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  1. Article ; Online: Malrotation of intestine with Carcinoma Colon in adult AUTHORS Dr. Dipankar Ray MS DNB FRCS* Prof. Gautam Chattopadhyay MS FRCS Dr. Surajit Das MS * Assistant Professor, Department of Surgical Gastroenterology Medical College Kolkata

    Dipankar Ray

    Journal of Nepal Medical Association, Vol 52, Iss

    2014  Volume 193

    Abstract: Malrotation of gut is a congenital anomaly and patients usually present in childhood. Occasionally it may present in adulthood. Patients are usually asymptomatic when malrotation of gut is detected during investigations, operation or autopsy. Also it can ...

    Abstract Malrotation of gut is a congenital anomaly and patients usually present in childhood. Occasionally it may present in adulthood. Patients are usually asymptomatic when malrotation of gut is detected during investigations, operation or autopsy. Also it can cause longstanding abdominal symptoms, volvulus of gut. Malrotation of gut may present with gastrointestinal neoplasms of stomach, hepato-biliary, pancreas and colo-rectal. We present a 60year old female presented with carcinoma caecum along with intestinal malrotation, which is first reported case from India. We also searched literature to find out any association between colo-rectal malignancy and intestinal malrotation, whether it should be considered as premalignant condition and its implication in children with malrotation
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher Nepal Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Outcomes of the management of corrosive injuries of the upper digestive tract in a tertiary care center.

    Biswas, Ravi Shankar / Ray, Dipankar

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2022  Volume 35, Issue 3

    Abstract: Esophageal stricture is the most common delayed sequelae of aerodigestive tract corrosive injuries. Early endoscopic dilatation is an integral part of corrosive injury management. Self-dilatation of the esophagus is effective in preventing stricture ... ...

    Abstract Esophageal stricture is the most common delayed sequelae of aerodigestive tract corrosive injuries. Early endoscopic dilatation is an integral part of corrosive injury management. Self-dilatation of the esophagus is effective in preventing stricture recurrence. In this prospective study, we included patients with corrosive aerodigestive tract injury from January 2009 to December 2020. We analyzed the outcome of the endoscopic dilatation and self-dilatation treatments administered to patients with a corrosive esophageal stricture. Among 295 patients, 164 had an esophageal injury, 73 had esophago-gastric injury, 55 had a gastric injury, and 3 had the pharyngeal injury. Of the 295 patients, 194 (81.85%) underwent dilatation, and 13 patients with diffuse esophageal injury underwent upfront surgery. Successful dilatation was performed in 169 (87.11%) patients. Of the 68 patients undergoing self-dilatation, 63 patients achieved nutritional autonomy by 28 days. Early endoscopic dilatation effectively prevents surgery, and self-dilatation appears promising to prevent recurrent esophageal stricture.
    MeSH term(s) Burns, Chemical/complications ; Burns, Chemical/therapy ; Caustics/toxicity ; Dilatation ; Esophageal Stenosis/chemically induced ; Esophageal Stenosis/therapy ; Esophagus/injuries ; Esophagus/surgery ; Humans ; Prospective Studies ; Tertiary Care Centers
    Chemical Substances Caustics
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doab096
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  3. Article ; Online: Prospects of 2D graphdiynes and their applications in desalination and wastewater remediation.

    Ghosh, Adrija / Orasugh, Jonathan Tersur / Ray, Suprakas Sinha / Chattopadhyay, Dipankar

    RSC advances

    2023  Volume 13, Issue 27, Page(s) 18568–18604

    Abstract: Water is an indispensable part of human life that affects health and food intake. Water pollution caused by rapid industrialization, agriculture, and other human activities affects humanity. Therefore, researchers are prudent and cautious regarding the ... ...

    Abstract Water is an indispensable part of human life that affects health and food intake. Water pollution caused by rapid industrialization, agriculture, and other human activities affects humanity. Therefore, researchers are prudent and cautious regarding the use of novel materials and technologies for wastewater remediation. Graphdiyne (GDY), an emerging 2D nanomaterial, shows promise in this direction. Graphdiyne has a highly symmetrical π-conjugated structure consisting of uniformly distributed pores; hence, it is favorable for applications such as oil-water separation and organic-pollutant removal. The acetylenic linkage in GDY can strongly interact with metal ions, rendering GDY applicable to heavy-metal adsorption. In addition, GDY membranes that exhibit 100% salt rejection at certain pressures are potential candidates for wastewater treatment and water reuse
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra01370g
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  4. Article ; Online: Integration of 3D Printing-Coelectrospinning: Concept Shifting in Biomedical Applications.

    Ghosh, Adrija / Orasugh, Jonathan Tersur / Ray, Suprakas Sinha / Chattopadhyay, Dipankar

    ACS omega

    2023  Volume 8, Issue 31, Page(s) 28002–28025

    Abstract: Porous structures with sizes between the submicrometer and nanometer scales can be produced using efficient and adaptable electrospinning technology. However, to approximate desirable structures, the construction lacks mechanical sophistication and ... ...

