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Article ; Online: CJEM journal club: corticosteroids use for critically ill COVID-19 patients.

Li, Siying S / Hohl, Corinne M

CJEM

2021 Volume 23, Issue 2, Page(s) 162–163

MeSH term(s)	Adrenal Cortex Hormones ; COVID-19 ; Critical Illness/therapy ; Dexamethasone ; Humans ; SARS-CoV-2
Chemical Substances	Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Editorial ; Comment
ISSN	1481-8043
ISSN (online)	1481-8043
DOI	10.1007/s43678-020-00056-w
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Article: Modulation of immunity by tryptophan microbial metabolites.

Li, Siying

Frontiers in nutrition

2023 Volume 10, Page(s) 1209613

Abstract: Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway (also the Serotonin pathway), and the Microbial pathway. Of these, the Microbial Trp ... ...

Abstract	Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway (also the Serotonin pathway), and the Microbial pathway. Of these, the Microbial Trp metabolic pathways in the gut have recently been extensively studied for their production of bioactive molecules. The gut microbiota plays an important role in host metabolism and immunity, and microbial Trp metabolites can influence the development and progression of various diseases, including inflammatory, cardiovascular diseases, neurological diseases, metabolic diseases, and cancer, by mediating the body's immunity. This review briefly outlines the crosstalk between gut microorganisms and Trp metabolism in the body, starting from the three metabolic pathways of Trp. The mechanisms by which microbial Trp metabolites act on organism immunity are summarized, and the potential implications for disease prevention and treatment are highlighted.
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1209613
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Article ; Online: The potential role of hydrogen sulfide in regulating macrophage phenotypic changes via PINK1/parkin-mediated mitophagy in sepsis-related cardiorenal syndrome.

Chen, Yuxuan / Cao, Wei / Li, Bin / Qiao, Xiaofei / Wang, Xiangdong / Yang, Guang / Li, Siying

Immunopharmacology and immunotoxicology

2023 Volume 46, Issue 2, Page(s) 139–151

Abstract: ... NaSH, and a slow-releasing H2S compound S-propargyl-cysteine (SPRC) which is derived from garlic, have ...

Abstract	Objective: Sepsis is one of major reasons of cardiorenal syndrome type 5 (CRS-5), resulting in irreversible tissue damage and organ dysfunction. Macrophage has been demonstrated to play key role in the pathophysiology of sepsis, highlighting the need to identify therapeutic targets for modulating macrophage phenotype in sepsis. Methods and results: In this study, a rapid-releasing hydrogen sulfide (H2S) donor NaSH, and a slow-releasing H2S compound S-propargyl-cysteine (SPRC) which is derived from garlic, have been studied for the immune-regulatory effects on macrophages. The NaSH and SPRC showed the potential to protect the heart and kidney from tissue injury induced by LPS. The immunohistochemistry of F4/80+ revealed that the infiltration of macrophages in the heart and kidney tissues of LPS-treated mice was reduced by NaSH and SPRC. In addition, in the LPS-triggered inflammatory cascade of RAW264.7 macrophage cells, NaSH and SPRC exhibited significantly inhibitory effects on the secretion of inflammatory cytokines, production of reactive oxygen species (ROS), and regulation of the macrophage phenotype from M1-like to M2-like. Moreover, autophagy, a crucial process involved in the elimination of impaired proteins and organelles during oxidative stress and immune response, was induced by NaSH and SPRC in the presence of LPS stimulation. Consequently, there was an increase in the number of mitochondria and an improvement in mitochondrial membrane potential. This process was mainly mediated by PINK1/Parkin pathway mediated mitophagy. Discussion: These results demonstrated that the immunoregulatory effects of H2S donors were through the PINK1/Parkin-mediated mitophagy pathway. Overall, our study provided a new therapeutic direction in LPS-induced cardiorenal injury.
MeSH term(s)	Animals ; Mice ; Cardio-Renal Syndrome/drug therapy ; Hydrogen Sulfide/pharmacology ; Lipopolysaccharides ; Macrophages/metabolism ; Mitophagy ; Non-alcoholic Fatty Liver Disease ; Protein Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Sepsis/complications ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Hydrogen Sulfide (YY9FVM7NSN) ; Lipopolysaccharides ; Protein Kinases (EC 2.7.-) ; Reactive Oxygen Species ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2023.2281901
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Article ; Online: Vitreoretinopathy-Associated Pediatric Retinal Detachment Treatment Outcomes: IRIS® Registry (Intelligent Research in Sight) Analysis.

