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Article ; Online: Corrigendum to "Second round statewide sentinel-based population survey for estimation of the burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population of Karnataka, India, during January-February 2021" [IJID Regions Vol 1(2021) pages 107-116].

Rajagopal Padma, M / Dinesh, Prameela / Sundaresan, Rajesh / Athreya, Siva / Shiju, Shilpa / Maroor, Parimala S / Lalitha Hande, R / Akhtar, Jawaid / Chandra, Trilok / Ravi, Deepa / Lobo, Eunice / Ana, Yamuna / Shriyan, Prafulla / Desai, Anita / Rangaiah, Ambica / Munivenkatappa, Ashok / Krishna, S / Basawarajappa, Shantala Gowdara / Sreedhara, H G /

Siddesh, K C / Kumari, B Amrutha / Umar, Nawaz / Mythri, B A / Mythri, K M / Sudarshan, Mysore Kalappa / Vasanthapuram, Ravi / Rathnaiah Babu, Giridhara

IJID regions

2024 Volume 10, Page(s) 150

Abstract: This corrects the article DOI: 10.1016/j.ijregi.2021.10.008.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.ijregi.2021.10.008.].
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Published Erratum
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2024.01.001
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Article: Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.

Shin, Jae Hun / Park, Jooyoung / Lim, Jaechul / Jeong, Jaekwang / Dinesh, Ravi K / Maher, Stephen E / Hong, Jun Young / Wysolmerski, John / Choi, Jungmin / Bothwell, Alfred L M

bioRxiv : the preprint server for biology

2024

Abstract: Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear. Here we report that Dickkopf-2 (DKK2) is ...

Abstract	Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear. Here we report that Dickkopf-2 (DKK2) is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. Splenic injection of
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.12.589235
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Article ; Online: HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation.

Wu, Lizhen / Shukla, Vipul / Yadavalli, Anurupa Devi / Dinesh, Ravi K / Xu, Dijin / Rao, Anjana / Schatz, David G

Genes & development

2022 Volume 36, Issue 7-8, Page(s) 433–450

Abstract: Somatic hypermutation (SHM) produces point mutations in immunoglobulin (Ig) genes in B cells when uracils created by the activation-induced deaminase are processed in a mutagenic manner by enzymes of the base excision repair (BER) and mismatch repair ( ... ...

Abstract	Somatic hypermutation (SHM) produces point mutations in immunoglobulin (Ig) genes in B cells when uracils created by the activation-induced deaminase are processed in a mutagenic manner by enzymes of the base excision repair (BER) and mismatch repair (MMR) pathways. Such uracil processing creates DNA strand breaks and is susceptible to the generation of deleterious deletions. Here, we demonstrate that the DNA repair factor HMCES strongly suppresses deletions without significantly affecting other parameters of SHM in mouse and human B cells, thereby facilitating the production of antigen-specific antibodies. The deletion-prone repair pathway suppressed by HMCES operates downstream from the uracil glycosylase UNG and is mediated by the combined action of BER factor APE2 and MMR factors MSH2, MSH6, and EXO1. HMCES's ability to shield against deletions during SHM requires its capacity to form covalent cross-links with abasic sites, in sharp contrast to its DNA end-joining role in class switch recombination but analogous to its genome-stabilizing role during DNA replication. Our findings lead to a novel model for the protection of Ig gene integrity during SHM in which abasic site cross-linking by HMCES intercedes at a critical juncture during processing of vulnerable gapped DNA intermediates by BER and MMR enzymes.
MeSH term(s)	Animals ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; DNA/genetics ; DNA-Binding Proteins ; Genes, Immunoglobulin/genetics ; Immunoglobulin Class Switching/genetics ; Mice ; Somatic Hypermutation, Immunoglobulin/genetics ; Uracil
Chemical Substances	DNA-Binding Proteins ; Hmces protein, mouse ; Uracil (56HH86ZVCT) ; DNA (9007-49-2) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.349438.122
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Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 54: Show issues

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Article ; Online: Bifunctional g-C

Bharagav, U / Ramesh Reddy, N / Nava Koteswara Rao, V / Ravi, P / Sathish, M / Rangappa, Dinesh / Prathap, K / Shilpa Chakra, Ch / Shankar, M V / Appels, Lise / Aminabhavi, Tejraj M / Kakarla, Raghava Reddy / Mamatha Kumari, M

Chemosphere

2022 Volume 311, Issue Pt 2, Page(s) 137030

Abstract: Ternary nanohybrids based on mesoporous graphitic carbon nitride (g- ... ...

Abstract	Ternary nanohybrids based on mesoporous graphitic carbon nitride (g-C
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.137030
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Zs.A 2540: Show issues

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Article: Effect of Heating Modes on Reactive Sintering of Ca

Teja, P Ravi / Annamalai, A Raja / Evangeline T, Gecil / Srikanth, Muthe / Agrawal, Dinesh K / Jen, Chun-Ping

Materials (Basel, Switzerland)

2021 Volume 14, Issue 2

Abstract: The traditional solid-state reaction method was employed to synthesize bulk calcium cobaltite (Ca349/ ... ...

