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  1. Article ; Online: Determining the impact of specialized care on health outcomes and health care utilization in Parkinsonism.

    Goerz, Conrad J / Kanungo, Anish / Lix, Lisa M / Leslie, William D / Burchill, Charles / Hobson, Douglas E

    Parkinsonism & related disorders

    2024  , Page(s) 106026

    Abstract: Background: Although care of Parkinsonism (PKM) is assumed to be optimally provided by movement disorder neurologists within an interdisciplinary clinic model, there is a paucity of published data to support this.: Objectives: To investigate the ... ...

    Abstract Background: Although care of Parkinsonism (PKM) is assumed to be optimally provided by movement disorder neurologists within an interdisciplinary clinic model, there is a paucity of published data to support this.
    Objectives: To investigate the impact of movement disorder neurologist care of individuals with Parkinsonism (PKM).
    Methods: A retrospective exposure design was adopted using administrative data. Incident PKM individuals were identified in billing claims. A nine-year exposure period to movement disorder neurologist, general neurologist and non-neurologist care was calculated based on the billing codes. Regression models were used to test the association of provider exposure on time to death and long-term care (LTC) admission. Linear models were used to test varying provider exposure and hospital admissions, hospital days and emergency department visits.
    Results: 1914 incident individuals were identified. There was no difference in PKM mortality, emergency visits, hospital admissions, or hospital days between providers, however exposure to general neurology and non-neurology care was associated with a significantly higher risk of admission to LTC compared to movement disorder neurologist care (HR 1.43; 95% CI 1.09-1.87 for general neurology (p-value = 0.0089); HR 1.61; 95% CI 1.25-2.05 for non-neurology (p-value = 0.0002), respectively.
    Conclusion: Movement disorder neurologist care is associated with a lower risk of admission to LTC over general neurologist care in individuals with PKM.
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106026
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    Zs.A 4553: Show issues Location:
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  2. Book ; Online: Denis Diderot 'Rameau's Nephew' - 'Le Neveu de Rameau' : A Multi-Media Bilingual Edition

    Diderot, Denis / Hobson, Marian

    2016  

    Keywords Individual composers & musicians, specific bands & groups ; Philosophy ; dialogue ; translation ; composers ; denis diderot ; satyre ; opera ; Charles Palissot de Montenoy ; Jean-Philippe Rameau ; Rameau's Nephew
    Size 1 electronic resource (262 pages)
    Publisher Open Book Publishers
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021026978
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The Venerable Subclavian Line.

    Teman, Nicholas / Hobson, Charles / Tribble, Reid / Tribble, Curt

    The heart surgery forum

    2021  Volume 24, Issue 5, Page(s) E925–E934

    Abstract: In this treatise, we will address one of the higher-risk procedures, subclavian vein cannulation, that a practitioner may undertake in the care of complex patients. All cardiothoracic surgeons and their trainees will need, on occasion, to put in central ... ...

    Abstract In this treatise, we will address one of the higher-risk procedures, subclavian vein cannulation, that a practitioner may undertake in the care of complex patients. All cardiothoracic surgeons and their trainees will need, on occasion, to put in central lines in a variety of circumstances, including in the operating room, in the intensive care unit, in emergency circumstances, and, occasionally, when other practitioners have been unsuccessful in their attempts to place a central line. We will describe, in detail, the anatomy of the subclavian vein, the preparation of the patient for subclavian vein cannulation, the infraclavicular approach to cannulation of the vein, and a few notes about the supraclavicular approach to the subclavian vein. It is self-evident that the priorities of central venous cannulation include safety of insertion, minimizing clot formation, and avoiding infection. We will dwell primarily on the principles of safe subclavian line insertion.
    MeSH term(s) Bandages ; Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Checklist ; Dilatation ; Disinfection ; Humans ; Informed Consent ; Medical Illustration ; Patient Positioning/methods ; Punctures/methods ; Skin ; Subclavian Vein/anatomy & histology ; Suction ; Surgical Drapes
    Language English
    Publishing date 2021-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2069188-9
    ISSN 1522-6662 ; 1098-3511
    ISSN (online) 1522-6662
    ISSN 1098-3511
    DOI 10.1532/hsf.4383
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  4. Article ; Online: A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5'AMP.