Belin, Peter J / Naravane, Ameay V / Lu, Siying / Li, Charles / Lum, Flora / Quiram, Polly A

Ophthalmology science

2023 Volume 3, Issue 3, Page(s) 100273

Abstract: ... cohort. Other hereditary vitreoretinopathies that are not encoded by specific ICD code(s) were captured ...

Abstract	Purpose: To determine the treatment patterns and outcomes of pediatric retinal detachments (RDs) associated with hereditary vitreoretinopathies. Design: Retrospective cohort analysis using IRIS® Registry (Intelligent Research in Sight) database. Participants: Patients < 18 years old with a rhegmatogenous RD and a systemic disorder associated with vitreoretinal degeneration (e.g., Stickler syndrome) or other malformation of the vitreous from 2013-2019. Methods: Cases were identified using International Classification of Diseases, Ninth and Tenth Revisions (ICD-9, ICD-10) diagnostic codes from the IRIS® Registry cohort. Other hereditary vitreoretinopathies that are not encoded by specific ICD code(s) were captured by text search. Nonspecific vitreous abnormality ICD codes were also included. Exclusion criteria included traumatic retinal detachments using ICD codes for ocular trauma and serous or exudative retinal detachment. Surgical procedures were identified using Current Procedural Terminology (CPT) codes for repair of retinal detachment. Baseline demographic information collected included age, gender, race/ethnicity, geographic region of the provider location, and health insurance status. Main outcome measures: Main outcomes measured in this study were average time to first surgery, number of eyes presenting with bilateral detachments, and choice of initial surgical procedure. Results: A total of 2115 eyes of 1722 patients were identified (mean age, 10.4 years; 58% male). The median time to first surgery was 7 days (interquartile range, 40 days). One thousand four hundred seven eyes of 1134 patients had ≥ 1 year of follow-up, with 506 eyes (36%) developing a fellow eye RD. Thirty-three percent of patients presenting with bilateral detachments, and 349 eyes had initial RD surgery within 1 year of the index date documented by CPT code. Fellow eye detachment occurred a mean of 32 days after initial presentation. The mean number of surgeries per eye within 1 year was 1.68. Best-corrected visual acuity did not improve from a baseline 20/54 to 20/62. The initial procedure was most commonly complex RD repair (n = 176), followed by scleral buckle (n = 102), pars plana vitrectomy (n = 89), laser (n = 59), cryotherapy (n = 5), and pneumatic retinopexy (n = 5). There were 51 new diagnoses of glaucoma and 37 new diagnoses of aphakia within 1 year after the surgical procedure. Conclusions: IRIS Registry data provide insight into rare pediatric vitreoretinopathy-associated RDs, which have a high rate of reoperation and fellow eye involvement. Financial disclosures: Proprietary or commercial disclosure may be found after the references.
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-9145
ISSN (online)	2666-9145
DOI	10.1016/j.xops.2023.100273
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Article ; Online: Li

Chen, Ben / Li, Boxin / Bi, Jingxuan / Du, Hongfang / Wang, Siying / Liu, Lei / Xie, Linghai / Sun, Jinmeng / Du, Zhuzhu / Ai, Wei

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 81, Page(s) 12140–12143

Abstract: ... effect of Li-S batteries, but the associated ionic transport would be a concurrent obstacle. Herein ... we present a Li-based crystal composited with carbon (LiPN ...

Abstract	Placing blocking layers between electrodes has shown paramount prospects in suppressing the shuttle effect of Li-S batteries, but the associated ionic transport would be a concurrent obstacle. Herein, we present a Li-based crystal composited with carbon (LiPN
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc03535b
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Article: Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle.

Li, Siying / Pan, Yangang / Teng, Honggang / Shan, Yuping / Yang, Guocheng / Wang, Hongda

Chemical research in Chinese universities

2022 Volume 38, Issue 3, Page(s) 838–842

Abstract: ... of (237.2±59.1) and (790.3±134.4) ms with the corresponding speed of 0.12 and 0.04 µm/s, respectively ...

Abstract	The rabies virus is a neurotropic virus that causes fatal diseases in humans and animals. Although studying the interactions between a single rabies virus and the cell membrane is necessary for understanding the pathogenesis, the internalization dynamic mechanism of single rabies virus in living cells remains largely elusive. Here, we utilized a novel force tracing technique based on atomic force microscopy(AFM) to record the process of single viral entry into host cell. We revealed that the force of the rabies virus internalization distributed at (65±25) pN, and the time was identified by two peaks with spacings of (237.2±59.1) and (790.3±134.4) ms with the corresponding speed of 0.12 and 0.04 µm/s, respectively. Our results provide insight into the effects of viral shape during the endocytosis process. This report will be meaningful for understanding the dynamic mechanism of rabies virus early infection. Electronic supplementary material: Supplementary material is available in the online version of this article at 10.1007/s40242-022-2069-y.
Language	English
Publishing date	2022-05-02
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2238839-4
ISSN	2210-3171 ; 1005-9040
ISSN (online)	2210-3171
ISSN	1005-9040
DOI	10.1007/s40242-022-2069-y
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Article ; Online: Protective effects of pumpkin polysaccharide hydrolysates on oxidative stress injury and its potential mechanism - Antioxidant mechanism of pumpkin polysaccharide hydrolysates.

Gao, Xiaofeng / Yang, Zeen / Huang, Lingte / Zuo, Siying / Li, Xinghan / Li, Jia / Jiang, Wen / Wang, Shuang / Zhang, Yongjun

International journal of biological macromolecules

2023 Volume 241, Page(s) 124423

Abstract: ... to reduce blood sugar and lipids. Our prior investigation discovered that hydrolysates (PPe-s) derived ... to explore the potential mechanism of PPe-s, utilizing Caenorhabditis elegans and MIN6 cells as models ... The results of this investigation revealed that PPe-s exhibited strong scavenging ability towards ABTS ...

Abstract	Pumpkin polysaccharides (PPe) exhibit multiple bioactive properties, including the ability to reduce blood sugar and lipids. Our prior investigation discovered that hydrolysates (PPe-s) derived from PPe demonstrated stronger antioxidant capabilities than PPe. The objective of the current study was to explore the potential mechanism of PPe-s, utilizing Caenorhabditis elegans and MIN6 cells as models. The results of this investigation revealed that PPe-s exhibited strong scavenging ability towards ABTS
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Cucurbita ; Caenorhabditis elegans/metabolism ; Oxidative Stress ; Polysaccharides/pharmacology ; Polysaccharides/metabolism ; Longevity ; Reactive Oxygen Species/metabolism
Chemical Substances	Antioxidants ; Polysaccharides ; Reactive Oxygen Species
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.124423
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Article ; Online: Timing of Delayed Retinal Pathology in Patients Presenting with Acute Posterior Vitreous Detachment in the IRIS® Registry (Intelligent Research in Sight).

Vangipuram, Gautam / Li, Charles / Li, Siying / Liu, Lynn / Harrison, Linda D / Lum, Flora / Shah, Gaurav K

Ophthalmology. Retina

2023 Volume 7, Issue 8, Page(s) 713–720

Abstract: ... at least once within 6 weeks, and sooner for eyes with higher-risk features.: Financial disclosure(s ...

