LIVIVO - Search results -

Search results

Result 1 - 10 of total 104

Search options

Article ; Online: Ecological predictors of mosquito population and arbovirus transmission synchrony estimates.

McMillan, Joseph R / Chaves, Luis Fernando / Armstrong, Philip M

2023 Volume 60, Issue 3, Page(s) 564–574

Abstract: Quantifying synchrony in species population fluctuations and determining its driving factors can inform multiple aspects of ecological and epidemiological research and policy decisions. We examined seasonal mosquito and arbovirus surveillance data ... ...

Abstract	Quantifying synchrony in species population fluctuations and determining its driving factors can inform multiple aspects of ecological and epidemiological research and policy decisions. We examined seasonal mosquito and arbovirus surveillance data collected in Connecticut, United States from 2001 to 2020 to quantify spatial relationships in 19 mosquito species and 7 arboviruses timeseries accounting for environmental factors such as climate and land cover characteristics. We determined that mosquito collections, on average, were significantly correlated up to 10 km though highly variable among the examined species. Few arboviruses displayed any synchrony and significant maximum correlated distances never exceeded 5 km. After accounting for distance, mixed effects models showed that mosquito or arbovirus identity explained more variance in synchrony estimates than climate or land cover factors. Correlated mosquito collections up to 10-20 km suggest that mosquito control operations for nuisance and disease vectors alike must expand treatment zones to regional scales for operations to have population-level impacts. Species identity matters as well, and some mosquito species will require much larger treatment zones than others. The much shorter correlated detection distances for arboviruses reinforce the notion that focal-level processes drive vector-borne pathogen transmission dynamics and risk of spillover into human populations.
MeSH term(s)	Animals ; Humans ; Arboviruses ; Arbovirus Infections ; Climate ; Mosquito Control ; Connecticut ; Mosquito Vectors ; Culicidae
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjad024
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 303: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: COVID-19-A theory of autoimmunity to ACE-2.

McMillan, Philip / Uhal, Bruce D

MOJ immunology

2020 Volume 7, Issue 1, Page(s) 17–19

Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Journal Article
ISSN	2373-4442
ISSN	2373-4442
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Electrochemotherapy vs radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies: A systematic review and narrative synthesis.

McMillan, Angus Torry / McElroy, Luke / O'Toole, Lorcan / Matteucci, Paolo / Totty, Joshua Philip

PloS one

2023 Volume 18, Issue 7, Page(s) e0288251

Abstract: Background: Electrochemotherapy has gained international traction and commendation in national guidelines as an effective tool in the management of cutaneous malignancies not amenable to surgical resection. Despite this, no level 5 evidence exists ... ...

Abstract	Background: Electrochemotherapy has gained international traction and commendation in national guidelines as an effective tool in the management of cutaneous malignancies not amenable to surgical resection. Despite this, no level 5 evidence exists comparing it to radiotherapy in the treatment of cutaneous malignancies. This systematic review aimed to examine the literature directly and indirectly comparing electrochemotherapy and radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies. Materials & methods: The protocol for this review was registered on the PROSPERO International Prospective Register of Systematic Reviews with the protocol ID CRD42021285415. Searches of MEDLINE, Embase, CINAHL, CENTRAL and ClinicalTrials.gov databases were undertaken from database inception to 28 December 2021. Studies in humans comparing treatment with electrochemotherapy to radiotherapy and reporting tumour response with a minimum four week follow-up were eligible. Risk of bias was assessed using the ROBINS-I tool. Results are provided as a narrative synthesis. Results: Two case series with a total of 92 patients were identified as relevant to this study. Both case series examined patients with cutaneous squamous cell carcinoma. One case series examined elderly patients with predominantly head/neck lesions. The other examined younger patients with predominantly limb lesions who had cutaneous squamous cell carcinoma directly attributable to a rare skin condition. Conclusion: There is little literature presenting comparative data for electrochemotherapy and radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases. Included studies were marred by serious risk of bias particularly due to confounding. The inherent bias and heterogeneity of the included studies precluded synthesis of a consolidated comparison of clinical outcomes between the two therapies. Further research is required in this domain in the form of clinical trials and observational studies to inform guidelines for electrochemotherapy treatment.
MeSH term(s)	Humans ; Aged ; Skin Neoplasms/drug therapy ; Skin Neoplasms/radiotherapy ; Skin Neoplasms/pathology ; Carcinoma, Squamous Cell/drug therapy ; Electrochemotherapy/methods
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Review ; Journal Article ; Systematic Review
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288251
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: COVID-19-A Theory of Autoimmunity Against ACE-2 Explained.

McMillan, Philip / Dexhiemer, Thomas / Neubig, Richard R / Uhal, Bruce D

Frontiers in immunology

2021 Volume 12, Page(s) 582166

Abstract: The COVID-19 pandemic caused by the coronavirus SARS-COV-2 has cost many lives worldwide. In dealing with affected patients, the physician is faced with a very unusual pattern of organ damage that is not easily explained on the basis of prior knowledge ... ...