    Hobson, Jessica J / Li, Zhijie / Hu, Hao / Carter, Charles W

    International journal of molecular sciences

    2022  Volume 23, Issue 8

    Abstract: Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided ... ...

    Abstract Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided conceptual and experimental models for their early evolution. Urzymes, containing ~120-130 amino acids excerpted from regions where genetic coding sequence complementarities have been identified, are key experimental models motivated by the proposal of a single bidirectional ancestral gene. Previous reports that Class I and Class II urzymes accelerate both amino acid activation and tRNA aminoacylation have not been extended to other synthetases. We describe a third urzyme (LeuAC) prepared from the Class IA
    MeSH term(s) Adenosine Diphosphate/metabolism ; Adenosine Monophosphate/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acids/metabolism ; Amino Acyl-tRNA Synthetases/metabolism ; Leucine-tRNA Ligase/genetics ; Leucine-tRNA Ligase/metabolism ; Phosphorylation
    Chemical Substances Amino Acids ; Adenosine Monophosphate (415SHH325A) ; Adenosine Diphosphate (61D2G4IYVH) ; Adenosine Triphosphate (8L70Q75FXE) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; Leucine-tRNA Ligase (EC 6.1.1.4)
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23084229
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  5. Article ; Online: Kidney and Brain, an Unbroken Chain.

    Bihorac, Azra / Hobson, Charles

    American journal of respiratory and critical care medicine

    2017  Volume 195, Issue 12, Page(s) 1546–1548

    Language English
    Publishing date 2017-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201611-2371ED
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  6. Article ; Online: A Leucyl-tRNA Synthetase Urzyme

    Jessica J. Hobson / Zhijie Li / Hao Hu / Charles W. Carter

    International Journal of Molecular Sciences, Vol 23, Iss 4229, p

    Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP

    2022  Volume 4229

    Abstract: Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided ... ...

    Abstract Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided conceptual and experimental models for their early evolution. Urzymes, containing ~120–130 amino acids excerpted from regions where genetic coding sequence complementarities have been identified, are key experimental models motivated by the proposal of a single bidirectional ancestral gene. Previous reports that Class I and Class II urzymes accelerate both amino acid activation and tRNA aminoacylation have not been extended to other synthetases. We describe a third urzyme (LeuAC) prepared from the Class IA Pyrococcus horikoshii leucyl-tRNA synthetase. We adduce multiple lines of evidence for the authenticity of its catalysis of both canonical reactions, amino acid activation and tRNA Leu aminoacylation. Mutation of the three active-site lysine residues to alanine causes significant, but modest reduction in both amino acid activation and aminoacylation. LeuAC also catalyzes production of ADP, a non-canonical enzymatic function that has been overlooked since it first was described for several full-length aaRS in the 1970s. Structural data suggest that the LeuAC active site accommodates two ATP conformations that are prominent in water but rarely seen bound to proteins, accounting for successive, in situ phosphorylation of the bound leucyl-5′AMP phosphate, accounting for ADP production. This unusual ATP consumption regenerates the transition state for amino acid activation and suggests, in turn, that in the absence of the editing and anticodon-binding domains, LeuAC releases leu-5′AMP unusually slowly, relative to the two phosphorylation reactions.
    Keywords genetic coding ; protein synthesis ; mechanistic enzymology ; protein engineering ; evolutionary intermediates ; validating weak catalytic activities ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 612
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: National chimpanzee breeding program: Primate research institute.

    Hobson, William C / Graham, Charles E / Rowell, Thomas J

    American journal of primatology

    2020  Volume 24, Issue 3-4, Page(s) 257–263

    Abstract: The Primate Research Institute (PRI) dedicated a colony of 81 proven breeders (60 females, 21 males) to the National Chimpanzee Breeding and Research Program (NCBRP). When possible, infants were left with their mothers for a minimum of 18 months. ... ...

