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Article: COVID-19, adrenal gland, glucocorticoids, and adrenal insufficiency.

Akbas, Emin Murat / Akbas, Nergis

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

2021 Volume 165, Issue 1, Page(s) 1–7

Abstract: The current Coronavirus disease outbreak requires that physicians work in collaboration with other physicians especially in intensive care and emergency units. To fight against this new disease, whose pathogenesis, effects, and results have not been ... ...

Abstract	The current Coronavirus disease outbreak requires that physicians work in collaboration with other physicians especially in intensive care and emergency units. To fight against this new disease, whose pathogenesis, effects, and results have not been clearly demonstrated, especially in patients with the pre-existing chronic disease, requires special expertise and perspectives. Due to the need for dynamic glucocorticoid treatment at different stages of the disease in patients with adrenal insufficiency, the existence of reports indicating that "coronavirus disease 2019" also affects the adrenal reserve, and the use of glucocorticoids also in advanced stages in patients with Coronavirus disease require this issue to be emphasized with precision. Herein, treatment of the pre-existing adrenal insufficiency in patients with actual Coronavirus disease and the effects of the this critical disease on the adrenal gland have been reviewed.
MeSH term(s)	Adrenal Glands/metabolism ; Adrenal Insufficiency/complications ; Adrenal Insufficiency/drug therapy ; Adrenal Insufficiency/metabolism ; COVID-19/complications ; COVID-19/therapy ; Disease Management ; Disease Progression ; Glucocorticoids/therapeutic use ; Hormone Replacement Therapy/methods ; Hospitalization ; Humans ; Hydrocortisone/therapeutic use ; Inflammation ; SARS-CoV-2 ; Stress, Physiological
Chemical Substances	Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2021-02-04
Publishing country	Czech Republic
Document type	Journal Article ; Review
ZDB-ID	17196-7
ISSN	1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
ISSN (online)	1804-7521
ISSN	1213-8118 ; 0231-5599 ; 0862-481X
DOI	10.5507/bp.2021.011
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Zs.A 6675: Show issues

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Article ; Online: Effect of felodipine on indomethacin-induced gastric ulcers in rats.

Akbaş, Nergis / Süleyman, Bahadır / Mammadov, Renad / Gülaboğlu, Mine / Akbaş, Emin Murat / Süleyman, Halis

Experimental animals

2023 Volume 72, Issue 4, Page(s) 505–512

Abstract: Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory ... ...

Abstract	Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically in animals treated with felodipine (5 mg/kg) and famotidine in combination with indomethacin. The results were compared with those of the healthy control group and the group administered indomethacin alone. It was observed that felodipine suppressed the indomethacin-induced malondialdehyde increase (P<0.001); reduced the decrease in total glutathione amount (P<0.001), reduced the decrease superoxide dismutase (P<0.001), and catalase activities (P<0.001); and significantly inhibited ulcers (P<0.001) at the tested dose compared with indomethacin alone. Felodipine at a dose of 5 mg/kg reduced the indomethacin-induced decrease in cyclooxygenase-1 activity (P<0.001) but did not cause a significant reduction in the decrease in cyclooxygenase-2 activity. The antiulcer efficacy of felodipine was demonstrated in this experimental model. These data suggest that felodipine may be useful in the treatment of nonsteroidal anti-inflammatory drug-induced gastric injury.
MeSH term(s)	Rats ; Animals ; Indomethacin/adverse effects ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Famotidine/adverse effects ; Felodipine/adverse effects ; Rats, Wistar ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Antioxidants/pharmacology
Chemical Substances	Indomethacin (XXE1CET956) ; Famotidine (5QZO15J2Z8) ; Felodipine (OL961R6O2C) ; Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants
Language	English
Publishing date	2023-06-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.23-0052
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Zs.B 1653: Show issues

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Article ; Online: Ocular Findings Associated with Hypoparathyroidism.

