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Article ; Online: Molecular evidence of sporadic Coxiella burnetii excretion in sheep milk, central Portugal.

Pires, Humberto / Santos-Silva, Sérgio / Cruz, Andreia V S / Cardoso, Luís / Lopes, Ana Patrícia / Pereira, Maria A / Nóbrega, Carmen / Mega, Ana Cristina / Santos, Carla / Cruz, Rita / Esteves, Fernando / Vala, Helena / Matos, Ana Cristina / Barradas, Patrícia F / Coelho, Ana Cláudia / Mesquita, João R

Veterinary research communications

2024

Abstract: Coxiella burnetii is the etiologic agent of Q fever, a worldwide zoonosis. Cattle, sheep and goats are considered the main reservoirs of the disease. Transmission to humans occurs mainly through the inhalation of infectious aerosols from milk, faeces, ... ...

Abstract	Coxiella burnetii is the etiologic agent of Q fever, a worldwide zoonosis. Cattle, sheep and goats are considered the main reservoirs of the disease. Transmission to humans occurs mainly through the inhalation of infectious aerosols from milk, faeces, urine, and birth products from infected ruminants. In this study, a 2-year longitudinal approach was performed to ascertain the excretion of C. burnetii in bulk tank milk samples of sheep from a mountain plateau in central Portugal, with sampling conducted during the years 2015 and 2016. From a total of 156 bulk tank milk samples tested by qPCR, only one showed to be positive for C. burnetii (1.28% [95%CI: 0.03-6.94]), from 2015, the first year of collection. Bidirectional sequencing and phylogenetic analysis of IS1111 transposase partial region confirmed the presence of C. burnetii DNA. The presence of C. burnetii in raw milk samples highlights the necessity for additional research to determine if raw milk is a potential source for human infection. Animal health surveillance and prevention measures against this zoonotic disease should be considered.
Language	English
Publishing date	2024-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-024-10389-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3453: Show issues

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Article ; Online: Evidence for the efficacy of anti-inflammatory plants used in Brazilian traditional medicine with ethnopharmacological relevance.

de Matos, Rafael C / Bitencourt, Ana F A / de Oliveira, Alexsandro D M / Prado, Vanessa R / Machado, Renes R / Scopel, Marina

Journal of ethnopharmacology

2024 Volume 329, Page(s) 118137

Abstract: Ethnopharmacological relevance: When exacerbated, inflammatory processes can culminate in physical and emotional disorders and, if not stopped, can be lethal. The high prevalence of inflammation has become a public health problem, and the need for new ... ...

Abstract	Ethnopharmacological relevance: When exacerbated, inflammatory processes can culminate in physical and emotional disorders and, if not stopped, can be lethal. The high prevalence of inflammation has become a public health problem, and the need for new drugs to treat this pathology is imminent. The use of medicinal plants has emerged as an alternative, and a survey of data that corroborates its application in inflammatory diseases is the starting point. Furthermore, Brazil harbors a megadiversity, and the traditional use of plants is relevant and needs to be preserved and carefully explored for the discovery of new medicines. Aim of the study: This review sought to survey the medicinal plants traditionally used in Brazil for the treatment of inflammatory processes and to perform, in an integrative way, a data survey of these species and analysis of their phytochemical, pharmacological, and molecular approaches. Materials and methods: Brazilian plants that are traditionally used for inflammation (ophthalmia, throat inflammation, orchitis, urinary tract inflammation, ear inflammation, and inflammation in general) are listed in the DATAPLAMT database. This database contains information on approximately 3400 native plants used by Brazilians, which were registered in specific documents produced until 1950. These inflammatory disorders were searched in scientific databases (PubMed/Medline, Scopus, Web of Science, Lilacs, Scielo, Virtual Health Library), with standardization of DECS/MESH descriptors for inflammation in English, Spanish, French, and Portuguese, without chronological limitations. For the inclusion criteria, all articles had to be of the evaluated plant species, without association of synthesized substances, and full articles free available in any of the four languages searched. Duplicated articles and those that were not freely available were excluded. Results: A total of 126 species were identified, culminating in 6181 articles in the search. After evaluation of the inclusion criteria, 172 articles representing 40 different species and 38 families were included in the study. Comparison of reproducibility in intra-species results became difficult because of the large number of extraction solvents tested and the wide diversity of evaluation models used. Although the number of in vitro and in vivo evaluations was high, only one clinical study was found (Abrus precatorius). In the phytochemical analyses, more than 225 compounds, mostly phenolic compounds, were identified. Conclusion: This review allowed the grouping of preclinical and clinical studies of several Brazilian species traditionally used for the treatment of many types of inflammation, corroborating new searches for their pharmacological properties as a way to aid public health. Furthermore, the large number of plants that have not yet been studied has encouraged new research to revive traditional knowledge.
Language	English
Publishing date	2024-04-02
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118137
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Zs.A 1494: Show issues

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Article ; Online: Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly.

