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  1. Article ; Online: SARS-CoV-2, Hypoxia, and Calcium Signaling: The Consequences and Therapeutic Options.

    Danta, Chhanda Charan

    ACS pharmacology & translational science

    2021  Volume 4, Issue 1, Page(s) 400–402

    Abstract: Currently, COVID-19 has created difficulties in understanding the pathological mechanisms and therapeutic options for treatment. COVID-19 patients have shown to be hypoxic, and hypoxia causes alteration of the cell calcium dynamics, which leads to ... ...

    Abstract Currently, COVID-19 has created difficulties in understanding the pathological mechanisms and therapeutic options for treatment. COVID-19 patients have shown to be hypoxic, and hypoxia causes alteration of the cell calcium dynamics, which leads to alterations in many signal transduction pathways and gene expression. Also, both viruses and hypoxia directly alter many pathological and biochemical pathways, such as inflammation, cytokine signaling, glycolysis, and calcium signaling. Therefore, understanding of these cellular events would be useful in finding therapeutic options.
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.0c00219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer's Dementia Patients with SARS-CoV-2 Infection.

    Danta, Chhanda Charan

    ACS chemical neuroscience

    2020  Volume 11, Issue 15, Page(s) 2145–2148

    Abstract: Studies have shown that the calcium ion ( ... ...

    Abstract Studies have shown that the calcium ion (Ca
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/psychology ; Betacoronavirus ; COVID-19 ; Calcium/metabolism ; Calcium Channel Blockers/chemistry ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Calcium Channels/metabolism ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/psychology ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Calcium Channel Blockers ; Calcium Channels ; Calcium (SY7Q814VUP)
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dipeptidyl Peptidase-4: A Potential Therapeutic Target in Diabetic Kidney Disease with SARS-CoV-2 Infection.

    Danta, Chhanda Charan

    ACS pharmacology & translational science

    2020  Volume 3, Issue 5, Page(s) 1020–1022

    Abstract: Dipeptidyl peptidase-4 (DPP-4) is expressed ubiquitously in many tissues, including kidney, respiratory tract, and immune cells. Human DPP-4 has been identified as a functional receptor for the spike glycoprotein of the Middle East respiratory syndrome ... ...

    Abstract Dipeptidyl peptidase-4 (DPP-4) is expressed ubiquitously in many tissues, including kidney, respiratory tract, and immune cells. Human DPP-4 has been identified as a functional receptor for the spike glycoprotein of the Middle East respiratory syndrome coronavirus. A large interface has been predicted in the docking of DPP-4/SARS-CoV-2 spike protein. Globally, 40% of diabetic patients develop diabetic kidney disease (DKD), a leading cause of end-stage renal disease. DPP-4 inhibitors possess anti-inflammatory properties which suggest their potential implication in DKD and SARS-CoV-2 immunopathogenesis.
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.0c00097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection.

    Danta, Chhanda Charan

    ACS chemical neuroscience

    2020  Volume 11, Issue 15, Page(s) 2137–2144

    Abstract: Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. ... ...

    Abstract Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. Targeting the treatment of brain infection, it has also been a challenge that the clinical drug should have good CNS penetration ability to cross the blood-brain barrier.
    MeSH term(s) Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/metabolism ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Alanine/metabolism ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/metabolism ; Antiviral Agents/administration & dosage ; Antiviral Agents/metabolism ; Betacoronavirus/drug effects ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/virology ; Brain/drug effects ; Brain/metabolism ; COVID-19 ; Central Nervous System Agents/administration & dosage ; Central Nervous System Agents/metabolism ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Drug Evaluation, Preclinical/methods ; Humans ; Methylprednisolone/administration & dosage ; Methylprednisolone/metabolism ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; Antiviral Agents ; Central Nervous System Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX) ; Methylprednisolone (X4W7ZR7023)
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dipeptidyl Peptidase-4

    Danta, Chhanda Charan

    ACS Pharmacology & Translational Science

    A Potential Therapeutic Target in Diabetic Kidney Disease with SARS-CoV-2 Infection