    Abstract The Primate Research Institute (PRI) dedicated a colony of 81 proven breeders (60 females, 21 males) to the National Chimpanzee Breeding and Research Program (NCBRP). When possible, infants were left with their mothers for a minimum of 18 months. Programs to define and reduce fetal wastage and neonatal mortality were implemented. Pregnancies were diagnosed both by RIA for serum chorionic gonadotropin and by ultrasound prior to day 30 of pregnancy. Of 65 pregnancies detected by ultrasound and RIA, 15 (23%) resulted in fetal loss. Without the use of ultrasound and RIA, only 8 of these losses would have been detected. Infant mortality (7 of 53 live births; 13%) was primarily due to maternal abuse or problems related to premature delivery. The incidence of losses due to maternal abuse has been reduced by placing females in single cages 2 weeks prior to their estimated delivery date so endangered infants can be recognized and removed. The new system provided the first opportunity for most of the mothers to care for their infants; 25 succeeded (in 2 instances in the second pregnancy only) and 12 did not (infants from 2 mothers were removed due to delivery of twins). During this 26-month period the colony grew by 46 infants (58%), half of which will be retained as future breeders. Thus, the NCBRP goal of achieving a self-sustaining population appears viable.
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.1350240311
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  8. Article ; Online: Acute kidney injury: Precision perioperative care protects the kidneys.

    Bihorac, Azra / Hobson, Charles E

    Nature reviews. Nephrology

    2017  Volume 14, Issue 1, Page(s) 8–10

    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/prevention & control ; Blood Pressure ; Humans ; Monitoring, Intraoperative/methods ; Perioperative Care/methods ; Precision Medicine/methods ; Surgical Procedures, Operative/adverse effects ; Surgical Procedures, Operative/methods
    Language English
    Publishing date 2017-12-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2017.170
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    Zs.MG 107: Show issues

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  9. Article: ‘My wood isn’t one of those dark and scary ones’: children’s experience and knowledge of woodland in the English rural landscape

    Lisewski-Hobson, Vivyan / Watkins, Charles

    Landscape research. 2019 July 4, v. 44, no. 5

    2019  

    Abstract: Recent studies of children have argued that children are suffering from a deficiency in nature experience. Some argue that a lack of experience leads to poor affective relations which for wooded environments may be manifested as fear. This study ... ...

    Abstract Recent studies of children have argued that children are suffering from a deficiency in nature experience. Some argue that a lack of experience leads to poor affective relations which for wooded environments may be manifested as fear. This study investigates a geographical knowledge gap in understanding children’s relationships with woodland. This interactive qualitative study included 21 junior age children living in a rural setting in Derbyshire, England, UK. Most were found to visit local woodlands regularly, though unsupervised visits were usually limited to woods adjacent to housing. The children demonstrated good levels of practical knowledge though explicit knowledge, such as tree names, was generally poor. The majority of children had positive attitudes towards woodland, especially those with the greatest experience. Adventure, calm and freedom were identified as major themes. Fear was widespread but rarely dominated and was often associated with exhilaration linked to cultural imaginaries such as computer games and films.
    Keywords attitudes and opinions ; children ; fearfulness ; games ; landscapes ; trees ; woodlands ; England
    Language English
    Dates of publication 2019-0704
    Size p. 507-525.
    Publishing place Routledge
    Document type Article
    ZDB-ID 2020719-0
    ISSN 0142-6397 ; 1469-9710 ; 0142-6397
    ISSN (online) 0142-6397 ; 1469-9710
    ISSN 0142-6397
    DOI 10.1080/01426397.2018.1493444
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Critical Care Delivery and ICU Structure-The Elephant in the Room.

    Hobson, Charles / Bihorac, Azra

    Critical care medicine

    2015  Volume 43, Issue 12, Page(s) e590–1

    MeSH term(s) Critical Care/standards ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/standards ; Models, Organizational ; Outcome and Process Assessment (Health Care) ; Quality Improvement
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000001252
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