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Article ; Online: DRUG RESISTANCE IN HELICOBACTER PYLORI.

Passos, Maria do Carmo Friche

2016 Volume 53, Issue 4, Page(s) 213–214

MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Brazil ; Drug Resistance, Microbial ; Gastritis/drug therapy ; Gastritis/microbiology ; Helicobacter Infections/drug therapy ; Helicobacter pylori/drug effects ; Humans
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2016-10
Publishing country	Brazil
Document type	Editorial ; Introductory Journal Article
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-28032016000400001
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Article ; Online: INTESTINAL MICROBIOTA IN DIGESTIVE DISEASES.

Passos, Maria do Carmo Friche / Moraes-Filho, Joaquim Prado

Arquivos de gastroenterologia

2017 Volume 54, Issue 3, Page(s) 255–262

Abstract: Background: In recent years, especially after the development of sophisticated metagenomic studies, research on the intestinal microbiota has increased, radically transforming our knowledge about the microbiome and its association with health ... ...

Abstract	Background: In recent years, especially after the development of sophisticated metagenomic studies, research on the intestinal microbiota has increased, radically transforming our knowledge about the microbiome and its association with health maintenance and disease development in humans. Increasing evidence has shown that a permanent alteration in microbiota composition or function (dysbiosis) can alter immune responses, metabolism, intestinal permeability, and digestive motility, thereby promoting a proinflammatory state. Such alterations can mainly impair the host's immune and metabolic functions, thus favoring the onset of diseases such as diabetes, obesity, digestive, neurological, autoimmune, and neoplastic diseases. This comprehensive review is a compilation of the available literature on the formation of the complex intestinal ecosystem and its impact on the incidence of diseases such as obesity, non-alcoholic steatohepatitis, irritable bowel syndrome, inflammatory bowel disease, celiac disease, and digestive neoplasms. Conclusion:: Alterations in the composition and function of the gastrointestinal microbiota (dysbiosis) have a direct impact on human health and seem to have an important role in the pathogenesis of several gastrointestinal diseases, whether inflammatory, metabolic, or neoplastic ones.
MeSH term(s)	Gastrointestinal Diseases/microbiology ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Obesity/microbiology
Language	English
Publishing date	2017-07
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-2803.201700000-31
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Article ; Online: DIAGNOSIS AND MANAGEMENT OF CHRONIC IDIOPATHIC CONSTIPATION: A NARRATIVE REVIEW FROM A BRAZILIAN EXPERT TASK FORCE.

Passos, Maria do Carmo Friche / Alvariz, Ricardo Cerqueira / André, Eduardo Antonio / Barbuti, Ricardo Correa / Fillmann, Henrique Sarubbi / Murad-Regadas, Sthela Maria / Rezende Filho, Joffre / Perrotti, Marcos / Guedes, Luciana

Arquivos de gastroenterologia

2022 Volume 59, Issue 1, Page(s) 137–144

Abstract: Background: Chronic idiopathic constipation (CIC) is a condition that widely affects the global population, represents relevant healthcare resource utilization and costs, and impacts the individual's well-being.: Objective: To review the consensus of ...

Abstract	Background: Chronic idiopathic constipation (CIC) is a condition that widely affects the global population, represents relevant healthcare resource utilization and costs, and impacts the individual's well-being. Objective: To review the consensus of expert societies and published guidelines on the diagnosis and treatment of CIC in adults, seeking to assist reasoning and decision-making for medical management of patients with CIC and provide a practical reference material. Methods: A Brazilian medical task force searched the scientific literature in the following electronic databases: MEDLINE/PubMed, SciELO, EMBASE and Cochrane, using the following descriptors: chronic constipation, diagnosis, management of chronic constipation. In addition, a review of articles on the mechanism of action, safety, and efficacy of therapeutic options available in Brazil was carried out. Results: The diagnostic approach and the understanding of the pathophysiology present in CIC are essential items to indicate the appropriate therapy and to understand the ecosystem of the patient's needs. Conclusion: CIC is a common condition in adults, occurring more frequently in the elderly and in women. Proper management is defined by detailed medical history and physical examination, together with appropriate therapeutics, regardless pharmacological or not, and depending on the best moment of indication. This way, the impact on quality of life is also optimized.
MeSH term(s)	Adult ; Aged ; Brazil ; Chronic Disease ; Constipation/drug therapy ; Constipation/therapy ; Ecosystem ; Female ; Humans ; Quality of Life
Language	English
Publishing date	2022-04-15
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-2803.202200001-23
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Article ; Online: High prevalence of functional dyspepsia in nonalcoholic fatty liver disease: a cross-sectional study.

Lima, Érika Cristina / Passos, Maria do Carmo Friche / Ferolla, Silvia Marinho / Costa, Raissa Soares Neves da / Lisboa, Quelson Coelho / Pereira, Lucas Ismael Dias / Nardelli, Mateus Jorge / Arantes, Vitor Nunes / Ferrari, Teresa Cristina de Abreu / Couto, Claudia Alves

Sao Paulo medical journal = Revista paulista de medicina

2022 Volume 140, Issue 2, Page(s) 199–206

Abstract: Background: Gastrointestinal (GI) symptoms are frequent complaints from individuals with nonalcoholic fatty liver disease (NAFLD). Dyspepsia is a universal clinical symptom and is among the most common GI complaints observed in the general population, ... ...

Abstract	Background: Gastrointestinal (GI) symptoms are frequent complaints from individuals with nonalcoholic fatty liver disease (NAFLD). Dyspepsia is a universal clinical symptom and is among the most common GI complaints observed in the general population, but its prevalence in the population with NAFLD has not been previously investigated. Objective: To compare the prevalence of functional dyspepsia (FD) between patients with NAFLD and controls without liver disease. Design and setting: Cross-sectional study at the Outpatient Liver Clinic, University Hospital, Belo Horizonte, Brazil. Methods: We included 96 NAFLD patients and 105 controls without liver disease. All participants were assessed for GI symptoms in accordance with the Rome III criteria. Evaluation methods included a questionnaire for FD (validated in Brazil), laboratory tests and upper GI endoscopy. Results: Mean age and sex were similar between the groups. The NAFLD group presented higher frequency of proton-pump inhibitor usage (31.3% vs 4.8%; P < 0.001) and prevalence of FD (25.0% versus 12.4%; P = 0.021). The symptom frequencies were as follows: postprandial distress, 22.9% versus 11.4% (P = 0.030); postprandial fullness, 18.8% versus 10.5% (P = 0.095); early satiation, 8.3% versus 5.7% (P = 0.466); and epigastric pain or burning, 18.8% versus 5.7% (P = 0.004), in NAFLD patients and controls, respectively. Multivariate analysis demonstrated that female sex (odds ratio, OR 6.97; 95% confidence interval, CI: 1.51-32.12; P = 0.013) and NAFLD diagnosis (OR 2.45; 95% CI: 1.14-5.27; P = 0.021) were independently associated with FD occurrence. Conclusion: FD occurs more frequently in individuals with NAFLD than in controls without hepatic disease.
MeSH term(s)	Abdominal Pain ; Cross-Sectional Studies ; Dyspepsia/diagnosis ; Dyspepsia/epidemiology ; Female ; Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Prevalence
Language	English
Publishing date	2022-01-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1203171-9
ISSN	1806-9460 ; 1516-3180 ; 0035-0362
ISSN (online)	1806-9460
ISSN	1516-3180 ; 0035-0362
DOI	10.1590/1516-3180.2021.0015.R1.14062021
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Article ; Online: High prevalence of functional dyspepsia in nonalcoholic fatty liver disease

Érika Cristina Lima / Maria do Carmo Friche Passos / Silvia Marinho Ferolla / Raissa Soares Neves da Costa / Quelson Coelho Lisboa / Lucas Ismael Dias Pereira / Mateus Jorge Nardelli / Vitor Nunes Arantes / Teresa Cristina de Abreu Ferrari / Claudia Alves Couto

São Paulo Medical Journal (2022)

a cross-sectional study

2022

Abstract: Abstract BACKGROUND: Gastrointestinal (GI) symptoms are frequent complaints from individuals with nonalcoholic fatty liver disease (NAFLD). Dyspepsia is a universal clinical symptom and is among the most common GI complaints observed in the general ... ...