Matias, Ana C / Matos, Joao / Dohmen, R Jürgen / Ramos, Paula C

Biomolecules

2022 Volume 13, Issue 1

Abstract: Whereas assembly of the 20S proteasome core particle (CP) in prokaryotes apparently occurs spontaneously, the efficiency of this process in eukaryotes relies on the dedicated assembly chaperones Ump1, Pba1-Pba2, and Pba3-Pba4. For mammals, it was ... ...

Abstract	Whereas assembly of the 20S proteasome core particle (CP) in prokaryotes apparently occurs spontaneously, the efficiency of this process in eukaryotes relies on the dedicated assembly chaperones Ump1, Pba1-Pba2, and Pba3-Pba4. For mammals, it was reported that CP assembly initiates with formation of a complete α-ring that functions as a template for β subunit incorporation. By contrast, we were not able to detect a ring composed only of a complete set of α subunits in
MeSH term(s)	Humans ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism
Chemical Substances	Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Saccharomyces cerevisiae Proteins ; Molecular Chaperones ; HSP70 Heat-Shock Proteins ; Pba1 protein, S cerevisiae ; Pba2 protein, S cerevisiae
Language	English
Publishing date	2022-12-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13010011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Impact of the COVID-19 Pandemic on Head and Neck Surgery Training: A Brazilian National Survey.

Leite, Ana Kober / Matos, Leandro Luongo / Cernea, Claudio R / Kowalski, Luiz Paulo

International archives of otorhinolaryngology

2021 Volume 25, Issue 3, Page(s) e339–e342

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2021-06-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0041-1730019
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Article ; Online: Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors.

Matos, Rita / Santos-Leite, Liliana / Cruz, Francisco / Charrua, Ana

Neurourology and urodynamics

2024 Volume 43, Issue 2, Page(s) 533–541

Abstract: Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain disorder with multiple phenotypes, one of which is associated with an overactive adrenergic system.: Objective: We investigated if the maternal deprivation model (MDM) ...

Abstract	Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain disorder with multiple phenotypes, one of which is associated with an overactive adrenergic system. Objective: We investigated if the maternal deprivation model (MDM) in female and male mice mimics IC/BPS phenotype and if the overstimulation of alpha 1A adrenoceptor (A1AAR) and the crosstalk with transient receptor potential vanilloid-1 (TRPV1) are involved in the generation of pain and bladder functional changes. Design, setting, and participants: C57BL/6 female and male mice were submitted to MDM. TRPV1 knockout (KO) mice were used to study TRPV1 involvement. Silodosin administration to MDM mice was used to study A1AAR involvement. Outcome measurements and statistical analysis: The primary outcome was chronic visceral pain measured by Von Frey filaments analysis (effect size: 3 for wild type, 3.9 for TRPV1 KO). Bladder changes were secondary outcome measurements. Unpaired T test, Mann-Whitney test, one-way analysis of variance followed by Newman-Keuls multiple comparisons test, and Kruskal-Wallis followed by Dunn's multiple comparisons test were used where appropriate. Results and limitations: MDM induces pain behavior in female and not in male mice. Bladder afferents seem sensitize as MDM also increase the number of small volume spots voided, the bladder reflex activity, and urothelial damage. These changes were similarly absent after A1AAR blockade with silodosin or by TRPV1 gene KO. The main limitation is the number/type of pain tests used. Conclusions: MDM induced in female mice is able to mimic IC/BPS phenotype, through mechanisms involving A1AAR and TRPV1. Therefore, the modulation of both receptors may represent a therapeutic approach to treat IC/BPS patients.
MeSH term(s)	Humans ; Adult ; Mice ; Male ; Female ; Animals ; Urinary Bladder ; Visceral Pain/etiology ; Mice, Inbred C57BL ; Cystitis, Interstitial ; Mice, Knockout ; TRPV Cation Channels/genetics
Chemical Substances	TRPV1 protein, human ; TRPV Cation Channels ; TRPV1 protein, mouse
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.25376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1828: Show issues

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Article: Ceftriaxone-Induced Encephalopathy in a Patient With Chronic Kidney Disease.

