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Article ; Online: A Comprehensive narrative review of transcriptomics and epigenomics of gallbladder cancer.

Tanwar, Pranay / Minocha, Shilpi / Gupta, Ishaan

Journal of cancer research and therapeutics

2024 Volume 19, Issue Suppl 2, Page(s) S499–S507

Abstract: Abstracts: Gallbladder cancer (GBC) is one of the quiet prevalent and aggressive biliary tract malignant neoplasms distinguished by significant cellular heterogeneity, metastatic activity, and a poor prognosis, with varied frequency worldwide. Most ... ...

Abstract	Abstracts: Gallbladder cancer (GBC) is one of the quiet prevalent and aggressive biliary tract malignant neoplasms distinguished by significant cellular heterogeneity, metastatic activity, and a poor prognosis, with varied frequency worldwide. Most cases are detected incidentally while routine screening imaging or pathological investigation of cholecystectomy tissues and usually present with advanced disease. The surgical resection is usually done in the initial clinical stage having limited spread. Despite the surgical therapy, the death rate is significant. Furthermore, the molecular mechanisms affecting the clinical course of inflammatory gallbladder to carcinogenesis remain poorly understood. There is an impending need for developing diagnostic biomarkers and targeted approaches for GBC. The newer molecular platform, such as next-generation sequencing (NGS), such as RNA-sequencing (RNAseq), single-cell sequencing, and microarray technology, has revolutionized the field of genomics, opened a new perspective in defining genetic and epigenetic characteristics identifying molecules as possible therapeutic targets. Therefore, in this review, we would analyze transcriptomic and epigenomics profiles of GBC using already published high-throughput sequencing-based studies published between 2010 and 2023. The review would also analyze the possible impact of the technological advancement on the patient management strategy and overall survival. This may also help identify target genes and pathways linked to GBC, which may help establish molecular biomarkers, for early GBC diagnosis, personalized therapy, and management.
MeSH term(s)	Humans ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/genetics ; Gallbladder Neoplasms/pathology ; Epigenomics ; Cholecystectomy ; Gene Expression Profiling ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-02-21
Publishing country	India
Document type	Review ; Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_1823_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Peroxiredoxins - Urinary Surveillance Biomarkers in Urothelial Cancer.

Kumari, Nitu / Vasudeva, Pawan / Tanwar, Pranay / Hussain, Showket / Kumar, Anup / Agrawal, Usha

Journal of Cancer

2022 Volume 13, Issue 9, Page(s) 2751–2756

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2022-06-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.69811
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Article: COVID-19 - An avoidable epidemic: A family medicine practitioner's perspective.

Tanwar, Pranay / Mourya, Meenakshi / Kumar, Ritesh

Journal of family medicine and primary care

2020 Volume 9, Issue 4, Page(s) 2132–2133

Keywords	covid19
Language	English
Publishing date	2020-04-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_409_20
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Article ; Online: In

Kumar, Rakesh / Kumar, Rahul / Tanwar, Pranay

Journal of biomolecular structure & dynamics

2021 Volume 40, Issue 16, Page(s) 7394–7407

Abstract: Severe acute respiratory syndrome-coronavirus2 (SARS-CoV2), a new coronavirus has emerged in Wuhan city of China, December 2019 causing pneumonia named Coronavirus disease-19 (COVID-19), which has spread to the entire world. By January 2021, number of ... ...

Abstract	Severe acute respiratory syndrome-coronavirus2 (SARS-CoV2), a new coronavirus has emerged in Wuhan city of China, December 2019 causing pneumonia named Coronavirus disease-19 (COVID-19), which has spread to the entire world. By January 2021, number of confirmed cumulative cases crossed ∼104 million worldwide. Till date, no effective treatment or drug is available for this virus. Availability of X-ray structures of SARS-CoV2 main protease (M
MeSH term(s)	COVID-19/drug therapy ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptide Hydrolases/metabolism ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; RNA, Viral ; SARS-CoV-2 ; Viral Nonstructural Proteins/chemistry
Chemical Substances	Ligands ; Protease Inhibitors ; RNA, Viral ; Viral Nonstructural Proteins ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2021-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.1897681
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Zs.A 2093: Show issues

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Article: Therapy related complications in plasmablastic lymphoma in immunocompetent individual.