Abstract	The COVID-19 pandemic caused by the coronavirus SARS-COV-2 has cost many lives worldwide. In dealing with affected patients, the physician is faced with a very unusual pattern of organ damage that is not easily explained on the basis of prior knowledge of viral-induced pathogenesis. It is established that the main receptor for viral entry into tissues is the protein angiotensin-converting enzyme-2 ["ACE-2", (1)]. In a recent publication (2), a theory of autoimmunity against ACE-2, and/or against the ACE-2/SARS-COV-2 spike protein complex or degradation products thereof, was proposed as a possible explanation for the unusual pattern of organ damage seen in COVID-19. In the light of more recent information, this manuscript expands on the earlier proposed theory and offers additional, testable hypotheses that could explain both the pattern and timeline of organ dysfunction most often observed in COVID-19.
MeSH term(s)	Angiotensin-Converting Enzyme 2/immunology ; Autoimmunity ; COVID-19/immunology ; Humans ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-03-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.582166
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Impacts of Lysinibacillus sphaericus on mosquito larval community composition and larval competition between Culex pipiens and Aedes albopictus.

McMillan, Joseph R / Olson, Michael M / Petruff, Tanya / Shepard, John J / Armstrong, Philip M

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18013

Abstract: Effectiveness of mosquito larvicide active ingredients (AI), such as Lysinibacillus sphaericus, varies between species, yet little is known regarding how differential effectiveness manifests in larval communities in applied settings. To examine how ... ...

Abstract	Effectiveness of mosquito larvicide active ingredients (AI), such as Lysinibacillus sphaericus, varies between species, yet little is known regarding how differential effectiveness manifests in larval communities in applied settings. To examine how differential effectiveness of L. sphaericus influences larval community dynamics, we performed two experiments. We performed a field experiment in which containers were seeded with a standardized nutrient treatment, mosquitoes colonized the containers, and then containers received one of three L. sphaericus applications. We then performed competition assays between Culex pipiens and Aedes albopictus in low nutrient environments using multiple interspecific ratios and the presence/absence of a low dose of L. sphaericus. Field results demonstrated elimination of Culex spp. from treated containers while container breeding Aedes spp. proliferated across all treatments. Lysinibacillus sphaericus did not influence competition between Cx. pipiens and Ae. albopictus, and the L. sphaericus application eliminated Cx. pipiens in all treatment replicates while survival of Ae. albopictus was similar between treated and untreated containers across interspecific ratios. Lysinibacillus sphaericus is an effective AI for control of Culex spp. However, different AIs should be utilized in habitats containing non-Culex genera while a mix of AIs should be utilized where coexistence of multiple genera is expected or confirmed.
MeSH term(s)	Animals ; Aedes ; Bacillus ; Culex ; Larva
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21939-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: COVID-19-A theory of autoimmunity to ACE-2

McMillan, Philip / Uhal, Bruce D.

MOJ immunology

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #642337
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.

Phillips, Jeffrey S / Adluru, Nagesh / Chung, Moo K / Radhakrishnan, Hamsanandini / Olm, Christopher A / Cook, Philip A / Gee, James C / Cousins, Katheryn A Q / Arezoumandan, Sanaz / Wolk, David A / McMillan, Corey T / Grossman, Murray / Irwin, David J

Frontiers in neuroscience

2024 Volume 18, Page(s) 1353306

Abstract: Introduction: Multimodal evidence indicates Alzheimer's disease (AD) is characterized by early white matter (WM) changes that precede overt cognitive impairment. WM changes have overwhelmingly been investigated in typical, amnestic mild cognitive ... ...

Abstract	Introduction: Multimodal evidence indicates Alzheimer's disease (AD) is characterized by early white matter (WM) changes that precede overt cognitive impairment. WM changes have overwhelmingly been investigated in typical, amnestic mild cognitive impairment and AD; fewer studies have addressed WM change in atypical, non-amnestic syndromes. We hypothesized each non-amnestic AD syndrome would exhibit WM differences from amnestic and other non-amnestic syndromes. Materials and methods: Participants included 45 cognitively normal (CN) individuals; 41 amnestic AD patients; and 67 patients with non-amnestic AD syndromes including logopenic-variant primary progressive aphasia (lvPPA, Results: Both amnestic and non-amnestic patients exhibited lower WM connection strength than CN participants in corpus callosum, cingulum, and inferior and superior longitudinal fasciculi. Overall, non-amnestic patients had more WM disease than amnestic patients. LvPPA patients had left-lateralized WM degeneration; PCA patients had reductions in connections to bilateral posterior parietal, occipital, and temporal areas. Topological analysis showed the non-amnestic but not the amnestic group had more connected components than controls, indicating persistently lower connectivity. Longer disease duration and cognitive impairment were associated with more connected components and fewer cycles in individuals' brain graphs. Discussion: We have previously reported syndromic differences in GM degeneration and tau accumulation between AD syndromes; here we find corresponding differences in WM tracts connecting syndrome-specific epicenters. Determining the reasons for selective WM degeneration in non-amnestic AD is a research priority that will require integration of knowledge from neuroimaging, biomarker, autopsy, and functional genetic studies. Furthermore, longitudinal studies to determine the chronology of WM vs. GM degeneration will be key to assessing evidence for WM-mediated tau spread.
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2024.1353306
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Redefining Medical Competencies for an Oral Medicine Specialty Training Curriculum Using a Modified Delphi Technique.

