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Article ; Online: The Difficulties of Assessing Return to Play and Return to Performance after UCL Reconstruction.

Berkson, Eric / O'Donnell, Evan / Cote, Mark / Mazzocca, Augustus D

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2024

Abstract: Ulnar collateral ligaments (UCL) tears have moved from a career ending injury to one where success is almost expected from reconstruction. In reality, though, success from a UCL reconstruction is not guaranteed. As we have attempted to assess the true ... ...

Abstract	Ulnar collateral ligaments (UCL) tears have moved from a career ending injury to one where success is almost expected from reconstruction. In reality, though, success from a UCL reconstruction is not guaranteed. As we have attempted to assess the true success rate of UCL reconstructions we have also learned the difficulties of this assessment. Rates of return to sport after ulnar collateral ligament reconstruction vary by level of play, the primary or revision status of the repair along with the specific surgical techniques performed, the chronicity of the tear, the rehab protocols associated with the surgery, and more. Return to sport is difficult to assess as high school, collegiate and even professional careers can be variable and there are no standard definitions of "returning to play". These variables also affect our assessments of performance after UCL reconstruction. Decisions for UCL reconstructions and appropriate counseling of patients regarding the likelihood of success currently remains an individual process.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Editorial
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2024.04.001
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Article ; Online: A Woman With Pyoderma Gangrenosum, Recurrent Abdominal Pain, and Hematochezia.

Equinozzi, Erin / O'Donnell, Michael / Lee, Clement D

Gastroenterology

2023 Volume 166, Issue 1, Page(s) 31–35

MeSH term(s)	Female ; Humans ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/drug therapy ; Colitis, Ulcerative ; Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Gastrointestinal Hemorrhage
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2023.08.045
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Article ; Online: Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process.

Langston, Lance D / Georgescu, Roxana E / O'Donnell, Michael E

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 52, Page(s) e2316466120

Abstract: DNA replication in all cells begins with the melting of base pairs at the duplex origin to allow access to single-stranded DNA templates which are replicated by DNA polymerases. In bacteria, origin DNA is presumed to be melted by accessory proteins that ... ...

Abstract	DNA replication in all cells begins with the melting of base pairs at the duplex origin to allow access to single-stranded DNA templates which are replicated by DNA polymerases. In bacteria, origin DNA is presumed to be melted by accessory proteins that allow loading of two ring-shaped replicative helicases around single-strand DNA (ssDNA) for bidirectional unwinding and DNA replication. In eukaryotes, by contrast, two replicative CMG (Cdc45-Mcm2-7-GINS) helicases are initially loaded head to head around origin double-strand DNA (dsDNA), and there does not appear to be a separate origin unwinding factor. This led us to investigate whether head-to-head CMGs use their adenosine triphosphate (ATP)-driven motors to initiate duplex DNA unwinding at the origin. Here, we show that CMG tracks on one strand of the duplex while surrounding it, and this feature allows two head-to-head CMGs to unwind dsDNA by using their respective motors to pull on opposite strands of the duplex. We further show that while CMG is capable of limited duplex unwinding on its own, the extent of unwinding is greatly and rapidly stimulated by addition of the multifunctional CMG-binding protein Mcm10 that is critical for productive initiation of DNA replication in vivo. On the basis of these findings, we propose that Mcm10 is a processivity or positioning factor that helps translate the work performed by the dual CMG motors at the origin into productive unwinding that facilitates bidirectional DNA replication.
MeSH term(s)	Minichromosome Maintenance Proteins/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; DNA Replication ; DNA/metabolism ; DNA, Single-Stranded/genetics
Chemical Substances	Minichromosome Maintenance Proteins (EC 3.6.4.12) ; Saccharomyces cerevisiae Proteins ; DNA (9007-49-2) ; DNA, Single-Stranded
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2316466120
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Article ; Online: The Impact of Climate Change on Aeromedical Retrieval Services in Remote Northern Australia: Planning for a Hotter Future.

Quilty, Simon / Lal, Aparna / Honan, Bridget / Chateau, Dan / O'Donnell, Elen / Mills, Jodie

International journal of environmental research and public health

2024 Volume 21, Issue 1

Abstract: ... category than other emergencies (i.e., more urgent), such an increase will impede overall retrieval service ...

