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  1. Article ; Online: CETP Activity: A Link between Lipid Metabolism and Coagulation System.

    Hatakeyama, Kinta

    Journal of atherosclerosis and thrombosis

    2016  Volume 23, Issue 10, Page(s) 1144–1146

    MeSH term(s) Blood Coagulation/physiology ; Cholesterol Ester Transfer Proteins/metabolism ; Humans ; Lipid Metabolism ; Venous Thrombosis/physiopathology
    Chemical Substances Cholesterol Ester Transfer Proteins
    Language English
    Publishing date 2016-10-01
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED053
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5192: Show issues Location:
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  2. Article: [Ascending Aortic Mural Thrombus Caused by Plaque Destruction:Report of a Case].

    Nagasaka, Shigeo / Kaneda, Kozo / Yoshida, Yuichi / Nishikawa, Hiroshi / Nishiwaki, Noboru / Hatakeyama, Kinta

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 6, Page(s) 473–476

    Abstract: A 52-year-old male with complaints of pain and cold sensation on left upper-extremity was admitted to a hospital. He was diagnosed with acute left brachial artery occlusion and accordingly underwent emergency thrombectomy. Contrast-enhanced computed ... ...

    Abstract A 52-year-old male with complaints of pain and cold sensation on left upper-extremity was admitted to a hospital. He was diagnosed with acute left brachial artery occlusion and accordingly underwent emergency thrombectomy. Contrast-enhanced computed tomography (CT) revealed an ascending aortic mural thrombus (AMT). After his transferring to our institution, the AMT was removed, and the ascending aorta was replaced under cardiac arrest. Based on histopathological findings, the thrombus was caused by the destruction of an atheromatous plaque. The patient's postoperative course was uneventful, and no recurrence of AMT was presented for 12 months after operation.
    MeSH term(s) Male ; Humans ; Middle Aged ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/surgery ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/etiology ; Aortic Diseases/surgery ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Thrombosis/surgery ; Thromboembolism ; Aorta/diagnostic imaging ; Aorta/surgery ; Heart Diseases
    Language Japanese
    Publishing date 2023-04-20
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Case Report: Postmortem brain and heart pathology unveiling the pathogenesis of coexisting acute ischemic stroke and electrocardiographic abnormality.

    Hattori, Yorito / Ikeda, Shuhei / Matsumoto, Manabu / Tagawa, Naoki / Hatakeyama, Kinta / Ihara, Masafumi

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1200640

    Abstract: Electrocardiography abnormalities have been occasionally reported at the onset of stroke. Simultaneous electrocardiographic abnormalities and stroke require a rapid differentiated diagnosis among several diseases. However, direct causal relationships ... ...

    Abstract Electrocardiography abnormalities have been occasionally reported at the onset of stroke. Simultaneous electrocardiographic abnormalities and stroke require a rapid differentiated diagnosis among several diseases. However, direct causal relationships remain unclear. A 92-year-old woman presented to our emergency department in a sudden-onset coma. The patient suffered from huge acute ischemic stroke with bilateral internal carotid artery occlusion assessed by brain magnetic resonance imaging, and her electrocardiography showed ST-segment elevation at II, III, aVF and V4-6, and atrial fibrillation (AF). However, the etiology of the medical condition was clinically unknown. Eventually, the patient died on day 4 of hospitalization before the diagnosis could be completed. Therefore, an autopsy was performed to investigate pathological findings after obtaining informed consent from the family. A postmortem pathological evaluation demonstrated that fibrin mural thrombi in the left atrial appendage (LAA), and the cerebral and coronary arteries possessed CD31-positive endothelial cells, and CD68-positive and CD168-positive macrophages in a similar fashion, suggesting the fibrin thrombi observed in the three sites implicated to be identical. We concluded that nearly concurrent cerebral and coronary artery embolism because of the fibrin thrombi in LAA developed by AF. Simultaneous cerebral infarction and myocardial infarction are referred to as cardiocerebral infarction (CCI), a rare disorder for which clear pathomechanisms remain unknown, although several mechanisms of CCI have been proposed. We first revealed the clear pathology of CCI using the autopsy. Additional pathological studies are warranted to establish clear pathomechanisms and preventive strategies of CCI.
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1200640
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  4. Article ; Online: Chlamydia pneumoniae

