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  1. Article: Allicin inhibits the biological activities of cervical cancer cells by suppressing circEIF4G2.

    Yifan, Mao / Rui, Xu / Yuan, Li / Feiyun, Jiang

    Food science & nutrition

    2024  Volume 12, Issue 4, Page(s) 2523–2536

    Abstract: Allicin is a safe herbal extract believed to have antitumor effects, which, however, remain unclear. The aim of the present work was to discuss Allicin antitumor effects on cervical cancer using cell experiments. Using Hela and Siha to our research ... ...

    Abstract Allicin is a safe herbal extract believed to have antitumor effects, which, however, remain unclear. The aim of the present work was to discuss Allicin antitumor effects on cervical cancer using cell experiments. Using Hela and Siha to our research objectives in our study, first step, difference concentration of Allicin (20, 40, and 80 μM) treated Hela and Siha cell lines, and next step, discuss circEIF4G2 effects in Allicin antitumor effects in Hela and Siha cell lines; the cell proliferation and EdU-positive cell number by CCK-8 and EdU staining; cell apoptosis rate by flow cytometry; invasion cell number by transwell assay; wound healing rate by wound healing assay; and relative mRNA and protein levels using qRT-PCR and WB assay. With Allicin supplement, the cell proliferation and EdU-positive cell number were significantly depressed with cell apoptosis rate significantly increasing; invasion cell number and wound healing rate significantly suppressed with circEIF4G2 mRNA expression significantly down-regulation (
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3935
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  2. Article: First Report of

    Guo, Yifan / Jiang, Tong

    Plant disease

    2024  

    Abstract: Sugarcane mosaic virus (SCMV genus Potyvirus, family Potyviridae) can infect maize, sugarcane, sorghum, other graminaceous crops, and some weed species (Alegria et al., 2003; Achon et al., 2007). In August 2023, the leaves of goose grass (Eleusine indica) ...

    Abstract Sugarcane mosaic virus (SCMV genus Potyvirus, family Potyviridae) can infect maize, sugarcane, sorghum, other graminaceous crops, and some weed species (Alegria et al., 2003; Achon et al., 2007). In August 2023, the leaves of goose grass (Eleusine indica) plants surrounding maize fields in a village of Liaocheng City, Shandong Province, China showed mosaic and chlorotic symptoms (26%, 11 of 43 grasses; Figure S1). Three symptomatic goose grass samples were selected and pooled for total RNA isolation using TRIzol reagent (Tiangen, Beijing, China). A small RNA library was created using 2.0 μg of total RNA and the mirVana miRNA Isolation Kit, followed by size selection (18-28 nt), adapter ligation, purification, reverse transcription (RT), and polymerase chain reaction (PCR) enrichment. High-throughput sequencing (HTS) was then performed on a HiSeq 2500 platform (Illumina, San Diego, CA, USA). The adapter sequences were removed and the reads were assembled de novo into larger contigs using ABySS software v. 1.9.0 with a k-mer of 32. Fifty-one contigs were obtained after the reads were spliced and screened (alignment length > 30 bp; e-value ≤ 0.05). The contigs were compared with viral sequences in GenBank using local BLASTn. Thirty-four contigs (34-64 nt) had the highest identities (97.18-100%) with the SCMV genome sequence, covering approximately 12.8% of the SCMV genome (Table S1). The low coverage of small contigs mapping to the SCMV genome in the HTS results may be attributed to variations in sequencing depth and sample preparation quality, biological aspects of the virus affecting siRNA production and detection, as well as the variability in viral genome and its size (Golyaev et al., 2019; Valenzuela et al., 2022). The other 17 contigs did not align to any plant virus sequences, but aligned to plant sequences, including Phragmites australis and Panicum virgatum. Potyvirus-degenerated primers PotyF (5'-ATGGTHTGGTGYATHGARAAYGG-3') and PotyR (5'-TGCTGCKGCYTTCATYTG-3') (Marie-Jeanne et al. 2000) were used in RT-PCR to detect SCMV in symptomatic leaves, yielding a ~300 bp amplicon. Sanger sequencing and BLASTn analysis confirmed the 97.98% nucleotide identity with SCMV isolate BJ (GenBank accession No. AY042184.1). The sequence was deposited in GenBank under accession number OR777055. In addition, specific SCMV primers SCMV-F (5'- TCCGGAACTGTGGATGCA-3') and SCMV-R (5'- GTGGTGCTGCTGCACTCCC-3') (coat protein region, 939 bp) detected the virus in all 11 symptomatic goose grass leaves, with no detection in asymptomatic leaves. Inoculation tests using extracts from symptomatic goose grass on maize plants resulted in mosaic symptoms (7 of 15 plants) at 4-6 days post-inoculation (Figure S2 and 3). However, no symptoms were observed in maize plants following inoculation with leaf extracts from healthy goose grass. RT-PCR confirmed the presence of SCMV in the diseased maize plants. Sequencing analysis revealed that all amplified fragments shared 100% identity with the partial CP-encoding sequence of SCMV. Taken together these results support the presence of SCMV in symptomatic goose grass. To the best of our knowledge, this is the first report of SCMV in E. indica in China. In general, potyviruses can be easily transmitted in multiple ways including aphid vectors, grafting, and wounding. Therefore, investigating SCMV in goose grass is crucial for developing integrated strategies to prevent its transmission to economically important plants such as maize.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-11-23-2514-PDN
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  3. Article: Editorial: Electrocatalysis Towards Carbon-Neutral Future.

    Jiang, Qiu / Jiang, Kun / Ye, Yifan / Xi, Kai / Xia, Chuan

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1159716

    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1159716
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  4. Article ; Online: Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis.

