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  1. Article ; Online: A critical analysis of the classifications of squamous cell carcinoma of the nasal vestibule.

    Ferreli, Fabio / Pirola, Francesca / Di Santo, Davide / De Virgilio, Armando / Spriano, Giuseppe / Mercante, Giuseppe

    Oral oncology

    2022  Volume 129, Page(s) 105880

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Humans ; Nasal Cavity/pathology ; Nose Neoplasms/pathology
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.105880
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    Zs.A 4869: Show issues Location:
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  2. Article ; Online: The impact of frailty on adjuvant treatment in patients with head and neck free flap reconstruction-A retrospective study using two independent frailty scores: Avoiding the wrong conclusion.

    Festa, Bianca Maria / Costantino, Andrea / Ferreli, Fabio / Spriano, Giuseppe / Mercante, Giuseppe / De Virgilio, Armando

    Oral oncology

    2022  Volume 134, Page(s) 106071

    MeSH term(s) Frailty ; Free Tissue Flaps ; Head and Neck Neoplasms/etiology ; Head and Neck Neoplasms/surgery ; Humans ; Neck ; Postoperative Complications/etiology ; Reconstructive Surgical Procedures/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.106071
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  3. Article ; Online: Endoscopic Trans-Sphenoidal Resection of a Giant Pituitary Neuroendocrine Tumor with Third Ventricle Invasion and Obstructive Hydrocephalus: Surgical Anatomy and Two-Dimensional Operative Video.

    Bono, Beatrice C / Milani, Davide / Ferreli, Fabio / Olei, Simone / Raspagliesi, Luca / Tropeano, Maria Pia / Lasio, Giovanni B / Pessina, Federico

    World neurosurgery

    2023  Volume 181, Page(s) 107

    MeSH term(s) Humans ; Third Ventricle/diagnostic imaging ; Third Ventricle/surgery ; Third Ventricle/pathology ; Neuroendocrine Tumors ; Endoscopy/methods ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/etiology ; Hydrocephalus/surgery
    Language English
    Publishing date 2023-10-21
    Publishing country United States
    Document type Video-Audio Media
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.10.075
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  4. Article ; Online: High-Definition 3D Exoscope in Thyroid Surgery.

    Mercante, Giuseppe / Costantino, Andrea / De Virgilio, Armando / Ferreli, Fabio / Spriano, Giuseppe

    Surgical innovation

    2022  Volume 30, Issue 2, Page(s) 205–209

    Abstract: Background: The high-definition 3D exoscope is an innovative and promising tool that was recently introduced in the clinical practice. It may be used during open surgical procedures to enhance the ability to perform precise dissection of fine structures. ...

    Abstract Background: The high-definition 3D exoscope is an innovative and promising tool that was recently introduced in the clinical practice. It may be used during open surgical procedures to enhance the ability to perform precise dissection of fine structures. We describe our preliminary experience with the 3D exoscope in thyroid surgery, discussing potential advantages of this system.
    Methods: A high-definition 3D exoscope (3D VITOM
    Results: The 3D exoscope was used in three patients without significant intra-operative delay or complications. Both thyroidectomy and central compartment dissection were performed. The 3D exoscope allows to perform precise dissection in the identification and preservation of the recurrent laryngeal nerve and the parathyroid glands.
    Conclusions: 3D exoscope-assisted thyroid surgery seems to be feasible and safe. Further studies should be encouraged to analyze potential clinical benefit in the post-operative period.
    MeSH term(s) Humans ; Thyroid Gland/surgery ; Parathyroid Glands ; Thyroidectomy/methods ; Dissection ; Germany
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506221097553
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  5. Article ; Online: Fatal Iatrogenic Pituitary Apoplexy after Surgery for Neuroophthalmological Disorder.

    Nioi, Matteo / Napoli, Pietro Emanuele / Ferreli, Fabio

    Anesthesiology

    2019  Volume 130, Issue 5, Page(s) 822

    MeSH term(s) Adenoma/surgery ; Fatal Outcome ; Female ; Humans ; Iatrogenic Disease ; Middle Aged ; Pituitary Apoplexy/etiology ; Pituitary Neoplasms/surgery ; Postoperative Complications/etiology ; Vision Disorders/surgery
    Language English
    Publishing date 2019-01-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000002584
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    Zs.MO 199: Show issues

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  6. Article: Outcomes of Endoscopic Endonasal Dacryocystorhinostomy in Glaucoma Patients.