    Otani, Tomoyuki / Nishihira, Kensaku / Azuma, Yoshinao / Yamashita, Atsushi / Shibata, Yoshisato / Asada, Yujiro / Hatakeyama, Kinta

    Clinical pathology (Thousand Oaks, Ventura County, Calif.)

    2022  Volume 15, Page(s) 2632010X221125179

    Abstract: Aim: To clarify whether there is any association between the extent of : Methods and results: Immunohistochemistry (IHC) and real-time polymerase chain reaction (RT-PCR) revealed the existence of : Conclusions: C. ... ...

    Abstract Aim: To clarify whether there is any association between the extent of
    Methods and results: Immunohistochemistry (IHC) and real-time polymerase chain reaction (RT-PCR) revealed the existence of
    Conclusions: C. pneumoniae
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2632-010X
    ISSN (online) 2632-010X
    DOI 10.1177/2632010X221125179
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  5. Article ; Online: Myocardial ischemic injury derived from multiple thromboemboli due to eosinophilic endomyocarditis (Löffler endocarditis) causing right ventricular rupture.

    Yoshizawa, Hidenori / Ikeda, Yoshihiko / Hatakeyama, Kinta / Yoshida, Ken-Ichi

    Pathology international

    2021  Volume 71, Issue 10, Page(s) 722–724

    MeSH term(s) Aged ; Endocarditis/complications ; Endocarditis/diagnosis ; Eosinophilia/complications ; Eosinophilia/diagnosis ; Heart Rupture/etiology ; Heart Ventricles/pathology ; Humans ; Male ; Myocardial Ischemia/pathology ; Myocarditis/complications ; Myocarditis/diagnosis ; Thromboembolism/complications ; Thromboembolism/etiology
    Language English
    Publishing date 2021-08-20
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1194850-4
    ISSN 1440-1827 ; 1320-5463
    ISSN (online) 1440-1827
    ISSN 1320-5463
    DOI 10.1111/pin.13152
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  6. Article: Fat biopsy from a pocket of cardiac implantable electronic device: An alternative diagnostic option for cardiac amyloidosis.

    Takano, Ryo / Ueda, Nobuhiko / Okada, Atsushi / Matsumoto, Manabu / Ikeda, Yoshihiko / Hatakeyama, Kinta / Izumi, Chisato / Kusano, Kengo

    HeartRhythm case reports

    2022  Volume 8, Issue 8, Page(s) 554–557

    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2022.05.008
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  7. Article ; Online: COVID-19-associated myocardial injury: A case report.

    Tadokoro, Tomonori / Ohta-Ogo, Keiko / Ikeda, Yoshihiko / Sugiyama, Masaya / Katano, Harutaka / Hatakeyama, Kinta / Matsumoto, Masanori / Tashiro, Hideki