    2020  Volume 3, Issue 5, Page(s) 1020–1022

    Keywords covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 2575-9108
    DOI 10.1021/acsptsci.0c00097
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

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    Inter-library loan at ZB MED

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  6. Article ; Online: Calcium Channel Blockers

    Danta, Chhanda Charan

    ACS Chemical Neuroscience

    A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer’s Dementia Patients with SARS-CoV-2 Infection

    2020  Volume 11, Issue 15, Page(s) 2145–2148

    Keywords Cell Biology ; Biochemistry ; Physiology ; Cognitive Neuroscience ; General Medicine ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-7193
    DOI 10.1021/acschemneuro.0c00391
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: CNS Penetration Ability

    Danta, Chhanda Charan

    ACS Chemical Neuroscience

    A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection

    2020  Volume 11, Issue 15, Page(s) 2137–2144

    Keywords Cell Biology ; Biochemistry ; Physiology ; Cognitive Neuroscience ; General Medicine ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-7193
    DOI 10.1021/acschemneuro.0c00335
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  8. Article: CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection

    Danta, Chhanda Charan

    ACS Chem Neurosci

    Abstract: Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. ... ...

    Abstract Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. Targeting the treatment of brain infection, it has also been a challenge that the clinical drug should have good CNS penetration ability to cross the blood-brain barrier.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #636269
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Dipeptidyl Peptidase-4: A Potential Therapeutic Target in Diabetic Kidney Disease with SARS-CoV-2 Infection

    Danta, Chhanda Charan

    ACS Pharm. Transl. Sci.

    Abstract: Dipeptidyl peptidase-4 (DPP-4) is expressed ubiquitously in many tissues, including kidney, respiratory tract, and immune cells. Human DPP-4 has been identified as a functional receptor for the spike glycoprotein of the Middle East respiratory syndrome ... ...

    Abstract Dipeptidyl peptidase-4 (DPP-4) is expressed ubiquitously in many tissues, including kidney, respiratory tract, and immune cells. Human DPP-4 has been identified as a functional receptor for the spike glycoprotein of the Middle East respiratory syndrome coronavirus. A large interface has been predicted in the docking of DPP-4/SARS-CoV-2 spike protein. Globally, 40% of diabetic patients develop diabetic kidney disease (DKD), a leading cause of end-stage renal disease. DPP-4 inhibitors possess anti-inflammatory properties which suggest their potential implication in DKD and SARS-CoV-2 immunopathogenesis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #766011
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer's Dementia Patients with SARS-CoV-2 Infection

    Danta, Chhanda Charan

    ACS Chem Neurosci

    Abstract: Studies have shown that the calcium ion (Ca2+) plays important roles both in Alzheimer's dementia and SARS-CoV S-mediated fusion to host cell entry. An elevated level of intracellular calcium causes neuronal dysfunction, cell death, and apoptosis. ... ...

    Abstract Studies have shown that the calcium ion (Ca2+) plays important roles both in Alzheimer's dementia and SARS-CoV S-mediated fusion to host cell entry. An elevated level of intracellular calcium causes neuronal dysfunction, cell death, and apoptosis. Dysregulation of calcium has also been shown to increase the production of amyloid beta (Aß) protein, the hallmark of Alzheimer's dementia. Reversely, deposition of Aß is also responsible for calcium dysregulation. On the other hand, it has been well investigated that viruses can disturb host cell Ca2+ homeostasis as well as modulate signal transduction mechanisms. Viruses can also hijack the host cell calcium channels and pumps to release more intracellular Ca2+ to utilize for their life cycle. Even though evidence has not been reported on SARS-CoV-2 concerning Ca2+ regulation, however, it has been well established that Ca2+ is essential for viral entry, viral gene replication, and virion maturation and release. Recent reports suggest that SARS-CoV needs two Ca2+ ions to fuse with the host cell at the entry step. Furthermore, some calcium channel blockers (CCBs), such as nimodipine, memantine, etc., have been reported to be effective in the treatment of dementia in Alzheimer's disease (AD) as well as have shown inhibition in various virus infections.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #646274
    Database COVID19

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