Atkin, Philip A / McMillan, Roddy

Journal of dental education

2019 Volume 83, Issue 12, Page(s) 1452–1456

Abstract: This article describes the development of medical competencies for oral medicine specialty training in the UK and Ireland by a collaborative working group using a modified Delphi technique. The current specialty training curriculum for oral medicine (OM) ...

Abstract	This article describes the development of medical competencies for oral medicine specialty training in the UK and Ireland by a collaborative working group using a modified Delphi technique. The current specialty training curriculum for oral medicine (OM) in the UK was developed by a working group including members of the British Society for Oral Medicine (BSOM) and members of the Specialty Advisory Committee for Additional Dental Specialties (SACADS) and adopted by the UK General Dental Council (GDC) in 2010. When the curriculum was developed, the entry requirements for specialty training in OM included undergraduate degrees in both dentistry and medicine. At the time of adoption, the requirement for a medical degree was removed. Medical competencies were assumed to have been delivered in medical undergraduate and postgraduate training. Accordingly, there was a need to define the medical competencies for OM specialty training to benefit trainees, trainers, and assessors. In 2018, a group comprising specialty trainers, recent former specialty trainees, and current specialty trainees in OM held face-to-face meetings in addition to email discussions and developed an updated curriculum document to better reflect the medical competencies required in specialty training. A collaborative modified Delphi approach was used to evaluate medical foundation competencies and to include only those that were considered relevant to OM specialty training. A list of relevant and achievable medical competencies was determined that has been approved by SACADS and will be incorporated into a revised OM curriculum from the UK GDC. The newly agreed-upon document for medical competencies in OM specialty training will serve as a reference for trainees, trainers, and assessors and reflects a successful use of a modified Delphi approach.
MeSH term(s)	Clinical Competence ; Curriculum ; Delphi Technique ; Ireland ; Oral Medicine ; Specialties, Dental
Language	English
Publishing date	2019-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	410579-5
ISSN	1930-7837 ; 0022-0337
ISSN (online)	1930-7837
ISSN	0022-0337
DOI	10.21815/JDE.019.137
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 428: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Patterns of mosquito and arbovirus community composition and ecological indexes of arboviral risk in the northeast United States.

McMillan, Joseph R / Armstrong, Philip M / Andreadis, Theodore G

PLoS neglected tropical diseases

2020 Volume 14, Issue 2, Page(s) e0008066

Abstract: Background: In the northeast United States (U.S.), mosquitoes transmit a number of arboviruses, including eastern equine encephalitis, Jamestown Canyon, and West Nile that pose an annual threat to human and animal health. Local transmission of each ... ...

Abstract	Background: In the northeast United States (U.S.), mosquitoes transmit a number of arboviruses, including eastern equine encephalitis, Jamestown Canyon, and West Nile that pose an annual threat to human and animal health. Local transmission of each arbovirus may be driven by the involvement of multiple mosquito species; however, the specificity of these vector-virus associations has not been fully quantified. Methodology: We used long-term surveillance data consistently collected over 18 years to evaluate mosquito and arbovirus community composition in the State of Connecticut (CT) based on land cover classifications and mosquito species-specific natural histories using community ecology approaches available in the R package VEGAN. We then used binomial-error generalized linear mixed effects models to quantify species-specific trends in arbovirus detections. Primary results: The composition of mosquito communities throughout CT varied more among sites than among years, with variation in mosquito community composition among sites explained mostly by a forested-to-developed-land-cover gradient. Arboviral communities varied equally among sites and years, and only developed and forested wetland land cover classifications were associated with the composition of arbovirus detections among sites. Overall, the avian host arboviruses, mainly West Nile and eastern equine encephalitis, displayed the most specific associations among mosquito species and sites, while in contrast, the mammalian host arboviruses (including Cache Valley, Jamestown Canyon, and Potosi) associated with a more diverse mix of mosquito species and were widely distributed throughout CT. Conclusions: We find that avian arboviruses act as vector specialists infecting a few key mosquito species that associate with discrete habitats, while mammalian arboviruses are largely vector generalists infecting a wide diversity of mosquito species and habitats in the region. These distinctions have important implications for the design and implementation of mosquito and arbovirus surveillance programs as well as mosquito control efforts.
MeSH term(s)	Animals ; Arboviruses/classification ; Arboviruses/physiology ; Connecticut ; Culicidae/virology ; Female ; Host-Pathogen Interactions ; Humans ; Mosquito Vectors/virology ; Retrospective Studies
Language	English
Publishing date	2020-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0008066
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Long-term cardiovascular risk prediction in the emergency department

Glen Philip Martin / Charles Reynard / Richard Body / Evangelos Kontopantelis / Brian McMillan / Anthony Heagerty / Anisa Jafar

BMJ Open, Vol 12, Iss

a mixed-methods study protocol

2022 Volume 4

Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED