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Article ; Online: Airborne

Ioannidou, Eleftheria / Papagiannis, Stefanos / Manousakas, Manousos Ioannis / Vestenius, Mika / Eleftheriadis, Konstantinos / Paatero, Jussi / Papadopoulou, Lambrini / Ioannidou, Alexandra

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2024 Volume 206, Page(s) 111252

Abstract: This study analyzed 16070 daily and 608 weekly air filter samples from the Helsinki metropolitan area collected between 1962 and 2005. The aim was to use the Potential Source Contribution Function (PSCF) to determine potential sources of silicon (Si), ... ...

Abstract	This study analyzed 16070 daily and 608 weekly air filter samples from the Helsinki metropolitan area collected between 1962 and 2005. The aim was to use the Potential Source Contribution Function (PSCF) to determine potential sources of silicon (Si), zinc (Zn), lead (Pb), and radioactive isotope
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2024.111252
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Article: The Effect of Breastfeeding on Food Allergies in Newborns and Infants.

Koukou, Zoi / Papadopoulou, Eleftheria / Panteris, Eleftherios / Papadopoulou, Styliani / Skordou, Anna / Karamaliki, Maria / Diamanti, Elisavet

Children (Basel, Switzerland)

2023 Volume 10, Issue 6

Abstract: Breastfeeding is the preferred method of infant feeding and its establishment is one of the primary goals for the infant. Allergic diseases are common in childhood, with increased morbidity. Food allergies are also associated with a strong negative ... ...

Abstract	Breastfeeding is the preferred method of infant feeding and its establishment is one of the primary goals for the infant. Allergic diseases are common in childhood, with increased morbidity. Food allergies are also associated with a strong negative impact on health-related quality of life and is a major public health problem. In addition, maternal exclusion of common allergens during pregnancy and/or lactation suggests that supplementation with regular cow's milk formula during the first week of life should be avoided. Breast milk contains many active immune factors, such as cytokines, inflammatory mediators, signaling molecules and soluble receptors, which may also reduce the risk of allergic disease. The prophylactic effects of breastfeeding have been the subject of many studies, some with weak evidence. In this narrative review, we aim to provide an up-to-date account of the effects of prophylactic breastfeeding on food allergy and other common allergies in infants and children up to 5 years of age. Colostrum in particular has been shown to be prophylactic against food allergy. The American Academy of Pediatrics cautions that the relationship between duration of breastfeeding and incidence of food allergy in early childhood is unclear. The protective role of breastfeeding has a positive effect on allergy prevention, which is opposed by the early introduction of solid foods, but larger studies are needed to confirm the evidence. There is evidence that breastfeeding is effective in providing partial protection to infants.
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10061046
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Article ; Online: Adaptive laboratory evolution to hypersaline conditions of lactic acid bacteria isolated from seaweed

Papadopoulou, Eleftheria / Rodriguez de Evgrafov, Mari Cristina / Kalea, Argyro / Tsapekos, Panagiotis / Angelidaki, I.

New BIOTECHNOLOGY. 2023 July, v. 75 p.21-30

2023

Abstract: Seaweed biomass has been proposed as a promising alternative carbon source for fermentation processes using microbial factories. However, the high salinity content of seaweed biomass is a limiting factor in large scale fermentation processes. To address ... ...

