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Book ; Online: Sea ice diatoms from Late Quaternary sediments in the Scotia Sea, supplementary data to: Allen, Claire Susannah; Pike, Jennifer; Pudsey, Carol J (2011): Last glacial-interglacial sea-ice cover in the SW Atlantic and its potential role in global deglaciation. Quaternary Science Reviews, 30(19-20), 2446-2458

Allen, Claire Susannah / Pike, Jennifer / Pudsey, Carol J

2011

Abstract: Sea-ice growth and decay in Antarctica is one of the biggest seasonal changes on Earth, expanding ice cover from 4x10**6 km**2 to a maximum of 19x10**6 km**2 during the austral winter. Analyses of six marine sediment cores from the Scotia Sea, SW ... ...

Abstract	Sea-ice growth and decay in Antarctica is one of the biggest seasonal changes on Earth, expanding ice cover from 4x106 km2 to a maximum of 19x106 km2 during the austral winter. Analyses of six marine sediment cores from the Scotia Sea, SW Atlantic, yield records of sea-ice migration across the basin since the Lateglacial. The cores span nearly ten degrees of latitude from the modern seasonal sea-ice zone to the modern Polar Front. Surface sediments in the cores comprise predominantly diatomaceous oozes and muddy diatom oozes that reflect Holocene conditions. The cores exhibit similar down-core stratigraphies with decreasing diatom concentrations and increasing magnetic susceptibility from modern through to the Last Glacial Maximum (LGM). Sediments in all cores contain sea-ice diatoms that preserve a signal of changing sea-ice cover and permit reconstruction of past sea-ice dynamics. The sea-ice records presented here are the first to document the position of both the summer and winter sea-ice cover at the Last Glacial Maximum (LGM) in the Scotia Sea. Comparison of the LGM and Holocene sea-ice conditions shows that the average winter sea-ice extent was at least 5? further north at the LGM. Average summer sea-ice extent was south of the most southerly core site at the LGM, and suggests that sea-ice expanded from approximately 61?S to 52?S each season. Our data also suggest that the average summer sea-ice position at the LGM was not the maximum extent of summer sea-ice during the last glacial. Instead, the sediments contain evidence of a pre-LGM maximum extent of summer sea-ice between ab. 30 ka and 22 ka that extended to ab. 59?S, close to the modern average winter sea-ice limit. Based on our reconstruction we propose that the timing of the maximum extent of summer sea-ice and subsequent retreat by 22 ka, could be insolation controlled and that the strong links between sea-ice and bottom water formation provide a potential mechanism by which Southern Hemisphere regional sea-ice dynamics at the LGM could have a global impact and promote deglaciation.
Language	English
Dates of publication	2011-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/j.quascirev.2011.04.002
DOI	10.1594/PANGAEA.762140
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Conference proceedings ; Online: (Table T1) Correlation of the postglacial laminated unit between ODP Holes 178-1098A, 178-1098B and 178-1098C, supplementary data to: Pike, Jennifer; Moreton, Steven Grahame; Allen, Claire Susannah (2001): Data report: Microfabric analysis of postglacial sediments from Palmer Deep, western Antarctic Peninsula. In: Barker, PF; Camerlenghi, A; Acton, GD; Ramsay, ATS (eds.) Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 178, 1-17

Pike, Jennifer / Allen, Claire Susannah / Moreton, Steven Grahame

2001

Abstract: The Antarctic Peninsula region is ideally suited to monitor how global change affects Antarctica because it is one of the most sensitive regions of the continent to rapid climate change. This has been clearly demonstrated by the recent break up of the ... ...

Abstract	The Antarctic Peninsula region is ideally suited to monitor how global change affects Antarctica because it is one of the most sensitive regions of the continent to rapid climate change. This has been clearly demonstrated by the recent break up of the Larsen A Ice Shelf. Drilling at Ocean Drilling Program Site 1098, Palmer Deep, western Antarctic Peninsula, recovered almost 50 m of sediments that record the paleoceanographic and paleoclimatic history of the region from the last glacial maximum through the rapid climate oscillations of deglaciation into the Holocene. This sedimentary section will provide a wealth of high-resolution paleoenvironmental data from Antarctica that will be useful for climate modelers and paleoceanographers alike. This data report presents the preliminary results of a high-resolution, microscale sediment fabric study of the postglacial sediments from Palmer Deep Site 1098. These sediments have previously been described as being annually laminated; however, this investigation shows that although the interpretation of this sequence as seasonal sediments is most likely correct, there are a number of features that indicate there is strong interannual variability affecting the laminations.
Language	English
Dates of publication	2001-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Conference proceedings ; Online
Note	This dataset is supplement to doi:10.2973/odp.proc.sr.178.226.2001
DOI	10.1594/PANGAEA.787320
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Top-Down Proteomics and the Challenges of True Proteoform Characterization.

