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  1. Article: Metabolic dysfunction-associated steatotic liver disease: Emerging risk factors for adverse pregnancy outcomes.

    Karachaliou, Georgia Sofia / Suzuki, Ayako

    Clinical liver disease

    2024  Volume 23, Issue 1, Page(s) e0121

    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1097/CLD.0000000000000121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Baseline and seasonal trends of

    Kobayashi, Ayako / Higashi, Hideaki / Shimada, Tomoe / Suzuki, Satowa

    Infection prevention in practice

    2023  Volume 5, Issue 2, Page(s) 100272

    Abstract: Background: Outbreaks of : Aim: This study determined baseline values for : Method: A retrospective analysis of : Findings: Bacillus: Conclusions: The increased detection rate ... ...

    Abstract Background: Outbreaks of
    Aim: This study determined baseline values for
    Method: A retrospective analysis of
    Findings: Bacillus
    Conclusions: The increased detection rate of
    Language English
    Publishing date 2023-02-11
    Publishing country England
    Document type Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2023.100272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complete genome sequence of PETase type IIa-harboring

    Suzuki, Yukako / Fukazawa, Ayako / Sugawara, Koki / Galipon, Josephine / Arakawa, Kazuharu

    Microbiology resource announcements

    2023  Volume 12, Issue 12, Page(s) e0086823

    Abstract: Marinobacter ... ...

    Abstract Marinobacter nanhaiticus
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00868-23
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  4. Article ; Online: Inflammatory Myofibroblastic Tumor of the Anus: A Case Report.

    Takayama, Tetsuyoshi / Nakame, Ayako / Suzuki, Masaomi / Asano, Hiroshi / Jin, Ling

    Journal of the anus, rectum and colon

    2024  Volume 8, Issue 1, Page(s) 39–42

    Abstract: Inflammatory myofibroblastic tumors (IMTs) are neoplastic lesions characterized by the proliferation of spindle cells with myofibroblastic features and lymphocyte infiltration. Primary lesions can develop in several locations but rarely arise in the ... ...

    Abstract Inflammatory myofibroblastic tumors (IMTs) are neoplastic lesions characterized by the proliferation of spindle cells with myofibroblastic features and lymphocyte infiltration. Primary lesions can develop in several locations but rarely arise in the colon as described herein. The present case was that of a 69-year-old woman who visited our hospital with complaints of bloody bowel discharge and a prolapsed mass from the anus. A 20-mm tumor was identified on visual and digital examination. Lower gastrointestinal endoscopy revealed a pedunculated, elevated lesion above the dentate line, which showed contrast enhancement on abdominal computed tomography. The patient was preoperatively diagnosed with an anal polyp, which was resected transanally. During the procedure, a mobile tumor coated by anal epithelium was observed at the 11 o'clock position above the dentate line. Deeper parts of the tumor were contiguous with the internal anal sphincter (IAS) muscle. Suspecting a neoplastic lesion, we resected the mass
    Language English
    Publishing date 2024-01-25
    Publishing country Japan
    Document type Case Reports
    ISSN 2432-3853
    ISSN (online) 2432-3853
    DOI 10.23922/jarc.2022-043
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  5. Article ; Online: Self-controlled Case Series Study for Acute Kidney Injury after Starting Proton Pump Inhibitors or Potassium-Competitive Acid Blocker in Patients with Cancer Using a Large Claims Database.

    Suzuki, Kosuke / Watanabe, Ayako / Kiryu, Yoshihiro / Inoue, Eisuke / Momo, Kenji

    Biological & pharmaceutical bulletin

    2024  Volume 47, Issue 2, Page(s) 518–526

    Abstract: To investigate the risk of acute kidney injury (AKI) in patients with cancer following the initiation of proton pump inhibitors (PPIs) and potassium-competitive acid blocker (PCAB), considering sex and anti-cancer drug use. We conducted a self-controlled ...

    Abstract To investigate the risk of acute kidney injury (AKI) in patients with cancer following the initiation of proton pump inhibitors (PPIs) and potassium-competitive acid blocker (PCAB), considering sex and anti-cancer drug use. We conducted a self-controlled case-series study using the Japan Medical Data Center claims data from 12422 patients with cancer who were prescribed PPIs or PCAB between January 2017 and December 2019. Considering the timing of PPI or PCAB, control period (days -120 to -1), risk period 1 (days 0 to +30), and risk period 2 (days +31 to +365) were defined. To assess the incidence rate ratio (IRR) and 95% confidence interval (CI) as the risk ratio, we adjusted for anti-cancer drugs to assess the risk of AKI. Additionally, we also examined sex differences to identify the risk of AKI. AKI was observed in risk period 1 [2.05 (1.12-3.72), p = 0.0192], but a slight reduction was noted in risk period 2 [0.60 (0.36-1.00), p = 0.0481]. A sex-specific increase in the risk of AKI was observed only in males during risk period 1 [2.18 (1.10-4.32), p = 0.0260], with a reduction in risk period 2 [0.48 (0.26-0.89), p = 0.0200]. We identified an increased risk of AKI in patients with cancer starting PPIs or PCAB particularly in males within 30 d after PPI or PCAB initiation, emphasizing the need for vigilant monitoring and management of AKI in this patient population.
    MeSH term(s) Humans ; Male ; Female ; Proton Pump Inhibitors/adverse effects ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Incidence ; Neoplasms/drug therapy ; Neoplasms/complications ; Databases, Factual ; Risk Factors ; Retrospective Studies
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2024-02-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00676
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1474: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Transmission dynamics of varicella before, during and after the COVID-19 pandemic in Japan: a modelling study.

    Suzuki, Ayako / Nishiura, Hiroshi

    Mathematical biosciences and engineering : MBE

    2022  Volume 19, Issue 6, Page(s) 5998–6012

    Abstract: Public health and social measures (PHSMs) targeting the coronavirus disease 2019 (COVID-19) pandemic have potentially affected the epidemiological dynamics of endemic infectious diseases. In this study, we investigated the impact of PHSMs for COVID-19, ... ...

    Abstract Public health and social measures (PHSMs) targeting the coronavirus disease 2019 (COVID-19) pandemic have potentially affected the epidemiological dynamics of endemic infectious diseases. In this study, we investigated the impact of PHSMs for COVID-19, with a particular focus on varicella dynamics in Japan. We adopted the susceptible-infectious-recovered type of mathematical model to reconstruct the epidemiological dynamics of varicella from Jan. 2010 to Sep. 2021. We analyzed epidemiological and demographic data and estimated the within-year and multi-year component of the force of infection and the biases associated with reporting and ascertainment in three periods: pre-vaccination (Jan. 2010-Dec. 2014), pre-pandemic vaccination (Jan. 2015-Mar. 2020) and during the COVID-19 pandemic (Apr. 2020-Sep. 2021). By using the estimated parameter values, we reconstructed and predicted the varicella dynamics from 2010 to 2027. Although the varicella incidence dropped drastically during the COVID-19 pandemic, the change in susceptible dynamics was minimal; the number of susceptible individuals was almost stable. Our prediction showed that the risk of a major outbreak in the post-pandemic era may be relatively small. However, uncertainties, including age-related susceptibility and travel-related cases, exist and careful monitoring would be required to prepare for future varicella outbreaks.
    MeSH term(s) COVID-19/epidemiology ; Chickenpox/epidemiology ; Humans ; Japan/epidemiology ; Pandemics ; SARS-CoV-2 ; Travel ; Travel-Related Illness
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2022280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Reconstructing the transmission dynamics of varicella in Japan: an elevation of age at infection.

    Suzuki, Ayako / Nishiura, Hiroshi

    PeerJ

    2022  Volume 10, Page(s) e12767

    Abstract: Background: In Japan, routine two-dose immunization against varicella has been conducted among children at ages of 12 and 36 months since 2014, and the vaccination coverage has reached around 90%. To understand the impact of routine varicella ... ...

    Abstract Background: In Japan, routine two-dose immunization against varicella has been conducted among children at ages of 12 and 36 months since 2014, and the vaccination coverage has reached around 90%. To understand the impact of routine varicella vaccination, we reconstructed the epidemiological dynamics of varicella in Japan.
    Methods: Epidemiological and demographic datasets over the past three decades were analyzed to reconstruct the number of susceptible individuals by age and year. To estimate the annual risk of varicella infection, we fitted a balance equation model to the annual number of cases from 1990 to 2019. Using parameter estimates, we reconstructed varicella dynamics starting from 1990 and modeled future dynamics until 2033.
    Results: Overall varicella incidence declined over time and the annual risk of infection among children younger than 10 years old decreased monotonically starting in 2014. Conversely, varicella incidence among teenagers (age 10 to 14 years) has increased each year since 2014. A substantial number of unvaccinated individuals born before the routine immunization era remained susceptible and aged without contracting varicella, while the annual risk of infection among teenagers aged 10 to 14 years increased starting in 2011 despite gradual expansion of varicella vaccine coverage. The number of susceptible individuals decreased over time in all age groups. Modeling indicated that susceptibility rates among pre-school children aged 1 to 4 years will remain low.
    Conclusion: Routine varicella vaccination has successfully reduced infections in pre-school and early primary school age children, but has also resulted in increased infection rates among adolescents. This temporary increase was caused both by the increased age of susceptible individuals and increased transmission risk among adolescents resulting from the dynamic nature of varicella transmission. Monitoring susceptibility among adolescents will be important to prevent outbreaks over the next decade.
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.12767
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  8. Article ; Online: Seasonal transmission dynamics of varicella in Japan: The role of temperature and school holidays.

    Suzuki, Ayako / Nishiura, Hiroshi

    Mathematical biosciences and engineering : MBE

    2022  Volume 20, Issue 2, Page(s) 4069–4081

    Abstract: In Japan, major and minor bimodal seasonal patterns of varicella have been observed. To investigate the underlying mechanisms of seasonality, we evaluated the effects of the school term and temperature on the incidence of varicella in Japan. We analyzed ... ...

    Abstract In Japan, major and minor bimodal seasonal patterns of varicella have been observed. To investigate the underlying mechanisms of seasonality, we evaluated the effects of the school term and temperature on the incidence of varicella in Japan. We analyzed epidemiological, demographic and climate datasets of seven prefectures in Japan. We fitted a generalized linear model to the number of varicella notifications from 2000 to 2009 and quantified the transmission rates as well as the force of infection, by prefecture. To evaluate the effect of annual variation in temperature on the rate of transmission, we assumed a threshold temperature value. In northern Japan, which has large annual temperature variations, a bimodal pattern in the epidemic curve was observed, reflecting the large deviation in average weekly temperature from the threshold value. This bimodal pattern was diminished with southward prefectures, gradually shifting to a unimodal pattern in the epidemic curve, with little temperature deviation from the threshold. The transmission rate and force of infection, considering the school term and temperature deviation from the threshold, exhibited similar seasonal patterns, with a bimodal pattern in the north and a unimodal pattern in the south. Our findings suggest the existence of preferable temperatures for varicella transmission and an interactive effect of the school term and temperature. Investigating the potential impact of temperature elevation that could reshape the epidemic pattern of varicella to become unimodal, even in the northern part of Japan, is required.
    MeSH term(s) Seasons ; Chickenpox/epidemiology ; Chickenpox/transmission ; Humans ; Japan/epidemiology ; Temperature ; Schools/statistics & numerical data ; Holidays/statistics & numerical data
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reconstructing the transmission dynamics of varicella in Japan

    Ayako Suzuki / Hiroshi Nishiura

    PeerJ, Vol 10, p e

    an elevation of age at infection

    2022  Volume 12767

    Abstract: Background In Japan, routine two-dose immunization against varicella has been conducted among children at ages of 12 and 36 months since 2014, and the vaccination coverage has reached around 90%. To understand the impact of routine varicella vaccination, ...

    Abstract Background In Japan, routine two-dose immunization against varicella has been conducted among children at ages of 12 and 36 months since 2014, and the vaccination coverage has reached around 90%. To understand the impact of routine varicella vaccination, we reconstructed the epidemiological dynamics of varicella in Japan. Methods Epidemiological and demographic datasets over the past three decades were analyzed to reconstruct the number of susceptible individuals by age and year. To estimate the annual risk of varicella infection, we fitted a balance equation model to the annual number of cases from 1990 to 2019. Using parameter estimates, we reconstructed varicella dynamics starting from 1990 and modeled future dynamics until 2033. Results Overall varicella incidence declined over time and the annual risk of infection among children younger than 10 years old decreased monotonically starting in 2014. Conversely, varicella incidence among teenagers (age 10 to 14 years) has increased each year since 2014. A substantial number of unvaccinated individuals born before the routine immunization era remained susceptible and aged without contracting varicella, while the annual risk of infection among teenagers aged 10 to 14 years increased starting in 2011 despite gradual expansion of varicella vaccine coverage. The number of susceptible individuals decreased over time in all age groups. Modeling indicated that susceptibility rates among pre-school children aged 1 to 4 years will remain low. Conclusion Routine varicella vaccination has successfully reduced infections in pre-school and early primary school age children, but has also resulted in increased infection rates among adolescents. This temporary increase was caused both by the increased age of susceptible individuals and increased transmission risk among adolescents resulting from the dynamic nature of varicella transmission. Monitoring susceptibility among adolescents will be important to prevent outbreaks over the next decade.
    Keywords Chickenpox ; Childhood immunization ; Epidemiology ; Mathematical model ; Herd immunity ; Transmission dynamics ; Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Long-Read Whole-Genome Sequencing Using a Nanopore Sequencer and Detection of Structural Variants in Cancer Genomes.

    Haga, Yasuhiko / Sakamoto, Yoshitaka / Arai, Miyuki / Suzuki, Yutaka / Suzuki, Ayako

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2632, Page(s) 177–189

    Abstract: Long-read sequencing technologies enable us to precisely identify structural variants (SVs), which would be occasionally associated with various types of diseases, including cancers. In this section, we introduce experimental and computational procedures ...

    Abstract Long-read sequencing technologies enable us to precisely identify structural variants (SVs), which would be occasionally associated with various types of diseases, including cancers. In this section, we introduce experimental and computational procedures for conducting long-read whole-genome sequencing (WGS) of cancer genomes from fresh frozen tissues/cells. We also demonstrate the analysis of SVs in cancer genomes using long-read WGS data from lung cancer cell lines by several representative computational tools, such as cuteSV and Sniffles2, as examples.
    MeSH term(s) Nanopores ; Genome ; Whole Genome Sequencing/methods ; High-Throughput Nucleotide Sequencing/methods ; Sequence Analysis, DNA/methods ; Neoplasms/genetics
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2996-3_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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