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Article ; Online: Prebiotic Strategies to Manage Lactose Intolerance Symptoms.

Angima, Gloria / Qu, Yunyao / Park, Si Hong / Dallas, David C

2024 Volume 16, Issue 7

Abstract: Lactose intolerance, which affects about 65-75% of the world's population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance ... ...

Abstract	Lactose intolerance, which affects about 65-75% of the world's population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, namely lactase persistence, allow some individuals to metabolize lactose effectively post-weaning, a trait thought to be an evolutionary adaptation to dairy consumption. Although lactase non-persistence cannot be altered by diet, prebiotic strategies, including the consumption of galactooligosaccharides (GOSs) and possibly low levels of lactose itself, may shift the microbiome and mitigate symptoms of lactose consumption. This review discusses the etiology of lactose intolerance and the efficacy of prebiotic approaches like GOSs and low-dose lactose in symptom management.
MeSH term(s)	Humans ; Lactose Intolerance/genetics ; Lactose ; Lactase/genetics ; Abdominal Pain ; Biological Evolution ; Prebiotics
Chemical Substances	Lactose (J2B2A4N98G) ; Lactase (EC 3.2.1.108) ; Prebiotics
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16071002
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Article: Screening Implications for Distribution of Colorectal Cancer Subsite by Age and Role of Flexible Sigmoidoscopy.

Lin, Gloria / Hein, David M / Liu, Po-Hong / Singal, Amit G / Sanford, Nina N

Cancers

2024 Volume 16, Issue 6

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2024-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061110
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Article ; Online: The Evolving Role of Echocardiography During the Coronavirus Disease 2019 Pandemic.

Hong, Gloria H / Hays, Allison G / Gilotra, Nisha A

Heart international

2022 Volume 16, Issue 1, Page(s) 28–36

Abstract: Coronavirus disease 2019 (COVID-19) has been associated with a wide spectrum of cardiovascular manifestations. Since the beginning of the pandemic, echocardiography has served as a valuable tool for triaging, diagnosing and managing patients with COVID- ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has been associated with a wide spectrum of cardiovascular manifestations. Since the beginning of the pandemic, echocardiography has served as a valuable tool for triaging, diagnosing and managing patients with COVID-19. More recently, speckle-tracking echocardiography has been shown to be effective in demonstrating subclinical myocardial dysfunction that is often not detected in standard echocardiography. Echocardiographic findings in COVID-19 patients include left or right ventricular dysfunction, including abnormal longitudinal strain and focal wall motion abnormalities, valvular dysfunction and pericardial effusion. Additionally, some of these echocardiographic abnormalities have been shown to correlate with biomarkers and adverse clinical outcomes, suggesting an additional prognostic value of echocardiography. With increasing evidence of cardiac sequelae of COVID-19, the use of echocardiography has expanded to patients with cardiopulmonary symptoms after recovery from initial infection. This article aims to highlight the available echocardiographic tools and to summarize the echocardiographic findings across the full spectrum of COVID-19 disease and their correlations with biomarkers and mortality.
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2514156-9
ISSN	2036-2579 ; 2036-2579
ISSN (online)	2036-2579
ISSN	2036-2579
DOI	10.17925/HI.2022.16.1.28
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Article ; Online: Association of psoriasis and systemic lupus erythematosus and mediation effects of tumor necrosis factor-α inhibitors: A cross-sectional study in the All of Us Research Program.

Chen, Gloria F / Hong, Suyeon / Ramachandran, Sarika M / Gehlhausen, Jeff R / Cohen, Jeffrey M

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 1, Page(s) 184–187

MeSH term(s)	Humans ; Tumor Necrosis Factor-alpha ; Cross-Sectional Studies ; Population Health ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Immunologic Factors ; Psoriasis/drug therapy ; Psoriasis/epidemiology
Chemical Substances	Tumor Necrosis Factor-alpha ; Immunologic Factors
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.09.028
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Article ; Online: Chromosome 6p25 deletion syndrome: A case report and review of ophthalmic features.

