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  1. Article ; Online: Review of article: Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 by Katherine M. Flegal, PhD; Margaret D. Carroll, MSPH; Brian K. Kit, MD; Cynthia L. Ogden, PhD (JAMA 2012;307:491-7).

    Fitzgerald, Karen R

    Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing

    2013  Volume 31, Issue 3, Page(s) 131–132

    MeSH term(s) Body Mass Index ; Female ; Humans ; Male ; Obesity/epidemiology
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1083367-5
    ISSN 1532-6578 ; 1062-0303
    ISSN (online) 1532-6578
    ISSN 1062-0303
    DOI 10.1016/j.jvn.2013.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3297: Show issues Location:
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  2. Article ; Online: Painful Growing Nodule on the Right Calf.

    Fitzgerald, Jesse Lee / Smith, Nathaniel E / Cebe, Katherine M

    Cutis

    2024  Volume 112, Issue 6, Page(s) 287–298

    MeSH term(s) Humans ; Leg ; Pain
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 44: Show issues

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  3. Article ; Online: STING channels its proton power.

    Dong, Mingqi / Fitzgerald, Katherine A

    Molecular cell

    2023  Volume 83, Issue 19, Page(s) 3402–3403

    Abstract: Induction of type I interferon by the STING pathway is a cornerstone of innate immunity. STING also turns on non-canonical autophagy and inflammasome activation although the underlying mechanisms remain ill defined. Liu et al. ...

    Abstract Induction of type I interferon by the STING pathway is a cornerstone of innate immunity. STING also turns on non-canonical autophagy and inflammasome activation although the underlying mechanisms remain ill defined. Liu et al.
    MeSH term(s) Membrane Proteins/metabolism ; Protons ; Immunity, Innate ; Inflammasomes ; Interferon Type I ; Nucleotidyltransferases
    Chemical Substances Membrane Proteins ; Protons ; Inflammasomes ; Interferon Type I ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.09.014
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    Zs.A 5055: Show issues Location:
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  4. Article ; Online: TBK1 inhibition unleashes RIPK1, resensitizing tumors to immunotherapy.

    Kelliher, Michelle A / Fitzgerald, Katherine A

    Trends in immunology

    2023  Volume 44, Issue 3, Page(s) 156–158

    Abstract: Resistance mechanisms have curbed the potential of immune checkpoint blockade (ICB) therapies. Understanding mechanisms that contribute to this resistance should reveal new targets for combinatorial therapy. Tank-binding kinase 1 (TBK1) represents such a ...

    Abstract Resistance mechanisms have curbed the potential of immune checkpoint blockade (ICB) therapies. Understanding mechanisms that contribute to this resistance should reveal new targets for combinatorial therapy. Tank-binding kinase 1 (TBK1) represents such a target. In recent work by Sun et al., inhibition of TBK1 restored the efficacy of such treatments by sensitizing tumors to RIPK1 kinase-dependent inflammatory cell death.
    MeSH term(s) Humans ; Neoplasms ; Cell Death ; Immunotherapy ; Receptor-Interacting Protein Serine-Threonine Kinases ; Protein Serine-Threonine Kinases
    Chemical Substances RIPK1 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-02-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 2: Show issues

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  5. Article ; Online: A path towards personalized medicine for autoinflammatory and related diseases.

    Miner, Jonathan J / Fitzgerald, Katherine A

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 3, Page(s) 182–189

    Abstract: The human genome project led to the advancement of genetic technologies and genomic medicine for a variety of human diseases, including monogenic autoimmune and autoinflammatory diseases. As a result, the genome of an individual can now be rapidly ... ...

