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  1. Article ; Online: Drugs to Inhibit the NLRP3 Inflammasome: Not Always On Target.

    Mauro, Adolfo Gabriele / Bonaventura, Aldo / Abbate, Antonio

    Journal of cardiovascular pharmacology

    2019  Volume 74, Issue 3, Page(s) 225–227

    MeSH term(s) Animals ; Carthamus tinctorius ; Chalcone/analogs & derivatives ; Glucosides ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Rats
    Chemical Substances Glucosides ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; Chalcone (5S5A2Q39HX) ; carthamine (P9ZT730WWS)
    Language English
    Publishing date 2019-08-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000000729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1471: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: COVID-19 Attacks the Kidney: Ultrastructural Evidence for the Presence of Virus in the Glomerular Epithelium.

    Abbate, Mauro / Rottoli, Daniela / Gianatti, Andrea

    Nephron

    2020  Volume 144, Issue 7, Page(s) 341–342

    MeSH term(s) Aged, 80 and over ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/virology ; Female ; Humans ; Kidney Glomerulus/ultrastructure ; Kidney Glomerulus/virology ; Microscopy, Electron, Transmission ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000508430
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: The segetal flora of Italy: an occurrence dataset from relevés in winter cereals and allied crop types.

    Fanfarillo, Emanuele / Latini, Marta / Iberite, Mauro / Abbate, Giovanna

    PhytoKeys

    2020  Volume 161, Page(s) 107–118

    Abstract: The segetal flora of winter crops includes mostly native or archaeophyte annual species that are often strong specialists of their habitats. Threatened by the intensification of agriculture, segetal flora is particularly valuable from a perspective of ... ...

    Abstract The segetal flora of winter crops includes mostly native or archaeophyte annual species that are often strong specialists of their habitats. Threatened by the intensification of agriculture, segetal flora is particularly valuable from a perspective of biodiversity conservation and evolution. Moreover, it contributes to maintain biodiversity in agroecosystems and provides several ecosystem services. The dataset here described was set up to provide the first inventory of the segetal flora of Italian winter cereal crops and allied crop types, the latter including flax and autumn-sown legumes. It includes 24,676 georeferenced occurrence data deriving from 1,240 floristic and phytosociological relevés. The data were collected from the greater part of Italian territory, in a temporal range spanning from 1946 to 2018.
    Language English
    Publishing date 2020-10-02
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.161.53915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis.

    Cerullo, Domenico / Rottoli, Daniela / Corna, Daniela / Abbate, Mauro / Benigni, Ariela / Remuzzi, Giuseppe / Zoja, Carlamaria

    Cells

    2022  Volume 11, Issue 15

    Abstract: Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need for ... ...

    Abstract Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need for new therapeutic strategies. The activation of Mas receptor/Angiotensin-(1-7) axis exerted renoprotection in chronic kidney disease. Here, we investigated the effect of adding the lanthionine-stabilized cyclic form of angiotensin-1-7 [cAng-(1-7)] to cyclophosphamide in a rat model of ANCA-GN. At the onset of proteinuria, Wistar Kyoto rats with ANCA-GN received vehicle or a single bolus of cyclophosphamide, with or without daily cAng-(1-7). Treatment with cAng-(1-7) plus cyclophosphamide reduced proteinuria by 85% vs. vehicle, and by 60% vs. cyclophosphamide, and dramatically limited glomerular crescents to less than 10%. The addition of cAng-(1-7) to cyclophosphamide protected against glomerular inflammation and endothelial rarefaction and restored the normal distribution of parietal epithelial cells. Ultrastructural analysis revealed a preserved GBM, glomerular endothelium and podocyte structure, demonstrating that combination therapy provided an additional layer of renoprotection. This study demonstrates that adding cAng-(1-7) to a partially effective dose of cyclophosphamide arrests the progression of renal disease in rats with ANCA-GN, suggesting that cAng-(1-7) could be a novel clinical approach for sparing immunosuppressants.
    MeSH term(s) Angiotensin I ; Animals ; Antibodies, Antineutrophil Cytoplasmic ; Cyclophosphamide/pharmacology ; Cyclophosphamide/therapeutic use ; Glomerulonephritis/drug therapy ; Peptide Fragments ; Proteinuria/complications ; Rats ; Rats, Inbred WKY
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Peptide Fragments ; Cyclophosphamide (8N3DW7272P) ; Angiotensin I (9041-90-1) ; angiotensin I (1-7) (IJ3FUK8MOF)
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11152434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diet-Induced Obesity HFpEF Murine Models.

    Carbone, Salvatore / Mauro, Adolfo G / Toldo, Stefano / Abbate, Antonio

    JACC. Basic to translational science

    2018  Volume 3, Issue 1, Page(s) 157

    Language English
    Publishing date 2018-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2018.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.

    Narayan, Pratyush / Trikantzopoulos, Elefterios / Mezzaroma, Eleonora / Mauro, Adolfo G / Vohra, Habeebah / Abbate, Antonio / Toldo, Stefano

    Cytokine

    2022  Volume 151, Page(s) 155811

    Abstract: Background: Aging is associated with metabolic and structural changes causing heart failure with preserved ejection fraction (HFpEF). Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging-related inflammation.: Objective: We sought to ...

    Abstract Background: Aging is associated with metabolic and structural changes causing heart failure with preserved ejection fraction (HFpEF). Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging-related inflammation.
    Objective: We sought to determine whether IL-1 mediates aging-related changes in the heart, as seen in HFpEF.
    Methods: We studied age-matched young (4-month-old), middle-aged (14-month-old), and old (23-month-old) wild-type (WT) C57BL/6J and IL-1 receptor type I deficient (IL1RI-KO) male mice. Echocardiography was used to evaluate left ventricular (LV) dimensions and systolic/diastolic function, and a pressure transducer was used to measure the LV end-diastolic pressure. Picrosirius red stain was used to assess for myocardial interstitial fibrosis (MIF) at pathology.
    Results: WT and IL-1RIKO mice showed a normal cardiac phenotype at young age, without any differences between the two groups. With aging, the WT mice developed LV concentric hypertrophy (as measured by a significant increase in LV mass [+42%, P < 0.01] and relative wall thickness [+34%, P < 0.01]), whereas the aging IL-1RI-KO mice did not. With aging, the WT mice also developed diastolic dysfunction (as measured by a significant increase in isovolumetric relaxation time [+148%, P < 0.01] and a significantly higher LV end-diastolic pressure [+174%, P < 0.01]), whereas the aging IL1RI-KO did not. Aged WT mice showed a significant increase in MIF (+124%, P < 0.01) at cardiac pathology, whereas the aging IL-1RI-KO did not.
    Conclusions: Genetically-modified mice lacking the IL-1RI receptor, not responsive to IL-1, are protected from aging-related LV hypertrophy, fibrosis, and diastolic dysfunction. These data support a central role of IL-1 in the pathophysiology of aging-related HFpEF.
    MeSH term(s) Age Factors ; Aging ; Animals ; Cardiomyopathies/genetics ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Heart Failure/genetics ; Heart Failure/metabolism ; Heart Failure/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Interleukin-1 Type I/metabolism ; Stroke Volume/physiology ; Ventricular Dysfunction, Left/genetics ; Ventricular Dysfunction, Left/metabolism ; Ventricular Dysfunction, Left/pathology
    Chemical Substances IL1R1 protein, mouse ; Receptors, Interleukin-1 Type I
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2022.155811
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    Zs.A 2840: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: COVID-19 Attacks the Kidney

    Abbate, Mauro / Rottoli, Daniela / Gianatti, Andrea

    Nephron

    Ultrastructural Evidence for the Presence of Virus in the Glomerular Epithelium

    2020  Volume 144, Issue 7, Page(s) 341–342

    Keywords covid19
    Language English
    Publisher S. Karger AG
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 207121-6
    ISSN 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
    ISSN (online) 1423-0186 ; 2235-3186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000508430
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Long-Term Field Evaluation of Conventional vs. Micropropagated Plants of Chrysanthemum cinerariifolium

