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Article ; Online: FISH painting for chromosome identification of aneuploid cauliflower (Brassica oleracea L. var. botrytis)

Ji, Xianwen / Aflitos, Saulo Alves / Peters, Sander / Schranz, Eric / Philipse-Berendsen, Jirska / Vogelaar, Aat / Lelivelt, Cilia / de Jong, Hans

Nucleus (India)

2023 Volume 66

Abstract: A common problem in the cultivation and breeding of cauliflower (Brassica oleracea L. var. botrytis ... of cauliflower (Brassica oleracea L. var. botrytis). Due to the genome triplication and various chromosome ... is the occurrence of aneuploids in offspring families. To reveal the chromosomal cause ...

Abstract	A common problem in the cultivation and breeding of cauliflower (Brassica oleracea L. var. botrytis) is the occurrence of aneuploids in offspring families. To reveal the chromosomal cause of such numerical variants, it was necessary to develop karyotype tools with which chromosomes can be easily identified. Since mitotic chromosomes in this crop are morphologically similar and lack differentiating banding patterns, we tested two Fluorescent in situ Hybridization (FISH) procedures for chromosome identification: (1) FISH painting with diagnostic repetitive DNA patterns and (2) cross-species chromosome painting. The first method consists of a five-colour FISH with 5s rDNA, 45S rDNA, and two Brassica rapa centromere-specific repeats, and a B. rapa BAC (KBrH092N02) containing a dispersed repeat of an unknown class. The second method is an advanced FISH technology based on hybridising DNA probes of a related species under adapted stringency conditions to identify their homoeologous loci. To this end, we applied four pools of BACs from Arabidopsis thaliana in a multicolour FISH for a banding pattern on the chromosomes of cauliflower (Brassica oleracea L. var. botrytis). Due to the genome triplication and various chromosome rearrangements of Brassica oleracea compared to Arabidopsis, we used MUMmer whole-genome alignment plot information to select Arabidopsis BAC pools with which all cauliflower chromosomes could be identified. In a sample of 21 plants with aberrant phenotypes, we demonstrated primary trisomy for chromosomes 1–6 and 8, and telo-trisomy for chromosomes 7 and 9. Finally, we discuss the advantages and drawbacks of the two painting methods and eventual alternatives for demonstrating numerical aberrations in the cauliflower populations. Graphical Abstract: [Figure not available: see fulltext.].
Keywords	Aneuploidy ; Brassica oleracea ; Cauliflower ; Chromosome identification ; Fluorescence in situ hybridisation
Subject code	580
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2589081-5
ISSN	0976-7975 ; 0029-568X
ISSN (online)	0976-7975
ISSN	0029-568X
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Freedom isn't free: Assessing the risks and benefits of steroid-free immunosuppression regimens in pediatric liver transplantation in a real-world setting.

Peters, Anna L / Perito, Emily R

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2023 Volume 30, Issue 3, Page(s) 242–243

MeSH term(s)	Humans ; Child ; Liver Transplantation/adverse effects ; Immunosuppression Therapy ; Immunosuppressive Agents/adverse effects ; Steroids/adverse effects ; Freedom ; Risk Assessment ; Graft Rejection/prevention & control
Chemical Substances	Immunosuppressive Agents ; Steroids
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Editorial
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1097/LVT.0000000000000307
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Zs.A 4702: Show issues

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Article ; Online: Decline in home births associated with faster increase in trend of postpartum haemorrhage and manual removal of the placenta.

Seijmonsbergen-Schermers, Anna E / Peters, Lilian L / Jans, Suze / Verhoeven, Corine J / de Jonge, Ank

Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

2024 Volume 40, Page(s) 100974

Abstract: In this study we explored the relationship between home birth rates and increasing rates of postpartum haemorrhage (PPH) and manual removal of the placenta (MROP). Data were used from the Dutch national perinatal registry (2000-2014) of women in midwife- ... ...