Abstract	Seaweed biomass has been proposed as a promising alternative carbon source for fermentation processes using microbial factories. However, the high salinity content of seaweed biomass is a limiting factor in large scale fermentation processes. To address this shortcoming, three bacterial species (Pediococcus pentosaceus, Lactobacillus plantarum, and Enterococcus faecium) were isolated from seaweed biomass and evolved to increasing concentrations of NaCl. Following the evolution period, P. pentosaceus reached a plateau at the initial NaCl concentration, whereas L. plantarum, and E. faecium showed a 1.29 and 1.75-fold increase in their salt tolerance, respectively. The impact that salt evolution had on lactic acid production using hypersaline seaweed hydrolysate was investigated. Salinity evolved L. plantarum produced 1.18-fold more lactic acid than the wild type, and salinity evolved E. faecium was able to produce lactic acid, while the wild type could not. No differences in lactic acid production were observed between the P. pentosaceus salinity evolved and wild type strains. Evolved lineages were analyzed for the molecular mechanisms underlying the observed phenotypes. Mutations were observed in genes affecting the ion balance in the cell, the composition of the cell membrane and proteins acting as regulators. This study demonstrates that bacterial isolates from saline niches are promising microbial factories for the fermentation of saline substrates, without the requirement of previous desalination steps, while preserving high final product yields.
Keywords	Enterococcus faecium ; Lactobacillus plantarum ; Pediococcus pentosaceus ; biomass ; biotechnology ; carbon ; cell membranes ; desalination ; evolution ; fermentation ; hydrolysates ; hypersalinity ; lactic acid ; macroalgae ; salt tolerance ; ME ; NC ; PC ; SD ; WT ; ALE ; LAB ; Adaptive laboratory evolution ; Lactic acid bacteria ; Brown seaweed
Language	English
Dates of publication	2023-07
Size	p. 21-30.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2400836-9
ISSN	1876-4347 ; 1871-6784
ISSN (online)	1876-4347
ISSN	1871-6784
DOI	10.1016/j.nbt.2023.03.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Non-Pharmacological Interventions on Pain in Amyotrophic Lateral Sclerosis Patients: A Systematic Review and Meta-Analysis.

Papadopoulou, Marianna / Papapostolou, Apostolos / Dimakopoulos, Rigas / Salakou, Stavroula / Koropouli, Eleftheria / Fanouraki, Stella / Bakola, Eleni / Moschovos, Christos / Tsivgoulis, Georgios

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 7

Abstract: Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neurons. Some ALS patients exhibit concomitant nonmotor signs; thus, ALS is considered a multisystemic disorder. Pain is an ... ...

Abstract	Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neurons. Some ALS patients exhibit concomitant nonmotor signs; thus, ALS is considered a multisystemic disorder. Pain is an important nonmotor symptom. Observational and case-control studies report high frequency of pain in ALS patients and it has been correlated with depression and quality of life. There are no specific scales for the assessment of pain and no randomized controlled trials (RCTs) regarding the drug management of pain in ALS. Aim: To systematically review the evidence for the nonpharmacological interventions (NPIs) in relieving pain in ALS, on March 2024, we searched the following databases: Pubmed, Scopus, Web of Science, and Cochrane. We also checked the bibliographies of trials identified to include further published or unpublished trials. Main results: A total of 1003 records were identified. Finally, five RCTs including 131 patients (64 in the intervention group and 67 in the control group) were included for meta-analysis. The interventions of the included RCTs consisted of muscle exercise, combined aerobics-strength intervention, and osteopathic manual treatment. The meta-analysis did not find a statistically significant difference in favor of NPIs for alleviating pain in ALS patients. Conclusions: ALS has a fulminant course and irreversibly leads to death. Pain in ALS patients, although a common nonmotor symptom, is often unrecognized and undertreated, and this is underlined by the lack of any RCTs on drug therapy for pain. Albeit NPIs are considered safe, as adverse effects are rarely reported, this systematic review did not provide sufficient evidence for a beneficial effect on pain. The scarceness of relevant literature highlights the need for future studies, with larger samples, more homogeneous in terms of interventions and population characteristics (stage of disease), and better choice of measurement scales to further investigate the efficacy, if any, of various pain interventions in ALS patients.
Language	English
Publishing date	2024-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12070770
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Article ; Online: Neuropsychological Profile of Hospitalized Patients Due to COVID-19: Clinical and Inflammatory Correlates.

Tsiaras, Yiannis / Kitsakis, Nikolaos / Papadopoulou, Eleftheria / Karanikas, Evangelos / Kourbetis, Dimitrios / Aretouli, Eleni

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

2023 Volume 38, Issue 8, Page(s) 1564–1577

Abstract: Objectives: In the present study, we investigated the pattern of cognitive difficulties in hospitalized patients due to COVID-19 and its relation with the clinical features of the disease.: Method: Forty hospitalized patients with COVID-19 [mean age: ...

Abstract	Objectives: In the present study, we investigated the pattern of cognitive difficulties in hospitalized patients due to COVID-19 and its relation with the clinical features of the disease. Method: Forty hospitalized patients with COVID-19 [mean age: 46.98 years (SD = 9.30); mean years of education: 13.65 (SD = 2.07) and 40 sex-, age- and education-matched healthy controls completed a set of neuropsychological measures administered by telephone. Participants' premorbid intellectual skills and patients' anxiety and depressive symptoms were also evaluated. The association of COVID-19-related biomarkers [oxygen saturation (SpO2), C-reactive protein (CRP), D-dimer and ferritin levels] with neuropsychological performances was examined with a series of hierarchical multiple linear regression analyses, after controlling for demographic and clinical characteristics, psychological distress and premorbid intellectual skills. Results: Patients performed worse than healthy participants on measures of verbal memory, attention and working memory. SpO2 levels were associated with patients' performance on verbal and working memory, whereas CRP levels were associated with performance on verbal memory, abstract reasoning and verbal fluency, after controlling for demographic and clinical characteristics. Ferritin levels predicted performance on the verbal fluency test, whereas D-dimer levels did not predict any of the neuropsychological measures. Conclusions: Cognitive difficulties in verbal memory, attention and working memory were noted in patients with COVID-19. Markers of hyperinflammation predicted patients' performance above and beyond demographic characteristics, duration of symptoms, length of hospitalization and psychological distress.
MeSH term(s)	Humans ; Middle Aged ; Neuropsychological Tests ; COVID-19/complications ; Memory, Short-Term ; Attention ; Ferritins
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	632972-x
ISSN	1873-5843 ; 0887-6177
ISSN (online)	1873-5843
ISSN	0887-6177
DOI	10.1093/arclin/acad038
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Article ; Online: Saccharina latissima, candy-factory waste, and digestate from full-scale biogas plant as alternative carbohydrate and nutrient sources for lactic acid production.

Papadopoulou, Eleftheria / Vance, Charlene / Rozene Vallespin, Paloma S / Tsapekos, Panagiotis / Angelidaki, Irini

Bioresource technology

2023 Volume 380, Page(s) 129078

Abstract: To substitute petroleum-based materials with bio-based alternatives, microbial fermentation combined with inexpensive biomass is suggested. In this study Saccharina latissima hydrolysate, candy-factory waste, and digestate from full-scale biogas plant ... ...

Abstract	To substitute petroleum-based materials with bio-based alternatives, microbial fermentation combined with inexpensive biomass is suggested. In this study Saccharina latissima hydrolysate, candy-factory waste, and digestate from full-scale biogas plant were explored as substrates for lactic acid production. The lactic acid bacteria Enterococcus faecium, Lactobacillus plantarum, and Pediococcus pentosaceus were tested as starter cultures. Sugars released from seaweed hydrolysate and candy-waste were successfully utilized by the studied bacterial strains. Additionally, seaweed hydrolysate and digestate served as nutrient supplements supporting microbial fermentation. According to the highest achieved relative lactic acid production, a scaled-up co-fermentation of candy-waste and digestate was performed. Lactic acid reached a concentration of 65.65 g/L, with 61.69% relative lactic acid production, and 1.37 g/L/hour productivity. The findings indicate that lactic acid can be successfully produced from low-cost industrial residues.
MeSH term(s)	Lactic Acid ; Biofuels ; Carbohydrates ; Fermentation ; Nutrients
Chemical Substances	Lactic Acid (33X04XA5AT) ; Biofuels ; Carbohydrates
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129078
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Article ; Online: Adaptive laboratory evolution to hypersaline conditions of lactic acid bacteria isolated from seaweed.

Papadopoulou, Eleftheria / Rodriguez de Evgrafov, Mari Cristina / Kalea, Argyro / Tsapekos, Panagiotis / Angelidaki, Irini