Abstract	Abstract BACKGROUND: Gastrointestinal (GI) symptoms are frequent complaints from individuals with nonalcoholic fatty liver disease (NAFLD). Dyspepsia is a universal clinical symptom and is among the most common GI complaints observed in the general population, but its prevalence in the population with NAFLD has not been previously investigated. OBJECTIVE: To compare the prevalence of functional dyspepsia (FD) between patients with NAFLD and controls without liver disease. DESIGN AND SETTING: Cross-sectional study at the Outpatient Liver Clinic, University Hospital, Belo Horizonte, Brazil. METHODS: We included 96 NAFLD patients and 105 controls without liver disease. All participants were assessed for GI symptoms in accordance with the Rome III criteria. Evaluation methods included a questionnaire for FD (validated in Brazil), laboratory tests and upper GI endoscopy. RESULTS: Mean age and sex were similar between the groups. The NAFLD group presented higher frequency of proton-pump inhibitor usage (31.3% vs 4.8%; P < 0.001) and prevalence of FD (25.0% versus 12.4%; P = 0.021). The symptom frequencies were as follows: postprandial distress, 22.9% versus 11.4% (P = 0.030); postprandial fullness, 18.8% versus 10.5% (P = 0.095); early satiation, 8.3% versus 5.7% (P = 0.466); and epigastric pain or burning, 18.8% versus 5.7% (P = 0.004), in NAFLD patients and controls, respectively. Multivariate analysis demonstrated that female sex (odds ratio, OR 6.97; 95% confidence interval, CI: 1.51-32.12; P = 0.013) and NAFLD diagnosis (OR 2.45; 95% CI: 1.14-5.27; P = 0.021) were independently associated with FD occurrence. CONCLUSION: FD occurs more frequently in individuals with NAFLD than in controls without hepatic disease.
Keywords	Gastrointestinal diseases ; Nonalcoholic fatty liver disease ; Dyspepsia ; Obesity ; Diabetes mellitus ; Functional gastrointestinal disorders ; NAFLD ; sIndigestion ; Body weight ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Associação Paulista de Medicina
Document type	Article ; Online
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Article ; Online: Pós-graduação no exterior

Maria do Carmo Friche Passos

Arquivos de Gastroenterologia, Vol 46, Iss 1, Pp 5-

vale a pena?

2009 Volume 6

Keywords	Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Portuguese
Publishing date	2009-03-01T00:00:00Z
Publisher	Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The use of probiotics as a supplementary therapy in the treatment of patients with asthma: a pilot study and implications.

Moura, Jonatas Christian Vieira / Moura, Isabel Cristina Gomes / Gaspar, Guilherme Rache / Mendes, Guilherme Matos Serretti / Faria, Bernardo Almeida Vial / Jentzsch, Nulma Souto / do Carmo Friche Passos, Maria / Kurdi, Amanj / Godman, Brian / Almeida, Alessandra Maciel

Clinics (Sao Paulo, Brazil)

2019 Volume 74, Page(s) e950

Abstract: Objectives: Evaluate the use of probiotics as an additional therapy in the treatment of children and adolescents with asthma in Belo Horizonte, MG-Brazil.: Methods: A pilot longitudinal, experimental and nonrandomized study with 30 patients from six ... ...

Abstract	Objectives: Evaluate the use of probiotics as an additional therapy in the treatment of children and adolescents with asthma in Belo Horizonte, MG-Brazil. Methods: A pilot longitudinal, experimental and nonrandomized study with 30 patients from six to 17 years old from Belo Horizonte. In the baseline appointment, all patients received beclomethasone, and one group also received a probiotic containing Lactobacillus reuteri (n=14). The patients were reassessed after at least 60 days with the Asthma Control Test, spirometry and self-report of the symptoms they experienced associated with asthma. Results: A predominance of male patients (56.7%) and a mean age of 10.6 years were observed. The groups using probiotics did not differ in terms of sex, age or atopy. In the longitudinal evaluation, an increase in the Asthma Control Test scores and a reduction in the number of symptoms were observed in the probiotic group. There was an increase in the peak expiratory flow among those who used probiotics. Conclusions: This pilot study supports the hypothesis that the administration of probiotics as a supplementary therapy for the treatment of children and adolescents with asthma improves the clinical condition of the patients. Further studies are needed to confirm the efficacy of probiotics in asthma treatment.
MeSH term(s)	Adolescent ; Asthma/drug therapy ; Asthma/prevention & control ; Brazil ; Case-Control Studies ; Child ; Female ; Humans ; Lactobacillus reuteri ; Longitudinal Studies ; Male ; Pilot Projects ; Probiotics/therapeutic use ; Respiratory Function Tests ; Spirometry
Language	English
Publishing date	2019-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182801-5
ISSN	1980-5322 ; 1807-5932
ISSN (online)	1980-5322
ISSN	1807-5932
DOI	10.6061/clinics/2019/e950
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Article ; Online: Pós-graduação no exterior: vale a pena?