Abstract	In this study we explored the relationship between home birth rates and increasing rates of postpartum haemorrhage (PPH) and manual removal of the placenta (MROP). Data were used from the Dutch national perinatal registry (2000-2014) of women in midwife-led care. Adjusting for place of birth flattened the increasing trends of PPH and MROP. By adjusting for place of birth, the rising trend of MROP among multiparous women disappeared. This suggests that if home birth rates had not declined, PPH and MROP rates might not have increased as much. This study supports policies of enabling women to choose home births.
Language	English
Publishing date	2024-04-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2541869-5
ISSN	1877-5764 ; 1877-5756
ISSN (online)	1877-5764
ISSN	1877-5756
DOI	10.1016/j.srhc.2024.100974
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Article ; Online: Distinct effects of racial and socioeconomic disparities on biliary atresia diagnosis and outcome.

Bonn, Julie / Gamm, Kristen / Ambrosino, Teresa / Orkin, Sarah H / Taylor, Amy / Peters, Anna L

Journal of pediatric gastroenterology and nutrition

2024 Volume 78, Issue 5, Page(s) 1038–1046

Abstract: Objectives: To identify and distinguish between racial and socioeconomic disparities in age at hepatology care, diagnosis, access to surgical therapy, and liver transplant-free survival in patients with biliary atresia (BA).: Methods: Single-center ... ...

Abstract	Objectives: To identify and distinguish between racial and socioeconomic disparities in age at hepatology care, diagnosis, access to surgical therapy, and liver transplant-free survival in patients with biliary atresia (BA). Methods: Single-center retrospective cohort study of 69 BA patients from 2010 to 2021. Patients were grouped into White and non-White cohorts. The socioeconomic milieu was analyzed utilizing neighborhood deprivation index, a census tract-based calculation of six socioeconomic variables. The primary outcomes of this study were timing of the first hepatology encounter, surgical treatment with hepatic portoenterostomy (HPE), and survival with native liver (SNL) at 2 years. Results: Patients were 55% male and 72% White. White patients were referred at a median of 34 days (interquartile range [IQR]: 17-65) vs. 67 days (IQR: 42-133; p = 0.001) in non-White patients. White infants were more likely to undergo HPE (42/50 patients; 84%) compared to non-White (10/19; 53%), odds ratio (OR) 4.73 (95% confidence interval: 1.46-15.31; p = 0.01). Independent of race, patients exposed to increased neighborhood-level deprivation were less likely to receive HPE (OR: 0.49, p = 0.04) and achieve SNL (OR: 0.54, p = 0.02). Conclusions: Racial and socioeconomic disparities are independently associated with timely BA diagnosis, access to surgical treatment, and transplant-free survival. Public health approaches to improve screening for pathologic jaundice in infants of diverse racial backgrounds and to test and implement interventions for socioeconomically at-risk families are needed.
MeSH term(s)	Humans ; Biliary Atresia/surgery ; Biliary Atresia/diagnosis ; Biliary Atresia/ethnology ; Biliary Atresia/mortality ; Male ; Retrospective Studies ; Female ; Infant ; Healthcare Disparities/statistics & numerical data ; Healthcare Disparities/ethnology ; Portoenterostomy, Hepatic ; Socioeconomic Factors ; Liver Transplantation/statistics & numerical data ; Infant, Newborn ; Health Services Accessibility/statistics & numerical data ; White People/statistics & numerical data ; Socioeconomic Disparities in Health
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1002/jpn3.12197
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Zs.A 1728: Show issues

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Article ; Online: Early allograft dysfunction in a pediatric liver allograft with an occult pathogenic mutation in the urea cycle.

Rezvani, Milad / Campbell, Kathleen M / Prada, Carlos E / Peters, Anna L

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2023 Volume 23, Issue 5, Page(s) 673–675

Abstract: Liver transplantation risks transferring a genetic defect in metabolic pathways, including the urea cycle. We present a case of pediatric liver transplantation complicated by metabolic crisis and early allograft dysfunction (EAD) in a previously healthy ... ...