New biotechnology

2023 Volume 75, Page(s) 21–30

Abstract	Seaweed biomass has been proposed as a promising alternative carbon source for fermentation processes using microbial factories. However, the high salinity content of seaweed biomass is a limiting factor in large scale fermentation processes. To address this shortcoming, three bacterial species (Pediococcus pentosaceus, Lactobacillus plantarum, and Enterococcus faecium) were isolated from seaweed biomass and evolved to increasing concentrations of NaCl. Following the evolution period, P. pentosaceus reached a plateau at the initial NaCl concentration, whereas L. plantarum, and E. faecium showed a 1.29 and 1.75-fold increase in their salt tolerance, respectively. The impact that salt evolution had on lactic acid production using hypersaline seaweed hydrolysate was investigated. Salinity evolved L. plantarum produced 1.18-fold more lactic acid than the wild type, and salinity evolved E. faecium was able to produce lactic acid, while the wild type could not. No differences in lactic acid production were observed between the P. pentosaceus salinity evolved and wild type strains. Evolved lineages were analyzed for the molecular mechanisms underlying the observed phenotypes. Mutations were observed in genes affecting the ion balance in the cell, the composition of the cell membrane and proteins acting as regulators. This study demonstrates that bacterial isolates from saline niches are promising microbial factories for the fermentation of saline substrates, without the requirement of previous desalination steps, while preserving high final product yields.
MeSH term(s)	Lactobacillales/genetics ; Sodium Chloride/pharmacology ; Fermentation ; Lactic Acid
Chemical Substances	Sodium Chloride (451W47IQ8X) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-03-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2400836-9
ISSN	1876-4347 ; 1876-4347
ISSN (online)	1876-4347
ISSN	1876-4347
DOI	10.1016/j.nbt.2023.03.001
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Article: Nipple candidiasis and painful lactation: an updated overview.

Plachouri, Kerasia-Maria / Mulita, Francesk / Oikonomou, Chrysa / Papadopoulou, Margarita / Akrida, Ioanna / Vryzaki, Eleftheria / Verras, Georgios-Ioannis / Georgiou, Sophia

Postepy dermatologii i alergologii

2022 Volume 39, Issue 4, Page(s) 651–655

Abstract: Nipple pain and discomfort during or after breastfeeding remains one of the most common reasons for premature cessation of lactation among the affected women. The belief that yeasts, and ... ...

Abstract	Nipple pain and discomfort during or after breastfeeding remains one of the most common reasons for premature cessation of lactation among the affected women. The belief that yeasts, and especially
Language	English
Publishing date	2022-05-31
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2022.116837
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Article ; Online: Author Correction: Methylprednisolone stimulated gene expression (GILZ, MCL-1) and basal cortisol levels in multiple sclerosis patients in relapse are associated with clinical response.

Evangelopoulos, Maria Eleftheria / Nasiri-Ansari, Narjes / Kassi, Eva / Papadopoulou, Anna / Evangelopoulos, Dimitrios Stergios / Moutsatsou, Paraskevi

Scientific reports

2021 Volume 11, Issue 1, Page(s) 22940

Language	English
Publishing date	2021-11-19
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-02415-8
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Article: Case Report: Intracranial Hypertension Secondary to Guillain-Barre Syndrome.

Doxaki, Christina / Papadopoulou, Eleftheria / Maniadaki, Iliana / Tsakalis, Nikolaos G / Palikaras, Konstantinos / Vorgia, Pelagia

Frontiers in pediatrics

2021 Volume 8, Page(s) 608695

Abstract: Guillain-Barre Syndrome (GBS), a common cause of acute flaccid paralysis, is characterized by a rapidly progressive, usually symmetric weakness of the extremities. Headache and intracranial hypertension (ICHT) are very rare complications of GBS. Herein ... ...

Abstract	Guillain-Barre Syndrome (GBS), a common cause of acute flaccid paralysis, is characterized by a rapidly progressive, usually symmetric weakness of the extremities. Headache and intracranial hypertension (ICHT) are very rare complications of GBS. Herein we report our current case of an obese girl with typical signs of GBS associated with autonomic dysfunction, cranial nerve deficits and increased intracranial pressure (ICP). We also perform a systematic study presenting and discussing previous case reports of GBS associated with ICHT, papilledema or hydrocephalus, highlighting the differences of the current case compared to previous studies. Although intracranial hypertension is a rare complication of pediatric GBS, clinicians should promptly detect it. Obesity may be a predisposing factor, given the strong association between idiopathic intracranial hypertension (IIH) and weight gain. Neurological evaluation, fundus examination and low threshold for intracranial imaging should be an integral part of medical practice in case of obesity, headache or visual changes in GBS patients.
Language	English
Publishing date	2021-01-20
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.608695
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