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  1. Article ; Online: SARS-CoV-2 rebound with and without antivirals.

    Petrosillo, Nicola

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 6, Page(s) 637–639

    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Antiviral Agents/pharmacology ; SARS-CoV-2 ; COVID-19 ; Virus Replication ; Dermatologic Agents
    Chemical Substances Antiviral Agents ; Dermatologic Agents
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00063-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Clostridioides difficile

    Petrosillo, Nicola

    Journal of clinical medicine

    2022  Volume 11, Issue 14

    Abstract: The most common worldwide cause of antibiotic-associated diarrhea/colitis is the toxin-producing ... ...

    Abstract The most common worldwide cause of antibiotic-associated diarrhea/colitis is the toxin-producing bacterium
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11144115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Introducing

    Petrosillo, Nicola

    Infectious disease reports

    2020  Volume 12, Issue 3, Page(s) 132–133

    Abstract: The first two decades of the New Millenium have faced several and threatening problems in healthcare [ ... ]. ...

    Abstract The first two decades of the New Millenium have faced several and threatening problems in healthcare [...].
    Language English
    Publishing date 2020-12-11
    Publishing country Switzerland
    Document type Editorial
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr12030024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: SARS-CoV-2, "common cold" coronaviruses' cross-reactivity and "herd immunity": The razor of Ockham (1285-1347)?

    Petrosillo, Nicola

    Infectious disease reports

    2020  Volume 12, Issue 2, Page(s) 8647

    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country Switzerland
    Document type Editorial
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.4081/idr.2020.8647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clostridioides difficile Infection

    Nicola Petrosillo

    Journal of Clinical Medicine, Vol 11, Iss 14, p

    A Never-Ending Challenge

    2022  Volume 4115

    Abstract: The most common worldwide cause of antibiotic-associated diarrhea/colitis is the toxin-producing bacterium Clostridioides difficile [.] ...

    Abstract The most common worldwide cause of antibiotic-associated diarrhea/colitis is the toxin-producing bacterium Clostridioides difficile [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Tackling the recurrence of Clostridium difficile infection.

    Petrosillo, N

    Medecine et maladies infectieuses

    2018  Volume 48, Issue 1, Page(s) 18–22

    Abstract: The pathogenesis of recurrent Clostridium difficile infection (CDI) is still poorly understood. The risk of recurrence is approximately 20% after an initial CDI episode and dramatically increases with subsequent CDI recurrences. Several factors may play ... ...

    Abstract The pathogenesis of recurrent Clostridium difficile infection (CDI) is still poorly understood. The risk of recurrence is approximately 20% after an initial CDI episode and dramatically increases with subsequent CDI recurrences. Several factors may play a role in recurrent CDI (rCDI), including conditions influencing germination, metabolic pathways that influence toxin production of C. difficile, and the microbiota composition offering protection against colonization and disease caused by C. difficile. Paradoxically, the currently recommended treatment for acute symptomatic CDI, i.e. metronidazole or vancomycin, can cause modification of the intestinal flora. Indeed, administration of anti-CDI antibiotics leads to suppression of C. difficile, along with collateral damage of the protective intestinal microbiota and opening of a "window of vulnerability" for recurrence. Host factors also have a prominent role, including innate and acquired humoral immunity, i.e. passive antibodies administration or active vaccination as a prevention strategy. They play a crucial role in the protection against severe and recurrent CDI. The assessment of risk factors of recurrence and modeling prediction scores could help in preventing the troublesome experience of CDI recurrence. Six studies have methodologically assessed prediction scores for rCDI. However, the definition of recurrence was heterogeneous, external validation was often not performed, and immunological factors were often not considered. There is a need for further studies on the pathophysiology of recurrence to design models for prediction that are sound and applicable in clinical practice.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Vaccines ; Clostridium Infections/drug therapy ; Clostridium Infections/immunology ; Clostridium Infections/prevention & control ; Clostridium Infections/therapy ; Cross Infection/drug therapy ; Cross Infection/prevention & control ; Cytokines/physiology ; Exotoxins/physiology ; Gastrointestinal Microbiome ; Host-Pathogen Interactions ; Humans ; Immunization, Passive ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; Recurrence ; Risk Factors ; Vaccination
    Chemical Substances Anti-Bacterial Agents ; Bacterial Vaccines ; Cytokines ; Exotoxins
    Language English
    Publishing date 2018-01-12
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 423536-8
    ISSN 1769-6690 ; 0399-077X ; 1166-8237
    ISSN (online) 1769-6690
    ISSN 0399-077X ; 1166-8237
    DOI 10.1016/j.medmal.2017.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Editorial:

    Granata, Guido / Barbut, Frédéric / Petrosillo, Nicola

    Frontiers in medicine

    2024  Volume 11, Page(s) 1372813

    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1372813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A One Health Platform for Future Epidemic Preparedness.

    Branda, Francesco / Scarpa, Fabio / Petrosillo, Nicola / Ciccozzi, Massimo

    Infectious disease reports

    2024  Volume 16, Issue 2, Page(s) 281–288

    Abstract: Here, we introduce the EpiConnect Intelligence Platform (ECIP), a platform facilitating rapid, transparent data sharing and analysis to support researchers and public health officials in Europe, with a focus on Italy. ECIP provides reliable, concise, ... ...

    Abstract Here, we introduce the EpiConnect Intelligence Platform (ECIP), a platform facilitating rapid, transparent data sharing and analysis to support researchers and public health officials in Europe, with a focus on Italy. ECIP provides reliable, concise, machine-readable data to aid in epidemiological understanding, standardize case characteristics, and estimate key parameters. The platform adheres to FAIR (findable, accessible, interoperable, reusable) principles, offering easily accessible and downloadable datasets for researchers' endeavors. Future enhancements include involving national public health authorities, expanding data streams, and fostering collaboration between experts and users for improved epidemic risk monitoring. Shared standards among diverse surveillance systems are advocated to achieve common strategic goals, emphasizing the need for forward-looking policies to empower professionals to analyze disease dynamics in the context of evolving health crises. The recent emergencies underscore the importance of collective efforts towards shared strategic goals, highlighting the necessity for coordinated action to address mutual concerns affecting everyone's lives.
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16020023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: On the SARS-CoV-2 Variants.

    Scarpa, Fabio / Branda, Francesco / Petrosillo, Nicola / Ciccozzi, Massimo

    Infectious disease reports

    2024  Volume 16, Issue 2, Page(s) 289–297

    Abstract: The evolutionary dynamics of viruses, particularly exemplified by SARS-CoV-2 during the ongoing COVID-19 pandemic, underscore the intricate interplay between genetics, host adaptation, and viral spread. This paper delves into the genetic evolution of ... ...

    Abstract The evolutionary dynamics of viruses, particularly exemplified by SARS-CoV-2 during the ongoing COVID-19 pandemic, underscore the intricate interplay between genetics, host adaptation, and viral spread. This paper delves into the genetic evolution of SARS-CoV-2, emphasizing the implications of viral variants on global health. Initially emerging from the Wuhan-Hu-1 lineage, SARS-CoV-2 rapidly diversified into numerous variants, each characterized by distinct mutations in the spike protein and other genomic regions. Notable variants such as B.1.1.7 (α), B.1.351 (β), P.1 (γ), B.1.617.2 (δ), and the Omicron variant have garnered significant attention due to their heightened transmissibility and immune evasion capabilities. In particular, the Omicron variant has presented a myriad of subvariants, raising concerns about its potential impact on public health. Despite the emergence of numerous variants, the vast majority have exhibited limited expansion capabilities and have not posed significant threats akin to early pandemic strains. Continued genomic surveillance is imperative to identify emerging variants of concern promptly. While genetic adaptation is intrinsic to viral evolution, effective public health responses must be grounded in empirical evidence to navigate the evolving landscape of the pandemic with resilience and precision.
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16020024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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