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Article ; Online: A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation.

Domínguez-Horta, Maria Del Carmen / Serrano-Díaz, Anabel / Hernández-Cedeño, Mabel / Martínez-Donato, Gillian / Guillén-Nieto, Gerardo

Frontiers in immunology

2023 Volume 14, Page(s) 1162739

Abstract: Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They are crucial in the progress of acute inflammatory diseases and autoimmunity. In fact, the inhibition of proinflammatory cytokines has been widely tested in the ... ...

Abstract	Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They are crucial in the progress of acute inflammatory diseases and autoimmunity. In fact, the inhibition of proinflammatory cytokines has been widely tested in the treatment of rheumatoid arthritis (RA). Some of these inhibitors have been used in the treatment of COVID-19 patients to improve survival rates. However, controlling the extent of inflammation with cytokine inhibitors is still a challenge because these molecules are redundant and pleiotropic. Here we review a novel therapeutic approach based on the use of the HSP60-derived Altered Peptide Ligand (APL) designed for RA and repositioned for the treatment of COVID-19 patients with hyperinflammation. HSP60 is a molecular chaperone found in all cells. It is involved in a wide diversity of cellular events including protein folding and trafficking. HSP60 concentration increases during cellular stress, for example inflammation. This protein has a dual role in immunity. Some HSP60-derived soluble epitopes induce inflammation, while others are immunoregulatory. Our HSP60-derived APL decreases the concentration of cytokines and induces the increase of FOXP3+ regulatory T cells (Treg) in various experimental systems. Furthermore, it decreases several cytokines and soluble mediators that are raised in RA, as well as decreases the excessive inflammatory response induced by SARS-CoV-2. This approach can be extended to other inflammatory diseases.
MeSH term(s)	Humans ; Arthritis, Rheumatoid ; COVID-19 ; Cytokines/metabolism ; Inflammation/drug therapy ; Peptides/pharmacology ; Peptides/therapeutic use ; SARS-CoV-2/metabolism ; Chaperonin 60/pharmacology ; Chaperonin 60/therapeutic use
Chemical Substances	Cytokines ; Peptides ; Chaperonin 60
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1162739
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Article ; Online: Determinación de los valores de referencia en el hemograma de caballos nacidos o criados entre 0 y 500 m.s.n.m. en la región litoral del Ecuador

Diego Fernando Luna Narváez / Karen Elizabeth Hernández Toro / Sergio Rolando Chacha Vega / Yolanda Mercedes Cedeño Prócel

La Granja: Revista de Ciencias de la Vida, Vol 28, Iss

2018 Volume 2

Abstract: ... previo, realizado a más de 3000 m.s.n.m en la sierra centro norte ecuatoriana. Se obtuvieron ... con parámetros sanguíneos homogéneos y una referencia de esta variedad antes solamente estudiada sobre los 3000 m ... s.n.m. Se encontraron los siguientes valores; eritrocitos: 4,90-9,38x106/mL, hematocrito: 24,83-45 ...

Abstract	El presente trabajo se realizó en la región litoral del Ecuador, en donde se analizaron los hemogramas de 100 caballos criollos clínicamente sanos, mayores a dos años de edad y criados entre los 0 y 500 metros sobre el nivel del mar, para cumplir con los objetivos de determinar los valores hematológicos de referencia y comparar los resultados obtenidos con los valores de referencia de un estudio previo, realizado a más de 3000 m.s.n.m en la sierra centro norte ecuatoriana. Se obtuvieron las muestras sanguíneas de animales en reposo, se realizaron los análisis de laboratorio con el equipo de auto-hematología Mindray RBC2800Vet y posteriormente se hizo un análisis estadístico utilizando el complemento de Microsoft Excel R“Reference Value Advisor” para determinar los valores de referencia y eliminar los valores anómalos. Se prefirió tomar la muestra de caballos criollos ecuatorianos para tener una muestra con parámetros sanguíneos homogéneos y una referencia de esta variedad antes solamente estudiada sobre los 3000 m.s.n.m. Se encontraron los siguientes valores; eritrocitos: 4,90-9,38x106/mL, hematocrito: 24,83-45,10%, hemoglobina: 8,59-14,87g/L, VCM: 42,35-55,19fL, HCM: 14,25-18,20pg, CHCM: 32,10-36,70g/L, glóbulos blancos: 5,64-12,81x103/mL, linfocitos: 1,04-5,85x103/mL, monocitos: 0,20-0,90x103/mL, granulocitos: 2,90-8,26x103/mL y plaquetas: 78,10-314,90x103/mL. En la comparación con los resultados obtenidos se encontraron diferencias significativas (P<0,05) en el contaje de eritrocitos, concentración de hemoglobina, hematocrito y contaje de plaquetas debido a la influencia de la altura; también se encontraron diferencias significativas (P<0,05) en la serie blanca (leucocitos, linfocitos, monocitos y granulocitos) pero esto debido a influencias fisiológicas o patológicas, mas no al efecto altitudinal.
Keywords	altura ; caballos ; hemograma ; hipoxia ; mar ; Agriculture ; S ; Agriculture (General) ; S1-972 ; Science (General) ; Q1-390
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	Universidad Politécnica Salesiana
Document type	Article ; Online
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Article ; Online: Jusvinza, an anti-inflammatory drug derived from the human heat-shock protein 60, for critically ill COVID-19 patients. An observational study.

Venegas-Rodríguez, Rafael / Serrano-Díaz, Anabel / Peña-Ruiz, Ruben / Santana-Sánchez, Raul / Hernández-Cedeño, Mabel / Rittoles Navarro, Aliusha / Grecesqui-Cruz, Inti / Pérez-Aguilera, Liam / Segura-Fernández, Anadys / Rosario-Cruz, Leticia / Martínez-Donato, Gilliam / Guillén-Nieto, Gerardo / Domínguez-Horta, Maria Del Carmen

PloS one

2023 Volume 18, Issue 2, Page(s) e0281111

Abstract: This paper presents the results of an observational and retrospective study on the therapeutic effects of Jusvinza, an immunomodulatory peptide with anti-inflammatory properties for critically ill COVID-19 patients. This peptide induces regulatory ... ...

Abstract	This paper presents the results of an observational and retrospective study on the therapeutic effects of Jusvinza, an immunomodulatory peptide with anti-inflammatory properties for critically ill COVID-19 patients. This peptide induces regulatory mechanisms on the immune response in experimental systems and in patients with Rheumatoid Arthritis. Exploratory research in COVID-19 patients revealed that Jusvinza promotes clinical and radiological improvement. The aim of this study is to describe the clinical outcome and variations of several inflammatory biomarkers in a cohort of critically ill COVID-19 patients, divided into two groups during the observational research: one group received Jusvinza and the other did not. Research physicians extracted the patients´ data from their hospital's clinical records. The study analyzed 345 medical records, and 249 records from critically ill patients were included. The data covered the demographic characteristics, vital signs, ventilatory parameters and inflammatory biomarkers. Survival outcome was significantly higher in the group receiving Jusvinza (90.4%) compared to the group without Jusvinza (39.5%). Furthermore, in patients treated with Jusvinza there was a significant improvement in ventilatory parameters and a reduction in inflammation and coagulation biomarkers. Our findings show that Jusvinza could control the extent of inflammation in COVID-19 patients. This study indicates that Jusvinza is a helpful drug for the treatment of diseases characterized by hyperinflammation.
MeSH term(s)	Humans ; COVID-19 ; Chaperonin 60 ; Retrospective Studies ; SARS-CoV-2 ; Critical Illness/therapy ; Inflammation ; Biomarkers ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Chaperonin 60 ; Biomarkers ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281111
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Article ; Online: CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.

Hernandez-Cedeño, M / Venegas-Rodriguez, R / Peña-Ruiz, R / Bequet-Romero, M / Santana-Sanchez, R / Penton-Arias, E / Martinez-Donato, G / Guillén-Nieto, G / Dominguez-Horta, María Del Carmen

Cell stress & chaperones

2021 Volume 26, Issue 3, Page(s) 515–525

Abstract: Hyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand ( ... ...

Abstract	Hyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that CIGB-258 was safe and reduced inflammation. The aim of this study was to examine specific biomarkers associated with hyperinflammation, some cytokines linked to the cytokine storm granzyme B and perforin in a cohort of COVID-19 patients treated with this peptide. All critically ill patients were under invasive mechanical ventilation and received the intravenous administration of 1 or 2 mg of CIGB-258 every 12 h. Seriously ill patients were treated with oxygen therapy receiving 1 mg of CIGB-258 every 12 h and all patients recovered from their severe condition. Biomarker levels associated with hyperinflammation, such as interleukin (IL)-6, IL-10, tumor necrosis factor (TNF-α), granzyme B, and perforin, significantly decreased during treatment. Furthermore, we studied the ability of CIGB-258 to induce Tregs in COVID-19 patients and found that Tregs were induced in all patients studied. Altogether, these results support the therapeutic potential of CIGB-258 for diseases associated with hyperinflammation. Clinical trial registry: RPCEC00000313.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; COVID-19/blood ; COVID-19/complications ; Chaperonin 60/chemistry ; Chaperonin 60/therapeutic use ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/complications ; Cytokine Release Syndrome/drug therapy ; Female ; Humans ; Inflammation/blood ; Inflammation/complications ; Inflammation/drug therapy ; Interleukin-10/blood ; Interleukin-6/blood ; Male ; Middle Aged ; SARS-CoV-2/drug effects ; T-Lymphocytes, Regulatory/drug effects ; Tumor Necrosis Factor-alpha/blood ; Young Adult ; COVID-19 Drug Treatment
Chemical Substances	Anti-Inflammatory Agents ; Chaperonin 60 ; IL10 protein, human ; IL6 protein, human ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2021-02-24
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1362749-1
ISSN	1466-1268 ; 1355-8145
ISSN (online)	1466-1268
ISSN	1355-8145
DOI	10.1007/s12192-021-01197-2
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Article ; Online: Design and Biological Assembly of Polyester Beads Displaying Pneumococcal Antigens as Particulate Vaccine.

González-Miró, Majela / Radecker, Anna-Maria / Rodríguez-Noda, Laura M / Fariñas-Medina, Mildrey / Zayas-Vignier, Caridad / Hernández-Cedeño, Mabel / Serrano, Yohana / Cardoso, Félix / Santana-Mederos, Darielys / García-Rivera, Dagmar / Valdés-Balbín, Yury / Vérez-Bencomo, Vicente / Rehm, Bernd H A

ACS biomaterials science & engineering

2018 Volume 4, Issue 9, Page(s) 3413–3424

Abstract: Streptococcus ... ...

Abstract	Streptococcus pneumoniae
Language	English
Publishing date	2018-08-14
Publishing country	United States
Document type	Journal Article
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.8b00579
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Article ; Online: Bioengineered polyester beads co-displaying protein and carbohydrate-based antigens induce protective immunity against bacterial infection.

González-Miró, Majela / Rodríguez-Noda, Laura M / Fariñas-Medina, Mildrey / Cedré-Marrero, Barbara / Madariaga-Zarza, Sandra / Zayas-Vignier, Caridad / Hernández-Cedeño, Mabel / Kleffmann, Torsten / García-Rivera, Dagmar / Vérez-Bencomo, Vicente / Rehm, Bernd H A

Scientific reports

2018 Volume 8, Issue 1, Page(s) 1888

Abstract: The efficacy of protein and carbohydrate antigens as vaccines can be improved via particulate delivery strategies. Here, protein and carbohydrate antigens used in formulations of vaccines against Neisseria menigitidis were displayed on in vivo assembled ... ...

Abstract	The efficacy of protein and carbohydrate antigens as vaccines can be improved via particulate delivery strategies. Here, protein and carbohydrate antigens used in formulations of vaccines against Neisseria menigitidis were displayed on in vivo assembled polyester beads using a combined bioengineering and conjugation approach. An endotoxin-free mutant of Escherichia coli was engineered to produce translational fusions of antigens (Neisseria adhesin A (NadA) and factor H binding protein (fHbp) derived from serogroup B) to the polyhydroxybutyrate synthase (PhaC), in order to intracellularly assemble polyester beads displaying the respective antigens. Purified beads displaying NadA showed enhanced immunogenicity compared to soluble NadA. Both soluble and particulate NadA elicited functional antibodies with bactericidal activity associated with protective immunity. To expand the antigen repertoire and to design a more broadly protective vaccine, NadA-PhaC beads were additionally conjugated to the capsular polysaccharide from serogroup C. Co-delivery of surface displayed NadA and the capsular polysaccharide induced a strong and specific Th1/Th17 mediated immune response associated with functional bactericidal antibodies. Our findings provide the foundation for the design of multivalent antigen-coated polyester beads as suitable carriers for protein and polysaccharide antigens in order to induce protective immunity.
MeSH term(s)	Adhesins, Bacterial/immunology ; Animals ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/immunology ; Bacterial Infections/immunology ; Bacterial Proteins/immunology ; Carbohydrates/chemistry ; Complement Factor H/immunology ; Escherichia coli/immunology ; Neisseria meningitidis/immunology ; Polyesters/chemistry ; Vaccines/chemistry ; Vaccines/immunology
Chemical Substances	Adhesins, Bacterial ; Antibodies, Bacterial ; Antigens, Bacterial ; Bacterial Proteins ; Carbohydrates ; Polyesters ; Vaccines ; Complement Factor H (80295-65-4)
Language	English
Publishing date	2018-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-20205-7
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Article ; Online: Enzymatic poly(gallic acid)-grafted α-l-lysine inhibits Staphylococcus aureus and Escherichia coli strains with no cytotoxicity for human cells.

Hernández-Valencia, Carmen G / Hernández-Valdepeña, Miguel A / Vázquez, Alfredo / Cedeño-Caero, Luis / Pedraza-Chaverri, José / Sánchez-Sánchez, Roberto / Gimeno, Miquel

Biomaterials advances

2022 Volume 138, Page(s) 212960

Abstract: The α-l-Lysine (LL) grafting onto the enzymatic poly(gallic acid) (PGAL) produces a helicoidal brush-like antimicrobial polymer containing outer positive-charged moieties. Best results are found with ca. 16 mol% α-LL-grafting for the inhibition of gram- ... ...

Abstract	The α-l-Lysine (LL) grafting onto the enzymatic poly(gallic acid) (PGAL) produces a helicoidal brush-like antimicrobial polymer containing outer positive-charged moieties. Best results are found with ca. 16 mol% α-LL-grafting for the inhibition of gram-positive Staphylococcus aureus and gram-negative Escherichia coli strains. Membrane permeability, confocal and scanning electron microscopy studies suggest a pore-formation and translocation mechanisms by initial electrostatic interaction of positive charged polymer at the negatively charged bacterial membranes. The attained polymer displays high concentration of hemolysis (Hc) in erythrocytes, and no lymphocyte mitochondrial activity. Interestingly, PGAL-LL is not cytotoxic on human dermal fibroblast. The antioxidant activity after the LL hybridization is also demonstrated by DPPH, ORAC, FRAP and hydroxyl radical scavenging, which enhances the preservation of human cells in addition to antimicrobial for this polymer.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Escherichia coli ; Escherichia coli Infections ; Gallic Acid ; Humans ; Lysine ; Polymers ; Staphylococcal Infections ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents ; Polymers ; Gallic Acid (632XD903SP) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2022-05-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2022.212960
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Article ; Online: Outer membrane vesicles extracted from Neisseria meningitidis serogroup X for prevention of meningococcal disease in Africa.

Pharmacological research

2017 Volume 121, Page(s) 194–201

Abstract: Meningococcal disease is caused mainly by serogroups A, B, C, Y, W of N. meningitidis. However, numerous cases of meningitis caused by serogroup X N. meningitidis (MenX) have recently been reported in several African countries. Currently, there are no ... ...

Abstract	Meningococcal disease is caused mainly by serogroups A, B, C, Y, W of N. meningitidis. However, numerous cases of meningitis caused by serogroup X N. meningitidis (MenX) have recently been reported in several African countries. Currently, there are no licensed vaccines against this pathogen and most of the MenX cases have been caused by meningococci from clonal complex (c.c) 181. Detergent extracted meningococcal outer membrane vesicle (dOMV) vaccines have previously shown to be safe and effective against epidemics of serogroup B meningococcal disease in all age groups. The aim of this work is therefore to obtain, characterize and evaluate the vaccine potential of dOMVs derived from a MenX strain (OMVx). Three experimental lots of OMVx were prepared by deoxycholate extraction from the MenX strain BF 2/97. Size and morphology of the vesicles was determined by Dynamic Light Scattering and electron microscopy, whereas the antigenic composition was characterized by gel electrophoresis and immunoblotting. OMVx were thereafter adsorbed to aluminium hydroxide (OMVx/AL) and two doses of OMVx were administered s.c. to groups of Balb/c mice three weeks apart. The immunogenicity and functional antibody activities in sera were evaluated by ELISA (anti-OMVx specific IgG responses) and serum bactericidal activity (SBA) assay. The size range of OMVx was shown to be between 90 and 120nm, whereas some of the antigens detected were the outer membrane proteins PorA, OpcA and RmpM. The OMVx/AL elicited high anti-OMVx antibody responses with bactericidal activity and no bactericidal activity was observed in the control group of no immunised mice. The results demonstrate that OMVx are immunogenic and could form part of a future vaccine to prevent the majority of meningococcal disease in the African meningitis belt.
Language	English
Publishing date	2017-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2017.04.030
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Article ; Online: Protease-catalyzed synthesis of α-poly-L-Lysine and amphiphilic poly(L-lysine-co-L-phenylalanine) in a neat non-toxic organic solvent.