    Pace, Gian Marco / Giombi, Francesco / Muci, Giovanna / Giunta, Gianmarco / Pirola, Francesca / Serra, Egidio / Zuppardo, Jessica / Ferreli, Fabio / Vinciguerra, Paolo / Mercante, Giuseppe / Maria, Alessandra Di / Spriano, Giuseppe / Malvezzi, Luca

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: Background: Anti-glaucoma eye drops have been investigated due to their production of fibrotic changes on the conjunctival surface, undermining the functioning of the upper lacrimal drainage system. We aimed to assess whether these effects may impair ... ...

    Abstract Background: Anti-glaucoma eye drops have been investigated due to their production of fibrotic changes on the conjunctival surface, undermining the functioning of the upper lacrimal drainage system. We aimed to assess whether these effects may impair the effectiveness of endoscopic endonasal dacryocystorhinostomy (EE-DCR).
    Methods: This is a single-center observational retrospective study on EE-DCR via a posterior approach. Resolution of epiphora and dacryocystitis were analyzed after 1 (T1) and 6-months (T2) from surgery. Surgical success was defined as anatomical (patency at irrigation, no recurring dacryocystitis) or complete (zeroing of Munk score).
    Results: Twenty patients (32 sides) were enrolled. Preoperatively, 93.75% (
    Conclusions: Despite the chronic uptake of anti-glaucoma eye drops, EE-DCR guaranteed high rates of clinical relief from epiphora and remarkable decreases in the rates of recurrent dacryocystitis.
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040348
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  7. Article ; Online: Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?

    Giombi, Francesco / Pace, Gian Marco / Pirola, Francesca / Cerasuolo, Michele / Ferreli, Fabio / Mercante, Giuseppe / Spriano, Giuseppe / Canonica, Giorgio Walter / Heffler, Enrico / Ferri, Sebastian / Puggioni, Francesca / Paoletti, Giovanni / Malvezzi, Luca

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Chronic rhinosinusitis (CRS) has recently undergone a significant paradigm shift, moving from a phenotypical classification towards an "endotype-based" definition that places more emphasis on clinical and therapeutic aspects. Similar to other airway ... ...

    Abstract Chronic rhinosinusitis (CRS) has recently undergone a significant paradigm shift, moving from a phenotypical classification towards an "endotype-based" definition that places more emphasis on clinical and therapeutic aspects. Similar to other airway diseases, like asthma, most cases of CRS in developed countries exhibit a dysregulated type-2 immune response and related cytokines. Consequently, the traditional distinction between upper and lower airways has been replaced by a "united airway" perspective. Additionally, type-2 related disorders extend beyond respiratory boundaries, encompassing conditions beyond the airways, such as atopic dermatitis. This necessitates a multidisciplinary approach. Moreover, consideration of possible systemic implications is crucial, particularly in relation to sleep-related breathing diseases like Obstructive Sleep Apnoea Syndrome (OSAS) and the alteration of systemic inflammatory mediators such as nitric oxide. The trends in epidemiological, economic, and social burden are progressively increasing worldwide, indicating syndemic characteristics. In light of these insights, this narrative review aims to present the latest evidence on respiratory type-2 related disorders, with a specific focus on CRS while promoting a comprehensive perspective on the "united airways". It also introduces a novel concept: viewing these conditions as a multiorgan, systemic, and syndemic disease.
    MeSH term(s) Humans ; Syndemic ; Asthma/epidemiology ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy ; Respiration ; Cytokines ; Sleep Wake Disorders
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020730
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  8. Article: Psychiatric Burden in Chronic Sinonasal Diseases: A Single-Center Cross-Sectional Observational Study.

    Giombi, Francesco / Canali, Luca / Zuppardo, Jessica / Pace, Gian Marco / Pirola, Francesca / Ferreli, Fabio / Mercante, Giuseppe / Spriano, Giuseppe / Cerasuolo, Michele / Malvezzi, Luca

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57471

    Abstract: Background and objectives: Chronic rhinosinusitis (CRS) and nasal septum deviation (SD) are two widely diffused clinical conditions in otorhinolaryngology clinical practice. Albeit nasal symptoms are the most commonly referred by patients affected by ... ...

