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  1. Article ; Online: Pregnancy and cardiac interventions: What are the optimal management options?

    Patel, Chandni / Akhtar, Hubba / Gupta, Shubhi / Harky, Amer

    Journal of cardiac surgery

    2020  Volume 35, Issue 7, Page(s) 1589–1596

    Abstract: Cardiac disease is the leading cause of maternal mortality in the United Kingdom. Major causes of cardiac death in pregnant women include cardiomyopathies, myocardial infarction, ischemic heart disease, and aortic dissection. Uncorrected congenital heart ...

    Abstract Cardiac disease is the leading cause of maternal mortality in the United Kingdom. Major causes of cardiac death in pregnant women include cardiomyopathies, myocardial infarction, ischemic heart disease, and aortic dissection. Uncorrected congenital heart disease and women who have had corrective or palliative surgery may have complicated pregnancies as well. Some women with significant cardiac disease are unable to meet the increased physiological demands of pregnancy. Of these, those who do not respond to medical treatment may require surgical correction such as coronary artery bypass grafting. The risk of cardiac operations for pregnant women is similar to that for nonpregnant women but the fetal mortality rate remains high. Contributing factors to high fetal mortality rates include timing, urgency of operation, and the fetal/fetoplacental response to cardiopulmonary bypass. The aim of this review is to summarize current evidence in utilizing the different management approaches of cardiac issues during pregnancy.
    MeSH term(s) Adult ; Cardiopulmonary Bypass ; Cardiovascular Surgical Procedures/methods ; Coronary Artery Bypass ; Decision Making ; Female ; Fetal Death/etiology ; Humans ; Interdisciplinary Communication ; Pregnancy ; Pregnancy Complications, Cardiovascular/physiopathology ; Pregnancy Complications, Cardiovascular/surgery ; Pregnancy Outcome ; Young Adult
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review.

    Akhtar, Hubba / Patel, Chandni / Abuelgasim, Eyad / Harky, Amer

    Gynecologic and obstetric investigation

    2020  Volume 85, Issue 4, Page(s) 295–306

    Abstract: Introduction: To review published studies related to the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with pregnancy, foetal, and neonatal outcomes during coronavirus disease 2019 (COVID-19) pandemic in a ... ...

    Abstract Introduction: To review published studies related to the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with pregnancy, foetal, and neonatal outcomes during coronavirus disease 2019 (COVID-19) pandemic in a systematic manner.
    Methods: A comprehensive electronic search was done through PubMed, Scopus, Medline, Cochrane database, and Google Scholar from December 01, 2019, to May 22, 2020, along with the reference list of all included studies. All cohort studies that reported on outcomes of COVID-19 during pregnancy were included. Qualitative assessment of included studies was performed using the Newcastle-Ottawa scale.
    Results: Upon admission, most pregnant women underwent a low-dose radiation CT scan; the reports of which included unilateral/bilateral pneumonia in most patients. A marked lymphopenia was also noted in many patients with COVID-19. 513 titles were screened, and 22 studies were included, which identified 156 pregnant women with COVID-19 and 108 neonatal outcomes. The most common maternal/foetal complications included intrauterine/foetal distress (14%) and premature rupture of membranes (8%). The neonatal clinical manifestations of COVID-19 commonly included shortness of breath (6%), gastrointestinal symptoms (4%), and fever (3%).
    Conclusion: COVID-19 infection in pregnancy leads to increased risk in pregnancy complications such as preterm birth, PPROM, and may possibly lead to maternal death in rare cases. There is no evidence to support vertical transmission of SARS-CoV-2 infection to the unborn child. Due to a paucity of inconsistent data regarding the impact of COVID-19 on the newborn, caution should be undertaken to further investigate and monitor possible infection in the neonates born to COVID-19-infected mothers.
    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Female ; Fetal Membranes, Premature Rupture/virology ; Fever/virology ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Maternal Mortality ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome ; Premature Birth/epidemiology ; Premature Birth/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 800003-7
    ISSN 1423-002X ; 0378-7346
    ISSN (online) 1423-002X
    ISSN 0378-7346
    DOI 10.1159/000509290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 (SARS-CoV-2) Infection in Pregnancy

    Akhtar, Hubba / Patel, Chandni / Abuelgasim, Eyad / Harky, Amer

    Gynecologic and Obstetric Investigation

    A Systematic Review

    2020  Volume 85, Issue 4, Page(s) 295–306

    Keywords Obstetrics and Gynaecology ; Reproductive Medicine ; covid19
    Language English
    Publisher S. Karger AG
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 800003-7
    ISSN 1423-002X ; 0378-7346
    ISSN (online) 1423-002X
    ISSN 0378-7346
    DOI 10.1159/000509290
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review

    Akhtar, Hubba / Patel, Chandni / Abuelgasim, Eyad / Harky, Amer

    Gynecol Obstet Invest

    Abstract: INTRODUCTION: To review published studies related to the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with pregnancy, foetal, and neonatal outcomes during coronavirus disease 2019 (COVID-19) pandemic in a ... ...

    Abstract INTRODUCTION: To review published studies related to the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with pregnancy, foetal, and neonatal outcomes during coronavirus disease 2019 (COVID-19) pandemic in a systematic manner. METHODS: A comprehensive electronic search was done through PubMed, Scopus, Medline, Cochrane database, and Google Scholar from December 01, 2019, to May 22, 2020, along with the reference list of all included studies. All cohort studies that reported on outcomes of COVID-19 during pregnancy were included. Qualitative assessment of included studies was performed using the Newcastle-Ottawa scale. RESULTS: Upon admission, most pregnant women underwent a low-dose radiation CT scan; the reports of which included unilateral/bilateral pneumonia in most patients. A marked lymphopenia was also noted in many patients with COVID-19. 513 titles were screened, and 22 studies were included, which identified 156 pregnant women with COVID-19 and 108 neonatal outcomes. The most common maternal/foetal complications included intrauterine/foetal distress (14%) and premature rupture of membranes (8%). The neonatal clinical manifestations of COVID-19 commonly included shortness of breath (6%), gastrointestinal symptoms (4%), and fever (3%). CONCLUSION: COVID-19 infection in pregnancy leads to increased risk in pregnancy complications such as preterm birth, PPROM, and may possibly lead to maternal death in rare cases. There is no evidence to support vertical transmission of SARS-CoV-2 infection to the unborn child. Due to a paucity of inconsistent data regarding the impact of COVID-19 on the newborn, caution should be undertaken to further investigate and monitor possible infection in the neonates born to COVID-19-infected mothers.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690184
    Database COVID19

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