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  1. Article ; Online: Reply to Moldawer, Darden, and Efron's Reply to "Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies".

    De Maio, Antonio

    Shock (Augusta, Ga.)

    2020  Volume 56, Issue 1, Page(s) 151–152

    MeSH term(s) Animals ; Humans ; Research Design ; Rodentia ; Sepsis/therapy
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000001689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3985: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies.

    De Maio, Antonio

    Shock (Augusta, Ga.)

    2020  Volume 54, Issue 5, Page(s) 631–632

    MeSH term(s) Animals ; Humans ; Mice ; Rats ; Sepsis/genetics ; Sepsis/metabolism ; Sepsis/mortality ; Sepsis/therapy ; Species Specificity
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000001538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3985: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Human urine exosomes: Another important member of the liquid biopsy family.

    De Maio, Antonio

    Methods in enzymology

    2020  Volume 645, Page(s) 195–208

    Abstract: Exosomes are small membrane encapsulated vesicles released by cells during normal and stress (pathological) conditions that may play multiple biological roles. They contain typical cellular components, including phospholipids, cholesterol, proteins, ... ...

    Abstract Exosomes are small membrane encapsulated vesicles released by cells during normal and stress (pathological) conditions that may play multiple biological roles. They contain typical cellular components, including phospholipids, cholesterol, proteins, glycoconjugates, nucleic acids and metabolites. A great deal of interest has risen about the possibility that they are an alternate form of intracellular communication. However, the increasing attraction has been centered on the prospect that exosomes could become disease biomarkers as part of the new concept of liquid biopsies. In this regard, attention has been directed at investigating the content of exosomes within urine, since this is an ideal body fluid because it could be collected in great quantities, recurrently, and with minimal intervention. Although urine exosomes are very abundant, their isolation has been challenging due to the contamination with many soluble factors within the fluid. Several methods have been developed with different degrees of success. In addition, a major effort has been directed at characterizing all components of urine exosomes.
    MeSH term(s) Body Fluids ; Exosomes ; Humans ; Liquid Biopsy
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2020.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epidemiology of group A streptococcal infection: are we ready for a new scenario?

    Massese, Miriam / La Sorda, Marilena / De Maio, Flavio / Gatto, Antonio / Rosato, Roberto / Pansini, Valeria / Caroselli, Anya / Fiori, Barbara / Sanguinetti, Maurizio / Chiaretti, Antonio / Posteraro, Brunella

    The Lancet. Microbe

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(24)00071-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Membrane phospholipids activate the inflammatory response in macrophages by various mechanisms.

    Cauvi, David M / Hawisher, Dennis / Derunes, Julia / Rodriguez, Enrique / De Maio, Antonio

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2024  Volume 38, Issue 8, Page(s) e23619

    Abstract: Exosomes, which are small membrane-encapsulated particles derived from all cell types, are emerging as important mechanisms for intercellular communication. In addition, exosomes are currently envisioned as potential carriers for the delivery of drugs to ...

    Abstract Exosomes, which are small membrane-encapsulated particles derived from all cell types, are emerging as important mechanisms for intercellular communication. In addition, exosomes are currently envisioned as potential carriers for the delivery of drugs to target tissues. The natural population of exosomes is very variable due to the limited amount of cargo components present in these small vesicles. Consequently, common components of exosomes may play a role in their function. We have proposed that membrane phospholipids could be a common denominator in the effect of exosomes on cellular functions. In this regard, we have previously shown that liposomes made of phosphatidylcholine (PC) or phosphatidylserine (PS) induced a robust alteration of macrophage (Mϕ) gene expression. We herewith report that these two phospholipids modulate gene expression in Mϕs by different mechanisms. PS alters cellular responses by the interaction with surface receptors, particularly CD36. In contrast, PC is captured by a receptor-independent process and likely triggers an activity within endocytic vesicles. Despite this difference in the capture mechanisms, both lipids mounted similar gene expression responses. This investigation suggests that multiple mechanisms mediated by membrane phospholipids could be participating in the alteration of cellular functions by exosomes.
    MeSH term(s) Macrophages/metabolism ; Animals ; Mice ; Phosphatidylserines/metabolism ; Exosomes/metabolism ; Phosphatidylcholines/metabolism ; Inflammation/metabolism ; Phospholipids/metabolism ; Mice, Inbred C57BL ; CD36 Antigens/metabolism ; CD36 Antigens/genetics ; Liposomes
    Chemical Substances Phosphatidylserines ; Phosphatidylcholines ; Phospholipids ; CD36 Antigens ; Liposomes
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202302471R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  6. Article ; Online: The interaction of heat shock proteins with cellular membranes: a historical perspective.