Abstract	Objective: To determine the timing of delayed retinal pathology in eyes presenting with acute posterior vitreous detachment (PVD). Design: Retrospective database study. Subjects: Patients in the Intelligent Research in Sight (IRIS) registry found to have acute PVD based on the International Classification of Diseases, Ninth and Tenth Revision, codes were followed. Methods: Patients coded to have a PVD from 2013 to 2018 along with common procedural technology coding of extended ophthalmoscopy were included. Ocular baseline characteristics included visual acuity, lens status, presence or absence of vitreous hemorrhage, myopia, lattice degeneration, and subspecialty training of the treating physician. Main outcome measures: Timing (days) to delayed retinal break or detachment RESULTS: A total of 434 046 eyes met inclusion/exclusion criteria, and 10 518 eyes (2.42%) presented with a delayed retinal break or detachment after initial PVD. The median time to retinal break and detachment after initial PVD was 42 (range, 1-365) days and 51 (range, 1-365) days, respectively. Eyes with vitreous hemorrhage (hazard ratio [HR], 9.30; 95% confidence interval [CI], 8.50-10.2), history of retinal break/retinal detachment in the fellow eye (HR, 3.91; 95% CI, 3.64-4.20), lattice degeneration (HR, 2.61; 95% CI, 2.35-2.90), and myopia (HR, 1.42; 95% CI, 1.33-1.53) were found to be at a higher risk of developing delayed break or detachment. Conclusions: Follow-up examination after initial PVD is necessary to diagnose delayed or missed retinal pathology. In eyes with no initial pathology, providers should consider repeat examination at least once within 6 weeks, and sooner for eyes with higher-risk features. Financial disclosure(s): Proprietary or commercial disclosure may be found after the references.
MeSH term(s)	Humans ; Retinal Perforations/diagnosis ; Vitreous Detachment/diagnosis ; Retrospective Studies ; Vitreous Hemorrhage/diagnosis ; Vitreous Hemorrhage/etiology ; Retinal Detachment/diagnosis ; Myopia ; Retinal Degeneration
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2468-6530
ISSN (online)	2468-6530
DOI	10.1016/j.oret.2023.04.004
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Article ; Online: Green Citrus Detection and Counting in Orchards Based on YOLOv5-CS and AI Edge System.

Lyu, Shilei / Li, Ruiyao / Zhao, Yawen / Li, Zhen / Fan, Renjie / Liu, Siying

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 2

Abstract: ... detecting a picture on the server is 0.017 s, and the inference speed on Nvidia Jetson Xavier NX is 0.037 s ...

Abstract	Green citrus detection in citrus orchards provides reliable support for production management chains, such as fruit thinning, sunburn prevention and yield estimation. In this paper, we proposed a lightweight object detection YOLOv5-CS (Citrus Sort) model to realize object detection and the accurate counting of green citrus in the natural environment. First, we employ image rotation codes to improve the generalization ability of the model. Second, in the backbone, a convolutional layer is replaced by a convolutional block attention module, and a detection layer is embedded to improve the detection accuracy of the little citrus. Third, both the loss function CIoU (Complete Intersection over Union) and cosine annealing algorithm are used to get the better training effect of the model. Finally, our model is migrated and deployed to the AI (Artificial Intelligence) edge system. Furthermore, we apply the scene segmentation method using the "virtual region" to achieve accurate counting of the green citrus, thereby forming an embedded system of green citrus counting by edge computing. The results show that the mAP@.5 of the YOLOv5-CS model for green citrus was 98.23%, and the recall is 97.66%. The inference speed of YOLOv5-CS detecting a picture on the server is 0.017 s, and the inference speed on Nvidia Jetson Xavier NX is 0.037 s. The detection and counting frame rate of the AI edge system-side counting system is 28 FPS, which meets the counting requirements of green citrus.
MeSH term(s)	Algorithms ; Artificial Intelligence ; Citrus ; Computers ; Fruit
Language	English
Publishing date	2022-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22020576
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Article ; Online: A Wolfram-like syndrome family: Case report.

Li, Siying / Li, Xiaoxin / Qu, Jinfeng

European journal of ophthalmology

2024 , Page(s) 11206721241237552

Abstract: Background: Wolfram-like syndrome (WFLS) is an autosomal dominant inherited disease characterized by a single heterozygous pathogenic variant in the : Case presentation: We reported a case of a 10-year-old boy and his family members who initially ... ...

Abstract	Background: Wolfram-like syndrome (WFLS) is an autosomal dominant inherited disease characterized by a single heterozygous pathogenic variant in the Case presentation: We reported a case of a 10-year-old boy and his family members who initially experienced hearing impairment (HI), followed by optic atrophy. Genetic testing revealed the presence of a Conclusion: Wolfram-like syndrome, a rare neurodegenerative genetic disorder, manifested as deafness, optic atrophy, and diabetes mellitus. There hasn't been a definite treatment yet. Early identification of the variant in the
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721241237552
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