ; host-pathogen relationships ; pathogens ; phosphorylation ; pneumolysin ; potassium ; proteins
Language	English
Size	p. .
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.09.051
Database	NAL-Catalogue (AGRICOLA)

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Article: Vitamin K intake and mortality in people with chronic kidney disease from NHANES III

Cheung, Ching-Lung / Bernard M.Y. Cheung / Chor-Wing Sing / Ian C.K. Wong / Shivani Sahni

Clinical nutrition. 2014,

2014

Abstract: ... CKD), partly due to increased vascular calcification. Vitamin K plays a role in preventing ... vascular calcification in CKD yet the relationship between vitamin K intake and mortality in CKD patients remains unclear ... Examination Survey. Vitamin K intake was estimated from 24-h dietary recalls (1988–94). Mortality was ...

Abstract	Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD), partly due to increased vascular calcification. Vitamin K plays a role in preventing vascular calcification in CKD yet the relationship between vitamin K intake and mortality in CKD patients remains unclear.This observational cohort study included 3401 participants with CKD from the Third National Health and Nutrition Examination Survey. Vitamin K intake was estimated from 24-h dietary recalls (1988–94). Mortality was determined from the National Death Index records through 2006. Cox-proportional hazards regression was used to estimate Hazard Ratios (HR) by comparing those with adequate intake of vitamin K to those with low intake, adjusting for advanced CKD covariates. For sensitivity analysis, these associations were also examined among those with different renal status.During a median follow-up of 13.3 years (37,408 person-years), 1815 and 876 participants died from all-cause and CVD causes, respectively. 72% of the participants had vitamin K intake lower than the recommended adequate intake. Participants with vitamin K intake higher than recommended adequate intake for vitamin K were associated with lower risk of all-cause (HR = 0.85; 95%: 0.72–1; P = 0.047) and CVD mortality (HR = 0.78; 95%: 0.64–95; P = 0.016). Sensitivity analyses in subgroups with advanced CKD revealed similar findings.This observational study suggests that adequate intake of vitamin K may be associated with reduced all-cause and CVD mortality in CKD patients. However, vitamin K may be a marker of a healthy diet; therefore clinical trials may help in clarifying the effect of vitamin K independent of a healthy diet.
Keywords	Adequate Intakes ; calcification ; cardiovascular diseases ; clinical trials ; cohort studies ; death ; diet recall ; healthy diet ; kidney diseases ; mortality ; National Health and Nutrition Examination Survey ; nutrition risk assessment ; observational studies ; patients ; vitamin K
Language	English
Size	p. .
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2014.03.011
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Modulation of SUR1 K ATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice

Wing Luu / James Bjork / Erin Salo / Nicole Entenmann / Taylor Jurgenson / Cole Fisher / Amanda H. Klein

International Journal of Molecular Sciences, Vol 20, Iss 9, p

2019 Volume 2251

Abstract: The ATP-sensitive K + channel (K ATP ) is involved in hypersensitivity during chronic pain and is ... presumed to be a downstream target of mu opioid receptors. Multiple subtypes of K ATP channels exist ... phenotypes in rodents. In this study, we investigated the different K ATP channel subunits that could be ...

Abstract	The ATP-sensitive K + channel (K ATP ) is involved in hypersensitivity during chronic pain and is presumed to be a downstream target of mu opioid receptors. Multiple subtypes of K ATP channels exist in the peripheral and central nervous system and their activity may be inversely correlated to chronic pain phenotypes in rodents. In this study, we investigated the different K ATP channel subunits that could be involved in neuropathic pain in mice. In chronic pain models utilizing spinal nerve ligation, SUR1 and Kir6.2 subunits were found to be significantly downregulated in dorsal root ganglia and the spinal cord. Local or intrathecal administration of SUR1-K ATP channel subtype agonists resulted in analgesia after spinal nerve ligation but not SUR2 agonists. In ex-vivo nerve recordings, administration of the SUR1 agonist diazoxide to peripheral nerve terminals decreased mechanically evoked potentials. Genetic knockdown of SUR1 through an associated adenoviral strategy resulted in mechanical hyperalgesia but not thermal hyperalgesia compared to control mice. Behavioral data from neuropathic mice indicate that local reductions in SUR1-subtype K ATP channel activity can exacerbate neuropathic pain symptoms. Since neuropathic pain is of major clinical relevance, potassium channels present a target for analgesic therapies, especially since they are expressed in nociceptors and could play an essential role in regulating the excitability of neurons involved in pain-transmission.
Keywords	neuropathy ; K ATP channels ; SUR1 ; Kir6.2 ; analgesia ; spinal nerve ligation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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