Po, Allen / Eyers, Claire E

Journal of proteome research

2023 Volume 22, Issue 12, Page(s) 3663–3675

Abstract: Top-down proteomics (TDP) aims to identify and profile intact protein forms (proteoforms) extracted from biological samples. True proteoform characterization requires that both the base protein sequence be defined and any mass shifts identified, ideally ... ...

Abstract	Top-down proteomics (TDP) aims to identify and profile intact protein forms (proteoforms) extracted from biological samples. True proteoform characterization requires that both the base protein sequence be defined and any mass shifts identified, ideally localizing their positions within the protein sequence. Being able to fully elucidate proteoform profiles lends insight into characterizing proteoform-unique roles, and is a crucial aspect of defining protein structure-function relationships and the specific roles of different (combinations of) protein modifications. However, defining and pinpointing protein post-translational modifications (PTMs) on intact proteins remains a challenge. Characterization of (heavily) modified proteins (>∼30 kDa) remains problematic, especially when they exist in a population of similarly modified, or kindred, proteoforms. This issue is compounded as the number of modifications increases, and thus the number of theoretical combinations. Here, we present our perspective on the challenges of analyzing kindred proteoform populations, focusing on annotation of protein modifications on an "average" protein. Furthermore, we discuss the technical requirements to obtain high quality fragmentation spectral data to robustly define site-specific PTMs, and the fact that this is tempered by the time requirements necessary to separate proteoforms in advance of mass spectrometry analysis.
MeSH term(s)	Tandem Mass Spectrometry/methods ; Proteomics/methods ; Proteins/metabolism ; Protein Processing, Post-Translational ; Amino Acid Sequence ; Proteome/analysis
Chemical Substances	Proteins ; Proteome
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00416
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Article ; Online: Building Team-based Primary Care: Lessons From an Academic-Community Network Partnership.

Coleman, Katie / Allen, Claire / Eslan, Alexia / Shepherd, Carolyn / Sanchez, Jessica

Progress in community health partnerships : research, education, and action

2024 Volume 17, Issue 4, Page(s) 679–687

Abstract: Background: Team-based care is fundamental to providing high-quality health care for patients. However, moving from a traditional, hierarchical way of providing care to team-based care is challenging and involves systematic and sustained process changes. ...

Abstract	Background: Team-based care is fundamental to providing high-quality health care for patients. However, moving from a traditional, hierarchical way of providing care to team-based care is challenging and involves systematic and sustained process changes. Objectives: To describe the implementation and evaluation of a partnership between academics, clinic, and community to improve team-based care in primary care practices serving vulnerable populations utilizing a structured change package and implementation support. Methods: The partners 1) created a six-strategy structured change package, 2) designed implementation support, and 3) evaluated implementation using an assessment scale at baseline and every 6 months. Results: Practices improved in all care-team functions from May 2015 to August 2018, with the most improvement seen in population management, planned care and empanelment. Conclusions: Academic-community partnerships can use evidence-based practice supports to measurably improve team-based care in primary care practices serving vulnerable populations.
MeSH term(s)	Humans ; Community Networks ; Community-Based Participatory Research ; Program Evaluation ; Quality of Health Care ; Primary Health Care
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2275483-0
ISSN	1557-055X ; 1557-0541
ISSN (online)	1557-055X
ISSN	1557-0541
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential.

Allen, Josh / Dames, Shannon S / Foldi, Claire J / Shultz, Sandy R

Molecular psychiatry

2024

Abstract: Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an increased risk of developing neurological and neurodegenerative ... ...

