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  1. Article ; Online: COVID-19 : caractéristiques cliniques, biologiques et radiologiques chez l’adulte, la femme enceinte et l’enfant. Une mise au point au cœur de la pandémie.

    Plaçais, L / Richier, Q

    La Revue de medecine interne

    2020  Volume 41, Issue 5, Page(s) 308–318

    Abstract: The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, ...

    Title translation COVID-19: Clinical, biological and radiological characteristics in adults, infants and pregnant women. An up-to-date review at the heart of the pandemic.
    Abstract The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the beginning of this pandemic. We focus on clinical, biological and CT markers predictive of severity or mortality. Finally, we discuss the impact of SARS-CoV-2 infection in populations suspected to be at high risk of severe forms.
    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/mortality ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/mortality ; Pregnancy ; Radiography/methods ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language French
    Publishing date 2020-04-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2020.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19: caractéristiques cliniques, biologiques et radiologiques chez l’adulte, l’enfant et la femme enceinte. Une mise au point au cœur de la pandémie

    Plaçais, L / Richier, Q

    La Revue de Médecine Interne

    Abstract: Abstract The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major ... ...

    Abstract Abstract The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the beginning of this pandemic. We focus on clinical, biological and CT markers predictive of severity or mortality. Finally, we discuss the impact of SARS-CoV-2 infection in populations suspected to be at high risk of severe forms.
    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.revmed.2020.04.004
    Database COVID19

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  3. Article ; Online: Infection with SARS-CoV-2 : a viral or inflammatory disease ?

    Richier, Quentin / Plaçais, Léo

    La Revue du praticien

    2022  Volume 72, Issue 5, Page(s) 501–504

    Abstract: PATHOGENESIS OF SARS-COV-2 INFECTION COVID-19 follows a rather stereotyped and reproducible course. While the first events are mediated by direct viral toxicity, resolution of the infection relies on a finely tuned immune response. In patients with ... ...

    Title translation Pathogenèse de l'infection par le SARS-CoV-2.
    Abstract PATHOGENESIS OF SARS-COV-2 INFECTION COVID-19 follows a rather stereotyped and reproducible course. While the first events are mediated by direct viral toxicity, resolution of the infection relies on a finely tuned immune response. In patients with severe forms, defects of the initial immune response have been reported, including insufficient type 1 interferon production or signaling, attenuated or skewed adaptative immune response, sometimes due to viral immune escape properties. These defects induce an hyperinflammatory state featuring hypersecretion of pro-inflammatory cytokines, excessive recruitment of immune cells in the lungs and parenchymal lesions, responsible for COVID-19 acute respiratory distress syndrome. Thus, COVID-19 is successively a viral and an inflammatory disease. Clarifying the chronology of these viral and immunological mechanisms allows us to identify a therapeutic logic, which sometimes involves contradictory treatments.
    MeSH term(s) COVID-19 ; Cytokines/physiology ; Humans ; SARS-CoV-2
    Chemical Substances Cytokines
    Language French
    Publishing date 2022-07-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Purple Urine after Catheterization.

    Plaçais, Léo / Denier, Christian

    The New England journal of medicine

    2019  Volume 381, Issue 18, Page(s) e33

    MeSH term(s) Aged ; Color ; Female ; Humans ; Hydrogen-Ion Concentration ; Indican/metabolism ; Klebsiella pneumoniae/isolation & purification ; Klebsiella pneumoniae/metabolism ; Tryptophan/metabolism ; Urinary Catheterization ; Urine/chemistry ; Urine/microbiology
    Chemical Substances Tryptophan (8DUH1N11BX) ; Indican (N187WK1Y1J)
    Language English
    Publishing date 2019-10-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1905446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Spaced training activates Miro/Milton-dependent mitochondrial dynamics in neuronal axons to sustain long-term memory.

    Pavlowsky, Alice / Comyn, Typhaine / Minatchy, Julia / Geny, David / Bun, Philippe / Danglot, Lydia / Preat, Thomas / Plaçais, Pierre-Yves

    Current biology : CB

    2024  Volume 34, Issue 9, Page(s) 1904–1917.e6

    Abstract: Neurons have differential and fluctuating energy needs across distinct cellular compartments, shaped by brain electrochemical activity associated with cognition. In vitro studies show that mitochondria transport from soma to axons is key to maintaining ... ...

