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  1. Article ; Online: Pathogenic Mechanism of Autoimmune Diabetes Mellitus in Humans: Potential Role of Streptozotocin-Induced Selective Autoimmunity against Human Islet

    Zhu, Bao Ting

    Cells

    2022  Volume 11, Issue 3

    Abstract: Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin- ... ...

    Abstract Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin-producing
    MeSH term(s) Animals ; Autoimmunity ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 1/metabolism ; Humans ; Insulin/metabolism ; Islets of Langerhans/metabolism ; Streptozocin
    Chemical Substances Insulin ; Streptozocin (5W494URQ81)
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11030492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biochemical mechanism underlying the pathogenesis of diabetic retinopathy and other diabetic complications in humans: the methanol-formaldehyde-formic acid hypothesis.

    Zhu, Bao Ting

    Acta biochimica et biophysica Sinica

    2022  Volume 54, Issue 4, Page(s) 415–451

    Abstract: Hyperglycemia in diabetic patients is associated with abnormally-elevated cellular glucose levels. It is hypothesized that increased cellular glucose will lead to increased formation of endogenous methanol and/or formaldehyde, both of which are then ... ...

    Abstract Hyperglycemia in diabetic patients is associated with abnormally-elevated cellular glucose levels. It is hypothesized that increased cellular glucose will lead to increased formation of endogenous methanol and/or formaldehyde, both of which are then metabolically converted to formic acid. These one-carbon metabolites are known to be present naturally in humans, and their levels are increased under diabetic conditions. Mechanistically, while formaldehyde is a cross-linking agent capable of causing extensive cytotoxicity, formic acid is an inhibitor of mitochondrial cytochrome oxidase, capable of inducing histotoxic hypoxia, ATP deficiency and cytotoxicity. Chronic increase in the production and accumulation of these toxic one-carbon metabolites in diabetic patients can drive the pathogenesis of ocular as well as other diabetic complications. This hypothesis is supported by a large body of experimental and clinical observations scattered in the literature. For instance, methanol is known to have organ- and species-selective toxicities, including the characteristic ocular lesions commonly seen in humans and non-human primates, but not in rodents. Similarly, some of the diabetic complications (such as ocular lesions) also have a characteristic species-selective pattern, closely resembling methanol intoxication. Moreover, while alcohol consumption or combined use of folic acid plus vitamin B is beneficial for mitigating acute methanol toxicity in humans, their use also improves the outcomes of diabetic complications. In addition, there is also a large body of evidence from biochemical and cellular studies. Together, there is considerable experimental support for the proposed hypothesis that increased metabolic formation of toxic one-carbon metabolites in diabetic patients contributes importantly to the development of various clinical complications.
    MeSH term(s) Animals ; Carbon ; Diabetes Mellitus ; Diabetic Retinopathy/etiology ; Formaldehyde ; Formates ; Glucose ; Humans ; Methanol/metabolism
    Chemical Substances Formates ; formic acid (0YIW783RG1) ; Formaldehyde (1HG84L3525) ; Carbon (7440-44-0) ; Glucose (IY9XDZ35W2) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2022-05-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2022012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pathogenic Mechanism of Autoimmune Diabetes Mellitus in Humans

    Bao Ting Zhu

    Cells, Vol 11, Iss 492, p

    Potential Role of Streptozotocin-Induced Selective Autoimmunity against Human Islet β -Cells

    2022  Volume 492

    Abstract: Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin-producing β -cells in pancreatic islets of genetically susceptible individuals. In this communication, a new hypothesis is postulated which is ... ...

    Abstract Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin-producing β -cells in pancreatic islets of genetically susceptible individuals. In this communication, a new hypothesis is postulated which is based on the observations that streptozotocin (STZ), a chemically reactive and cytotoxic compound produced by certain gram-positive bacteria, can be preferentially taken up into islet β -cells and induce cytotoxicity and autoimmunity. It is hypothesized that humans might be occasionally exposed to STZ through opportunistic infections with the STZ-producing bacteria and/or through ingestion of certain food products that contain STZ. In addition, the potential presence of the STZ-producing bacteria in the gut microbiota of some individuals might be another source of long-term STZ exposure. Because of the high chemical reactivity of STZ and its breakdown products, these chemicals can covalently modify certain cellular macromolecules (e.g., DNA and proteins), and the covalently modified cellular components would serve as new antigens, potentially capable of inducing both humoral and cellular autoimmune responses in the islets of certain individuals. In addition to STZ exposure, the eventual development of autoimmunity against STZ-exposed islet β -cells also depends critically on the genetic predisposition of the susceptible individuals plus the opportunistic presence of a conducive, strong environmental trigger, which often is presented as severe febrile viral infections subsequently inducing strong aberrant reactions of the body’s immune system. The proposed pathogenic hypothesis is supported by a considerable body of direct and indirect evidence from laboratory animal studies and clinical observations. Certainly, more experimental and clinical studies are needed to carefully further examine each of the key components of the proposed pathogenic hypothesis.
    Keywords autoimmune diabetes ; pathogenic mechanism ; streptozotocin-induced β -cell damage ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: An Important Structural Requirement for the Superconductor Material

    Zhu, Bao Ting

    A Hypothesis

    2022  

    Abstract: On a microscopic scale, resistivity during electric conduction is caused by collisions of the free conduction electrons with the obstructing atoms or molecules of the conductor material, resulting in heat production. Based on this fundamental ... ...