Abstract	The traditional solid-state reaction method was employed to synthesize bulk calcium cobaltite (Ca349/Ca
Language	English
Publishing date	2021-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14020273
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Article: Comparison of Two Different Serological Viral Marker Testing Assays for Screening of Apheresis Donors: Which Assay Provides Optimum Safety for Transfusion?

Tiwari, Aseem K / Setya, Divya / Dara, Ravi / Arora, Dinesh / Mehta, Swati Pabbi / Aggarwal, Geet / Bhardwaj, Gunjan

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

2022 Volume 39, Issue 2, Page(s) 300–307

Abstract: While whole blood testing has evolved over the years, viral marker testing for plateletpheresis donors is still performed by Rapid Diagnostic Tests (RDT). Aim of this study was to compare diagnostic accuracy of RDT and Chemiluminescence Immunoassay (CLIA) ...

Abstract	While whole blood testing has evolved over the years, viral marker testing for plateletpheresis donors is still performed by Rapid Diagnostic Tests (RDT). Aim of this study was to compare diagnostic accuracy of RDT and Chemiluminescence Immunoassay (CLIA) in serological testing for HBsAg, anti-HCV and anti-HIV antibodies. A prospective, analytical study was conducted in the department of Transfusion Medicine at a tertiary healthcare center in India between September 2016 and August 2018. Samples were simultaneously tested by CLIA, RDT and a confirmatory test. Sensitivity, specificity, negative and positive predictive values and mean time taken to report results were calculated. A total of 102 (1.48%) of the 6883 samples were found to be reactive by either or both the assays. A total of 74 (1.08%) samples were HBsAg reactive, 23 (0.33%) were reactive for anti-HCV antibodies and 5 (0.07%) were reactive for anti-HIV I and II antibodies. A combined sero-prevalence of 1.05% (72) was observed; 0.78% (54) for HBsAg, 0.26% (18) for anti-HCV antibodies and none for anti-HIV I and II antibodies. Four (3.85%) reactive samples were missed by RDT and therefore sensitivity of RDT was quite less as compared to CLIA. RDT and CLIA both were found to have a statistically significant shorter turnaround time than confirmatory tests. There is increasing need to develop a safe donor screening strategy for plateletpheresis. CLIA offers an excellent alterative to RDT for viral marker testing in terms of sensitivity.
Language	English
Publishing date	2022-08-17
Publishing country	India
Document type	Journal Article
ZDB-ID	2422370-0
ISSN	0974-0449 ; 0971-4502
ISSN (online)	0974-0449
ISSN	0971-4502
DOI	10.1007/s12288-022-01553-x
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Article ; Online: Descriptive epidemiology of SARS-CoV-2 infection in Karnataka state, South India: Transmission dynamics of symptomatic vs. asymptomatic infections.

Kumar, Narendra / Shahul Hameed, Shafeeq K / Babu, Giridhara R / Venkataswamy, Manjunatha M / Dinesh, Prameela / Kumar Bg, Prakash / John, Daisy A / Desai, Anita / Ravi, Vasanthapuram

EClinicalMedicine

2021 Volume 32, Page(s) 100717

Abstract: Background: The huge surge in COVID-19 cases in Karnataka state, India, during early phase of the pandemic especially following return of residents from other states and countries required investigation with respect to transmission dynamics, clinical ... ...

Abstract	Background: The huge surge in COVID-19 cases in Karnataka state, India, during early phase of the pandemic especially following return of residents from other states and countries required investigation with respect to transmission dynamics, clinical status, demographics, comorbidities and mortality. Knowledge on the role of symptomatic and asymptomatic cases in transmission of SARS-CoV-2 was not available. Methods: The study included all the cases reported from March 8 - May 31, 2020. Individuals with a history of international or domestic travel from high burden states, Influenza-like Illness or Severe Acute Respiratory Illness and high-risk contacts of COVID-19 cases were included. Detailed analysis based on contact tracing data available from the line-list of state surveillance unit was performed using cluster network analysis software. Findings: Amongst the 3404 COVID-19 positive cases, 3096 (91%) were asymptomatic while 308 (9%) were symptomatic. Majority of asymptomatic cases were in the age range of 16 and 45 years while symptomatic cases were between 31 and 65 years. Mortality rate was especially higher among middle-aged and elderly cases with co-morbidities, 34/38 (89·4%). Cluster network analysis of 822 cases indicated that the secondary attack rate, size of the cluster and superspreading events were higher when the source case was symptomatic as compared to an asymptomatic. Interpretation: Our findings indicate that both asymptomatic and symptomatic SARS-CoV-2 cases transmit the infection, although symptomatic cases were the main driving force within the state during the beginning of the pandemic. Considering the large proportion of asymptomatic cases, their ability to spread infection cannot be overlooked. Notwithstanding the limitations and bias in identifying asymptomatic cases, the findings have major implications for testing policies. Active search, early testing and treatment of symptomatic elderly patients with comorbidities should be prioritized for containing the spread of COVID-19 and reducing mortality. Funding: Intermediate Fellowship, Wellcome Trust-DBT India Alliance to Giridhara R Babu, Grant number: IA/CPHI/14/1/501499.
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2020.100717
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Article ; Online: Ventilator malfunction.

