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Article ; Online: DNA Methylation Dysfunction in Chronic Kidney Disease.

Ingrosso, Diego / Perna, Alessandra F

2020 Volume 11, Issue 7

Abstract: Renal disease is the common denominator of a number of underlying disease conditions, whose prevalence has been dramatically increasing over the last two decades. Two aspects are particularly relevant to the subject of this review: (I) most cases are ... ...

Abstract	Renal disease is the common denominator of a number of underlying disease conditions, whose prevalence has been dramatically increasing over the last two decades. Two aspects are particularly relevant to the subject of this review: (I) most cases are gathered under the umbrella of chronic kidney disease since they require-predictably for several lustrums-continuous clinical monitoring and treatment to slow down disease progression and prevent complications; (II) cardiovascular disease is a terrible burden in this population of patients, in that it claims many lives yearly, while only a scant minority reach the renal disease end stage. Why indeed a review on DNA methylation and renal disease? As we hope to convince you, the present evidence supports the role of the existence of various derangements of the epigenetic control of gene expression in renal disease, which hold the potential to improve our ability, in the future, to more effectively act toward disease progression, predict outcomes and offer novel therapeutic approaches.
MeSH term(s)	Cardiovascular Diseases/genetics ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/prevention & control ; DNA Methylation/physiology ; Disease Progression ; Epigenesis, Genetic/physiology ; Humans ; Kidney Failure, Chronic/genetics ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/prevention & control ; Prognosis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/therapy ; Therapies, Investigational/methods ; Therapies, Investigational/trends
Language	English
Publishing date	2020-07-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes11070811
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Homocysteine and chronic kidney disease: an ongoing narrative.

Perna, Alessandra F / Ingrosso, Diego

Journal of nephrology

2019 Volume 32, Issue 5, Page(s) 673–675

MeSH term(s)	Homocysteine/metabolism ; Humans ; Renal Insufficiency, Chronic/metabolism
Chemical Substances	Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2019-06-21
Publishing country	Italy
Document type	Editorial
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-019-00622-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?

García-Martínez, Yuselys / Borriello, Margherita / Capolongo, Giovanna / Ingrosso, Diego / Perna, Alessandra F

Biology

2023 Volume 12, Issue 2

Abstract: Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant ... ...

Abstract	Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppressive metabolism, gastrointestinal toxicity, and diarrhea. The gut microbiota has emerged as a potential therapeutic target for personalizing immunosuppressive therapy and managing post-transplant complications. This review reports current evidence on gut microbial dysbiosis in kidney transplant recipients, alterations in their gut microbiota associated with kidney transplantation outcomes, and the application of gut microbiota intervention therapies in treating post-transplant complications.
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12020163
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Article ; Online: [Hyponatremia and Electrolyte Disorders in Cancer Patients].

Florio, Giulia / Iervolino, Anna / Simeoni, Mariadelina / Perna, Alessandra F / Trepiccione, Francesco

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2023 Volume 40, Issue Suppl 81

Abstract: Onconephrology is a rising and rapidly expanding field of medicine in which nephrology and oncology meet each other. Besides multidisciplinary meetings, oncologists and nephrologists often discuss on timing of the treatment, dosage, and side effects ... ...