    Abstract Porous structures with sizes between the submicrometer and nanometer scales can be produced using efficient and adaptable electrospinning technology. However, to approximate desirable structures, the construction lacks mechanical sophistication and conformance and requires three-dimensional solitary or multifunctional structures. The diversity of high-performance polymers and blends has enabled the creation of several porous structural conformations for applications in advanced materials science, particularly in biomedicine. Two promising technologies can be combined, such as electrospinning with 3D printing or additive manufacturing, thereby providing a straightforward yet flexible technique for digitally controlled shape-morphing fabrication. The hierarchical integration of configurations is used to imprint complex shapes and patterns onto mesostructured, stimulus-responsive electrospun fabrics. This technique controls the internal stresses caused by the swelling/contraction mismatch in the in-plane and interlayer regions, which, in turn, controls the morphological characteristics of the electrospun membranes. Major innovations in 3D printing, along with additive manufacturing, have led to the production of materials and scaffold systems for tactile and wearable sensors, filtration structures, sensors for structural health monitoring, tissue engineering, biomedical scaffolds, and optical patterning. This review discusses the synergy between 3D printing and electrospinning as a constituent of specific microfabrication methods for quick structural prototypes that are expected to advance into next-generation constructs. Furthermore, individual techniques, their process parameters, and how the fabricated novel structures are applied holistically in the biomedical field have never been discussed in the literature. In summary, this review offers novel insights into the use of electrospinning and 3D printing as well as their integration for cutting-edge applications in the biomedical field.
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Isoform alterations in the ubiquitination machinery impacting gastrointestinal malignancies.

    Kasturirangan, Srimathi / Nancarrow, Derek J / Shah, Ayush / Lagisetty, Kiran H / Lawrence, Theodore S / Beer, David G / Ray, Dipankar

    Cell death & disease

    2024  Volume 15, Issue 3, Page(s) 194

    Abstract: The advancement of RNAseq and isoform-specific expression platforms has led to the understanding that isoform changes can alter molecular signaling to promote tumorigenesis. An active area in cancer research is uncovering the roles of ubiquitination on ... ...

    Abstract The advancement of RNAseq and isoform-specific expression platforms has led to the understanding that isoform changes can alter molecular signaling to promote tumorigenesis. An active area in cancer research is uncovering the roles of ubiquitination on spliceosome assembly contributing to transcript diversity and expression of alternative isoforms. However, the effects of isoform changes on functionality of ubiquitination machineries (E1, E2, E3, E4, and deubiquitinating (DUB) enzymes) influencing onco- and tumor suppressor protein stabilities is currently understudied. Characterizing these changes could be instrumental in improving cancer outcomes via the identification of novel biomarkers and targetable signaling pathways. In this review, we focus on highlighting reported examples of direct, protein-coded isoform variation of ubiquitination enzymes influencing cancer development and progression in gastrointestinal (GI) malignancies. We have used a semi-automated system for identifying relevant literature and applied established systems for isoform categorization and functional classification to help structure literature findings. The results are a comprehensive snapshot of known isoform changes that are significant to GI cancers, and a framework for readers to use to address isoform variation in their own research. One of the key findings is the potential influence that isoforms of the ubiquitination machinery have on oncoprotein stability.
    MeSH term(s) Humans ; Ubiquitination ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Gastrointestinal Neoplasms/genetics ; Carcinogenesis ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Protein Isoforms ; Tumor Suppressor Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-024-06575-z
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  6. Article: Multicellular String-Like Structure Formation by

    Varghese, Alan / Ray, Semanti / Verma, Taru / Nandi, Dipankar

    Frontiers in microbiology

    2020  Volume 11, Page(s) 613704

    Abstract: Bacteria face diverse stresses in the environment and, sometimes, respond by forming multi-cellular structures, e.g., biofilms. Here, we report a novel macroscopic and multi-cellular structure formed ... ...

    Abstract Bacteria face diverse stresses in the environment and, sometimes, respond by forming multi-cellular structures, e.g., biofilms. Here, we report a novel macroscopic and multi-cellular structure formed by
    Language English
    Publishing date 2020-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.613704
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  7. Article ; Online: Insights into coumarin-mediated inhibition of biofilm formation in

    Thakur, Samriddhi / Ray, Semanti / Jhunjhunwala, Siddharth / Nandi, Dipankar

    Biofouling

    2020  Volume 36, Issue 4, Page(s) 479–491

    Abstract: Coumarins have been shown to possess antimicrobial, anti-quorum sensing and anti-biofilm properties against a wide range of pathogenic bacteria. This study aimed to shed light on the effects of non-substituted coumarin on biofilm formation by the ... ...