Abstract	It is known that environmental heat is associated with increased morbidity manifesting as increasing demand on acute care health services including pre-hospital transport and emergency departments. These services play a vital role in emergency care, and in rural and remote locations, where resource capacity is limited, aeromedical and other retrieval services are a vital part of healthcare delivery. There is no research examining how heat impacts remote retrieval service delivery. The Northern Territory (NT) of Australia is characterised by very remote communities with limited acute healthcare capacities and is a region subject to regular extreme tropical heat. In this study, we examine the relationship between aeromedical retrievals and hot weather for all NT retrievals between February 2018 and December 2019. A regression analysis was performed on the number of retrievals by clinical reason for retrieval matched to the temperature on the day of retrieval. There was a statistically significant exposure response relationship with increasing retrievals of obstetric emergencies in hotter weather in the humid climate zone and surgical retrievals in the arid zone. Retrieval services appeared to be at capacity at all times of the year. Given that there are no obstetric services in remote communities and that obstetric emergencies are a higher triage category than other emergencies (i.e., more urgent), such an increase will impede overall retrieval service delivery in hot weather. Increasing surgical retrievals in the arid zone may reflect an increase in soft tissue infections occurring in overcrowded houses in the hotter months of the year. Given that retrieval services are at capacity throughout the year, any increase in demand caused by increasing environmental heat will have broad implications for service delivery as the climate warms. Planning for a hotter future must include building resilient communities by optimising local healthcare capacity and addressing housing and other socioeconomic inequities that amplify heat-related illness.
MeSH term(s)	Humans ; Hot Temperature ; Air Ambulances ; Climate Change ; Emergencies ; Northern Territory
Language	English
Publishing date	2024-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph21010114
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Article ; Online: Direct evidence for effective cleaning and decontamination of the internal air and water channels, heads and head-gears of multiple contra-angle dental handpieces using an enzymatic detergent and automated washer-disinfection in a dental hospital setting.

Coleman, D C / Deasy, E C / Swan, J S / O'Donnell, M J / Scott, T A

The Journal of hospital infection

2023 Volume 135, Page(s) 204–205

MeSH term(s)	Humans ; Disinfection ; Detergents ; Decontamination ; Sterilization ; Equipment Contamination ; Aquaporins ; Hospitals
Chemical Substances	Detergents ; Aquaporins
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2023.03.001
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Article ; Online: Language and self-regulation: Interrelated sources of disparities in reading achievement and opportunities for reducing inequity.

Clemens, Nathan H / Mason, Sarah / O'Donnell, Katherine E

School psychology (Washington, D.C.)

2022 Volume 38, Issue 1, Page(s) 15–29

Abstract: ... i.e., General American English), and limited self-regulation skills relevant to reading, compared ...

Abstract	Language and self-regulation develop bidirectionally, and they synergistically affect most aspects of acquiring reading proficiency. Children and youth from historically marginalized communities tend to have less expansive knowledge of academic vocabulary and dialect common to instruction and academic text (i.e., General American English), and limited self-regulation skills relevant to reading, compared to less-marginalized peers. In this article, we argue that language and self-regulation are factors in demographic-related reading opportunity gaps, and that in addition to improving students' access to high-quality explicit phonics instruction, understanding their interactive relationship offers opportunities for schools to reduce disparities in reading outcomes. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Child ; Adolescent ; Humans ; United States ; Reading ; Language ; Vocabulary ; Schools ; Self-Control
Language	English
Publishing date	2022-12-15
Publishing country	United States
Document type	Journal Article
ISSN	2578-4226
ISSN (online)	2578-4226
DOI	10.1037/spq0000522
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Article ; Online: Trend analysis and prediction of seasonal changes in milk composition from a pasture-based dairy research herd.

Hayes, E / Wallace, D / O'Donnell, C / Greene, D / Hennessy, D / O'Shea, N / Tobin, J T / Fenelon, M A

Journal of dairy science

2023 Volume 106, Issue 4, Page(s) 2326–2337

Abstract: The composition of seasonal pasture-produced milk is influenced by stage of lactation, animal genetics, and nutrition, which affects milk nutritional profile and processing characteristics. The objective was to study the effect of lactation stage (early, ...

Abstract	The composition of seasonal pasture-produced milk is influenced by stage of lactation, animal genetics, and nutrition, which affects milk nutritional profile and processing characteristics. The objective was to study the effect of lactation stage (early, mid, and late lactation) and diet on milk composition in an Irish spring calving dairy research herd from 2012 to 2020 using principal component and predictive analytics. Crude protein, casein, fat, and solids increased from 2012 to 2020, whereas lactose concentration peaked in 2017, then decreased. Based on seasonal data from 2013 to 2016, forecasting models were successfully created to predict milk composition for 2017 to 2020. The diet of cows in this study is dependent upon grass growth rates across the milk production season, which in turn, are influenced by weather patterns, whereby extreme weather conditions (rainfall and temperature) were correlated with decreasing grass growth and increasing nonprotein nitrogen levels in milk. The study demonstrates a significant change in milk composition since 2012 and highlights the effect that seasonal changes such as weather and grass growth have on milk composition of pasture-based systems. The potential to forecast milk composition at different stages of lactation benefits processers by facilitating the optimization of in-process and supply logistics of dairy products.
MeSH term(s)	Female ; Cattle ; Animals ; Milk/metabolism ; Seasons ; Lactation ; Poaceae ; Diet/veterinary ; Animal Feed/analysis
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2021-21483
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Article: Spectroscopic technologies and data fusion: Applications for the dairy industry.