Abstract	Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an increased risk of developing neurological and neurodegenerative disorders. These symptoms can stem from various neurophysiological insults, including neuroinflammation, oxidative stress, imbalances in neurotransmission, and impaired neuroplasticity. Despite advancements in medical technology and treatment interventions, managing ABI remains a significant challenge. Emerging evidence suggests that psychedelics may rapidly improve neurobehavioral outcomes in patients with various disorders that share physiological similarities with ABI. However, research specifically focussed on psychedelics for ABI is limited. This narrative literature review explores the neurochemical properties of psychedelics as a therapeutic intervention for ABI, with a focus on serotonin receptors, sigma-1 receptors, and neurotrophic signalling associated with neuroprotection, neuroplasticity, and neuroinflammation. The promotion of neuronal growth, cell survival, and anti-inflammatory properties exhibited by psychedelics strongly supports their potential benefit in managing ABI. Further research and translational efforts are required to elucidate their therapeutic mechanisms of action and to evaluate their effectiveness in treating the acute and chronic phases of ABI.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02360-0
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Article: Using document analysis to revise competency frameworks: Perspectives from the revision of competency standards for dietitians.

Allen, Louise M / Palermo, Claire

Frontiers in medicine

2022 Volume 9, Page(s) 900636

Abstract: Introduction/objective: In resource poor environments, low cost methods are needed to review competency standards to ensure they remain reflective of the current health workforce. This study aims to show how document analysis can be used to inform the ... ...

Abstract	Introduction/objective: In resource poor environments, low cost methods are needed to review competency standards to ensure they remain reflective of the current health workforce. This study aims to show how document analysis can be used to inform the revision of competency frameworks and standards. Methods: Altheide and Schneider's document analysis was modified to revise the National Competency Standards for Dietitians in Australia. This involved an eight-step process: (i) define the goal, (ii) identify documents for analysis, (iii) choose the analysis approach, (iv) engage with the documents and perform the analysis, (v) draft revisions, (vi) stakeholder engagement, (vii) final revisions, (viii) dissemination. Documents were sought through a combination of literature searches, review of document databases, and targeted document sourcing for documents relevant to contemporary dietetic practice. Framework analysis was used to analyse the data, with the thematic framework including four categories: (i) Aboriginal and Torres Strait Islander peoples, (ii) Consumer perspectives, (iii) Contemporary and future dietetic roles, and (iv) Contemporary wording and structure of competency. All included documents were indexed and charted which informed revisions to the standards. Results: Sixty-seven documents were reviewed. Four new competency standards were added to address the skills and attributes required of dietitians to work effectively with Aboriginal and Torres Strait Islander peoples. One competency standard was modified to include an individualized approach as this was deemed important by consumers but not previously included in the standards. The revised standards also place greater emphasis on dietitian's role in teaching and learning. In addition, there are now multiple standards that refer to advocacy, sustainability is referenced multiple times, a new standard specific to advanced care planning has been included, and their structure and wording was revised to ensure it was contemporary. Conclusion: Using document analysis to revise competency standards offers an efficient and low-cost method to update competency standards in a resource poor environment. This addresses a key issue with competency standards where unless revised frequently they can become rapidly out of date. Further research is needed to learn if document analysis can be used as a method to create rather than revise competency standards.
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.900636
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Longitudinal MRI brain studies in live adult zebrafish.

Hamilton, Noémie / Allen, Claire / Reynolds, Steven

NMR in biomedicine

2023 Volume 36, Issue 7, Page(s) e4891

Abstract: Zebrafish (Danio rerio) has been successfully used for decades in developmental studies and disease modelling. The remarkable uptake of zebrafish as a model system is partly due to its transparency during the early weeks of its development, allowing in ... ...

Abstract	Zebrafish (Danio rerio) has been successfully used for decades in developmental studies and disease modelling. The remarkable uptake of zebrafish as a model system is partly due to its transparency during the early weeks of its development, allowing in vivo imaging of cellular and molecular processes. However, this key advantage wears off when tissues become opaque as the animal reaches juvenile and adult stages, rendering access to tissues for live imaging and longitudinal studies difficult. Here we provide a novel approach to image and assess tissue integrity of adult zebrafish using MRI on live zebrafish suitable for longitudinal studies. We built a 3D-printed life support chamber and designed a protocol-directed sedation regime to recover adult zebrafish after scanning in a 9.4 T MRI scanner. Our life support chamber is cheap and easy to create using 3D printing, allowing other groups to copy our template for quick setup. Additionally, we optimized the delivery of contrast agent to enhance brain signals in order to refine current delivery, usually delivered intravenously in rodents. We show here that immersion in gadolinium was a viable alternative to intraperitoneal injection to reduce T
MeSH term(s)	Animals ; Zebrafish ; Contrast Media ; Magnetic Resonance Imaging ; Neuroimaging ; Brain/diagnostic imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1000976-0
ISSN	1099-1492 ; 0952-3480
ISSN (online)	1099-1492
ISSN	0952-3480
DOI	10.1002/nbm.4891
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Article ; Online: Using document analysis to revise competency frameworks