    Abstract On a microscopic scale, resistivity during electric conduction is caused by collisions of the free conduction electrons with the obstructing atoms or molecules of the conductor material, resulting in heat production. Based on this fundamental understanding, a hypothesis concerning a physical requirement of the superconductor material is proposed, which suggests that for superconductivity (i.e., with zero resistivity) to occur, the conductor material must have nano-sized, continuous and straight vacuum tunnels inside with effective radius size large enough to allow collision-free conduction of free electrons. Besides, some of the composite atoms of the conductor should be able to readily release electrons to form the conduction band; in fact, this basic requirement is for all forms of electrical conductors, not just for superconductors. The proposed hypothesis is supported by experimental observations in the literature, and also offers a plausible explanation for some of the poorly-understood experimental phenomena observed in the past. In addition, the hypothesis offers practical strategies for the rational design of electrical conductors with (quasi-)superconductivity. Lastly, the proposed new hypothesis also suggests a novel mechanism for neural microtubule-mediated electrical quasi-superconductance in the nervous system.

    Comment: 14 pages in total, 3 figures
    Keywords Condensed Matter - Superconductivity
    Subject code 621
    Publishing date 2022-07-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos.

    Su, Yufang / Fang, Lei / Zhong, Kaili / Wang, Ting / Bao, Mingjie / Zhou, Ting / Zhu, Yuan

    Environmental toxicology

    2023  Volume 38, Issue 3, Page(s) 654–665

    Abstract: Isoliquiritigenin (ISL) is used in many households' personal hygiene and medicinal products, and the average human daily ISL exposure is 1-2 mg/kg. However, the molecular mechanisms of ISL toxicity in zebrafish embryos have not been fully elucidated. We ... ...

    Abstract Isoliquiritigenin (ISL) is used in many households' personal hygiene and medicinal products, and the average human daily ISL exposure is 1-2 mg/kg. However, the molecular mechanisms of ISL toxicity in zebrafish embryos have not been fully elucidated. We investigated whether exposure to ISL induces oxidative stress and inflammatory responses in zebrafish. And exposure to ISL significantly affects the expression of immune response-related genes in zebrafish embryos following oxidative stress and the release of pro-inflammatory mediators through Toll-like receptor signaling.
    MeSH term(s) Animals ; Humans ; Zebrafish/metabolism ; Oxidative Stress ; Chalcones/toxicity ; Immunity
    Chemical Substances isoliquiritigenin (B9CTI9GB8F) ; Chalcones
    Language English
    Publishing date 2023-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23715
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    Zs.A 2676: Show issues Location:
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  6. Article: Effect of stem cell conditional medium-loading adhesive hydrogel on TGF-β1-induced endometrial stromal cell fibrosis.

    Zhu, Yuan / Wang, Ting / Bao, Ming-Jie / Qu, Xiao-Hui / Li, Zeng-Ming

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1168136

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1168136
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  7. Article ; Online: Attenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells.

    Li, Jing / Wang, Pan / Hou, Ming-Jie / Zhu, Bao Ting

    MedComm

    2023  Volume 4, Issue 4, Page(s) e301

    Abstract: Alzheimer's disease (AD) is a common form of neurodegenerative disease in the elderly. Amyloid- ...

    Abstract Alzheimer's disease (AD) is a common form of neurodegenerative disease in the elderly. Amyloid-
    Language English
    Publishing date 2023-06-19
    Publishing country China
    Document type Journal Article
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.301
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  8. Article ; Online: Novel therapeutic targets, including IGFBP3, of umbilical cord mesenchymal stem-cell-conditioned medium in intrauterine adhesion.

    Zhu, Yuan / Bao, Mingjie / Wang, Ting / Ai, Xiaoyan / Qiu, Dewen / Wang, Changhua

    Biology open

    2024  Volume 13, Issue 2

    Abstract: Mesenchymal stem cells play important roles in repairing injured endometrium. However, the molecular targets and potential mechanism of the endometrial recipient cells for stem cell therapy in intrauterine adhesion (IUA) are poorly understood. In this ... ...