Le, Hong / Jin, Eva / Jewell, Ann / Jackson-Cook, Colleen / Haskell, Gloria T / Couser, Natario

American journal of medical genetics. Part A

2023 Volume 191, Issue 6, Page(s) 1639–1645

Abstract: The 6p25 deletion syndrome is a rare genetic disorder characterized by a wide spectrum of congenital anomalies. Ophthalmic abnormalities appear to be highly associated with the syndrome, although this relationship has not been well characterized to date. ...

Abstract	The 6p25 deletion syndrome is a rare genetic disorder characterized by a wide spectrum of congenital anomalies. Ophthalmic abnormalities appear to be highly associated with the syndrome, although this relationship has not been well characterized to date. We conducted a systematic literature review to highlight the ocular features in patients with this deletion syndrome and describe a 7-month-old female who has a 6.07 MB 6p25.1p25.3 deletion and a 4.25 MB 17q25.3 duplication. Our patient presented with multiple congenital anomalies, including macrocephaly, frontal bossing, low set ears, tent-shaped mouth, saddle nose, flat midface, and hearing impairment. Her ophthalmic features included proptosis, down-slanting palpebral fissures, hypertelorism, nystagmus, bilateral posterior embryotoxon, and decentered and abnormally shaped pupils. A systematic review of the published cases with sufficient clinical eye descriptions included 63 cases with a confirmed 6p25 deletion. The most common eye findings observed were posterior embryotoxon, iris hypoplasia, corectopia, cornea opacity, and glaucoma.
MeSH term(s)	Humans ; Female ; Infant ; Chromosome Deletion ; Eye Abnormalities/diagnosis ; Eye Abnormalities/genetics ; Glaucoma/genetics ; Syndrome ; Chromosomes
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Systematic Review ; Case Reports
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.63186
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Zs.A 1376/A: Show issues

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Article ; Online: Computer versus human-expert ranking of posterior pole vascular tortuosity and dilation using retinal vessel maps generated from bedside optical coherence tomography: a proof-of-concept study.

Seely, Kai R / Freedman, Sharon F / Grace, Sara / Weinert, Marguerite C / Hong, Gloria J / Toth, Cynthia A / Grace Prakalapakorn, S

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

2023 Volume 27, Issue 6, Page(s) 351–354

Abstract: Semiautomated computer software (ie, ROPtool) can trace and analyze optical coherence tomography (OCT)-generated retinal vessel maps for plus/pre-plus disease with high reliability and accuracy. This proof-of-concept study found that ROPtool can reliably ...

Abstract	Semiautomated computer software (ie, ROPtool) can trace and analyze optical coherence tomography (OCT)-generated retinal vessel maps for plus/pre-plus disease with high reliability and accuracy. This proof-of-concept study found that ROPtool can reliably rank OCT-generated vessel maps for tortuosity and combined tortuosity/dilation, which correlated well with human-expert rankings and clinical examination.
MeSH term(s)	Infant, Newborn ; Humans ; Diagnosis, Computer-Assisted/methods ; Tomography, Optical Coherence ; Reproducibility of Results ; Dilatation ; Retinopathy of Prematurity/diagnosis ; Dilatation, Pathologic ; Retinal Vessels/diagnostic imaging ; Computers
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Case Reports ; Research Support, N.I.H., Extramural
ZDB-ID	1412476-2
ISSN	1528-3933 ; 1091-8531
ISSN (online)	1528-3933
ISSN	1091-8531
DOI	10.1016/j.jaapos.2023.08.009
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Zs.A 5188: Show issues

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Article: Screening Implications for Distribution of Colorectal Cancer Subsite by Age.

Lin, Gloria / Hein, David M / Liu, Po-Hong / Singal, Amit G / Sanford, Nina N

medRxiv : the preprint server for health sciences

2023

Abstract: Objectives: The effectiveness of colonoscopy to reduce colorectal cancer (CRC) mortality is extrapolated from cohort studies in the absence of randomized controlled trial (RCT) data, whereas flexible sigmoidoscopy is supported by RCT data and may be ... ...

