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  1. Article ; Online: Flashback Foreword: Nivolumab in Advanced Melanoma: Survival and Long-Term Safety.

    Schwartz, Gary K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 5, Page(s) 941–942

    MeSH term(s) Humans ; Nivolumab/therapeutic use ; Melanoma/drug therapy ; Skin Neoplasms/drug therapy ; Ipilimumab/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Nivolumab (31YO63LBSN) ; Ipilimumab
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  2. Article ; Online: Flashback Foreword: Adjuvant Interferon α-2b for High-Risk Melanoma.

    Schwartz, Gary K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 3, Page(s) 423–424

    MeSH term(s) Humans ; Interferon-alpha/adverse effects ; Melanoma/drug therapy ; Recombinant Proteins ; Chemotherapy, Adjuvant ; Skin Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use
    Chemical Substances Interferon-alpha ; Recombinant Proteins ; Antineoplastic Agents
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  3. Article ; Online: Ripretinib and the Failure to Advance GI Stromal Tumor Therapy in the Age of Precision Medicine.

    Schwartz, Gary K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 34, Page(s) 3903–3906

    MeSH term(s) Humans ; Precision Medicine ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/pathology ; Naphthyridines/therapeutic use ; Urea ; Gastrointestinal Neoplasms/drug therapy
    Chemical Substances ripretinib (9XW757O13D) ; Naphthyridines ; Urea (8W8T17847W)
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Flashback Foreword: Prognostic Factors in Osteosarcoma.

    Maki, Robert G / Schwartz, Gary K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 27, Page(s) 4321–4322

    MeSH term(s) Humans ; Prognosis ; Osteosarcoma/therapy ; Bone Neoplasms/therapy
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Combination cancer therapy

    Schwartz, Gary K.

    modulators and potentiators

    (Cancer drug discovery and development)

    2005  

    Author's details ed. by Gary K. Schwartz
    Series title Cancer drug discovery and development
    Keywords Neoplasms / drug therapy ; Drug Therapy, Combination
    Language English
    Size X, 284 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014096260
    ISBN 1-58829-200-2 ; 978-1-58829-200-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 1546 order for loan Magazin

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  6. Article ; Online: Reply to S. Rastogi et al.

    Schwartz, Gary K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2016  Volume 34, Issue 29, Page(s) 3584

    Language English
    Publishing date 2016--10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.68.3037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Novel Therapeutics in the Treatment of Uterine Sarcoma.

    Bose, Sminu / Schwartz, Gary K / Ingham, Matthew

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2022  Volume 42, Page(s) 900–909

    Abstract: Uterine sarcomas reflect the diversity of sarcoma as a whole. The most common histologies include leiomyosarcoma, high- and low-grade endometrial stromal sarcoma, and adenosarcoma. These are clinically and biologically heterogeneous diseases that are ... ...

    Abstract Uterine sarcomas reflect the diversity of sarcoma as a whole. The most common histologies include leiomyosarcoma, high- and low-grade endometrial stromal sarcoma, and adenosarcoma. These are clinically and biologically heterogeneous diseases that are challenging to treat in the advanced setting. Recent advances in our understanding of the cancer biology of uterine sarcomas has improved diagnostic evaluation and therapeutic management. Promising approaches for patients with advanced uterine leiomyosarcoma include targeting DNA damage repair pathways and depleting immunosuppressive macrophage populations. A subset of endometrial stromal sarcomas harbor potentially actionable alterations in the Wnt, cyclin D-CDK4/6-Rb, and MDM2-p53 pathways. There remains an urgent need to translate molecular findings into prospective clinical trials of novel agents for patients with these diseases; progress will depend on academic collaborations and enrollment of patients with uterine sarcoma in biomarker-driven basket studies.
    MeSH term(s) Endometrial Neoplasms ; Female ; Humans ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/drug therapy ; Leiomyosarcoma/genetics ; Prospective Studies ; Sarcoma/diagnosis ; Sarcoma/drug therapy ; Sarcoma/genetics ; Soft Tissue Neoplasms ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/drug therapy ; Uterine Neoplasms/genetics
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_350541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Trabectedin and the L-Sarcomas: A Decade-Long Odyssey.

    Schwartz, Gary K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2016  Volume 34, Issue 8, Page(s) 769–771

    MeSH term(s) Antineoplastic Agents, Alkylating/therapeutic use ; Humans ; Sarcoma/drug therapy
    Chemical Substances Antineoplastic Agents, Alkylating
    Language English
    Publishing date 2016-03-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2015.63.5938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Exceptional Response to Dacarbazine in Uterine Leiomyosarcoma With Homozygous

    Ingham, Matthew A / McGuinness, Julia E / Kalinsky, Kevin / Schwartz, Gary K

    JCO precision oncology

    2022  Volume 2, Page(s) 1–6

    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.18.00131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells.

    Ambrosini, Grazia / Natale, Christopher A / Musi, Elgilda / Garyantes, Tina / Schwartz, Gary K

    Cancer research communications

    2023  Volume 3, Issue 4, Page(s) 540–547

    Abstract: Uveal melanoma is the most common primary intraocular malignancy in adults and has a high incidence of metastatic disease. Current treatments have shown limited clinical activity in patients with uveal melanoma with metastasis and there is an urgent need ...

    Abstract Uveal melanoma is the most common primary intraocular malignancy in adults and has a high incidence of metastatic disease. Current treatments have shown limited clinical activity in patients with uveal melanoma with metastasis and there is an urgent need for new effective therapies. Recent findings have shown that women with uveal melanoma have better survival rates than men. The G protein-coupled estrogen receptor-1 (GPER) has distinct functions from those of the classic estrogen receptors ERα/β and its activation by specific agonists has tumor-suppressive roles in several cancers. However, the role of GPER had not previously been investigated in uveal melanoma. We demonstrated that downregulation of GPER in uveal melanoma cells decreased expression of p53 and stimulated cell growth. In contrast, the clinical GPER agonist, LNS8801, upregulated p53 and p21, induced melanocytic differentiation markers, inhibited cell proliferation and cell migration, and induced apoptosis. Furthermore, LNS8801 treatment arrested the cells in G
    Significance: Current treatments against metastatic uveal melanoma have shown limited clinical activity and there is an urgent need for effective therapies. Here, we demonstrate that the GPER agonist LNS8801 induced both GPER-dependent and GPER-independent effects and elicited potent anticancer activities
    MeSH term(s) Male ; Adult ; Humans ; Female ; Tumor Suppressor Protein p53/pharmacology ; Melanoma/drug therapy ; Estrogens/metabolism ; Apoptosis ; Cell Line, Tumor
    Chemical Substances Tumor Suppressor Protein p53 ; Estrogens
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-22-0399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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