Krishna Kumar, Br / Ravi, M / Dinesh, K / Nanda, A

Journal of anaesthesiology, clinical pharmacology

2011 Volume 27, Issue 4, Page(s) 576

Language	English
Publishing date	2011-09-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2253976-1
ISSN	2231-2730 ; 0970-9185
ISSN (online)	2231-2730
ISSN	0970-9185
DOI	10.4103/0970-9185.86623
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Article ; Online: Potential role of blood biomarkers in patients with fibromyalgia: a systematic review with meta-analysis.

Kumbhare, Dinesh / Hassan, Samah / Diep, Dion / Duarte, Felipe C K / Hung, Jasper / Damodara, Sreekant / West, Daniel W D / Selvaganapathy, P Ravi

Pain

2021 Volume 163, Issue 7, Page(s) 1232–1253

Abstract: Abstract: Fibromyalgia (FM) is a complex chronic pain condition. Its symptoms are nonspecific, and to date, no objective test exists to confirm FM diagnosis. Potential objective measures include the circulating levels of blood biomarkers. This ... ...

Abstract	Abstract: Fibromyalgia (FM) is a complex chronic pain condition. Its symptoms are nonspecific, and to date, no objective test exists to confirm FM diagnosis. Potential objective measures include the circulating levels of blood biomarkers. This systematic review and meta-analysis aim to review studies assessing blood biomarkers' levels in patients with FM compared with healthy controls. We systematically searched the PubMed, MEDLINE, EMBASE, and PsycINFO databases. Fifty-four studies reporting the levels of biomarkers in blood in patients with FM were included. Data were extracted, and the methodological quality was assessed independently by 2 authors. The methodological quality of 9 studies (17%) was low. The results of most studies were not directly comparable given differences in methods and investigated target immune mediators. Thus, data from 40 studies only were meta-analyzed using a random-effects model. The meta-analysis showed that patients with FM had significantly lower levels of interleukin-1 β and higher levels of IL-6, IL-8, tumor necrosis factor-alpha, interferon gamma, C-reactive protein, and brain-derived neurotrophic factor compared with healthy controls. Nevertheless, this systematic literature review and meta-analysis could not support the notion that these blood biomarkers are specific biomarkers of FM. Our literature review, however, revealed that these same individual biomarkers may have the potential role of identifying underlying pathologies or other conditions that often coexist with FM. Future research is needed to evaluate the potential clinical value for these biomarkers while controlling for the various confounding variables.
MeSH term(s)	Biomarkers ; C-Reactive Protein ; Chronic Pain ; Fibromyalgia/metabolism ; Humans ; Tumor Necrosis Factor-alpha
Chemical Substances	Biomarkers ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-10-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000002510
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Zs.A 1158: Show issues

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Article: Prevalence of Psychiatric Comorbidity among Patients of Type 2 Diabetes Mellitus in a Hilly State of North India.

Kanwar, Neeraj / Sharma, Ravi C / Sharma, Dinesh D / Ramesh / Mokta, Kiran / Mokta, Jatinder K

Indian journal of endocrinology and metabolism

2019 Volume 23, Issue 6, Page(s) 602–608

Abstract: Background: Psychiatric comorbidity with diabetes mellitus is common. Comorbidity of diabetes and psychiatric disorders can present in different patterns, which are associated with impaired quality of life, increased cost of care, poor treatment ... ...

Abstract	Background: Psychiatric comorbidity with diabetes mellitus is common. Comorbidity of diabetes and psychiatric disorders can present in different patterns, which are associated with impaired quality of life, increased cost of care, poor treatment adherence, poor glycaemia control and increased emergency room visits. The present study was planned to assess the psychiatric comorbidity in type 2 diabetic patients at tertiary care hospital in a hilly state of North India. Objectives: To study the prevalence of psychiatric comorbidity among patients of type 2 diabetes mellitus and to study the association between psychiatric comorbidity, sociodemographic and clinical variables in such patients. Materials and methods: A cross-sectional study was conducted after enrolling the eligible diabetic patients attending outpatient department services of medicine department, Indira Gandhi Medical College, Shimla. The Brief Illness Perception Questionnaire was used to assess the cognitive and emotional aspects of illness, Hamilton Depression Rating Scale for assessment of depression, Hamilton Anxiety Rating Scale for assessing severity of anxiety and Mini-International Neuropsychiatric Interview 6.0 for screening all major Axis I disorders. Results: Out of 320 patients of type 2 diabetes mellitus screened, 202 eligible patients were enrolled. Depression was the most common psychiatric comorbid illness present in (41.9%) patients. Depression was slightly higher in female patients and persons aged >50 years. Greater prevalence of depressive episodes was there in people with longer duration of diabetes. Conclusion: There were a significant percentage of diabetic patients having psychiatric illnesses. Their attitude towards these comorbidities may be changed by psychiatric counselling at regular intervals.
Language	English
Publishing date	2019-10-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/ijem.IJEM_521_19
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