Taşlı, Nurdan Gamze / Akbaş, Emin Murat

Ocular immunology and inflammation

2020 Volume 29, Issue 7-8, Page(s) 1287–1291

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Adult ; Anterior Chamber/pathology ; Calcium/blood ; Corneal Diseases/blood ; Corneal Diseases/diagnosis ; Female ; Humans ; Hypoparathyroidism/blood ; Hypoparathyroidism/diagnosis ; Male ; Middle Aged ; Nerve Fibers/pathology ; Parathyroid Hormone/blood ; Phosphorus/blood ; Retinal Diseases/blood ; Retinal Diseases/diagnosis ; Retinal Ganglion Cells/pathology ; Tomography, Optical Coherence ; Visual Acuity/physiology
Chemical Substances	Parathyroid Hormone ; Phosphorus (27YLU75U4W) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2020.1735451
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Zs.A 4004: Show issues

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Article ; Online: The relationship between serum free testosterone level and body composition in geriatric and non-geriatric male hemodialysis patients.

Kara, Ali Veysel / Doğan, Mehmet / Olmez, Hasan / Tunc, Yesim / Ozcicek, Fatih / Akbas, Emin Murat

Journal of nephrology

2023 Volume 36, Issue 7, Page(s) 2151–2154

MeSH term(s)	Humans ; Male ; Aged ; Renal Dialysis/adverse effects ; Testosterone ; Body Composition
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-06-11
Publishing country	Italy
Document type	Letter
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01673-1
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Zs.A 3369: Show issues

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Article ; Online: Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats.

Akbaş, Nergis / Akbaş, Emin Murat / Süleyman, Zeynep / Çiçek, Betül / Ağgül, Ahmet Gökhan / Mokhtare, Behzad / Süleyman, Halis

Cutaneous and ocular toxicology

2023 Volume 42, Issue 1, Page(s) 32–37

Abstract: Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been ... ...

Abstract	Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage. Materials and methods: Using a rat model, ATP 25 mg/kg was injected intraperitoneally in the ATP + Ribociclib (ATR) group ( Results: In the histopathological evaluation of the RCB group, dermal necrosis, degeneration in hair follicles, and pycnosis in keratinocytes were observed. Only mild degeneration was observed in the ATR group; the HC group had a normal histological appearance. The malondialdehyde (MDA) values were significantly higher and the superoxide dismutase (SOD), catalase (CAT), and total glutathione (tGSH) levels were significantly lower in the RCB group in comparison to the HC group ( Conclusion: ATP may be useful in the treatment of ribociclib-induced skin damage.
MeSH term(s)	Rats ; Animals ; Rats, Wistar ; Glutathione/metabolism ; Superoxide Dismutase ; Solvents ; Water
Chemical Substances	ribociclib (TK8ERE8P56) ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1) ; Solvents ; Water (059QF0KO0R)
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	605635-0
ISSN	1556-9535 ; 1556-9527 ; 0731-3829
ISSN (online)	1556-9535
ISSN	1556-9527 ; 0731-3829
DOI	10.1080/15569527.2023.2166524
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Zs.A 1782: Show issues

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Article ; Online: The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats.

Demirtas, Levent / Gürbüzel, Mehmet / Akbas, Emin Murat / Tahirler, Hilal / Karatas, Ozhan / Kemal Arslan, Yusuf

Chemistry & biodiversity

2023 Volume 20, Issue 2, Page(s) e202200704

Abstract: Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the ... ...

Abstract	Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups - (1) control group (C) administered interperitoneally with a single dose 0.9 % saline, (2) Cis group administered a single dose (7 mg/kg) of cisplatin, (3) Sun group administered 10 mg/kg sunitinib for seven days, and (4) Cis+Sun group administered 10 mg/kg sunitinib for seven days after a single dose (7 mg/kg) of cisplatin. After these applications, the rats were sacrificed, and blood and tissue samples were taken for biochemical and histopathological evaluations. Sunitinib did not show any effect on urea, creatine, and kidney IL1β and TGF-β3 expression levels when administered alone; it increased ALT, AST, and IL-38 levels. When sunitinib was given to the cisplatin-induced rats, it was observed that the increase in ALT, AST, and IL-38 levels increased more than the rats that was given only sunitinib. According to the data obtained, sunitinib does not cause a significant change in kidney tissue under both normal and stress conditions, while it creates stress in liver tissue. In addition, its toxicity in the liver becomes more certain as a result of its combination with cisplatin.
MeSH term(s)	Rats ; Animals ; Cisplatin/pharmacology ; Sunitinib/pharmacology ; Carcinoma, Renal Cell ; Kidney Neoplasms ; Antineoplastic Agents/pharmacology ; Oxidative Stress
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Sunitinib (V99T50803M) ; Antineoplastic Agents
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200704
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Article: The effects of sorafenib in healthy and cisplatin-treated rats.

Demirtas, Levent / Gürbüzel, Mehmet / Tahirler, Hilal / Akbas, Emin Murat / Karatas, Ozhan / Arslan, Yusuf Kemal

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2022 Volume 32, Issue 4, Page(s) 449–456

Abstract: Background: Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer.: Objectives: The literature on this agent is scarce. This study aimed to evaluate the effects of ... ...

Abstract	Background: Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer. Objectives: The literature on this agent is scarce. This study aimed to evaluate the effects of sorafenib when administered to both healthy and cisplatin-induced rats. Material and methods: The animals were divided into 4 groups: 1) control group that received 0.9% saline intraperitoneally (C); 2) group administered a single dose (7 mg/kg) of cisplatin (Cis); 3) a group administered 20 mg/kg of sorafenib for 7 days (Sor); 4) group administered 20 mg/kg of sorafenib followed by 7 mg/kg of cisplatin for 7 days (Cis+Sor). All animals were sacrificed 7 days after the completion of their treatment arm, and serum and tissue samples were taken. Results: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and interleukin 38 (IL-38) levels were increased in the Sor and Cis+Sor groups compared to the control group. When compared with the control group, serum urea, creatinine, kidney IL-1β, and tumor necrosis factor alpha (TNF-α) levels did not change in the Sor group. When compared to the Cis group, the levels of these parameters decreased in the Cis+Sor group. Conclusions: According to the data obtained, sorafenib caused liver toxicity when given to both healthy and cisplatin-induced rats. While sorafenib did not cause any significant changes in the kidneys when given to healthy rats, it had a healing effect in kidneys after stress induced by cisplatin.
MeSH term(s)	Rats ; Animals ; Cisplatin/pharmacology ; Sorafenib/metabolism ; Sorafenib/pharmacology ; Kidney/metabolism ; Antioxidants/pharmacology ; Liver Neoplasms/pathology ; Oxidative Stress
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Sorafenib (9ZOQ3TZI87) ; Antioxidants
Language	English
Publishing date	2022-11-21
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/155216
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Zs.A 6489: Show issues

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Article ; Online: Transrectal vacuum treatment for low colorectal anastomotic leaks.

Dasiran, Fatih / Akbas, Ahmet / Angin, Yavuz / Yildirim, Murat / Daldal, Emin / Dagmura, Hasan / Okan, Ismail / Basak, Mustafa

Annali italiani di chirurgia

2022 Volume 92, Page(s) 715–719

Abstract: Background: Anastomotic leakage after rectal resection is a major complication which increases the rates of morbidity and mortality. A small number of patients with generalised peritonitis need radical surgical treatments. Stable patients with local ... ...

Abstract	Background: Anastomotic leakage after rectal resection is a major complication which increases the rates of morbidity and mortality. A small number of patients with generalised peritonitis need radical surgical treatments. Stable patients with local peritonitis can be treated conservatively. The aim of this study is to evaluate the effects of transrectal vacuum treatment on the healing of low colorectal anastomotic leaks. Methods: Medical records of fourteen patients managed conservatively with transrectal vacuum treatment for anastomotic leakage after rectal resection between September 2015 and September 2018, were retrospectively reviewed. Anastomotic leakage was documented and evaluated with computerised tomography and rectosigmoidoscopy. Results: 10 of 14 patients had successful closure of the perianastomotic abscess cavity after a mean of 19 days of vacuum treatment. 2 patients in this group had stricture on the anastomotic site as a late complication which was successfully treated with repeated dilatations. 4 of 14 patients had eventually a permanent sigmoid colostomy. Conclusion: Our results suggest that transrectal vacuum treatment can be safely used to all stable patients without generalised peritonitis in the management of low colorectal anastomotic leakages. Key words: Anastomotic leakage, Rectosigmoidoscopy, Vacuum treatment, VAC.
MeSH term(s)	Anastomosis, Surgical/adverse effects ; Anastomotic Leak/surgery ; Colorectal Neoplasms/surgery ; Humans ; Rectal Neoplasms ; Retrospective Studies ; Vacuum
Language	English
Publishing date	2022-02-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article ; Online: The evaluation of Ramadan fasting experience of patients with gastric cancer who underwent curative resection