    Abstract Coumarins have been shown to possess antimicrobial, anti-quorum sensing and anti-biofilm properties against a wide range of pathogenic bacteria. This study aimed to shed light on the effects of non-substituted coumarin on biofilm formation by the foodborne pathogen
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Coumarins/pharmacology ; Salmonella typhimurium
    Chemical Substances Anti-Bacterial Agents ; Coumarins ; coumarin (A4VZ22K1WT)
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1029-2454
    ISSN (online) 1029-2454
    DOI 10.1080/08927014.2020.1773447
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  8. Article ; Online: Salmonella

    Ray, Semanti / Da Costa, Rochelle / Thakur, Samriddhi / Nandi, Dipankar

    Microbiology (Reading, England)

    2020  Volume 166, Issue 5, Page(s) 460–473

    Abstract: The ability of bacteria to form biofilms increases their survival under adverse environmental conditions. Biofilms have enormous medical and environmental impact; consequently, the factors that influence biofilm formation are an important area of study. ... ...

    Abstract The ability of bacteria to form biofilms increases their survival under adverse environmental conditions. Biofilms have enormous medical and environmental impact; consequently, the factors that influence biofilm formation are an important area of study. In this investigation, the roles of two cold shock proteins (CSP) during biofilm formation were investigated in
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/physiology ; Biofilms/growth & development ; Biological Phenomena ; Cold Shock Proteins and Peptides/genetics ; Cold Shock Proteins and Peptides/physiology ; Gene Expression Regulation, Bacterial ; Genetic Complementation Test ; Movement ; Mutation ; Salmonella typhimurium/genetics ; Salmonella typhimurium/physiology ; Salmonella typhimurium/ultrastructure ; Up-Regulation
    Chemical Substances Bacterial Proteins ; Cold Shock Proteins and Peptides
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.000900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Randomized Controlled Trial Comparing Remission Induction with Modified Multitarget Therapy with Intravenous Cyclophosphamide in Proliferative Lupus Nephritis.

    Pal, Atanu / Chaudhury, Arpita Ray / Bhunia, Abhirup / Bhattacharya, Koushik / Chatterjee, Suparna / Divyaveer, Smita Subhash / Sircar, Dipankar / Sen, Debabrata

    Indian journal of nephrology

    2023  Volume 33, Issue 5, Page(s) 340–347

    Abstract: Introduction: Therapy of proliferative lupus nephritis (PLN) is yet to be optimized. Standard of care for induction consists of intravenous (IV) cyclophosphamide (CYC) and steroids, which shows an improved outcome, but end-stage renal disease (ESRD) ... ...

    Abstract Introduction: Therapy of proliferative lupus nephritis (PLN) is yet to be optimized. Standard of care for induction consists of intravenous (IV) cyclophosphamide (CYC) and steroids, which shows an improved outcome, but end-stage renal disease (ESRD) progression, increased mortality, and therapy-related adverse effects remain a major concern. The other treatment reported to induce early remission was the multitarget therapy comprising tacrolimus, mycophenolate, and steroid, but infections were high in the multitarget therapy. Considering azathioprine as a potentially safer and effective alternative anti-B-cell therapy, modified multitarget therapy (MMTT) was planned replacing mycophenolate with azathioprine.
    Material and methods: A single-center, 24-week, open-label, randomized controlled trial comprising adults of age 18-65 years with biopsy-proven PLN was carried out. The intervention groups were 1) MMTT: tacrolimus 0.075 mg/kg/day and azathioprine 2 mg/kg/day and 2) IV CYC group with a starting dose of 0.75 (adjusted to 0.5-1.0) g/m
    Results: Among 100 randomized patients, 48 were in MMTT arm and 52 were in IV CYC arm. At the end of 24 weeks, overall remission (complete and partial) was comparable in both the arms: MMTT (86.36%) and IV CYC (87.75%). There was comparable proteinuria reduction and systemic lupus erythematosus disease activity index (SLEDAI) score improvement with recovery of complement level C3 in both groups. Major adverse events were numerically more in the IV CYC group, including one death from pneumonia.
    Conclusion: The MMTT arm is as effective as IV CYC in improving short-term outcome in PLN, with a comparable safety profile.
    Language English
    Publishing date 2023-07-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2134388-3
    ISSN 1998-3662 ; 0971-4065
    ISSN (online) 1998-3662
    ISSN 0971-4065
    DOI 10.4103/ijn.ijn_355_21
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  10. Article ; Online: Antithyroid arthritis syndrome in a case of post-COVID-19 subacute thyroiditis.

    Ghosh, Ritwik / Dubey, Souvik / Sarkar, Anupam / Biswas, Dipankar / Ray, Adrija / Roy, Dipayan / Chatterjee, Subhankar / Benito-León, Julián

    Diabetes & metabolic syndrome

    2021  Volume 15, Issue 3, Page(s) 683–686

    MeSH term(s) Antithyroid Agents/adverse effects ; Arthritis/chemically induced ; COVID-19/complications ; Carbimazole/adverse effects ; Humans ; Male ; Middle Aged ; Thyroiditis, Subacute/drug therapy ; Thyroiditis, Subacute/virology
    Chemical Substances Antithyroid Agents ; Carbimazole (8KQ660G60G)
    Language English
    Publishing date 2021-03-25
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2021.03.015
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