Espinoza-González, Ángel / Hernández-Valencia, Carmen / Cedeño-Caero, Luis / Sánchez-Sánchez, Roberto / Montiel, Carmina / Gimeno, Miquel

Bioprocess and biosystems engineering

2022 Volume 46, Issue 4, Page(s) 515–522

Abstract: Subtilisin Carlsberg (alkaline protease from Bacillus licheniformis) catalyzes the syntheses of high molecular weights (ca. 20 KDa) cationic α-poly-L-lysine and amphiphilic poly(α-L-lysine-co-L-phenylalanine) in neat organic solvent. The synthesis is ... ...

Abstract	Subtilisin Carlsberg (alkaline protease from Bacillus licheniformis) catalyzes the syntheses of high molecular weights (ca. 20 KDa) cationic α-poly-L-lysine and amphiphilic poly(α-L-lysine-co-L-phenylalanine) in neat organic solvent. The synthesis is conducted in liquid 1,1,1,2-tetrafluoroethane solvent, which is a hydrophobic non-toxic gas that does not deplete the ozone layer and approved for pharmaceutical applications. Solubility of substrates and adequate protease activity in this system with low water environment limits the reaction of hydrolysis of the growing peptide chains. The pressurization of this organic compressed fluid to liquid has low-pressure requirements (25 bar, 40 ºC), and its complete evaporation at atmospheric pressure after completing the reaction ensures solvent-free residues in products. The resulting polypeptides present null cytotoxicity according to MTT and NR analyses, as well as Calcein/EthD-1 assay in human cells.
MeSH term(s)	Humans ; Peptide Hydrolases ; Polylysine ; Phenylalanine ; Peptides ; Solvents ; Pharmaceutical Preparations ; Catalysis
Chemical Substances	Peptide Hydrolases (EC 3.4.-) ; Polylysine (25104-18-1) ; Phenylalanine (47E5O17Y3R) ; Peptides ; Solvents ; Pharmaceutical Preparations
Language	English
Publishing date	2022-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1476357-6
ISSN	1615-7605 ; 1432-0797 ; 1615-7591
ISSN (online)	1615-7605 ; 1432-0797
ISSN	1615-7591
DOI	10.1007/s00449-022-02836-3
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Article ; Online: Gram-negative ESKAPE bacteria bloodstream infections in patients during the COVID-19 pandemic.

Alcántar-Curiel, María Dolores / Huerta-Cedeño, Manuel / Jarillo-Quijada, Ma Dolores / Gayosso-Vázquez, Catalina / Fernández-Vázquez, José Luis / Hernández-Medel, María Luisa / Zavala-Pineda, Manuelita / Morales-Gil, Miguel Ángel / Hernández-Guzmán, Verónica Alejandra / Bolaños-Hernández, Manuel Ismael / Giono-Cerezo, Silvia / Santos-Preciado, José Ignacio

PeerJ

2023 Volume 11, Page(s) e15007

Abstract: Bloodstream infections due to bacteria are a highly consequential nosocomial occurrences and the organisms responsible for them are usually multidrug-resistant. The aims of this study were to describe the incidence of bacteremia caused by Gram-negative ... ...

Abstract	Bloodstream infections due to bacteria are a highly consequential nosocomial occurrences and the organisms responsible for them are usually multidrug-resistant. The aims of this study were to describe the incidence of bacteremia caused by Gram-negative ESKAPE bacilli during the COVID-19 pandemic and characterize the clinical and microbiological findings including antimicrobial resistance. A total of 115 Gram-negative ESKAPE isolates were collected from patients with nosocomial bacteremia (18% of the total bacteremias) in a tertiary care center in Mexico City from February 2020 to January 2021. These isolates were more frequently derived from the Respiratory Diseases Ward (27), followed by the Neurosurgery (12), Intensive Care Unit (11), Internal Medicine (11), and Infectious Diseases Unit (7). The most frequently isolated bacteria were
MeSH term(s)	Humans ; Pandemics ; COVID-19/epidemiology ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacteria/genetics ; Klebsiella pneumoniae/genetics ; Enterobacter ; Anti-Infective Agents ; Bacteremia/drug therapy ; Cross Infection/drug therapy ; Sepsis/epidemiology
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15007
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