    De Maio, Antonio / Hightower, Lawrence

    Cell stress & chaperones

    2021  Volume 26, Issue 5, Page(s) 769–783

    Abstract: The interaction of heat shock proteins (HSP) with cellular membranes has been an enigmatic process, initially observed by morphological studies, inferred during the purification of HSP70s, and confirmed after the detection of these proteins on the ... ...

    Abstract The interaction of heat shock proteins (HSP) with cellular membranes has been an enigmatic process, initially observed by morphological studies, inferred during the purification of HSP70s, and confirmed after the detection of these proteins on the surface of cancer cells and their insertion into artificial lipid bilayers. Today, the association of several HSP with lipid membranes is well established. However, the mechanisms for membrane insertion have been elusive. There is conclusive evidence indicating that HSP70s have a great selectivity for negatively charged phospholipids, whereas other HSP have a broader spectrum of lipid specificity. HSP70 also oligomerizes upon membrane insertion, forming ion conductance channels. The functional role of HSP70 lipid interactions appears related to membrane stabilization that may play a role during cell membrane biogenesis. They could also play a role as membrane chaperones as well as during endocytosis, microautophagy, and signal transduction. Moreover, HSP membrane association is a key component in the extracellular export of these proteins. The presence of HSP70 on the surface of cancer cells and its interaction with lysosome membranes have been envisioned as potential therapeutic targets. Thus, the biology and function of HSP membrane association are reaching a new level of excitement. This review is an attempt to preserve the recollection of the pioneering contributions of many investigators that have participated in this endeavor.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Heat-Shock Proteins/metabolism ; Heat-Shock Response ; Humans ; Lipid Bilayers/metabolism ; Models, Biological ; Protein Binding
    Chemical Substances Heat-Shock Proteins ; Lipid Bilayers
    Language English
    Publishing date 2021-09-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-021-01228-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Reply to "Bacterial Proliferation May Be the Key Component of Sepsis Mortality".

    De Maio, Antonio

    Infection and immunity

    2018  Volume 86, Issue 11

    MeSH term(s) Animals ; Anti-Bacterial Agents ; Bacteria ; Cell Proliferation ; Models, Animal ; Sepsis
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00201-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Phosphatidylcholine Liposomes Reprogram Macrophages toward an Inflammatory Phenotype.

    Cauvi, David M / Hawisher, Dennis / Derunes, Julia / De Maio, Antonio

    Membranes

    2023  Volume 13, Issue 2

    Abstract: Phospholipids are the major components of cellular membranes and cell-derived vesicles such as exosomes. They are also key components of artificial lipid nanoparticles, allowing the encapsulation and transport of various biological or chemical cargos. ... ...