Abstract	Objectives: The effectiveness of colonoscopy to reduce colorectal cancer (CRC) mortality is extrapolated from cohort studies in the absence of randomized controlled trial (RCT) data, whereas flexible sigmoidoscopy is supported by RCT data and may be easier to implement in practice. We characterized the anatomic distribution of CRC to determine the proportion that is visible with sigmoidoscopy. Methods: Patients with a primary diagnosis of colorectal adenocarcinoma were identified in the Surveillance, Epidemiology, and End Results program (2000-2020). Tumors from the rectum to descending colon were categorized as visible by sigmoidoscopy, whereas more proximal tumors as requiring colonoscopy. Differential prognosis between tumor locations, stratified by age groups and stage, were assessed using overall restricted mean survival time (RMST) at 2, 5, and 10 years. Results: Among 309,466 patients, 58% had tumors visible by sigmoidoscopy, including 73% of those under age 50 (OR 2.10, 95%CI 2.03-2.16 age <45, OR 2.20, 95%CI 2.13-2.27 age 45-49 versus age > 50). Male sex (OR 1.54, 95%CI 1.51-1.56) and Asian or Pacific Islander race (OR 1.60, 95%CI 1.56-1.64) were also positively associated with tumors visualizable by sigmoidoscopy. Across age groups, for local disease, RMST was comparable for tumors visible versus not visible on sigmoidoscopy. For regional and metastatic cancer, patients with tumors visible by sigmoidoscopy had improved RMST versus those with more proximal tumors. Conclusions: Most CRC arise in locations visible by flexible sigmoidoscopy. Flexible sigmoidoscopy should be considered as a viable option for CRC screening, particularly in younger patients unwilling or unable to undergo colonoscopy.
Language	English
Publishing date	2023-07-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.18.23292663
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Article: Rank correlation inferences for clustered data with small sample size.

Hunsberger, Sally / Long, Lori / Reese, Sarah E / Hong, Gloria H / Myles, Ian A / Zerbe, Christa S / Chetchotisakd, Pleonchan / Shih, Joanna H

Statistica Neerlandica

2022 Volume 76, Issue 3, Page(s) 309–330

Abstract: This paper develops methods to test for associations between two variables with clustered data using ... ...

Abstract	This paper develops methods to test for associations between two variables with clustered data using a
Language	English
Publishing date	2022-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1466958-4
ISSN	1467-9574 ; 0039-0402
ISSN (online)	1467-9574
ISSN	0039-0402
DOI	10.1111/stan.12261
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Article ; Online: Prognostic Value of Left Ventricular Global Longitudinal Strain in Transcatheter Edge-to-Edge Repair for Chronic Primary Mitral Regurgitation.

Shechter, Alon / Hong, Gloria J / Kaewkes, Danon / Patel, Vivek / Visrodia, Parth / Tacon, P Ryan / Koren, Ofir / Koseki, Keita / Nagasaka, Takashi / Skaf, Sabah / Makar, Moody / Chakravarty, Tarun / Makkar, Raj R / Siegel, Robert J

European heart journal. Cardiovascular Imaging

2024

Abstract: Aims: Left ventricular global longitudinal strain (LVGLS) is a known outcome predictor in transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR). We aimed to assess its prognostic yield in the setting of TEER for chronic ... ...

