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  1. Book ; Online ; E-Book: Toxicological risk assessment and multi-system health impacts from exposure

    Tsatsakis, Aristidis M,

    2021  

    Author's details edited by Aristidis M. Tsatsakis
    Keywords Environmental toxicology
    Subject code 615.902
    Language English
    Size 1 online resource (686 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-85358-7 ; 0-323-85215-7 ; 978-0-323-85358-3 ; 978-0-323-85215-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; E-Book: GMOs and political stance

    Nawaz, Muhammad Amjad / Chung, Gyuhwa / Golokhvast, K. S. / Tsatsakis, Aristidis M.

    global GMO regulation, certification, labeling, and consumer preferences

    2023  

    Abstract: GMOS and Political Stance: Global GMO Regulation, Certification, Labeling, and Consumer Preferences provides a foundational-to-current challenges resource for those involved in developing and applying regulations to these important resources. Beginning ... ...

    Author's details edited by Muhammad Amjad Nawaz, Gyuhwa Chung, Kirill Sergeyevich Golokhvast, Aristidis M. Tsatsakis
    Abstract "GMOS and Political Stance: Global GMO Regulation, Certification, Labeling, and Consumer Preferences provides a foundational-to-current challenges resource for those involved in developing and applying regulations to these important resources. Beginning with basics of GMOs, the book first familiarizes the reader with the history, economic status, associated risks, global politics, and socio-economics of GMOs. From exploring the necessity of GMO regulations with the existing GMO technology as well as new gene editing technologies to discussion by GMO regulations experts from different continents and countries, readers will find the information necessary to understand the laws, rules, regulations and policies at domestic and international scale. A last chapter delivers an update and future look on gene-edited food and feed and discusses the possibilities on the future risk assessment, legislation and regulation of gene-edited products. GMOS and Political Stance provides a unique and applicable synchronization of all regulatory information on GMOs to facilitate effective and efficient regulatory development and adherence." -- Amazon
    Keywords Genetic engineering/Law and legislation ; Transgenic organisms/Law and legislation
    Subject code 660.65
    Language English
    Size 1 online resource (323 pages)
    Publisher Academic press
    Publishing place London, England ; San Diego, California ; Cambridge, Massachusetts
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-823904-2 ; 9780128239032 ; 978-0-12-823904-9 ; 0128239034
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Conference proceedings: Abstracts of the 45th Congress of the European Societies of Toxicology

    Tsatsakis, Aristidis M.

    Rhodes, Greece, 5th - 8th October 2008

    (Toxicology letters ; 180S)

    2008  

    Event/congress EUROTOX (45, 2008)
    Author's details guest ed. Aristidis M. Tsatsakis
    Series title Toxicology letters ; 180S
    Collection
    Language English
    Size VIII, S246 S.
    Publisher Elsevier
    Publishing place Shannon
    Publishing country Ireland
    Document type Book ; Conference proceedings
    HBZ-ID HT015678684
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1367 -180S- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: microRNAs: Potential biomarkers of toxicity: A special issue of the journal

    Sahu, Saura C / Tsatsakis, Aristidis

    Toxicology reports

    2020  Volume 7, Page(s) 198–199

    Language English
    Publishing date 2020-01-13
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2020.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Approaching reactive species in the frame of their clinical significance: A toxicological appraisal.

    Veskoukis, Aristidis S / Tsatsakis, Aristidis / Kouretas, Demetrios

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2020  Volume 138, Page(s) 111206

    Abstract: Redox biology and toxicology are interrelated fields that have produced valuable evidence regarding the role and clinical significance of reactive species. These issues are analyzed herein by presenting 6 arguments, as follows: Argument 1: There is no ... ...

    Abstract Redox biology and toxicology are interrelated fields that have produced valuable evidence regarding the role and clinical significance of reactive species. These issues are analyzed herein by presenting 6 arguments, as follows: Argument 1: There is no direct connection of redox-related pathologies with specific reactive species; Argument 2: The measurement of reactive species concentration is a major challenge due to their very short half lives; Argument 3: There is an interplay between reactive species generation and fundamental biological processes, such as energy metabolism; Argument 4: Reactive species exert beneficial biological action; Argument 5: Reactive species follow the hormesis phenomenon; Argument 6: Oxidative modifications of redox-related molecules are not necessarily interpreted as oxidative damage. We conclude that reactive species do not seem to exert clinical significance, which means that they lack a measurable cause-effect relation with chronic diseases. Unpredictable results could, nevertheless, arise through novel experimental setups applied in the field of toxicology. These are related to the real-life exposure scenario via the regimen of long-term low-dose (far below NOAEL) exposure to mixtures of xenobiotics and can potentially offer perspectives in order to investigate in depth whether or not reactive species can be introduced as clinically significant redox biomarkers.
    MeSH term(s) Chronic Disease ; Hormesis ; No-Observed-Adverse-Effect Level ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species ; Toxicity Tests ; Toxicological Phenomena
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2020.111206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 529: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Editorial: Recent advances in keratinocyte carcinomas: From molecular mechanisms to clinical perspectives.