    Abstract Mesenchymal stem cells play important roles in repairing injured endometrium. However, the molecular targets and potential mechanism of the endometrial recipient cells for stem cell therapy in intrauterine adhesion (IUA) are poorly understood. In this study, umbilical cord mesenchymal stem-cell-conditioned medium (UCMSCs-CM) produced positive effects on a Transforming growth factor beta (TGF-β) induced IUA cell model. RNA-sequencing was performed on clinical IUA tissues, and the top 40 upregulated and top 20 downregulated mRNAs were selected and verified using high-throughput (HT) qPCR in both tissues and cell models. Based on a bioinformatic analysis of RNA-sequencing and HT-qPCR results, 11 mRNAs were uncovered to be the intervention targets of UCMSCs-CM on IUA endometrium cell models. Among them, IGFBP3 was striking as a key pathogenic gene and a potential diagnostic marker of IUA, which exhibited the area under the curve (AUC), sensitivity, specificity were 0.924, 93.1% and 80.6%, respectively in 60 endometrial tissues. The silencing of IGFBP3 exerted positive effects on the IUA cell model through partially upregulating MMP1 and KLF2. In conclusion, RNA-sequencing combined with HT qPCR based on clinical tissues and IUA cell models were used in IUA research and our results may provide some scientific ideas for the diagnosis and treatment of IUA.
    MeSH term(s) Female ; Humans ; Culture Media, Conditioned/pharmacology ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Mesenchymal Stem Cells ; RNA/metabolism ; Tissue Adhesions/metabolism ; Tissue Adhesions/pathology ; Tissue Adhesions/therapy ; Umbilical Cord/metabolism ; Umbilical Cord/pathology ; Uterine Diseases/metabolism ; Uterine Diseases/pathology ; Uterine Diseases/therapy
    Chemical Substances Culture Media, Conditioned ; IGFBP3 protein, human ; Insulin-Like Growth Factor Binding Protein 3 ; RNA (63231-63-0)
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.060141
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  9. Article ; Online: Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells.

    Hou, Ming-Jie / Wang, Pan / Zhu, Bao Ting

    Acta biochimica et biophysica Sinica

    2023  Volume 55, Issue 5, Page(s) 853–865

    Abstract: Ferroptosis is a new form of nonapoptotic cell death closely associated with glutathione (GSH) peroxidase 4 inhibition and/or GSH depletion, resulting in the accumulation of cellular iron and lipid peroxides. The exact mechanism by which GSH depletion ... ...

    Abstract Ferroptosis is a new form of nonapoptotic cell death closely associated with glutathione (GSH) peroxidase 4 inhibition and/or GSH depletion, resulting in the accumulation of cellular iron and lipid peroxides. The exact mechanism by which GSH depletion causes the accumulation of reactive oxygen species (ROS) and lipid-ROS and subsequent ferroptotic cell death in neuronal cells remains unclear. In the present study, using immortalized HT22 mouse hippocampal neuronal cells as a model, we show that nitric oxide (NO) accumulation via protein disulfide isomerase (PDI)-mediated neuronal nitric oxide synthase (nNOS) activation plays a critical role in chemically-induced ferroptosis. Mechanistically, we find that erastin-induced GSH depletion leads to activation of PDI, which then mediates ferroptosis by catalyzing nNOS dimerization, followed by accumulation of cellular NO, ROS and lipid ROS and ultimately ferroptotic cell death. Pharmacological inhibition of PDI enzymatic activity or selective
    MeSH term(s) Mice ; Animals ; Reactive Oxygen Species/metabolism ; Lipid Peroxidation ; Cell Death ; Lipids
    Chemical Substances Reactive Oxygen Species ; erastin ; Lipids
    Language English
    Publishing date 2023-05-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2023058
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  10. Article ; Online: Chelativorans salis

    Gao, Lei / She, Ting-Ting / Liu, Yong-Hong / Chen, Zhong-Yan / Liu, Jia-Yi / Jiang, Hong-Chen / Fang, Bao-Zhu / Li, Wen-Jun

    International journal of systematic and evolutionary microbiology

    2024  Volume 74, Issue 4

    Abstract: A Gram-stain-negative, non-motile, and slightly halophilic alphaproteobacterium, designated strain EGI ... ...

    Abstract A Gram-stain-negative, non-motile, and slightly halophilic alphaproteobacterium, designated strain EGI FJ00035
    MeSH term(s) Fatty Acids/chemistry ; Phospholipids/chemistry ; Ubiquinone/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Lakes/analysis ; Base Composition ; Bacterial Typing Techniques ; DNA, Bacterial/genetics ; Sequence Analysis, DNA ; China ; Phyllobacteriaceae/genetics
    Chemical Substances Fatty Acids ; Phospholipids ; Ubiquinone (1339-63-5) ; RNA, Ribosomal, 16S ; DNA, Bacterial
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.006340
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 409: Show issues Location:
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