Martins, Ana Filipa / Dias, Mónica / Matos Sousa, Rita / Regadas, Maria João

Cureus

2024 Volume 16, Issue 2, Page(s) e54476

Abstract: Neurotoxicity is an acknowledged side effect of third and fourth-generation cephalosporins, but its occurrence with ceftriaxone is not widely recognized. This article presents a case involving a 56-year-old woman with multiple comorbidities who sought ... ...

Abstract	Neurotoxicity is an acknowledged side effect of third and fourth-generation cephalosporins, but its occurrence with ceftriaxone is not widely recognized. This article presents a case involving a 56-year-old woman with multiple comorbidities who sought medical attention after experiencing lipothymia. The initial diagnosis suggested a urinary tract infection with acute kidney failure, leading to the initiation of ceftriaxone and hemodialysis. Subsequently, the patient exhibited a progressive deterioration of her neurological state, characterized by agitation and chorea. Metabolic encephalopathy, seizure/nonconvulsive status epilepticus, and acute central nervous system lesions were considered primary differential diagnoses, all of which were subsequently ruled out through thorough investigations. Days later, a remarkable recovery of the patient's neurological state was observed. A retrospective analysis revealed a correlation between the improvement and the fourth day of antimicrobial suspension. Consequently, a presumptive diagnosis of ceftriaxone-induced encephalopathy was made. This unusual case underscores the importance of recognizing the potential for pharmacological encephalopathy, particularly with ceftriaxone, and emphasizes its reversibility upon discontinuation of the implicated drug. Clinicians should remain vigilant to this uncommon adverse effect, promoting timely intervention and improved patient outcomes.
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54476
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors.

Silva, Gabriela / Rodrigues, Ana F / Ferreira, Susana / Matos, Carolina / Eleutério, Rute P / Marques, Gonçalo / Kucheryava, Khrystyna / Lemos, Ana R / Sousa, Pedro M F / Castro, Rute / Barbas, Ana / Simão, Daniel / Alves, Paula M

Biomolecules

2023 Volume 13, Issue 3

Abstract: The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is associated with poor clinical prognosis. Hence, therapies targeting oncogenic JAG1 hold great potential for the treatment of certain tumors. Here, we report the ... ...

Abstract	The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is associated with poor clinical prognosis. Hence, therapies targeting oncogenic JAG1 hold great potential for the treatment of certain tumors. Here, we report the identification of specific anti-JAG1 single-chain variable fragments (scFvs), one of them endowing chimeric antigen receptor (CAR) T cells with cytotoxicity against JAG1-positive cells. Anti-JAG1 scFvs were identified from human phage display libraries, reformatted into full-length monoclonal antibodies (Abs), and produced in mammalian cells. The characterization of these Abs identified two specific anti-JAG1 Abs (J1.B5 and J1.F1) with nanomolar affinities. Cloning the respective scFv sequences in our second- and third-generation CAR backbones resulted in six anti-JAG1 CAR constructs, which were screened for JAG1-mediated T-cell activation in Jurkat T cells in coculture assays with JAG1-positive cell lines. Studies in primary T cells demonstrated that one CAR harboring the J1.B5 scFv significantly induced effective T-cell activation in the presence of JAG1-positive, but not in JAG1-knockout, cancer cells, and enabled specific killing of JAG1-positive cells. Thus, this new anti-JAG1 scFv represents a promising candidate for the development of cell therapies against JAG1-positive tumors.
MeSH term(s)	Animals ; Humans ; Immunotherapy, Adoptive/methods ; Ligands ; Cell Line, Tumor ; Jurkat Cells ; Single-Chain Antibodies/genetics ; Mammals/metabolism ; Jagged-1 Protein/genetics ; Jagged-1 Protein/metabolism
Chemical Substances	Ligands ; Single-Chain Antibodies ; JAG1 protein, human ; Jagged-1 Protein
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13030459
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The (Poly)phenol-Carbohydrate Combination for Diabetes: Where Do We Stand?

de Matos, Ana Marta / Menezes, Regina

Nutrients

2023 Volume 15, Issue 4

Abstract: The type 2 diabetes epidemic is real and hardly coming to an end in the upcoming years. The efforts of the scientific community to develop safer and more effective compounds for type 2 diabetes based on the structure of natural (poly)phenols are ... ...