Abstract	Aims: Left ventricular global longitudinal strain (LVGLS) is a known outcome predictor in transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR). We aimed to assess its prognostic yield in the setting of TEER for chronic primary MR. Methods and results: We conducted a single-center, retrospective analysis of 323 consecutive patients undergoing isolated, first-time procedures. Stratified by baseline LVGLS quartiles (≤-19%, -18.9-(-16)%, -15.9-(-12)%, > -12%), the cohort was evaluated for the primary composite outcome of all-cause mortality or heart failure hospitalizations, as well as secondary endpoints consisting of mitral reinterventions and the persistence of significant residual MR and/or functional disability - all along the first year after intervention. Subjects with worse (i.e., less negative) LVGLS exhibited higher comorbidity, more advanced HF, and elevated procedural risk. Post-TEER, those belonging to the worst LVGLS quartile group sustained increased mortality (16.9 vs 6.3%, Log-Rank p = 0.005, HR 1.75, 95% CI 1.08-4.74, p = 0.041) and, when affected by LV dysfunction/dilatation, more primary outcome events (21.1 vs 11.5%, Log-Rank p = 0.037, HR 1.68, 95% CI 1.02-5.46, p = 0.047). No association was demonstrated with other endpoints. Upon exploratory analysis, 1-month postprocedural LVGLS directly correlated with and was worse than its baseline counterpart by 1.6%, and a more impaired 1-month value - but not the presence/extent of deterioration - conferred heightened risk for the primary outcome. Conclusion: TEER for chronic primary MR is feasible, safe, and efficacious irrespective of baseline LVGLS. Yet, worse baseline LVGLS forecasts a less favorable postprocedural course, presumably reflecting a higher-risk patient profile.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeae083
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Zs.A 5614: Show issues

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Article ; Online: Trends in antipsychotic use for youth with attention-deficit/hyperactivity disorder and disruptive behavior disorders.

dosReis, Susan / Saini, Jannat / Hong, Kyungwan / Reeves, Gloria / Spence, O' Mareen

Pharmacoepidemiology and drug safety

2022 Volume 31, Issue 7, Page(s) 810–814

Abstract: Purpose: To examine trends in off-label antipsychotic use for youth with attention-deficit/hyperactivity disorder with and without a comorbid disruptive behavior disorder.: Method: This cross-sectional study of annual trends from 2007 through 2015 ... ...

Abstract	Purpose: To examine trends in off-label antipsychotic use for youth with attention-deficit/hyperactivity disorder with and without a comorbid disruptive behavior disorder. Method: This cross-sectional study of annual trends from 2007 through 2015 used the IQVIA PharMetrics® Plus for Academics data. We identified 165 794 commercially-insured youth 3-18-year-old who had a diagnosis of attention-deficit/hyperactivity disorder and classified them into subgroups with and without disruptive behavior disorders comorbidities. Antipsychotic use, with or without a stimulant, was the primary dependent outcome. Logistic regression estimated the odds of antipsychotic use associated with comorbid attention-deficit/hyperactivity disorder and disruptive behavior disorders, adjusting for age, sex, study year, and other psychotropic use. Results: Over 70% of the 165 794 youth with attention-deficit/hyperactivity disorder were 5-14-year-old and male, and 12% had disruptive behavior disorders. Antipsychotic prevalence, with or without a stimulant, was 4.4% in 2007 and 3.4% in 2015. Stimulants with antipsychotics increased significantly from 2007 to 2015 for females (19.5%-28.7%) and youth 15-18-year-old (25.9%-32.7%). Adjusting for age, sex, study year, and other psychotropic use, youth with a comorbid disruptive behavior had a 2.5 (95% CI: 2.3, 2.7) higher likelihood of receiving an antipsychotic than youth with attention-deficit/hyperactivity disorder and no comorbidities. Conclusions: Antipsychotic use was associated with comorbid disruptive behaviors in youth with attention-deficit/hyperactivity disorder. Off-label antipsychotic use has increased for females and older adolescents.
MeSH term(s)	Adolescent ; Antipsychotic Agents/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit and Disruptive Behavior Disorders/drug therapy ; Attention Deficit and Disruptive Behavior Disorders/epidemiology ; Central Nervous System Stimulants/adverse effects ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Male
Chemical Substances	Antipsychotic Agents ; Central Nervous System Stimulants
Language	English
Publishing date	2022-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.5445
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