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  1. Article: Initial use of subcutaneous plasma-derived C1 inhibitor in prophylaxis of acute attacks of hereditary angioedema in pregnant patients in Slovakia.

    Hrubišková, Katarína / Jeseňák, Miloš / Payer, Juraj

    Vnitrni lekarstvi

    2023  Volume 69, Issue 4, Page(s) 265–268

    Abstract: Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women ... ...

    Title translation Prvé použitie podkožného C1 inhibítora v profylaxii atakov hereditárneho angioedému u tehotných pacientok na Slovensku.
    Abstract Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women in reproductive age require specific management of the disease regarding both the course of the disease and treatment options. It is not only the treatment in female patients that is specific, but also the situations (pregnancy, breastfeeding). We present a case report of the initial use of a subcutaneous C1 inhibitor in the long-term prophylaxis of HAE attacks in two pregnant patients.
    MeSH term(s) Pregnancy ; Humans ; Female ; Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/prevention & control ; Subcutaneous Tissue ; Slovakia ; Angioedema
    Language English
    Publishing date 2023-06-09
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    DOI 10.36290/vnl.2023.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Definition of the immune parameters related to COVID-19 severity.

    Tincati, Camilla / de Vries, Rory / Jesenak, Milos / Marchetti, Giulia

    Frontiers in immunology

    2023  Volume 14, Page(s) 1204125

    MeSH term(s) Humans ; COVID-19/immunology
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1204125
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  3. Article ; Online: Managing T2-high severe asthma in HIV-infected patients.

    Terl, Milan / Jesenak, Milos

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 2, Page(s) 1041–1043

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Asthma/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans
    Chemical Substances Antibodies, Monoclonal, Humanized ; mepolizumab (90Z2UF0E52)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.11.015
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  4. Article: Identification of a novel

    Kolkova, Zuzana / Durdik, Peter / Holubekova, Veronika / Durdikova, Anna / Jesenak, Milos / Banovcin, Peter

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1339664

    Abstract: Background: The mutations in the : Methods: Two young brothers from a non-consanguineous Slovak family with diagnosed retinal dystrophy and recurrent respiratory infections were examined. Suspected PCD was diagnosed based on a PICADAR questionnaire, ... ...

    Abstract Background: The mutations in the
    Methods: Two young brothers from a non-consanguineous Slovak family with diagnosed retinal dystrophy and recurrent respiratory infections were examined. Suspected PCD was diagnosed based on a PICADAR questionnaire, nasal nitric oxide analysis, transmission electron microscopy, high-speed video microscopy analysis, and genetic testing.
    Results: We identified a novel frameshift
    Conclusion: The identified novel pathogenic mutation in the
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1339664
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  5. Article ; Online: Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection.

    Vojtková, Jarmila / Bánovčin, Peter / Ďurdíková, Anna / Nováková, Elena / Jeseňák, Miloš

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 5

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Child ; Humans ; Hyperglycemia/complications ; COVID-19/complications ; Child, Hospitalized ; Prognosis ; Hospitalization
    Language English
    Publishing date 2023-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59050944
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  6. Article ; Online: Blood eosinophils: In quest of a Holy Grail for personalized asthma treatment with biologicals.

    Jesenak, Milos / Diamant, Zuzana

    Allergy

    2020  Volume 75, Issue 6, Page(s) 1294–1297

    MeSH term(s) Asthma/drug therapy ; Biological Products/therapeutic use ; Eosinophils ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-03-31
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14253
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  7. Article ; Online: Adherence to application technique of inhaled corticosteroid in patients with asthma and COVID-19 improves outcomes.

    Tichopád, Aleš / Žigmond, Jan / Jeseňák, Miloš / Solovič, Ivan / Breciková, Katarína / Rybář, Marian / Rožánek, Martin / Sedlák, Vratislav

    BMJ open respiratory research

    2024  Volume 11, Issue 1

    Abstract: Background: Inhaled corticosteroids have been widely reported as a preventive measure against the development of severe forms of COVID-19 not only in patients with asthma.: Methods: In 654 Czech and Slovak patients with asthma who developed COVID-19, ...