Hayes, Elena / Greene, Derek / O'Donnell, Colm / O'Shea, Norah / Fenelon, Mark A

Frontiers in nutrition

2023 Volume 9, Page(s) 1074688

Abstract: Increasing consumer awareness, scale of manufacture, and demand to ensure safety, quality and sustainability have accelerated the need for rapid, reliable, and accurate analytical techniques for food products. Spectroscopy, coupled with Artificial ... ...

Abstract	Increasing consumer awareness, scale of manufacture, and demand to ensure safety, quality and sustainability have accelerated the need for rapid, reliable, and accurate analytical techniques for food products. Spectroscopy, coupled with Artificial Intelligence-enabled sensors and chemometric techniques, has led to the fusion of data sources for dairy analytical applications. This article provides an overview of the current spectroscopic technologies used in the dairy industry, with an introduction to data fusion and the associated methodologies used in spectroscopy-based data fusion. The relevance of data fusion in the dairy industry is considered, focusing on its potential to improve predictions for processing traits by chemometric techniques, such as principal component analysis (PCA), partial least squares regression (PLS), and other machine learning algorithms.
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1074688
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Article ; Online: CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism.

Yao, Nina Y / Zhang, Dan / Yurieva, Olga / O'Donnell, Michael E

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 4

Abstract: The adenosine triphosphate (ATP) analog ATPγS often greatly slows or prevents enzymatic ATP hydrolysis. The eukaryotic CMG (Cdc45, Mcm2 to 7, GINS) replicative helicase is presumed unable to hydrolyze ATPγS and thus unable to perform DNA unwinding, as ... ...

Abstract	The adenosine triphosphate (ATP) analog ATPγS often greatly slows or prevents enzymatic ATP hydrolysis. The eukaryotic CMG (Cdc45, Mcm2 to 7, GINS) replicative helicase is presumed unable to hydrolyze ATPγS and thus unable to perform DNA unwinding, as documented for certain other helicases. Consequently, ATPγS is often used to "preload" CMG onto forked DNA substrates without unwinding before adding ATP to initiate helicase activity. We find here that CMG does hydrolyze ATPγS and couples it to DNA unwinding. Indeed, the rate of unwinding of a 20- and 30-mer duplex fork of different sequences by CMG is only reduced 1- to 1.5-fold using ATPγS compared with ATP. These findings imply that a conformational change is the rate-limiting step during CMG unwinding, not hydrolysis. Instead of using ATPγS for loading CMG onto DNA, we demonstrate here that nonhydrolyzable adenylyl-imidodiphosphate (AMP-PNP) can be used to preload CMG onto a forked DNA substrate without unwinding.
MeSH term(s)	Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Cell Cycle Proteins/metabolism ; DNA/chemistry ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA Replication ; DNA-Binding Proteins/metabolism ; Multiprotein Complexes/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Cell Cycle Proteins ; DNA-Binding Proteins ; Multiprotein Complexes ; Saccharomyces cerevisiae Proteins ; adenosine 5'-O-(3-thiotriphosphate) (35094-46-3) ; Adenosine Triphosphate (8L70Q75FXE) ; DNA (9007-49-2) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2119580119
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Article ; Online: O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies.

Karampini, Ellie / Doherty, Dearbhla / Bürgisser, Petra E / Garre, Massimiliano / Schoen, Ingmar / Elliott, Stephanie / Bierings, Ruben / O'Donnell, James S

Blood advances

2024

Abstract: ... within endothelial cells (EC) prior to secretion. This includes significant N- and O-linked glycosylation. Previous studies ... In contrast, although abnormalities in VWF O-linked glycans (OLG) have been associated with enhanced VWF ... significantly reduced in the context of O-glycosylation inhibition. Finally, altered OLG on VWF not only reduced ...

Abstract	Von Willebrand factor (VWF) undergoes complex post-translational modification within endothelial cells (EC) prior to secretion. This includes significant N- and O-linked glycosylation. Previous studies have demonstrated that changes in N-linked glycan structures significantly influence VWF biosynthesis. In contrast, although abnormalities in VWF O-linked glycans (OLG) have been associated with enhanced VWF clearance, their effect on VWF biosynthesis remains poorly explored. Herein, we report a novel role for OLG determinants in regulating VWF biosynthesis and trafficking within EC. We demonstrate that alterations in OLG (notably reduced terminal sialylation) lead to activation of the A1 domain of VWF within EC. In the presence of altered OLG, VWF multimerization is reduced and Weibel-Palade body (WPB) formation significantly impaired. Consistently, the amount of VWF secreted from WPB following EC activation was significantly reduced in the context of O-glycosylation inhibition. Finally, altered OLG on VWF not only reduced the amount of VWF secreted following EC activation, but also affected its hemostatic efficacy. Notably, VWF secreted following WPB exocytosis consisted predominantly of low molecular weight multimers and the length of tethered VWF string formation on the surface of activated ECs was significantly reduced. In conclusion, our data therefore support the hypothesis that alterations in O-glycosylation pathways directly impact VWF trafficking within human EC. These findings are interesting given that previous studies have reported altered OLG on plasma VWF (notably increased T antigen expression) in patients with von Willebrand disease.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023012499
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