    Caruntu, Constantin / Tsatsakis, Aristidis M / Tampa, Mircea / Georgescu, Simona-Roxana / Gonzalez, Salvador

    Frontiers in medicine

    2022  Volume 9, Page(s) 1078020

    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1078020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Erratum: [Corrigendum] CD271

    Stancioiu, Felician / Papadakis, Georgios Z / Lazopoulos, George / Spandidos, Demetrios A / Tsatsakis, Aristidis / Floroiu, Marius / Badiu, Corin

    Experimental and therapeutic medicine

    2023  Volume 26, Issue 6, Page(s) 544

    Abstract: This corrects the article DOI: 10.3892/etm.2020.8948.]. ...

    Abstract [This corrects the article DOI: 10.3892/etm.2020.8948.].
    Language English
    Publishing date 2023-10-06
    Publishing country Greece
    Document type Published Erratum
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2023.12243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Amphiphilic Poly-

    Kuskov, Andrey / Nikitovic, Dragana / Berdiaki, Aikaterini / Shtilman, Mikhail / Tsatsakis, Aristidis

    Pharmaceutics

    2022  Volume 14, Issue 5

    Abstract: Nanoparticles are increasingly utilized as drug delivery agents. Previously, we have developed a drug delivery system based on amphiphilic derivatives of poly-N-vinylpyrrolidone (PVP-OD4000) with excellent biocompatibility. In the current study, we ... ...

    Abstract Nanoparticles are increasingly utilized as drug delivery agents. Previously, we have developed a drug delivery system based on amphiphilic derivatives of poly-N-vinylpyrrolidone (PVP-OD4000) with excellent biocompatibility. In the current study, we assessed the pharmacokinetics, anti-inflammatory profile, and ulcerogenic potential of indomethacin (IMC)-loaded PVP-OD4000 nanoparticles compared to the free drug. Wistar male rats were utilized for a pharmacokinetics study and an anti-inflammatory study. Loaded IMC exhibited a slower elimination rate (p < 0.05) and a higher blood plasma concentration at 8 and 24 h after intraperitoneal injection compared with free IMC. In addition, decreased uptake of loaded IMC in the liver and kidney compared to free IMC (p < 0.05) was detected. Furthermore, PVP-OD4000 nanoparticles loaded with IMC showed an enhanced anti-inflammatory effect compared to free IMC (p < 0.05) in carrageenan-induced and complete Freund’s adjuvant-induced−(CFA) sub-chronic and chronic paw edema treatment (p < 0.01; p < 0.01). Notably, upon oral administration of loaded IMC, animals had a significantly lower ulcer score and Paul’s Index (3.9) compared to the free drug (p < 0.05). The obtained results suggest that IMC loaded to PVP nanoparticles exhibit superior anti-inflammatory activity in vivo and a safe gastrointestinal profile and pose a therapeutic alternative for the currently available NSAIDs’ administration.
    Language English
    Publishing date 2022-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14050925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Second Conference of the Romanian Society of Immuno-Dermatology, Bucharest, September 27-29, 2018.

    Boda, Daniel / Tsatsakis, Aristidis

    Experimental and therapeutic medicine

    2018  Volume 17, Issue 2, Page(s) 979–981

    Language English
    Publishing date 2018-12-06
    Publishing country Greece
    Document type Editorial
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2018.7067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQ

    Goumenou, Marina / Tsatsakis, Aristidis

    Toxicology reports

    2019  Volume 6, Page(s) 632–636

    Abstract: A hazard quotient (HQ) for a single chemical and the hazard index (HI) for a mixture of chemicals were first described as approaches for risk characterisation by the EPA. HQ is defined as the ratio of exposure to an appropriate reference dose such as the ...

    Abstract A hazard quotient (HQ) for a single chemical and the hazard index (HI) for a mixture of chemicals were first described as approaches for risk characterisation by the EPA. HQ is defined as the ratio of exposure to an appropriate reference dose such as the ADI. HI is the sum of the HQs of the chemicals in a mixture. HQ and HI have been used to characterise risk after various exposure scenarios. However, both approaches have a significant limitation in the way they are used. The accurate use of HQ or HI requires estimation of aggregate exposure, that is, exposure to a given chemical(s) from all possible relevant sources. In many studies, risk is assessed assuming exposure from a specific source such as, consumption of water or a specific food item, in which chemical(s) concentration(s) have been measured. In this case the classic HQ/HI approach can result in significant underestimation of risk. For this purpose, we developed an alternative approach, named as Source Related HQ (HQs) where HQ
    Language English
    Publishing date 2019-06-21
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2019.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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