Louise M. Allen / Claire Palermo

Frontiers in Medicine, Vol

Perspectives from the revision of competency standards for dietitians

2022 Volume 9

Abstract: Introduction/ObjectiveIn resource poor environments, low cost methods are needed to review competency standards to ensure they remain reflective of the current health workforce. This study aims to show how document analysis can be used to inform the ... ...

Abstract	Introduction/ObjectiveIn resource poor environments, low cost methods are needed to review competency standards to ensure they remain reflective of the current health workforce. This study aims to show how document analysis can be used to inform the revision of competency frameworks and standards.MethodsAltheide and Schneider's document analysis was modified to revise the National Competency Standards for Dietitians in Australia. This involved an eight-step process: (i) define the goal, (ii) identify documents for analysis, (iii) choose the analysis approach, (iv) engage with the documents and perform the analysis, (v) draft revisions, (vi) stakeholder engagement, (vii) final revisions, (viii) dissemination. Documents were sought through a combination of literature searches, review of document databases, and targeted document sourcing for documents relevant to contemporary dietetic practice. Framework analysis was used to analyse the data, with the thematic framework including four categories: (i) Aboriginal and Torres Strait Islander peoples, (ii) Consumer perspectives, (iii) Contemporary and future dietetic roles, and (iv) Contemporary wording and structure of competency. All included documents were indexed and charted which informed revisions to the standards.ResultsSixty-seven documents were reviewed. Four new competency standards were added to address the skills and attributes required of dietitians to work effectively with Aboriginal and Torres Strait Islander peoples. One competency standard was modified to include an individualized approach as this was deemed important by consumers but not previously included in the standards. The revised standards also place greater emphasis on dietitian's role in teaching and learning. In addition, there are now multiple standards that refer to advocacy, sustainability is referenced multiple times, a new standard specific to advanced care planning has been included, and their structure and wording was revised to ensure it was contemporary.ConclusionUsing document ...
Keywords	document analysis ; competency framework ; competency standard ; qualitative research ; framework analysis ; Medicine (General) ; R5-920
Subject code	380
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contributing Areas to Domestic Wells in Dipping Sedimentary Rocks under Extreme Recharge Events.

Tiedeman, Claire R / Shapiro, Allen M

Ground water

2022 Volume 60, Issue 4, Page(s) 460–476

Abstract: We use particle tracking to determine contributing areas (CAs) to wells for transient flow models that simulate cyclic domestic pumping and extreme recharge events in a small synthetic watershed underlain by dipping sedimentary rocks. The CAs consist of ... ...

Abstract	We use particle tracking to determine contributing areas (CAs) to wells for transient flow models that simulate cyclic domestic pumping and extreme recharge events in a small synthetic watershed underlain by dipping sedimentary rocks. The CAs consist of strike-oriented bands at locations where the water table intersects high-hydraulic conductivity beds, and from which groundwater flows to the pumping well. Factors that affect the size and location of the CAs include topographic flow directions, rock dip direction, cross-bed fracture density, and position of the well relative to streams. For an effective fracture porosity (n
MeSH term(s)	Geology ; Groundwater ; Porosity ; Water Movements ; Water Wells
Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	246212-6
ISSN	1745-6584 ; 0017-467X
ISSN (online)	1745-6584
ISSN	0017-467X
DOI	10.1111/gwat.13169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 - Where should we go now?

Allen, Claire / Heaven Taylor, Ben / Winchester, Chris

Integrative medicine research

2020 Volume 9, Issue 3, Page(s) 100468

Keywords	covid19
Language	English
Publishing date	2020-06-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	2213-4220
ISSN	2213-4220
DOI	10.1016/j.imr.2020.100468
Database	MEDical Literature Analysis and Retrieval System OnLINE

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