    Abstract Background: Inhaled corticosteroids have been widely reported as a preventive measure against the development of severe forms of COVID-19 not only in patients with asthma.
    Methods: In 654 Czech and Slovak patients with asthma who developed COVID-19, we investigated whether the correct use of inhaler containing corticosteroids was associated with a less severe course of COVID-19 and whether this had an impact on the need for hospitalisation, measurable lung functions and quality of life (QoL).
    Results: Of the studied cohort 51.4% had moderate persistent, 29.9% mild persistent and 7.2% severe persistent asthma. We found a significant adverse effect of poor inhaler adherence on COVID-19 severity (p=0.049). We also observed a lower hospitalisation rate in patients adequately taking the inhaler with OR of 0.83. Vital capacity and forced expiratory lung volume deterioration caused by COVID-19 were significantly reversed, by approximately twofold to threefold, in individuals who inhaled correctly.
    Conclusion: Higher quality of inhalation technique of corticosteroids measured by adherence to an inhaled medication application technique (A-AppIT) score had a significant positive effect on reversal of the vital capacity and forced expiratory lung volume in 1 s worsening (p=0.027 and p<0.0001, respectively) due to COVID-19. Scoring higher in the A-AppIT was also associated with significantly improved QoL. All measured variables concordantly and without exception showed a positive improvement in response to better adherence. We suggest that corticosteroids provide protection against the worsening of lungs in patients with COVID-19 and that correct and easily assessable adherence to corticosteroids with appropriate inhalation technique play an important role in preventing severe form of COVID-19.
    MeSH term(s) Humans ; Quality of Life ; COVID-19 ; Asthma/drug therapy ; Adrenal Cortex Hormones ; Forced Expiratory Volume
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-001874
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  8. Article ; Online: Lung eosinophils-A novel "virus sink" that is defective in asthma?

    Jesenak, Milos / Schwarze, Jürgen

    Allergy

    2019  Volume 74, Issue 10, Page(s) 1832–1834

    MeSH term(s) Asthma/diagnosis ; Asthma/etiology ; Asthma/metabolism ; Biomarkers ; Disease Management ; Disease Susceptibility ; Eosinophils/immunology ; Eosinophils/metabolism ; Eosinophils/pathology ; Humans ; Lung/immunology ; Lung/metabolism ; Lung/pathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-06-02
    Publishing country Denmark
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13811
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  9. Article ; Online: Natural Products and Skin Diseases.

    Majtan, Juraj / Bucekova, Marcela / Jesenak, Milos

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 15

    Abstract: The skin is the largest multifunctional organ in the human body, serving as an excellent barrier against chemical and biological hazards [ ... ]. ...

    Abstract The skin is the largest multifunctional organ in the human body, serving as an excellent barrier against chemical and biological hazards [...].
    MeSH term(s) Biological Products/therapeutic use ; Humans ; Skin/metabolism ; Skin/pathology ; Skin Diseases/drug therapy ; Skin Diseases/metabolism ; Skin Diseases/pathology
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-07-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26154489
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  10. Article ; Online: Asthma in the era of COVID-19.

    Assaf, Sara / Stenberg, Henning / Jesenak, Milos / Tarasevych, Svitlana P / Hanania, Nicola A / Diamant, Zuzana

    Respiratory medicine

    2023  Volume 218, Page(s) 107373

    Abstract: Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/ ... ...

    Abstract Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptoms and signs consistent with post-COVID manifestations. Patients with asthma were initially thought to be at increased risk and severity for SARS-CoV-2 infection. However, accumulating evidence demonstrates that asthma endotypes/phenotypes and comorbidities influence the risk stratification in this population. Furthermore, initial concerns about the potentially increased risk of poor outcomes with asthma treatments such as inhaled corticosteroids and biologics have not been substantiated. In this review, we provide an update on COVID-19 and asthma, including risk of susceptibility, clinical manifestations and course in this population as well as discuss recommendations for management.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/complications ; SARS-CoV-2 ; Asthma/diagnosis ; Comorbidity ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107373
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