Abstract	Onconephrology is a rising and rapidly expanding field of medicine in which nephrology and oncology meet each other. Besides multidisciplinary meetings, oncologists and nephrologists often discuss on timing of the treatment, dosage, and side effects management. Cancer patients often encounter different electrolyte disorders. They are mostly secondary to the tumor itself or consequences of its treatment. In the last years, the great efforts to find new therapies like targeted, immune, and cell-based led us to many new side effects. Hyponatremia, hypokalemia, hyperkalemia, hypercalcemia, and hypomagnesemia are among the most common electrolyte disorders. Data have shown a worse prognosis in patients with electrolytic imbalances. Additionally, they cause a delay in chemotherapy or even an interruption. It is important to diagnose promptly these complications and treat them. In this review, we provide a special focus on hyponatremia and its treatment as the most common electrolytes disorder in cancer patients, but also on newly described cases of hypo- and hyperkalemia and metabolic acidosis.
MeSH term(s)	Humans ; Hyponatremia/diagnosis ; Hyponatremia/etiology ; Hyponatremia/therapy ; Hyperkalemia/therapy ; Hyperkalemia/complications ; Hypernatremia/complications ; Water-Electrolyte Imbalance/etiology ; Neoplasms/complications ; Hypokalemia/etiology ; Electrolytes
Chemical Substances	Electrolytes
Language	Italian
Publishing date	2023-10-03
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article: Secondary Hyperparathyroidism and Hypertension: An Intriguing Couple.

Simeoni, Mariadelina / Perna, Alessandra F / Fuiano, Giorgio

Journal of clinical medicine

2020 Volume 9, Issue 3

Abstract: ...

Abstract	:
Language	English
Publishing date	2020-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9030629
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Article ; Online: The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?

García-Martínez, Yuselys / Borriello, Margherita / Capolongo, Giovanna / Ingrosso, Diego / Perna, Alessandra F.

Biology (Basel). 2023 Jan. 20, v. 12, no. 2

2023

Abstract	Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppressive metabolism, gastrointestinal toxicity, and diarrhea. The gut microbiota has emerged as a potential therapeutic target for personalizing immunosuppressive therapy and managing post-transplant complications. This review reports current evidence on gut microbial dysbiosis in kidney transplant recipients, alterations in their gut microbiota associated with kidney transplantation outcomes, and the application of gut microbiota intervention therapies in treating post-transplant complications.
Keywords	diarrhea ; dysbiosis ; gastrointestinal system ; immunosuppression ; intestinal microorganisms ; kidney transplant ; metabolism ; morbidity ; mortality ; quality of life ; renal failure ; toxicity
Language	English
Dates of publication	2023-0120
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12020163
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes.

Farahat, Sarah / Kherkheulidze, Salome / Nopp, Stephan / Kainz, Alexander / Borriello, Margherita / Perna, Alessandra F / Cohen, Gerald

Toxins

2023 Volume 15, Issue 3

Abstract: Impaired polymorphonuclear leukocyte (PMNL) functions contribute to increased infections and cardiovascular diseases in chronic kidney disease (CKD). Uremic toxins reduce hydrogen sulfide ( ... ...

Abstract	Impaired polymorphonuclear leukocyte (PMNL) functions contribute to increased infections and cardiovascular diseases in chronic kidney disease (CKD). Uremic toxins reduce hydrogen sulfide (H
MeSH term(s)	Cysteine/pharmacology ; Cysteine/metabolism ; Escherichia coli ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/metabolism ; Neutrophils ; Phosphatidylinositol 3-Kinases/metabolism
Chemical Substances	Cysteine (K848JZ4886) ; diallyl trisulfide (0ZO1U5A3XX) ; GYY 4137 ; Hydrogen Sulfide (YY9FVM7NSN) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; sodium bisulfide (FWU2KQ177W) ; sodium sulfide (YGR27ZW0Y7) ; diallyl disulfide (5HI47O6OA7)
Language	English
Publishing date	2023-03-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins15030198
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Article ; Online: [Methods for calculating the number of nephrons from ultrasound scans and kidney biopsies for nephrologists' use].

Borriello, Gianmarco / Gravina, Ilenia / Perna, Alessandra F / Viggiano, Davide / Pollastro, Rosa Maria

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2022 Volume 39, Issue 6

Abstract: The interest in determining the number of nephrons in the kidney dates back to the 1960s, when an influential laboratory method for determining ex vivo the number of nephrons in the kidneys was described by Bricker. Over the years, various methods have ... ...

Abstract	The interest in determining the number of nephrons in the kidney dates back to the 1960s, when an influential laboratory method for determining ex vivo the number of nephrons in the kidneys was described by Bricker. Over the years, various methods have been developed to estimate the number of nephrons in living beings as accurately as possible. These modern methods combine data such as the glomerular density, the percentage of glomeruli in sclerosis calculated from biopsy samples, and the kidney volume, which can be precisely estimated from magnetic resonance, CT scan, or specific ultrasound methods. As the reduction in the number of functioning nephrons is closely connected with an increased risk of progression of renal disease (especially in patients with nephrotic syndrome) and hypertension, its introduction into clinical practice could allow a precise stratification of progression risk in patients with kidney disease and a better understanding of the mechanisms that contribute to the loss of functioning nephrons.
MeSH term(s)	Humans ; Nephrologists ; Nephrons ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Glomerulus/pathology ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/pathology ; Biopsy
Language	Italian
Publishing date	2022-12-21
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins.

Coppola, Annapaola / Lombari, Patrizia / Mazzella, Elvira / Capolongo, Giovanna / Simeoni, Mariadelina / Perna, Alessandra F / Ingrosso, Diego / Borriello, Margherita

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Chronic kidney disease (CKD) is an increasing health care problem. About 10% of the general population is affected by CKD, representing the sixth cause of death in the world. Cardiovascular events are the main mortality cause in CKD, with a ... ...

Abstract	Chronic kidney disease (CKD) is an increasing health care problem. About 10% of the general population is affected by CKD, representing the sixth cause of death in the world. Cardiovascular events are the main mortality cause in CKD, with a cardiovascular risk 10 times higher in these patients than the rate observed in healthy subjects. The gradual decline of the kidney leads to the accumulation of uremic solutes with a negative effect on every organ, especially on the cardiovascular system. Mammalian models, sharing structural and functional similarities with humans, have been widely used to study cardiovascular disease mechanisms and test new therapies, but many of them are rather expensive and difficult to manipulate. Over the last few decades, zebrafish has become a powerful non-mammalian model to study alterations associated with human disease. The high conservation of gene function, low cost, small size, rapid growth, and easiness of genetic manipulation are just some of the features of this experimental model. More specifically, embryonic cardiac development and physiological responses to exposure to numerous toxin substances are similar to those observed in mammals, making zebrafish an ideal model to study cardiac development, toxicity, and cardiovascular disease.
MeSH term(s)	Animals ; Humans ; Uremic Toxins ; Zebrafish/physiology ; Toxins, Biological/toxicity ; Uremia/complications ; Cardiovascular Diseases/complications ; Renal Insufficiency, Chronic/complications ; Heart ; Mammals
Chemical Substances	Uremic Toxins ; Toxins, Biological
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065656
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Article ; Online: Secondary Hyperparathyroidism and Hypertension

Mariadelina Simeoni / Alessandra F. Perna / Giorgio Fuiano

Journal of Clinical Medicine, Vol 9, Iss 3, p

An Intriguing Couple

2020 Volume 629

Abstract: Secondary hyperparathyroidism (SHPTH) is a major complication in patients on maintenance hemodialysis burdened with high cardiovascular risk. Hypertension is also a high prevalence complication contributing to an increase in the mortality rate in ... ...

Abstract	: Secondary hyperparathyroidism (SHPTH) is a major complication in patients on maintenance hemodialysis burdened with high cardiovascular risk. Hypertension is also a high prevalence complication contributing to an increase in the mortality rate in hemodialysis patients. A possible association between SHPTH and hypertension has been widely reported in the literature and several pathogenetic mechanisms have been described. There is evidence that the decrease of plasma iPTH levels are correlated with hypertension correction in hemodialysis patients undergoing parathyroidectomy and oral calcimimetics administration. We have observed a similar behaviour also in a patient on chronic hemodialysis treated with Etelcalcetide. Even if this is an isolated observation, it could stimulate future investigation, possibly in dedicated clinical trials.
Keywords	secondary hyperparathyroidism ; hypertension ; hemodialysis ; calcimimetic ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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