    Abstract The human genome project led to the advancement of genetic technologies and genomic medicine for a variety of human diseases, including monogenic autoimmune and autoinflammatory diseases. As a result, the genome of an individual can now be rapidly sequenced at a low cost, and this technology is beginning to change the practice of rheumatology. In this Perspective, we describe how new sequencing technologies combined with careful clinical phenotyping have led to the discovery of rare rheumatic diseases and their corresponding disease-causing mutations. Additionally, we explore ways in which single-gene mutations, including somatic mutations, are creating opportunities to develop personalized medicines. To illustrate this idea, we focus on diseases affecting the TREX1-cGAS-STING pathway, which is associated with monogenic autoinflammatory diseases and vasculopathies. For many of the affected patients and families, there is an urgent, unmet need for the development of personalized therapies. New innovations related to small molecular inhibitors and gene therapies have the potential to benefit these families, and might help drive further innovations that could prove useful for patients with more common forms of autoimmunity and autoinflammation.
    MeSH term(s) Humans ; Inflammation ; Precision Medicine ; Autoimmunity ; Hereditary Autoinflammatory Diseases ; Autoimmune Diseases
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-022-00904-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lnc-ing RNA to intestinal homeostasis and inflammation.

    Fitzgerald, Katherine A / Shmuel-Galia, Liraz

    Trends in immunology

    2024  Volume 45, Issue 2, Page(s) 127–137

    Abstract: Long noncoding RNAs (lncRNAs) play important roles in numerous biological processes, including the immune system. Initial research in this area focused on cell-based studies, but recent advances underscore the profound significance of lncRNAs at the ... ...

    Abstract Long noncoding RNAs (lncRNAs) play important roles in numerous biological processes, including the immune system. Initial research in this area focused on cell-based studies, but recent advances underscore the profound significance of lncRNAs at the organismal level, providing invaluable insights into their roles in inflammatory diseases. In this rapidly evolving field, lncRNAs have been described with pivotal roles in the intestinal tract where they regulate intestinal homeostasis and inflammation by influencing processes such as immune cell development, inflammatory signaling pathways, epithelial barrier function, and cellular metabolism. Understanding the regulation and function of lncRNAs in this tissue may position lncRNAs not only as potential disease biomarkers but also as promising targets for therapeutic intervention in inflammatory bowel disease and related diseases.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; Intestines ; Inflammation ; Inflammatory Bowel Diseases/genetics ; Homeostasis
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.12.005
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  7. Article ; Online: ERADication of STING limits inflammation.

    Gao, Kevin MingJie / Fitzgerald, Katherine A

    Nature cell biology

    2023  Volume 25, Issue 5, Page(s) 635–636

    MeSH term(s) Humans ; Inflammation ; Signal Transduction
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01142-8
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    Zs.A 5169: Show issues Location:
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    Zs.MG 12: Show issues

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  8. Article ; Online: Molecular mechanisms and functions of pyroptosis.

    Shao, Feng / Fitzgerald, Katherine A

    Journal of molecular biology

    2022  Volume 434, Issue 4, Page(s) 167461

    MeSH term(s) Caspases/metabolism ; Phosphate-Binding Proteins ; Pyroptosis
    Chemical Substances Phosphate-Binding Proteins ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2022-01-19
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2022.167461
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    Zs.A 867: Show issues Location:
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  9. Article ; Online: Hold your horses! Reining in your fastest pores with caspase-7.

    Zhou, Jeffrey Y / Fitzgerald, Katherine A

    Immunity

    2022  Volume 55, Issue 8, Page(s) 1340–1342

    Abstract: During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid ... ...

    Abstract During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid shingomyelinase (ASM)-mediated membrane repair of gasdermin and perforin pores to delay cell death.
    MeSH term(s) Caspase 7 ; Cell Membrane/metabolism ; Perforin/metabolism ; Pore Forming Cytotoxic Proteins
    Chemical Substances Pore Forming Cytotoxic Proteins ; Perforin (126465-35-8) ; Caspase 7 (EC 3.4.22.-)
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.07.013
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  10. Article ; Online: Time-lapse mesoscopy of

    Baxter, Katherine J / Sargison, Fiona A / Fitzgerald, J Ross / McConnell, Gail / Hoskisson, Paul A

    Microbiology (Reading, England)

    2024  Volume 170, Issue 1

    Abstract: Polymicrobial infection ... ...

    Abstract Polymicrobial infection with
    MeSH term(s) Candida albicans ; Hyphae ; Staphylococcus aureus ; Time-Lapse Imaging ; Biofilms ; Staphylococcal Infections
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001426
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