Abstract	Liver transplantation risks transferring a genetic defect in metabolic pathways, including the urea cycle. We present a case of pediatric liver transplantation complicated by metabolic crisis and early allograft dysfunction (EAD) in a previously healthy unrelated deceased donor. Allograft function improved with supportive care, and retransplantation was avoided. Because hyperammonemia suggested an enzymatic defect in the allograft, genetic testing from donor-derived deoxyribonucleic acid revealed a heterozygous mutation in the ASL gene, which encodes the urea cycle enzyme argininosuccinate lyase. Homozygous ASL mutations precipitate metabolic crises during fasting or postoperative states, whereas heterozygous carriers retain sufficient enzyme activity and are asymptomatic. In the described case, postoperative ischemia/reperfusion injury created a metabolic demand that exceeded the enzymatic capacity of the allograft. To our knowledge, this is the first report of an acquired argininosuccinate lyase deficiency by liver transplantation and underscores the importance of considering occult metabolic variants in the allograft during EAD.
MeSH term(s)	Humans ; Child ; Mutation ; Argininosuccinic Aciduria/genetics ; Liver ; Allografts ; Urea
Chemical Substances	Urea (8W8T17847W)
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Case Reports ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1016/j.ajt.2023.02.027
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Zs.A 5542: Show issues

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Article ; Online: Pediatric Acute Liver Failure Due to Type 2 Autoimmune Hepatitis Associated With SARS-CoV-2 Infection: A Case Report.

Osborn, Julie / Szabo, Sara / Peters, Anna L

JPGN reports

2022 Volume 3, Issue 2, Page(s) e204

Abstract: Although elevated liver enzymes are common in hospitalized children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, pediatric acute liver failure is an uncommon manifestation of COVID-19 disease. We describe the case of a 3- ... ...

Abstract	Although elevated liver enzymes are common in hospitalized children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, pediatric acute liver failure is an uncommon manifestation of COVID-19 disease. We describe the case of a 3-year-old previously healthy female who developed acute liver failure secondary to type 2 autoimmune hepatitis preceded by mild infection with SARS-CoV-2. Testing for viral hepatitis was negative, and the patient did not meet diagnostic criteria for multisystem inflammatory disease in children (MIS-C). A liver biopsy showed acute submassive hepatocyte necrosis with brisk CD3+ T lymphocyte infiltration and no evidence of fibrosis or chronic liver disease. Treatment with high-dose methylprednisolone resulted in rapid normalization of alanine aminotransferase (ALT), aspartate aminotransferase (AST), international normalized ratio (INR), and ammonia levels, and liver transplantation was avoided. This case highlights a possible association between SARS-CoV-2 infection and subsequent development of autoimmune liver disease presenting with acute liver failure.
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Case Reports
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000204
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Article ; Online: 50 Years Ago in The Journal of Pediatrics: The Diagnosis of Complete Extrahepatic Obstruction by Rose Bengal I

Peters, Anna L

The Journal of pediatrics

2016 Volume 180, Page(s) 162

MeSH term(s)	Biliary Atresia/diagnosis ; Biliary Atresia/history ; Cholestasis, Extrahepatic/diagnosis ; Cholestasis, Extrahepatic/history ; Diagnosis, Differential ; History, 20th Century ; Humans ; Imino Acids ; Infant ; Mass Screening/history ; Mass Screening/methods ; Pediatrics/history ; Rose Bengal/administration & dosage
Chemical Substances	Imino Acids ; Rose Bengal (1ZPG1ELY14) ; lidofenin (EK22QV7701)
Language	English
Publishing date	2016-12-23
Publishing country	United States
Document type	Classical Article ; Historical Article ; Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2016.08.022
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Um IV Zs.116: Show issues

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Article ; Online: 50 Years Ago in TheJournal ofPediatrics: Extrahepatic Biliary Atresia: Comments on the Frequency of Potentially Operable Cases.

Peters, Anna L

The Journal of pediatrics

2016 Volume 174, Page(s) 246

MeSH term(s)	Biliary Atresia/history ; Biliary Atresia/surgery ; History, 20th Century ; Humans ; Infant ; Laparotomy/history ; Laparotomy/methods ; Pediatrics/history ; Portoenterostomy, Hepatic/history ; Portoenterostomy, Hepatic/methods
Language	English
Publishing date	2016-06-21
Publishing country	United States
Document type	Classical Article ; Historical Article ; Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2016.01.047
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Article: Defining the T cell transcriptional landscape in pediatric liver transplant rejection at single cell resolution.