Passos, Maria do Carmo Friche

Arquivos de gastroenterologia

2009 Volume 46, Issue 1, Page(s) 5–6

Title translation	Foreign Postgraduate education: is it worth?.
MeSH term(s)	Decision Making ; Education, Graduate/organization & administration ; Emigration and Immigration ; Humans
Language	Portuguese
Publishing date	2009-02-03
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/s0004-28032009000100005
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Article ; Online: Infecção pelo Helicobacter pylori

Maria do Carmo Friche Passos

Arquivos de Gastroenterologia, Vol 44, Iss 2, Pp 91-

prevalência e associação com lesões gástricas Helicobacter pylori infection: prevalence and association with gastric lesions

2007 Volume 92

Keywords	Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Portuguese
Publishing date	2007-06-01T00:00:00Z
Publisher	Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE
Document type	Article ; Online
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Article ; Online: THE EFFECT OF PROBIOTIC FERMENTED MILK THAT INCLUDES BIFIDOBACTERIUM LACTIS CNCM I-2494 ON THE REDUCTION OF GASTROINTESTINAL DISCOMFORT AND SYMPTOMS IN ADULTS: A NARRATIVE REVIEW.

Waitzberg, Dan L / Quilici, Flávio A / Michzputen, Sender / Friche Passos, Maria do Carmo

Nutricion hospitalaria

2015 Volume 32, Issue 2, Page(s) 501–509

Abstract: Aim: determine the effectiveness of fermented milk that included Bifidobacterium lactis CNCM I-2429 for reducing gastrointestinal (GI) discomfort in healthy adults.: Methods: we conducted a systematic literature search to identify studies reporting ... ...

Abstract	Aim: determine the effectiveness of fermented milk that included Bifidobacterium lactis CNCM I-2429 for reducing gastrointestinal (GI) discomfort in healthy adults. Methods: we conducted a systematic literature search to identify studies reporting the use of B. animalis spp. lactis for GI discomfort/comfort in healthy adults. A total of 5329 records were identified, of these 99 full-text articles were assessed. Searches for additional trials were conducted using the names of authors of each identified study and several relevant databases. The study selection was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were included if they were randomized controlled trials; the included subjects were healthy adults; and the intervention group received B. lactis CNCM I-2494. Studies were excluded if they were non-randomized trials, if they included adults who were not healthy, if they included the use of any other intervention, or if they compared different products without a placebo group. The methodological quality of the studies was evaluated using the Oxford Quality Scale and the Cochrane Concealment Assessment. A meta-analysis was not possible. Results: the search strategy identified two studies that included a total of 538 healthy women, aged 18-60 years, normal weight or overweight (BMI 18-30 kg/m2). GI well-being was significantly improved in the Probiotic group vs. the Control group in one study, with no differences in the other. The percentage of responders for GI well-being was higher in the Probiotic group vs. the Control group in the first study but not in the second. GI symptoms were significantly decreased in the Probiotic group vs. the Control group in both studies. Bowel function was assessed by one study; the stool frequency did not differ between the groups, but a decrease in stool consistency was observed in the Probiotic group but not in the Control group. Possible mechanisms of action (gut motility, hypersensitivity, gut permeability, and gut microbiota) were also described. Conclusion: probiotic fermented milk containing B. lactis CNCM I-2494 by healthy women may improve GI well- being and decrease the frequency of GI symptoms.
MeSH term(s)	Bifidobacterium animalis ; Case-Control Studies ; Cultured Milk Products ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/diet therapy ; Gastrointestinal Diseases/etiology ; Humans ; Probiotics ; Quality of Life ; Randomized Controlled Trials as Topic ; Treatment Outcome
Language	English
Publishing date	2015-08-01
Publishing country	Spain
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	1481223-x
ISSN	1699-5198 ; 0212-1611
ISSN (online)	1699-5198
ISSN	0212-1611
DOI	10.3305/nh.2015.32.2.9232
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