    Caterina Catalano / Angela Carra / Francesco Carimi / Antonio Motisi / Loredana Abbate / Mauro Sarno / Alessandra Carrubba

    Agronomy, Vol 12, Iss 2756, p

    2022  Volume 2756

    Abstract: Pyrethrum is a perennial herbaceous plant endemic to the eastern coast of the Adriatic Sea, and introduced in large areas of nearly all continents, where it is cultivated for the industrial extraction of pyrethrins. Pyrethrins are a group of six closely ... ...

    Abstract Pyrethrum is a perennial herbaceous plant endemic to the eastern coast of the Adriatic Sea, and introduced in large areas of nearly all continents, where it is cultivated for the industrial extraction of pyrethrins. Pyrethrins are a group of six closely related monoterpene esters, widely used as natural insecticides. The world production of natural pyrethrins is lower than the market demand, and a wider introduction of this crop within the Mediterranean agrosystems could be an appealing opportunity for farmers and manufacturers. The availability of adequate amounts of selected plant material to bring into cultivation is, however, one of the major issues. Therefore, the in vitro propagation of elite pyrethrum genotypes could be a suitable alternative to conventional propagation methods. In this paper, we present the results of a 9-year field comparison between pyrethrum plants coming from an in vitro propagation protocol and plants obtained by cutting from the same mother plants. Furthermore, since plantlets derived from in vitro regeneration may experience ploidy changes, we evaluated the stability of the ploidy level of pyrethrum-micropropagated plants by flow cytometry (FCM) analysis. FCM screening revealed no differences among the morphotypes and between them and the mother plant. Likewise, the field evaluation of plants gave no significant differences between flower yields in both groups. Hence, micropropagation was confirmed as an easy, efficient and reproducible method to obtain large quantities of selected pyrethrum genotypes.
    Keywords establishment in field ; ex vitro acclimatization ; flow cytometry ; micropropagation ; natural insecticides ; Agriculture ; S
    Subject code 580
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis

    Domenico Cerullo / Daniela Rottoli / Daniela Corna / Mauro Abbate / Ariela Benigni / Giuseppe Remuzzi / Carlamaria Zoja

    Cells, Vol 11, Iss 2434, p

    2022  Volume 2434

    Abstract: Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need for ... ...

    Abstract Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need for new therapeutic strategies. The activation of Mas receptor/Angiotensin-(1-7) axis exerted renoprotection in chronic kidney disease. Here, we investigated the effect of adding the lanthionine-stabilized cyclic form of angiotensin-1-7 [cAng-(1-7)] to cyclophosphamide in a rat model of ANCA-GN. At the onset of proteinuria, Wistar Kyoto rats with ANCA-GN received vehicle or a single bolus of cyclophosphamide, with or without daily cAng-(1-7). Treatment with cAng-(1-7) plus cyclophosphamide reduced proteinuria by 85% vs. vehicle, and by 60% vs. cyclophosphamide, and dramatically limited glomerular crescents to less than 10%. The addition of cAng-(1-7) to cyclophosphamide protected against glomerular inflammation and endothelial rarefaction and restored the normal distribution of parietal epithelial cells. Ultrastructural analysis revealed a preserved GBM, glomerular endothelium and podocyte structure, demonstrating that combination therapy provided an additional layer of renoprotection. This study demonstrates that adding cAng-(1-7) to a partially effective dose of cyclophosphamide arrests the progression of renal disease in rats with ANCA-GN, suggesting that cAng-(1-7) could be a novel clinical approach for sparing immunosuppressants.
    Keywords crescentic glomerulonephritis ; myeloperoxidase ; anti-neutrophil cytoplasmic antibodies ; cyclophosphamide ; angiotensin-(1-7) ; glomerular crescents ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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