Abstract	The type 2 diabetes epidemic is real and hardly coming to an end in the upcoming years. The efforts of the scientific community to develop safer and more effective compounds for type 2 diabetes based on the structure of natural (poly)phenols are remarkable and have indeed proven worthwhile after the introduction of gliflozins in clinical practice. However, low-quality reports on the antidiabetic potential of plant-derived lipophilic (poly)phenols continue to pile up in the literature. Many of these compounds continue to be published as promising functional nutrients and antidiabetic pharmaceutical leads without consideration of their Pan-Assay Interference Compounds (PAINS) profile. This evidence-based opinion article conveys the authors' perspectives on the natural (poly)phenol artillery as a valuable and reliable source of bioactive compounds for diabetes. Ultimately, in light of the already established membrane-perturbing behavior of lipophilic (poly)phenols, together with the multiple benefits that may come with the introduction of a
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Phenol ; Phenols/chemistry ; Hypoglycemic Agents/chemistry ; Carbohydrates
Chemical Substances	Phenol (339NCG44TV) ; Phenols ; Hypoglycemic Agents ; Carbohydrates
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15040996
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Article ; Online: Cultural probes for environmental education: Designing learning materials to engage children and teenagers with local biodiversity.

Matos, Sónia / Silva, Alexandra R / Sousa, Duarte / Picanço, Ana / R Amorim, Isabel / Ashby, Simone / Gabriel, Rosalina / Arroz, Ana Moura

PloS one

2022 Volume 17, Issue 2, Page(s) e0262853

Abstract: Direct contact with nature is paramount in deepening children's and teenagers' interest in biodiversity. Learning materials chosen to convey information and engage participants during outings in nature-rich environments are varied and can support rich ... ...

Abstract	Direct contact with nature is paramount in deepening children's and teenagers' interest in biodiversity. Learning materials chosen to convey information and engage participants during outings in nature-rich environments are varied and can support rich learning experiences. For this purpose, learning materials can be acquired "off-the-shelf" or developed for site-specific locations or projects. However, there is little guidance on potential techniques for those wishing to generate contextually relevant materials. With the view of responding to this challenge, we propose the cultural probes technique. We demonstrate that the technique, commonly used in qualitative research to generate novel insights in conversation with participants, can instigate innovative and thoughtful approaches to materials designed for children and teenagers to explore nature. We present a toolkit that draws on the literature on cultural probes, inquiry-based learning, and the value of sensory, emotional, and aesthetic experiences in environmental education for structuring interactions with participants. To test our approach, we applied a descriptive research design and mixed-methods approach for collecting questions from youths between the ages of 10 and 18, inspired by a nature walk and a set of exploratory tasks executed through the toolkit. Specifically, we tested our toolkit along a trail in the Nature Park of Terceira, situated in the Azores, a Portuguese volcanic archipelago in the North Atlantic. Here, we present and reflect on the data collected during one visit organized over two days with two groups of participants and one post-trail activity directed at both groups. Results demonstrate that the open-ended and playful nature of cultural probes offers a novel way to engage youths with nature-rich environments through questioning. This contribution further highlights the potential of cultural probes for instigating encounters that tap into the value of sensory, emotional, and aesthetic experience in nature, with positive outcomes for participants.
MeSH term(s)	Adolescent ; Biodiversity ; Child ; Culture ; Environment ; Female ; Humans ; Learning ; Male ; Problem-Based Learning
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0262853
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of Diluents and Storage Time on the Cryopreservation of Collared Peccary (

Santos, Romário P / Silva, Andréia M / Pereira, Ana G / Cavalcante, Yasmim C S / Matos, Yuri G / Bezerra, Gabriel S C / Dantas, Lilian L / Silva, Alexandre R

Animals : an open access journal from MDPI

2024 Volume 14, Issue 6

Abstract: We verified the possibility of cooling peccary semen for 4, 24, and 48 h before cryopreservation, using different dilution media (TRIS + egg yolk (20%) and PRIMXcell Ultra). Ten ejaculates were divided equally into six aliquots and then diluted. Two ... ...

Abstract	We verified the possibility of cooling peccary semen for 4, 24, and 48 h before cryopreservation, using different dilution media (TRIS + egg yolk (20%) and PRIMXcell Ultra). Ten ejaculates were divided equally into six aliquots and then diluted. Two aliquots were stored in a biological incubator (4 h), and the remaining aliquots were stored in a commercial container, the Botutainer
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14060934
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