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  1. Article ; Online: Higher-order evidence.

    Cole, Stephen R / Shook-Sa, Bonnie E / Zivich, Paul N / Edwards, Jessie K / Richardson, David B / Hudgens, Michael G

    European journal of epidemiology

    2024  Volume 39, Issue 1, Page(s) 1–11

    Abstract: Higher-order evidence is evidence about evidence. Epidemiologic examples of higher-order evidence include the settings where the study data constitute first-order evidence and estimates of misclassification comprise the second-order evidence (e.g., ... ...

    Abstract Higher-order evidence is evidence about evidence. Epidemiologic examples of higher-order evidence include the settings where the study data constitute first-order evidence and estimates of misclassification comprise the second-order evidence (e.g., sensitivity, specificity) of a binary exposure or outcome collected in the main study. While sampling variability in higher-order evidence is typically acknowledged, higher-order evidence is often assumed to be free of measurement error (e.g., gold standard measures). Here we provide two examples, each with multiple scenarios where second-order evidence is imperfectly measured, and this measurement error can either amplify or attenuate standard corrections to first-order evidence. We propose a way to account for such imperfections that requires third-order evidence. Further illustrations and exploration of how higher-order evidence impacts results of epidemiologic studies is warranted.
    MeSH term(s) Humans ; Bias ; Sensitivity and Specificity
    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-023-01062-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unconventional modes of peptide-HLA-I presentation change the rules of TCR engagement.

    Hopkins, Jade R / MacLachlan, Bruce J / Harper, Stephen / Sewell, Andrew K / Cole, David K

    Discovery immunology

    2022  Volume 1, Issue 1, Page(s) kyac001

    Abstract: The intracellular proteome of virtually every nucleated cell in the body is continuously presented at the cell ... ...

    Abstract The intracellular proteome of virtually every nucleated cell in the body is continuously presented at the cell surface
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-2483
    ISSN (online) 2754-2483
    DOI 10.1093/discim/kyac001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The ultimate mix and match: making sense of HLA alleles and peptide repertoires.

    Cole, David K

    Immunology and cell biology

    2015  Volume 93, Issue 6, Page(s) 515–516

    MeSH term(s) Epitopes, T-Lymphocyte/immunology ; Histocompatibility Antigens Class I/immunology ; Humans ; Peptides/immunology
    Chemical Substances Epitopes, T-Lymphocyte ; Histocompatibility Antigens Class I ; Peptides
    Language English
    Publishing date 2015-03-31
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2015.40
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Decreased Susceptibility of Marginal Odds Ratios to Finite-sample Bias.

    Ross, Rachael K / Cole, Stephen R / Richardson, David B

    Epidemiology (Cambridge, Mass.)

    2021  Volume 32, Issue 5, Page(s) 648–652

    Abstract: Parameters representing adjusted treatment effects may be defined marginally or conditionally on covariates. The choice between a marginal or covariate-conditional parameter should be driven by the study question. However, an unappreciated benefit of ... ...

    Abstract Parameters representing adjusted treatment effects may be defined marginally or conditionally on covariates. The choice between a marginal or covariate-conditional parameter should be driven by the study question. However, an unappreciated benefit of marginal estimators is a reduction in susceptibility to finite-sample bias relative to the unpenalized maximum likelihood estimator of the covariate-conditional odds ratio (OR). Using simulation, we compare the finite-sample bias of different marginal and conditional estimators of the OR. We simulated a logistic model to have 15 events per parameter and two events per parameter. We estimated the covariate-conditional OR by maximum likelihood with and without Firth's penalization. We used three estimators of the marginal OR: g-computation, inverse probability of treatment weighting, and augmented inverse probability of treatment weighting. At 15 events per parameter, as expected, all estimators were effectively unbiased. At two events per parameter, the unpenalized covariate-conditional estimator was notably biased but penalized covariate-conditional and marginal estimators exhibited minimal bias.
    MeSH term(s) Bias ; Computer Simulation ; Humans ; Logistic Models ; Odds Ratio ; Probability
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1053263-8
    ISSN 1531-5487 ; 1044-3983
    ISSN (online) 1531-5487
    ISSN 1044-3983
    DOI 10.1097/EDE.0000000000001370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Significant Changes in Resting Metabolic Rate Over a Competitive Match Week Are Accompanied by an Absence of Nutritional Periodization in Male Professional Soccer Players.

    Carter, Jennie L / Lee, David J / Perrin, Craig G / Ranchordas, Mayur K / Cole, Matthew

    International journal of sport nutrition and exercise metabolism

    2023  Volume 33, Issue 6, Page(s) 349–359

    Abstract: Resting metabolic rate (RMR) is an important component of total daily energy expenditure; however, it is currently not understood how it varies across a typical competitive match week in professional soccer players. For the first time, we aimed to assess ...