    Abstract Background and objectives: Chronic rhinosinusitis (CRS) and nasal septum deviation (SD) are two widely diffused clinical conditions in otorhinolaryngology clinical practice. Albeit nasal symptoms are the most commonly referred by patients affected by both conditions, recent evidence has explored the impairment of nasal function beyond its local implication. Indeed, the prevalence of psychiatric disorders, specifically anxiety and depression, was found higher in patients suffering from SD or CRS than in the general population. The aim of this study was to evaluate the psychiatric burden of these conditions in terms of anxiety and depression and to assess its relationship with clinical phenotype and age.
    Methods: Monocentric cross-sectional observational study. Consecutive patients affected by CRS with or without nasal polyps or by SD were considered eligible. At referral, each patient underwent nasal endoscopy for clinical diagnosis and had to fill in the Hospital Anxiety and Depression Scale (HADS), the Sinonasal Outcome Test-22 (SNOT-22), and the Visual Analogue Scale (VAS) for global nasal symptoms. The population was grouped according to disease and age.
    Results: One hundred fifty patients were enrolled. We observed a statistically significant difference in mean HADS score between patients affected by CRS with nasal polyps and those suffering from CRS without nasal polyps or SD both in the overall population and by age groups. Nevertheless, there was no significant difference in the HADS score between younger patients affected by CRS and SD. The mean HADS score was significantly higher in younger patients affected by SD compared to older. Furthermore, we observed an inverse correlation between age and HADS score in each disease group, statistically significant for SD. On the contrary, in the overall population, HADS score and patient-related outcomes (PROs) were directly correlated.  Conclusions: In the era of personalized medicine, our work remarks on the critical impact of anxiety and depression on the quality of life (QoL) of patients affected by sinonasal conditions. According to our results, age affects patient-reported outcomes (PROs) and should, therefore, be enhanced in the therapeutic decision process.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57471
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  9. Article ; Online: Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

    Russo, Elena / Guizzardi, Mathilda / Canali, Luca / Gaino, Francesca / Costantino, Andrea / Mazziotti, Gherardo / Lania, Andrea / Uccella, Silvia / Di Tommaso, Luca / Ferreli, Fabio / Malvezzi, Luca / Spriano, Giuseppe / Mercante, Giuseppe

    Reviews in endocrine & metabolic disorders

    2023  Volume 25, Issue 2, Page(s) 449–450

    Language English
    Publishing date 2023-11-18
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09851-z
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  10. Article ; Online: Applications of Co

    Giombi, Francesco / Di Santo, Davide / Spriano, Giuseppe / Mercante, Giuseppe / Ferreli, Fabio / Colombo, Giovanni

    American journal of otolaryngology

    2021  Volume 43, Issue 3, Page(s) 103281

    Abstract: Objective: The aim of the study is to assess safety, effectiveness, and potential advantages of CO₂ fiber laser during endoscopic endonasal surgery for the resection of sinonasal neoplasms. We present text, images, and videos to show our experience with ...

    Abstract Objective: The aim of the study is to assess safety, effectiveness, and potential advantages of CO₂ fiber laser during endoscopic endonasal surgery for the resection of sinonasal neoplasms. We present text, images, and videos to show our experience with this new device recently introduced in endoscopic endonasal surgery and as a potential tool for educational purpose.
    Methods: Six patients affected by benign or malignant sinonasal tumors who underwent endoscopic resection between January and May 2021 were enrolled in the study. Surgical approach was conducted via standardized centripetal endonasal technique. During the surgery we evaluated instrument ergonomics, quality in section on both healthy tissue and tumor, coagulation, and bleeding control from major vessels.
    Results: In our experience, CO₂ fiber laser has proved to have good ergonomics, as well as to be a safe and effective tool for the resection of both neoplastic and healthy tissues. Cauterization was efficient only in vessels with average diameter lower than 1 cm. Prolonged procedural time, costs, and necessity of learning-curve and expertise are possible drawbacks.
    Conclusion: Co2-fiber laser is an effective tool which can aid the surgeon during endoscopic endonasal approach to sinonasal neoplasms.
    MeSH term(s) Carbon Dioxide ; Endoscopy/methods ; Humans ; Lasers ; Nose Neoplasms/surgery ; Paranasal Sinus Neoplasms/pathology ; Skull Base Neoplasms/surgery
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2021.103281
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