Peters, Anna L / DePasquale, Erica A K / Begum, Gousia / Roskin, Krishna M / Woodle, E Steve / Hildeman, David A

bioRxiv : the preprint server for biology

2024

Abstract: Acute cellular rejection (ACR) affects >80% of pediatric liver transplant recipients within 5 years, and late ACR is associated with graft failure. Traditional anti-rejection therapy for late ACR is ineffective and has remained unchanged for six decades. ...

Abstract	Acute cellular rejection (ACR) affects >80% of pediatric liver transplant recipients within 5 years, and late ACR is associated with graft failure. Traditional anti-rejection therapy for late ACR is ineffective and has remained unchanged for six decades. Although CD8+ T cells promote late ACR, little has been done to define their specificity and gene expression. Here, we used single-cell sequencing and immune repertoire profiling (10X Genomics) on 30 cryopreserved 16G liver biopsies from 14 patients (5 pre-transplant or with no ACR, 9 with ACR). We identified expanded intragraft CD8+ T cell clonotypes (CD8
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.26.582173
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Article ; Online: Anti-thymocyte globulin induction with delayed introduction of tacrolimus preserves renal function in pediatric liver transplant recipients.

Rogers, Michael E / Ambrosino, Teresa / Hatcher, Laura / Bondoc, Alex / Tiao, Greg / Peters, Anna L

Pediatric transplantation

2023 Volume 27, Issue 4, Page(s) e14509

Abstract: Background: Tacrolimus (TAC)-mediated renal disease occurs in up to 70% of pediatric liver transplant (LT) recipients. The safety and efficacy of renal-sparing immunosuppression using anti-thymocyte globulin (ATG) induction and delayed TAC ... ...

Abstract	Background: Tacrolimus (TAC)-mediated renal disease occurs in up to 70% of pediatric liver transplant (LT) recipients. The safety and efficacy of renal-sparing immunosuppression using anti-thymocyte globulin (ATG) induction and delayed TAC administration has not been studied in children. We evaluated the safety and efficacy of ATG induction on preserving renal function in children within the first year (Y1) post-LT in a single-center retrospective cohort study. Methods: Children under age 18 years of who received isolated LT from 2008 to 2020 with a GFR < 70 received renal-sparing (RS) protocol consisting of ATG with methylprednisolone (MP), delayed TAC administration, lower initial TAC trough goals, and mycophenolate mofetil (MMF). The RS group was matched 1:2 by age and LT indication with standard immunosuppression (SI) group. Changes in renal function as well as adverse events within Y1 post-LT were compared. Results: Forty-four pediatric patients were included in the analysis, of which 13 received RS. As expected, the RS group had significantly lower mean TAC trough levels at 30 days (10.3 vs. 13.2, p = .001) post-LT. Renal function was significantly preserved at 6 (-0.26 vs. 0.21, p = .004) and 12 months (-0.33 vs. 0.11, p = .003) post-LT in the RS versus SI group as measured by mean change in serum creatinine, with similar trends observed in eGFR and cystatin C. ACR, sepsis, viremia, graft loss and mortality occurred at similar rates in both RS and SI groups. Conclusion: Induction immunosuppression with ATG and delayed TAC administration in children with renal impairment is safe and effectively preserves renal function during Y1 post-LT.
MeSH term(s)	Humans ; Child ; Adolescent ; Tacrolimus/therapeutic use ; Antilymphocyte Serum/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Retrospective Studies ; Liver Transplantation/adverse effects ; Mycophenolic Acid/therapeutic use ; Kidney/physiology ; Graft Rejection/prevention & control ; Graft Survival
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Antilymphocyte Serum ; Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
Language	English
Publishing date	2023-03-15
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14509
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Zs.A 4947: Show issues

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