    Abstract Neurons have differential and fluctuating energy needs across distinct cellular compartments, shaped by brain electrochemical activity associated with cognition. In vitro studies show that mitochondria transport from soma to axons is key to maintaining neuronal energy homeostasis. Nevertheless, whether the spatial distribution of neuronal mitochondria is dynamically adjusted in vivo in an experience-dependent manner remains unknown. In Drosophila, associative long-term memory (LTM) formation is initiated by an early and persistent upregulation of mitochondrial pyruvate flux in the axonal compartment of neurons in the mushroom body (MB). Through behavior experiments, super-resolution analysis of mitochondria morphology in the neuronal soma and in vivo mitochondrial fluorescence recovery after photobleaching (FRAP) measurements in the axons, we show that LTM induction, contrary to shorter-lived memories, is sustained by the departure of some mitochondria from MB neuronal soma and increased mitochondrial dynamics in the axonal compartment. Accordingly, impairing mitochondrial dynamics abolished the increased pyruvate consumption, specifically after spaced training and in the MB axonal compartment, thereby preventing LTM formation. Our results thus promote reorganization of the mitochondrial network in neurons as an integral step in elaborating high-order cognitive processes.
    MeSH term(s) Animals ; Memory, Long-Term/physiology ; Mitochondrial Dynamics/physiology ; Axons/metabolism ; Axons/physiology ; Mushroom Bodies/physiology ; Mushroom Bodies/metabolism ; Drosophila melanogaster/physiology ; Mitochondria/metabolism ; Mitochondria/physiology ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Neurons/metabolism ; Neurons/physiology
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.03.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tocilizumab in Coronavirus Disease 2019: Give It Time!

    Richier, Quentin / Plaçais, Léo / Lacombe, Karine / Hermine, Olivier

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 12, Page(s) 2368–2369

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: COVID-19 : encore une place pour le tocilizumab ?

    Richier, Q / Plaçais, L / Lacombe, K / Hermine, O

    La Revue de medecine interne

    2020  Volume 42, Issue 2, Page(s) 73–78

    Title translation COVID-19: Still a place for tocilizumab?
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/epidemiology ; COVID-19/pathology ; Humans ; Interleukin-6/physiology ; Pandemics ; Randomized Controlled Trials as Topic/statistics & numerical data ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Severity of Illness Index ; Treatment Outcome ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; IL6 protein, human ; Interleukin-6 ; tocilizumab (I031V2H011)
    Language French
    Publishing date 2020-11-27
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2020.11.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19

    Plaçais, L. / Richier, Q.

    La Revue de Médecine Interne

    caractéristiques cliniques, biologiques et radiologiques chez l’adulte, la femme enceinte et l’enfant. Une mise au point au cœur de la pandémie

    2020  Volume 41, Issue 5, Page(s) 308–318

    Keywords Internal Medicine ; Gastroenterology ; covid19
    Language French
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2020.04.004
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: [COVID-19

    Plaçais, L. / Richier, Q.

    ISSN: 0248-8663 ; EISSN: 1768-3122 ; La Revue De Médecine Interne ; https://hal.sorbonne-universite.fr/hal-02611180 ; La Revue De Médecine Interne, Elsevier, 2020, 41 (5), pp.308-318. ⟨10.1016/j.revmed.2020.04.004⟩

    Clinical, biological and radiological characteristics in adults, infants and pregnant women. An up-to-date review at the heart of the pandemic]. ; COVID-19 : caractéristiques cliniques, biologiques et radiologiques chez l’adulte, la femme enceinte et l’enfant. Une mise au point au cœur de la pandémie

    2020  

    Abstract: ... charge au quotidien des patients atteints de COVID-19. Nous détaillons les premiers signes et l’évolution ... et scannographiques prédictifs de sévérité ou de mortalité. Enfin, nous discutons de l’impact de l ...

    Abstract International audience

    The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the beginning of this pandemic. We focus on clinical, biological and CT markers predictive of severity or mortality. Finally, we discuss the impact of SARS-CoV-2 infection in populations suspected to be at high risk of severe forms.

    La propagation du nouveau coronavirus SARS-CoV-2, découvert en Chine en janvier 2020, a mené à une pandémie dès mars 2020, obligeant chaque système de soins des pays touchés à une adaptation rapide. Pour mieux faire face à cette crise sanitaire majeure, qui a donné lieu à de nombreuses publications scientifiques, nous avons synthétisé les principales études cliniques originales afin de faciliter la prise en charge au quotidien des patients atteints de COVID-19. Nous détaillons les premiers signes et l’évolution de la maladie ainsi que les différentes formes cliniques, y compris extra-pulmonaires, telles qu’elles sont connues au début de cette pandémie. Nous insistons sur les marqueurs cliniques, biologiques et scannographiques prédictifs de sévérité ou de mortalité. Enfin, nous discutons de l’impact de l’infection par le SARS-CoV-2 dans les populations suspectes d’être à haut risque de formes sévères.
    Keywords Epidemiology ; Clinical ; SARS-CoV-2 ; Novel coronavirus ; COVID-19 ; Nouveau coronavirus ; Épidémiologie ; Clinique ; [SDV]Life Sciences [q-bio] ; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: COVID-19 : caractéristiques cliniques, biologiques et radiologiques chez l'adulte, la femme enceinte et l'enfant. Une mise au point au cœur de la pandémie./ [COVID-19: Clinical, biological and radiological characteristics in adults, infants and pregnant women. An up-to-date review at the heart of the pandemic]

    Plaçais, L / Richier, Q

    Rev Med Interne

    Abstract: The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, ...

    Abstract The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the beginning of this pandemic. We focus on clinical, biological and CT markers predictive of severity or mortality. Finally, we discuss the impact of SARS-CoV-2 infection in populations suspected to be at high risk of severe forms.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #72047
    Database COVID19

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