Dubey, Harshita / Gupta, Swati / Jha, Tanvi / Tanwar, Khushi / Verma, Saransh / Ranjan, Amar / Tanwar, Pranay

American journal of blood research

2022 Volume 12, Issue 5, Page(s) 168–171

Abstract: Background: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma seen in immunocompromised individuals. It has a diffuse growth pattern, with no standard therapy and a poor survival rate. Due to overlap in ... ...

Abstract	Background: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma seen in immunocompromised individuals. It has a diffuse growth pattern, with no standard therapy and a poor survival rate. Due to overlap in presenting features with lymphoma and myeloma, PBL is often a diagnostic dilemma. We present a case of PBL in a young immunocompetent female who developed treatment associated complications. Case report: A 36-year-old presented with a lesion extending from the oral cavity to the pharynx and involving the angle of the mandible. Radiology and laryngoscopy described a growth pattern that was diagnosed to be PBL on histopathology. The patient underwent chemotherapy using level II DA-EPOCH (dose-adjusted-etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) and prophylactic granulocyte-colony stimulating factor along with radiotherapy and ultimately, achieved metabolic response. However, she developed several episodes of paralytic ileus, cytopenia, oral ulcers, dermatitis and long-standing hypothyroidism as therapy-related complications and has been on treatment for the same ever since. Conclusions: Thus, a high index of suspicion is necessary for early diagnosis and rapid initiation of therapy. Further, there is a need to detect and address therapy related complications early to prevent long-standing, therapy-related side effects from developing and deteriorating the patient's quality of life.
Language	English
Publishing date	2022-10-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2620435-6
ISSN	2160-1992
ISSN	2160-1992
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Article ; Online: Efficacy and Safety of Olanzapine for the Prevention of Chemotherapy-induced Nausea and Vomiting in Children: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Meena, Jagdish Prasad / Gupta, Aditya Kumar / Jat, Kana Ram / Anandani, Garima / Sasidharan, Anju / Tanwar, Pranay

Journal of pediatric hematology/oncology

2023 Volume 45, Issue 7, Page(s) 361–369

Abstract: Chemotherapy-induced nausea and vomiting (CINV) remain the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). This meta-analysis was conducted to evaluate the efficacy and ... ...

Abstract	Chemotherapy-induced nausea and vomiting (CINV) remain the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). This meta-analysis was conducted to evaluate the efficacy and safety of olanzapine containing regimen in preventing CINV in children on HEC and MEC. We searched PubMed, Embase, and Cochrane central register of controlled trials electronic databases to identify randomized clinical trials that compared 2 groups who either got olanzapine (olanzapine group) or placebo/no olanzapine (control group) for the prevention of CINV in children. The primary outcome was to determine the efficacy of olanzapine (complete response). The secondary outcomes were nausea control, the need for rescue medications, and adverse events of olanzapine. Three randomized clinical trials (n=394 patients) were included in this meta-analysis (olanzapine group, n=194, and placebo/control group, n=200). The pooled analysis of this meta-analysis found that olanzapine had a higher complete response in all phases of emesis in the HEC group and only in the acute phase in HEC/MEC groups compared with the control group. Olanzapine had higher nausea control in all phases of HEC but no nausea control in HEC/MEC. Olanzapine also reduced the need for rescue medications. A significant number of patients in the olanzapine group experienced somnolence (grades 1 and 2), but none of the participants discontinued the study due to side effects. In conclusion, this meta-analysis showed that olanzapine significantly prevented CINV in HEC. There was also a lesser need for rescue medications in the olanzapine group. Somnolence was higher in the olanzapine group, but it was clinically insignificant.
MeSH term(s)	Humans ; Child ; Olanzapine/adverse effects ; Antiemetics/therapeutic use ; Sleepiness ; Randomized Controlled Trials as Topic ; Nausea/chemically induced ; Nausea/prevention & control ; Vomiting/chemically induced ; Vomiting/prevention & control ; Antineoplastic Agents/adverse effects ; Neoplasms/drug therapy
Chemical Substances	Olanzapine (N7U69T4SZR) ; Antiemetics ; Antineoplastic Agents
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002737
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Zs.A 1537: Show issues

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Article ; Online: Evaluation of high-risk human papillomavirus in sinonasal papillomas and squamous cell carcinomas.

Kakkar, Aanchal / Satapathy, Shraddhanjali / Sikka, Kapil / Tanwar, Pranay / Deo, Svs / Jain, Deepali

Virchows Archiv : an international journal of pathology

2023 Volume 483, Issue 3, Page(s) 381–392

Abstract: The sinonasal tract is considered a second hotspot for human papillomavirus (HPV)-related tumors in the head and neck, with HPV being identified in up to 62% of squamous cell carcinomas (SCCs) and 38% of papillomas. There is limited data from ... ...

Abstract	The sinonasal tract is considered a second hotspot for human papillomavirus (HPV)-related tumors in the head and neck, with HPV being identified in up to 62% of squamous cell carcinomas (SCCs) and 38% of papillomas. There is limited data from geographical regions with low prevalence of high-risk (HR)-HPV on the association of HR-HPV in sinonasal neoplasms and on utility of p16 as a surrogate marker. p16 immunohistochemistry, HR-HPV mRNA ISH and quantitative real-time PCR (qPCR) were performed on a retrospective cohort of sinonasal papillomas and SCCs. KRAS mutation analysis was done in oncocytic papillomas. p16 positivity was present in 22/142 cases (15.5%) including eight inverted papillomas, one oncocytic papilloma (OP), and 13 SCC. Among these, mRNA ISH showed HR-HPV in the OP and two SCC, while another SCC was found to harbour HPV18 by qPCR. Two HPV-associated SCCs had foci of OP. mRNA ISH was negative in all p16 negative cases. p16 immunohistochemistry showed 68% concordance with mRNA ISH, and had sensitivity and negative predictive value of 100%; specificity was 67%, and positive predictive value was 14.3%. Association with HR-HPV in sinonasal papillomas and SCC is rare, and may be seen in cases demonstrating oncocytic morphology. p16 immunohistochemistry has low specificity and positive predictive value in low-prevalence populations; thus, reflex direct HR-HPV testing should be performed in p16 immunopositive cases. This two-step approach is viable in resource-limited settings, as the proportion of p16 positive cases is small.
MeSH term(s)	Humans ; Human Papillomavirus Viruses ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/genetics ; Retrospective Studies ; In Situ Hybridization ; Head and Neck Neoplasms ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Papilloma, Inverted/pathology ; RNA, Messenger/genetics ; Cyclin-Dependent Kinase Inhibitor p16/analysis ; Papillomaviridae/genetics
Chemical Substances	RNA, Messenger ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2023-07-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-023-03601-x
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Article ; Online: Structural based screening of potential inhibitors of SMAD4: a step towards personalized medicine for gall bladder and other associated cancers.

Kumar, Rakesh / Kumar, Rahul / Tanwar, Pranay

Molecular diversity

2021 Volume 25, Issue 3, Page(s) 1945–1961

Abstract: Gall bladder cancer (GBC) is an aggressive and most common malignancy of biliary tract lacking effective treatment due to unavailability of suitable biomarkers and therapeutics. SMAD4 is an essential mediator of transforming growth factor-β pathway ... ...

Abstract	Gall bladder cancer (GBC) is an aggressive and most common malignancy of biliary tract lacking effective treatment due to unavailability of suitable biomarkers and therapeutics. SMAD4 is an essential mediator of transforming growth factor-β pathway involved in various cellular processes like growth, differentiation and apoptosis and also recognized as therapeutic target for GBC and other gastrointestinal tract cancers. In the present study, 3D structure of SMAD4 mutants was optimized through molecular dynamics simulation (MDS) along with wildtype. Furthermore, binding site of protein was predicted through hybrid approach and structural based virtual screening against two drug libraries was performed followed by docking. MDS of top docking score protein-ligand complexes were carried, and binding free energy was rescored. Two potential inhibitors, namely ZINC2098840 and ZINC8789167, were screened that displayed higher binding affinity towards mutant proteins compared with wildtype and both hydrophilic as well as hydrophobic interactions play a crucial role during protein-ligand binding. Current study identified novel and potent inhibitors of SMAD4 mutant that could be used as a drug candidate for the development of personalized medicine for gall bladder and other associated cancers.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Binding Sites ; Drug Discovery ; Humans ; Ligands ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutant Proteins ; Protein Binding ; Smad4 Protein/antagonists & inhibitors ; Smad4 Protein/chemistry ; Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents ; Ligands ; Mutant Proteins ; SMAD4 protein, human ; Smad4 Protein
Language	English
Publishing date	2021-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-021-10210-w
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Zs.A 4946: Show issues

