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  1. Book ; Online ; E-Book: Oral submucous fibrosis

    Warnakulasuriya, Saman / Ranganathan, Kannan

    a guide to diagnosis and management

    (Textbooks in contemporary dentistry)

    2023  

    Author's details Saman Warnakulasuriya, Kannan Ranganathan editors
    Series title Textbooks in contemporary dentistry
    Keywords Dentistry ; Oncology
    Language English
    Size 1 Online-Ressource (XVIII, 389 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030016690
    ISBN 978-3-031-12855-4 ; 9783031128547 ; 3-031-12855-9 ; 3031128540
    DOI 10.1007/978-3-031-12855-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: NLP and oral health information.

    Selvan, Preetha / Thavarajah, Rooban / Ranganathan, Kannan

    Journal of oral and maxillofacial pathology : JOMFP

    2023  Volume 27, Issue 1, Page(s) 15–17

    Language English
    Publishing date 2023-03-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.jomfp_85_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: COVID - 19 fact sheet for the dental professional.

    Ranganathan, Kannan / Smitha, T

    Journal of oral and maxillofacial pathology : JOMFP

    2020  Volume 24, Issue 1, Page(s) 8–10

    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.JOMFP_149_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: E-cadherin Expression in Premalignant Lesions, Premalignant Conditions, Oral Squamous Cell Carcinoma, and Normal Mucosa: An Immunohistochemical Study.

    Kalaimani, Gnanambigai / Rao, Uma Devi K / Joshua, Elizabeth / Ranganathan, Kannan

    Cureus

    2023  Volume 15, Issue 8, Page(s) e44266

    Abstract: Background Oral squamous cell carcinoma (OSCC) is a multi-step process. Epithelial-mesenchymal transition (EMT) is an important step in the progression of OSCC. One of the components that influence EMT is E-cadherin. The aim of this study was to ... ...

    Abstract Background Oral squamous cell carcinoma (OSCC) is a multi-step process. Epithelial-mesenchymal transition (EMT) is an important step in the progression of OSCC. One of the components that influence EMT is E-cadherin. The aim of this study was to determine the expression of E-cadherin in oral submucous fibrosis (OSMF), various grades of epithelial dysplasia, OSCC, and to compare it with the expression in the normal mucosa. Material and methods E-cadherin immunohistochemical detection was done using a monoclonal antibody of clone EP-6
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.44266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Expression of CD44 in Head and Neck Squamous Cell Carcinoma-An

    Kavitha, Loganathan / Vijayashree Priyadharsini, Jayaseelan / Kattula, Deepthi / Rao, Umadevi Krishna Mohan / Balaji Srikanth, Rajabather / Kuzhalmozhi, Manogaran / Ranganathan, Kannan

    Global medical genetics

    2023  Volume 10, Issue 3, Page(s) 221–228

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1772459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A systematic review and meta-analysis of circulating serum and plasma microRNAs in TB diagnosis.

    Gunasekaran, Harinisri / Sampath, Pavithra / Thiruvengadam, Kannan / Malaisamy, Muniyandi / Ramasamy, Rathinasabapati / Ranganathan, Uma Devi / Bethunaickan, Ramalingam

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 402

    Abstract: Background: Tuberculosis (TB) ranks as the second leading cause of death globally among all infectious diseases. This problem is likely due to the lack of biomarkers to differentiate the heterogeneous spectrum of infection. Therefore, the first step in ... ...

    Abstract Background: Tuberculosis (TB) ranks as the second leading cause of death globally among all infectious diseases. This problem is likely due to the lack of biomarkers to differentiate the heterogeneous spectrum of infection. Therefore, the first step in solving this problem is to identify biomarkers to distinguish the different disease states of an individual and treat them accordingly. Circulating microRNA (miRNA) biomarkers are promising candidates for various diseases. In fact, we are yet to conceptualize how miRNA expression influences and predicts TB disease outcomes. Thus, this systematic review and meta-analysis aimed to assess the diagnostic efficacy of circulating miRNAs in Latent TB (LTB) and Active Pulmonary TB (PTB).
    Methods: Literature published between 2012 and 2021 was retrieved from PubMed, Web of Science, Cochrane, Scopus, Embase, and Google Scholar. Articles were screened based on inclusion and exclusion criteria, and their quality was assessed using the QUADAS-2 tool. Funnel plots and forest plots were generated to assess the likelihood of study bias and heterogeneity, respectively.
    Results: After the screening process, seven articles were selected for qualitative analysis. The study groups, which consisted of Healthy Control (HC) vs. TB and LTB vs. TB, exhibited an overall sensitivity of 81.9% (95% CI: 74.2, 87.7) and specificity of 68.3% (95% CI: 57.8, 77.2), respectively. However, our meta-analysis results highlighted two potentially valuable miRNA candidates, miR-197 and miR-144, for discriminating TB from HC. The miRNA signature model (miR197-3p, miR-let-7e-5p, and miR-223-3p) has also been shown to diagnose DR-TB with a sensitivity of 100%, but with a compromised specificity of only 75%.
    Conclusion: miRNA biomarkers show a promising future for TB diagnostics. Further multicentre studies without biases are required to identify clinically valid biomarkers for different states of the TB disease spectrum.
    Systematic review registration: PROSPERO (CRD42022302729).
    MeSH term(s) Humans ; MicroRNAs/genetics ; Tuberculosis/diagnosis ; Tuberculosis, Pulmonary/diagnosis ; Biomarkers ; Latent Tuberculosis
    Chemical Substances MicroRNAs ; Biomarkers
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09232-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Where do we go from here.