    ESC heart failure

    2023  Volume 10, Issue 2, Page(s) 1461–1466

    Abstract: Coronavirus disease 2019 (COVID-19) is often accompanied by pneumonia and can be fatal. We report a case of COVID-19-associated myocardial injury mimicking fulminant myocarditis. Endomyocardial biopsy revealed numerous von Willebrand factor-rich ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is often accompanied by pneumonia and can be fatal. We report a case of COVID-19-associated myocardial injury mimicking fulminant myocarditis. Endomyocardial biopsy revealed numerous von Willebrand factor-rich microthrombi with small myocardial necrotic areas, complement deposits in small vessels/microthrombi, and macrophage-predominant interstitial infiltration. These findings, distinct from those of typical lymphocytic myocarditis, show diffuse endothelial injury, complement activation, and activated macrophages as characteristic features of COVID-19-associated pathogenesis. Dysregulated serum cytokine profiles predicting severe/critical COVID-19-associated myocardial injury were also determined. This case emphasizes the occurrence of fatal cardiac manifestation with microthrombotic injury in the early stage of COVID-19.
    MeSH term(s) Humans ; COVID-19/complications ; Myocarditis/diagnosis ; Myocarditis/etiology ; SARS-CoV-2 ; Heart ; Myocardial Infarction
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14295
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  8. Article ; Online: Plaque Ulcerations are Associated with Recurrence in Symptomatic Low-Grade Carotid Stenosis.

    Shimonaga, Koji / Ikedo, Taichi / Yamada, Naoto / Niwa, Akihiro / Kushi, Yuji / Hamano, Eika / Yamada, Kiyofumi / Imamura, Hirotoshi / Mori, Hisae / Hatakeyama, Kinta / Iihara, Koji / Kataoka, Hiroharu

    World neurosurgery

    2024  Volume 183, Page(s) e886–e891

    Abstract: Objective: Surgical indications for low-grade carotid stenosis have not yet been established. This study aimed to clarify the characteristics of low-grade carotid stenosis refractory to medical treatment.: Methods: We retrospectively analyzed 48 ... ...

    Abstract Objective: Surgical indications for low-grade carotid stenosis have not yet been established. This study aimed to clarify the characteristics of low-grade carotid stenosis refractory to medical treatment.
    Methods: We retrospectively analyzed 48 patients with symptomatic low-grade carotid stenosis (<50%). Recurrence was defined as an ipsilateral ischemic event in the symptomatic lesions during the follow-up period. Patient demographics and imaging findings were compared between the recurrence and nonrecurrence groups to investigate risk factors associated with medical treatment.
    Results: The mean age was 74.1 (58-90 years), and the mean follow-up period was 35.4 months (2.0-97 months). Recurrence occurred in 15 of the symptomatic patients. Ulceration was significantly associated with recurrence under medical treatment (P = 0.001). The median time to recurrence was 26.1 months in patients with ulcers and 54.3 months in those without ulcers (P = 0.04). Pathological study with recurrence showed plaque rupture with multilayered lesions, indicating lesions refractory to medical treatment.
    Conclusions: In cases of low-grade carotid stenosis, lesions with ulcerations are likely refractory to medical therapy. Consideration of the indications for surgical treatment may be warranted for lesions with ulceration, even if the degree of stenosis is low.
    MeSH term(s) Humans ; Aged ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Retrospective Studies ; Ulcer/complications ; Ulcer/diagnostic imaging ; Ulcer/surgery ; Plaque, Atherosclerotic/pathology ; Brain Ischemia/etiology ; Risk Factors ; Recurrence ; Stroke/etiology
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.01.051
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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  9. Article ; Online: Can right ventricular endomyocardial biopsy predict left ventricular fibrosis beforehand in dilated cardiomyopathy?

    Amemiya, Kisaki / Matsuyama, Taka-Aki / Ishibashi-Ueda, Hatsue / Morita, Yoshiaki / Matsumoto, Manabu / Ohta-Ogo, Keiko / Ikeda, Yoshihiko / Tsukamoto, Yasumasa / Fukushima, Norihide / Fukushima, Satsuki / Fujita, Tomoyuki / Hatakeyama, Kinta

    ESC heart failure

    2024  Volume 11, Issue 2, Page(s) 1001–1008

    Abstract: Aims: Myocardial fibrosis of the left ventricle (LV) is a prognostic factor in dilated cardiomyopathy (DCM). This study aims to evaluate whether fibrosis of right ventricular (RV) endomyocardial biopsy (EMB) can predict the degree of LV fibrosis ... ...