    Abstract Resting metabolic rate (RMR) is an important component of total daily energy expenditure; however, it is currently not understood how it varies across a typical competitive match week in professional soccer players. For the first time, we aimed to assess RMR throughout an in-season competitive week in professional soccer players. Additionally, we aimed to assess energy and carbohydrate intake across the same week. Twenty-four professional soccer players from an English Premier League club (age: 18 ± 1.6 years) completed the study. RMR was assessed each morning of a typical competitive match week (match day [MD] -3, -2, -1, +1, +2, and + 3), and dietary intake (including MD) was assessed daily via the remote food photography method and 24-hr recall. Daily training load was quantified using Global Positioning System, daily muscle soreness ratings were recorded, and body composition was assessed via dual-energy X-ray absorptiometry. There was a significant (p = .0004) increase in mean RMR of ∼261 kcal/day on MD + 1, compared with MD - 1. Additionally, volume of oxygen consumed significantly increased at MD + 1 (p = .0002) versus MD - 1. There were no significant differences in daily energy or carbohydrate intake across the competitive week (p > .05), with inadequate carbohydrate intakes on MD - 1 (∼3.9 g/kg body mass), MD (∼4.2 g/kg body mass), and MD + 1 (∼3.6 g/kg body mass) in relation to current recommendations. We report, for the first time, that RMR is significantly increased following a competitive match in professional soccer players. In addition, we confirm previous findings to reinforce that players exhibit inadequate nutrition periodization practices, which may impair physical performance and recovery.
    MeSH term(s) Humans ; Male ; Adolescent ; Young Adult ; Adult ; Energy Intake ; Basal Metabolism ; Soccer/physiology ; Seasons ; Carbohydrates
    Chemical Substances Carbohydrates
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101115-4
    ISSN 1543-2742 ; 1050-1606 ; 1526-484X
    ISSN (online) 1543-2742
    ISSN 1050-1606 ; 1526-484X
    DOI 10.1123/ijsnem.2023-0069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Perspectives of the barriers and enablers to nutritional adherence in professional male academy football players.

    Carter, Jennie L / Lee, David J / Ranchordas, Mayur K / Cole, Matthew

    Science & medicine in football

    2022  Volume 7, Issue 4, Page(s) 394–405

    Abstract: Background: Nutritional intake is important for young football players; however, little is known about the factors that influence their nutritional adherence.: Purpose: The aim of this study was to investigate players', sports nutritionists',and ... ...

    Abstract Background: Nutritional intake is important for young football players; however, little is known about the factors that influence their nutritional adherence.
    Purpose: The aim of this study was to investigate players', sports nutritionists',and coaches' perspectives of the barriers and enablers to adhering to nutritional recommendations within a professional football club.
    Method: Individual interviews, based on the Capability, Opportunity, Motivation - Behaviour (COM-B) model and Theoretical Domains Framework (TDF), were conducted with 13 players (18 ± 1.3 years), 12 sports nutritionists, and 10 coaches from 2, 12, and 10 professional football clubs, respectively. Thematic analysis was used to interpret the data.
    Results: Seven key themes were generated relating to the players' barriers and enablers to nutritional adherence: (1) Capability: (a) Nutritional Knowledge; (b) Cooking Skills; (2) Opportunity: (c) Training Venue Food Provision; (d) Nutritionist Accessibility and Approachability; (e) Living Status: (3) Motivation: (f) Performance Implications; and (g) Role Modelling.
    Conclusion: Inadequate food provision within the training and home environment, and limited time with the sports nutritionist were key barriers to nutritional adherence in youth football players. Football clubs should allocate more time for sports nutritionists to deliver nutrition support and sports nutritionists should aim to control the players environment to support optimal nutritional intake.
    MeSH term(s) Adolescent ; Humans ; Male ; Athletes ; Eating ; Soccer
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Journal Article
    ISSN 2473-4446
    ISSN (online) 2473-4446
    DOI 10.1080/24733938.2022.2123554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reliable

    Crean, Rory M / Pudney, Christopher R / Cole, David K / van der Kamp, Marc W

    Journal of chemical information and modeling

    2022  Volume 62, Issue 3, Page(s) 577–590

    Abstract: Accurate and ... ...

    Abstract Accurate and efficient
    MeSH term(s) Entropy ; Humans ; Ligands ; Molecular Dynamics Simulation ; Protein Binding ; Proteins/chemistry
    Chemical Substances Ligands ; Proteins
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.1c00765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Social norms explain prioritization of climate policy.