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Article ; Online: Computational investigation reveals that the mutant strains of SARS-CoV2 have differential structural and binding properties.

Kumar, Rakesh / Kumar, Rahul / Goel, Harsh / Tanwar, Pranay

Computer methods and programs in biomedicine

2021 Volume 215, Page(s) 106594

Abstract: Background and objectives: Remarkable infectivity of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) is due to the rapid emergence of various strains which enable the virus to ruling the world. Over the course of SARS-CoV2 pandemic, the ... ...

Abstract	Background and objectives: Remarkable infectivity of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) is due to the rapid emergence of various strains which enable the virus to ruling the world. Over the course of SARS-CoV2 pandemic, the scientific communities worldwide are responding to newly emerging genetic variants. However, mechanism behind the persistent infection of these variants is still not known due to the paucity of study of these variants at molecular level. In this scenario, computational methods have immense utility in understanding the molecular and functional properties of different variants. Methods: The various mutants (MTs) of SpikeS1 receptor binding domain (RBD) of highly infectious SARS-CoV2 strains were manifested and elucidated the protein structure and binding strength using molecular dynamics (MD) simulation and protein-protein docking approaches. Results: MD simulation study showed that all MTs exhibited stable structures with altered functional properties. Furthermore, the binding strength of different MTs along with WT (wildtype) was revealed that MTs showed differential binding affinities to host protein with high binding strength exhibited by V367F and V483A MTs. Conclusion: Hence, this study shed light on the molecular basis of infection caused by different variants of SARS-CoV2, which might play an important role in to cease the transmission and pathogenesis of virus and also implicate in rational designing of a specific drug.
MeSH term(s)	COVID-19 ; Humans ; Protein Binding ; RNA, Viral ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	RNA, Viral ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-12-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2021.106594
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Article ; Online: Mutant strains of SARS-CoV-2 are more prone to infect obese patient: a review.

Ningombam, Somorjit Singh / Kumar, Rakesh / Tanwar, Pranay

Wiener klinische Wochenschrift

2021 Volume 133, Issue 7-8, Page(s) 383–392

Abstract: The current review critically analyzes obesity as an important risk factor for increased predisposition towards coronavirus disease 2019 (COVID-19), its severity and causal death in current pandemic. Countries with higher prevalence of exposed obese ... ...

Abstract	The current review critically analyzes obesity as an important risk factor for increased predisposition towards coronavirus disease 2019 (COVID-19), its severity and causal death in current pandemic. Countries with higher prevalence of exposed obese individuals experienced the highest number of mortalities. The analysis also proved that individuals having more adipose tissue in body have a higher level of angiotensin-converting enzyme 2 (ACE2), which is identified as functional receptor for COVID-19. Therefore, obese individuals are worse in condition because of a higher presence of adiposity increases the number of ACE2 expressing cells. Furthermore, in silico interactions of ACE2 and different variants of coronavirus 2 (CoV-2) spike S1 protein suggest that mutant strains are more infectious than wildtype as they bind to host ACE2 protein with high binding affinities. Certain specific cancers including cervical cancer, pancreatic and rectal adenocarcinomas have more expression of such receptors and pose additional risk to already immunocompromised cancer patients. This review emphasizes obesity, as the covert risk factor of COVID-19 infection and sensitizes about of calorie restrictions, immunity building and preventive measures.
MeSH term(s)	COVID-19 ; Humans ; Obesity/epidemiology ; Obesity/genetics ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-02-17
Publishing country	Austria
Document type	Journal Article ; Review
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-021-01819-w
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