    Abstract Phospholipids are the major components of cellular membranes and cell-derived vesicles such as exosomes. They are also key components of artificial lipid nanoparticles, allowing the encapsulation and transport of various biological or chemical cargos. Both artificial and natural vesicles could be captured by cells delivering important information that could modulate cellular functions. However, the potential contribution of phospholipids within vesicles altering cellular physiology has been largely underestimated. Here, we showed that macrophages exposed to liposomes made exclusively with palmitoyl oleoyl phosphatidylcholine (POPC) in vivo resulted in a dramatic alteration of the transcriptome profile. Differential gene expression analysis indicated that the exposure to POPC liposomes resulted in a change in the expression of 1598 genes. Moreover, 146 genes were upregulated, and 69 genes were downregulated by incubation with POPC liposomes in contrast to palmitoyl oleoyl phosphatidylserine (POPS) exposure. Signaling pathway impact analysis revealed that 24 signaling pathways were significantly modulated after exposure to POPC liposomes, including the activation of the NF-κB pathway. Indeed, the expression of several cytokines (TNF-α, IL-6, and IL-10) and chemokines (Cxcl1 and Cxcl2) were increased. These observations were validated by the exposure of macrophages to POPC liposomes in culture conditions. In addition, the proteomic analysis of peritoneal cells exposed to POPC liposomes performed by mass spectrometry revealed that the expression of 107 proteins was downregulated after POPC exposure, whereas the expression of 12 proteins was significantly upregulated by this treatment, including seven proteins involved in the neutrophil degranulation pathway. This observation was confirmed by flow cytometry analysis showing the rapid recruitment of neutrophils into the peritoneal cavity after POPC exposure. Overall, these findings demonstrate that the presence of phospholipids within artificial and natural vesicles could be responsible for changes in the function of target cells.
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13020141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Power-Aperture Resource Allocation for a MPAR with Communications Capabilities

    Aubry, Augusto / De Maio, Antonio / Pallotta, Luca

    2023  

    Abstract: Multifunction phased array radars (MPARs) exploit the intrinsic flexibility of their active electronically steered array (ESA) to perform, at the same time, a multitude of operations, such as search, tracking, fire control, classification, and ... ...

    Abstract Multifunction phased array radars (MPARs) exploit the intrinsic flexibility of their active electronically steered array (ESA) to perform, at the same time, a multitude of operations, such as search, tracking, fire control, classification, and communications. This paper aims at addressing the MPAR resource allocation so as to satisfy the quality of service (QoS) demanded by both line of sight (LOS) and reflective intelligent surfaces (RIS)-aided non line of sight (NLOS) search operations along with communications tasks. To this end, the ranges at which the cumulative detection probability and the channel capacity per bandwidth reach a desired value are introduced as task quality metrics for the search and communication functions, respectively. Then, to quantify the satisfaction level of each task, for each of them a bespoke utility function is defined to map the associated quality metric into the corresponding perceived utility. Hence, assigning different priority weights to each task, the resource allocation problem, in terms of radar power aperture (PAP) specification, is formulated as a constrained optimization problem whose solution optimizes the global radar QoS. Several simulations are conducted in scenarios of practical interest to prove the effectiveness of the approach.

    Comment: 14 pages, 16 figures
    Keywords Electrical Engineering and Systems Science - Signal Processing
    Subject code 600
    Publishing date 2023-07-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Profiling the Gastrointestinal Microbiota.

    Posteraro, Brunella / De Maio, Flavio / Gasbarrini, Antonio

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2283, Page(s) 83–92

    Abstract: In this chapter, we provide a methodological description of the process to perform gastrointestinal (GIT) microbiota profiling on human stool samples. The process includes: (i) collection of feces, (ii) isolation of DNA from fecal community bacteria, ( ... ...

    Abstract In this chapter, we provide a methodological description of the process to perform gastrointestinal (GIT) microbiota profiling on human stool samples. The process includes: (i) collection of feces, (ii) isolation of DNA from fecal community bacteria, (iii) selection of both 16S rDNA sequencing target and next-generation sequencing platform, and (iv) analysis and interpretation of sequence data. The process culminates into a comprehensive report on the GIT microbiota composition and structure that may translate into clinically actionable results.
    MeSH term(s) Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; DNA, Bacterial/genetics ; DNA, Ribosomal/genetics ; Feces/microbiology ; Gastrointestinal Microbiome ; High-Throughput Nucleotide Sequencing ; Humans ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA/methods
    Chemical Substances DNA, Bacterial ; DNA, Ribosomal ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1302-3_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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