    Ranganathan, Kannan

    Journal of oral and maxillofacial pathology : JOMFP

    2012  Volume 16, Issue 3, Page(s) 311

    Language English
    Publishing date 2012-12-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/0973-029X.102470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Do Clear Cell Changes in Oral Squamous Cell Carcinoma Warrant It Being Recognised as a Variant?

    Mahamad Apandi, Nurul Inaas / Ramanathan, Anand / Ismail, Siti Mazlipah / Ranganathan, Kannan

    Cureus

    2022  Volume 14, Issue 5, Page(s) e25057

    Abstract: Histological variants of oral squamous cell carcinoma (OSCC) include verrucous, basaloid, spindle cell, adenosquamous, papillary, and acantholytic types. Clear-cell changes in OSCC are rare. We report a case of a 65-year-old male Chinese patient who ... ...

    Abstract Histological variants of oral squamous cell carcinoma (OSCC) include verrucous, basaloid, spindle cell, adenosquamous, papillary, and acantholytic types. Clear-cell changes in OSCC are rare. We report a case of a 65-year-old male Chinese patient who presented with a swelling in the lower-left mandible for three weeks, causing ill-fitting of his lower denture and an ulcer on the floor of the mouth. Histologically, the lesion showed a dense proliferation of malignant tumor cells arranged in islands and sheets consisting of squamoid cells intermixed with signet ring-shaped clear cells. The clear cells were negative for mucicarmine, periodic acid Schiff (PAS), periodic acid Schiff-diastase (PAS-D), and alcian blue (AB). Immunohistochemistry showed the tumor cells were immuno-positive for cytokeratin (CK) and p63, but CK7, CK20, and S100 were immuno-negative. Therefore, a metastatic tumor in the oral cavity was suggested. However, the CT scan did not show any primary tumors in other sites. Histopathologically, the surgical specimen showed signet-ring-shaped clear cells in the stroma with squamoid cells invading the underlying connective tissue from the surface epithelium, suggesting a diagnosis of clear cell changes in OSCC. Follow-up showed recurrent OSCC at the base of the tongue with lymph node metastasis and distant metastasis in the lung. Only a few cases of clear-cell changes have been reported, with most having a poor prognosis. This case report adds one more case of clear cell changes in the OSCC with a poor prognosis. We reviewed the literature to understand their clinical behavior. Due to the rarity of its (clear cell changes) occurrence, further research is required in order to obtain a better understanding of the clinical behavior and prognosis of these clear cell changes seen in OSCC.
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.25057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders.

    Ranganathan, Kannan / Kavitha, Loganathan

    Journal of oral and maxillofacial pathology : JOMFP

    2019  Volume 23, Issue 1, Page(s) 19–27

    Abstract: After more than a decade, the World Health Organization (WHO) published the revised grading system for oral epithelial dysplasia in 2017. The revised classification has changes reflecting our evolution of understanding of the dysplastic process. Although ...

    Abstract After more than a decade, the World Health Organization (WHO) published the revised grading system for oral epithelial dysplasia in 2017. The revised classification has changes reflecting our evolution of understanding of the dysplastic process. Although the WHO 2017 three-tier grading system is the gold standard for histological diagnosis of oral potentially malignant disorders, it has certain limitations. Suggestions to overcome these limitations include the use of clinical determinants and molecular markers to supplement the grading system. It has also been suggested that a two-tier system may be more reproducible and clinically translatable for better management. These advances in the understanding of epithelial dysplasia are very important globally and for us in the Indian subcontinent, given the prevalence of habits (tobacco/areca nut) and burden of oral cancer in this part of the world. The following review traces the evolution of the grading system of dysplasia, its relevance and clinical utility.
    Language English
    Publishing date 2019-05-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.JOMFP_13_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Common oral opportunistic infections in Human Immunodeficiency Virus infection/Acquired Immunodeficiency Syndrome: Changing epidemiology; diagnostic criteria and methods; management protocols.

    Ranganathan, Kannan / Umadevi, Krishna Mohan Rao

    Periodontology 2000

    2019  Volume 80, Issue 1, Page(s) 177–188

    Abstract: There were 36.9 million in the world living with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) as of 2017, and new infections have seen a reduction by 18% since 2010. But this rate of decline is not sufficient for ...

    Abstract There were 36.9 million in the world living with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) as of 2017, and new infections have seen a reduction by 18% since 2010. But this rate of decline is not sufficient for the goal of eradication of AIDS by 2030. Only 21.7  million people infected with HIV have accesses to antiretroviral therapy, with the rest at risk of the potential complications of HIV infection. It has been shown that oral lesions are diagnostic and prognostic of HIV infection, and many oral opportunistic infections continue to be a major problem, particularly in developing countries. It is therefore important that dental surgeons be aware and updated to recognize and manage the oral effects of HIV infection/AIDS. This chapter describes the classification, diagnosis, and management of oral lesions in these patients, based on our current understanding of the infection. This review also discusses the standardization of diagnosis of oral lesions in HIV infection/AIDS patients, immune reconstitution inflammatory syndrome case definition, and the research priorities formulated at the 7th World Workshop on Oral Health and Disease in AIDS.
    MeSH term(s) Acquired Immunodeficiency Syndrome ; HIV Infections ; Humans ; Opportunistic Infections
    Language English
    Publishing date 2019-05-14
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1200504-6
    ISSN 1600-0757 ; 0906-6713
    ISSN (online) 1600-0757
    ISSN 0906-6713
    DOI 10.1111/prd.12274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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