    Cole, Jennifer C / Ehret, Phillip J / Sherman, David K / Van Boven, Leaf

    Climatic change

    2022  Volume 173, Issue 1-2, Page(s) 10

    Abstract: Most people in the United States recognize the reality of climate change and are concerned about its consequences, yet climate change is a low priority relative to other policy issues. Recognizing that belief in climate change does not necessarily ... ...

    Abstract Most people in the United States recognize the reality of climate change and are concerned about its consequences, yet climate change is a low priority relative to other policy issues. Recognizing that belief in climate change does not necessarily translate to prioritizing climate policy, we examine psychological factors that may boost or inhibit prioritization. We hypothesized that perceived social norms from people's own political party influence their climate policy prioritization beyond their personal belief in climate change. In Study 1, a large, diverse sample of Democratic and Republican participants (
    Supplementary information: The online version contains supplementary material available at 10.1007/s10584-022-03396-x.
    Language English
    Publishing date 2022-07-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 751086-x
    ISSN 0165-0009
    ISSN 0165-0009
    DOI 10.1007/s10584-022-03396-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Social norms explain prioritization of climate policy

    Cole, Jennifer C. / Ehret, Phillip J. / Sherman, David K. / Van Boven, Leaf

    Climatic change. 2022 July, v. 173, no. 1-2

    2022  

    Abstract: Most people in the United States recognize the reality of climate change and are concerned about its consequences, yet climate change is a low priority relative to other policy issues. Recognizing that belief in climate change does not necessarily ... ...

    Abstract Most people in the United States recognize the reality of climate change and are concerned about its consequences, yet climate change is a low priority relative to other policy issues. Recognizing that belief in climate change does not necessarily translate to prioritizing climate policy, we examine psychological factors that may boost or inhibit prioritization. We hypothesized that perceived social norms from people’s own political party influence their climate policy prioritization beyond their personal belief in climate change. In Study 1, a large, diverse sample of Democratic and Republican participants (N = 887) reported their prioritization of climate policy relative to other issues. Participants’ perceptions of their political ingroup’s social norms about climate policy prioritization were the strongest predictor of personal climate policy prioritization—stronger even than participants’ belief in climate change, political orientation, environmental identity, and environmental values. Perceptions of political outgroup norms did not predict prioritization. In Study 2 (N = 217), we experimentally manipulated Democratic and Republican descriptive norms of climate policy prioritization. Participants’ prioritization of climate policy was highest when both the political ingroup and the outgroup prioritized climate policy. Ingroup norms had a strong influence on personal policy prioritization whereas outgroup norms did not. These findings demonstrate that, beyond personal beliefs and other individual differences, ingroup social norms shape the public’s prioritization of climate change as a policy issue.
    Keywords climate change ; environmental policy ; people ; politics ; prioritization
    Language English
    Dates of publication 2022-07
    Size p. 10.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 751086-x
    ISSN 0165-0009
    ISSN 0165-0009
    DOI 10.1007/s10584-022-03396-x
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: A Bespoke Instrumental Variable Approach to Correction for Exposure Measurement Error.

    Richardson, David B / Keil, Alexander P / Edwards, Jessie K / Cole, Stephen R / Tchetgen Tchetgen, Eric J

    American journal of epidemiology

    2022  Volume 191, Issue 11, Page(s) 1954–1961

    Abstract: A covariate-adjusted estimate of an exposure-outcome association may be biased if the exposure variable suffers measurement error. We propose an approach to correct for exposure measurement error in a covariate-adjusted estimate of the association ... ...

    Abstract A covariate-adjusted estimate of an exposure-outcome association may be biased if the exposure variable suffers measurement error. We propose an approach to correct for exposure measurement error in a covariate-adjusted estimate of the association between a continuous exposure variable and outcome of interest. Our proposed approach requires data for a reference population in which the exposure was a priori set to some known level (e.g., 0, and is therefore unexposed); however, our approach does not require an exposure validation study or replicate measures of exposure, which are typically needed when addressing bias due to exposure measurement error. A key condition for this method, which we refer to as "partial population exchangeability," requires that the association between a measured covariate and outcome in the reference population equals the association between that covariate and outcome in the target population in the absence of exposure. We illustrate the approach using simulations and an example.
    MeSH term(s) Humans ; Bias ; Research Design
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2937-3
    ISSN 1476-6256 ; 0002-9262
    ISSN (online) 1476-6256
    ISSN 0002-9262
    DOI 10.1093/aje/kwac133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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