İsmail Okan / Hasan Dagmura / Emin Daldal / Murat Yıldırım / Yavuz Angın / Fatih Göğüş / Mehmet Fatih Daşıran / Ahmet Akbaş

Journal of Contemporary Medicine, Vol 11, Iss 3, Pp 639-

2021 Volume 373

Abstract: Objective: Patients who had curative treatment after a malignant disease frequently ask about their religious practices and especially Ramadan fasting. The aim of this study is to evaluate the survivors of gastric cancer patients whether they keep ... ...

Abstract	Objective: Patients who had curative treatment after a malignant disease frequently ask about their religious practices and especially Ramadan fasting. The aim of this study is to evaluate the survivors of gastric cancer patients whether they keep Ramadan fasting and the health conditions they experienced during the month of Ramadan. Materials and Methods: For this cross sectional observational study, first the files of patients who had gastrectomy due to malignancy between January 2011 and January 2018 in Gaziosmanpasa University Hospital were examined retrospectively. The surviving patients were scheduled for a meeting and a questionnaire was conducted in outpatient setting. Patients who were conceiving to fast in next Ramadan were invited for at least 2 visits again within one month before and one month after Ramadan. On their arrival, their weight was measured, laboratory test including albumin, haemoglobin, haematocrit, BUN and creatinine levels were obtained. Results: 11 (21%) of the 52 interviewed patients kept fasting in 2019 Ramadan. 5 of these patients were able to complete fasting (30 days) and 6 of them could partially (between 1-7 days). There was no weight loss in fasting patients after Ramadan (p> 0.05). In addition, no significant change was found in albumin, haemoglobin, haematocrit and creatinine values after Ramadan (p> 0.05). However increase in BUN level was statistically significant (p <0.05). Conclusion: Health professionals are likely to see fasting patients all over the world and they must be familiar with the physiological and psychological effects of fasting considering the spiritual and religious needs of the patients.
Keywords	fasting ; gastrectomy ; ramadan ; spirituality ; oruç ; gastrektomi ; ramazan ; maneviyat ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Rabia Yılmaz
Document type	Article ; Online
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Article ; Online: Metformin-Associated Lactic Acidosis Detected Days after Acute Gastroenteritis

Emin Murat Akbaş / Adem Güngör / Volkan Arslan

Turkish Journal of Endocrinology and Metabolism, Vol 19, Iss 4, Pp 139-

2015 Volume 141

Abstract: Metformin-associated lactic acidosis in a diabetic patient is a rare and severe complication. The severity of the condition is associated with the underlying disease. The diagnosis may be delayed due to its rarity and the fact that its symptoms and signs ...

Abstract	Metformin-associated lactic acidosis in a diabetic patient is a rare and severe complication. The severity of the condition is associated with the underlying disease. The diagnosis may be delayed due to its rarity and the fact that its symptoms and signs are frequently confused with other pathologies. In such cases, generally, the underlying renal disease helps to establish the diagnosis. In this paper, we present the case of lactic acidosis in a patient without a serious underlying disease who was using metformin, ramipril and spironolacton for diabetes and hypertension. The level of blood creatinine was found to be 1.4 mg/dL. It should be kept in mind that metformin can cause life-threatening lactic acidosis, especially in patients using renin-angiotensin-aldosterone system blockers, even without a serious deterioration in renal functions.
Keywords	Metformin ; lactic asidosis ; acut gastroenteritis ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	610
Publishing date	2015-12-01T00:00:00Z
Publisher	Galenos Yayincilik
Document type	Article ; Online
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