    Abstract Aims: Myocardial fibrosis of the left ventricle (LV) is a prognostic factor in dilated cardiomyopathy (DCM). This study aims to evaluate whether fibrosis of right ventricular (RV) endomyocardial biopsy (EMB) can predict the degree of LV fibrosis beforehand in DCM.
    Methods and results: Fibrosis extent in 70 RV-EMB specimens of DCM diagnosis was compared with that in the whole cross-sectional LV of excised hearts in the same patients (52 explanted hearts for transplant and 18 autopsied hearts). The median interval between biopsy and excision was 4.1 (0.13-19.3) years. The fibrosis area ratio of the EMBs and excised hearts were evaluated via image analysis. The distribution of cardiovascular magnetic resonance-late gadolinium enhancement (LGE) in the intraventricular septum was classified into four quartile categories. The fibrosis area ratio in RV-EMB correlated significantly with that in the short-axis cut of the LV of excised hearts (r = 0.82, P < 0.0001) and with a diffuse pattern of LGE (r = 0.71, P = 0.003). In a multivariate model, after adjusting for the interval between biopsy performance and heart excision, the fibrosis area ratio in RV-EMB was associated with that in LV-excised heart (regression coefficient, 0.82; 95% confidence interval, 0.68-0.95; P < 0.0001).
    Conclusions: The fibrosis observed in RV-EMB positively correlated with the extent of fibrosis in the LV of excised hearts in patients with DCM. The study findings may help predict LV fibrosis, considered a prognostic factor of DCM through relatively accessible biopsy techniques.
    MeSH term(s) Humans ; Cardiomyopathy, Dilated/diagnosis ; Myocardium/pathology ; Heart Ventricles ; Contrast Media ; Cross-Sectional Studies ; Gadolinium ; Fibrosis ; Biopsy/methods
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14642
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  10. Article: A 5-year survivor of endarterectomy for sclerosing undifferentiated intimal sarcoma of the pulmonary artery: Importance of clinical suspicion and careful histologic evaluation.

    Amemiya, Kisaki / Nishihira, Morikazu / Ishibashi-Ueda, Hatsue / Ohta-Ogo, Keiko / Ogo, Takeshi / Ikeda, Yoshihiko / Hatakeyama, Kinta / Sasaki, Hiroaki / Ogino, Hitoshi

    Pulmonary circulation

    2023  Volume 13, Issue 4, Page(s) e12315

    Abstract: We present a diagnostically challenging case of intimal sarcoma of the pulmonary artery (PA) due to the histologic finding of a sclerosing appearance with no appreciable spindle/pleomorphic cell proliferation. Initial endarterectomy specimens were ... ...

    Abstract We present a diagnostically challenging case of intimal sarcoma of the pulmonary artery (PA) due to the histologic finding of a sclerosing appearance with no appreciable spindle/pleomorphic cell proliferation. Initial endarterectomy specimens were composed of sclerosing extracellular matrix with a few bland cells, some recanalization, and fibrin thrombi, impeding the confirmation of intimal sarcoma as these findings were also consistent with chronic thromboembolic pulmonary hypertension. However, the patient experienced recurrence 5 years later, and the second endarterectomy specimens revealed more firm and solid mass and the proliferation of atypical spindle/pleomorphic cells within a myxomatous matrix in the distal PA, leading to the definitive diagnosis of undifferentiated intimal sarcoma of the PA. The archival specimens from the endarterectomy confirmed intense MDM2 expression by immunohistochemistry, suggesting its role as a potential diagnostic marker for intimal sarcoma. This case highlights that prominent sclerosing extracellular matrix with very few atypical cells should raise the possibility of intimal sarcoma of the PA and that high index of suspicion, generous sampling, and ancillary tests are critical for accurate diagnosis. In this case, the tumor was incidentally removed by endarterectomy, resulting in 5 years of survival.
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12315
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