    Zhang, Yifan / Jiang, Chengshi / Meng, Ning

    Mini reviews in medicinal chemistry

    2024  

    Abstract: Since ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and ... ...

    Abstract Since ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis. The primary mechanism is to affect the occurrence and development of atherosclerosis through intracellular iron homeostasis, ROS and lipid peroxide production and metabolism, and a variety of intracellular signaling pathways. Inhibition of ferroptosis is effective in inhibiting the development of atherosclerosis, and it can bring a new direction for treating atherosclerosis. In this review, we discuss the mechanism of ferroptosis and focus on the relationship between ferroptosis and atherosclerosis, summarize the different types of ferroptosis inhibitors that have been widely studied, and discuss some issues worthy of attention in the treatment of atherosclerosis by targeting ferroptosis.
    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/0113895575273164231130070920
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  5. Article ; Online: Driving carbon emission reduction in China through green finance and green innovation: an endogenous growth perspective.

    Li, Kunming / Lin, Weiyuan / Jiang, Tingjun / Mao, Yifan / Shi, Wenming

    Environmental science and pollution research international

    2024  Volume 31, Issue 9, Page(s) 14318–14332

    Abstract: Discovering drivers of carbon dioxide ( ... ...

    Abstract Discovering drivers of carbon dioxide (CO
    MeSH term(s) Carbon Dioxide ; China ; Cities ; Economic Development ; Government
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-01-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32067-w
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  6. Article ; Online: Inversed virtual water flow pattern and its influencing factors in Northwest China

    Shi Shen / Yifan Jiang / Changxiu Cheng

    Ecological Indicators, Vol 158, Iss , Pp 111340- (2024)

    1481  

    Abstract: Northwest China faces an imbalance between scarce water resources and increasing water use demands for agricultural production and economic growth. However, the shifts in virtual water flow (VWF) patterns in Northwest China and its the driving factors ... ...

    Abstract Northwest China faces an imbalance between scarce water resources and increasing water use demands for agricultural production and economic growth. However, the shifts in virtual water flow (VWF) patterns in Northwest China and its the driving factors are still unclear. In this study, we employed the Multiregional Input–Output (MRIO) method to investigate the evolution of VWF patterns among Northwest China’s primary, secondary, and tertiary industries and analyze their driving factors through Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model. The results show that (1) Northwest China changed from 7.24 × 108 m3 net inflow to 175.70 × 108 m3 net outflow from 2002 to 2007. (2) More than 90 % of virtual water of the primary industry was used locally, but both secondary and tertiary industries depended more on virtual water inflow in Northwest China. (3) The virtual water outflow from Northwest China is mostly to the Jing-Jin Region, followed by the Northern Coast, and the main inflow is from the Central Region. (4) Population, economy, and technology affect virtual water from inflow to outflow, and technological development helps to decrease virtual water flow volumes. In conclusion, dramatic decrease of second and third industries inflow is the main reason for the changes from net inflow to net outflow of Northwest China. Meanwhile, it is feasible to increase technological support to further reducing virtual water consumption in primary industry, and strengthen virtual water trades of secondary and tertiary industrial virtual water inflows by promoting population and economic conditions.
    Keywords Virtual water flow ; Northwest China ; Multiregional Input–Output (MRIO) model ; Stochastic Impacts by Regression on Population ; Affluence ; and Technology (STIRPAT) model ; Ecology ; QH540-549.5
    Subject code 950
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Revealing genomic heterogeneity and commonality: A penalized integrative analysis approach accounting for the adjacency structure of measurements.

    Wang, Xindi / Jiang, Yu / Sun, Yifan

    Genetic epidemiology

    2024  Volume 48, Issue 3, Page(s) 114–140

    Abstract: Advancements in high-throughput genomic technologies have revolutionized the field of disease biomarker identification by providing large-scale genomic data. There is an increasing focus on understanding the relationships among diverse patient groups ... ...

    Abstract Advancements in high-throughput genomic technologies have revolutionized the field of disease biomarker identification by providing large-scale genomic data. There is an increasing focus on understanding the relationships among diverse patient groups with distinct disease subtypes and characteristics. Complex diseases exhibit both heterogeneity and shared genomic factors, making it essential to investigate these patterns to accurately detect markers and comprehensively understand the diseases. Integrative analysis has emerged as a promising approach to address this challenge. However, existing studies have been limited by ignoring the adjacency structure of genomic measurements, such as single nucleotide polymorphisms (SNPs) and DNA methylations. In this study, we propose a structured integrative analysis method that incorporates a spline type penalty to accommodate this adjacency structure. We utilize a fused lasso type penalty to identify both heterogeneity and commonality across the groups. Extensive simulations demonstrate its superiority compared to several direct competing methods. The analysis of The Cancer Genome Atlas melanoma data with DNA methylation measurements and GENEVA diabetes data with SNP measurements exhibit that the proposed analysis lead to meaningful findings with better prediction performance and higher selection stability.
    MeSH term(s) Humans ; Models, Genetic ; Genomics/methods ; DNA Methylation/genetics
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605785-8
    ISSN 1098-2272 ; 0741-0395
    ISSN (online) 1098-2272
    ISSN 0741-0395
    DOI 10.1002/gepi.22549
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  8. Article ; Online: High-throughput photo-chemiluminescence imaging for HIV DNA determination based on a sulfur-doped graphitic carbonitride photocatalyst.

    Zhang, Huilan / Jiang, Yifan / Wang, Jian / Jiang, Zhou

    Analytical methods : advancing methods and applications

    2023  Volume 15, Issue 17, Page(s) 2114–2120

    Abstract: In this work, a novel photo-chemiluminescence (PCL) array imaging technique was developed to detect HIV DNA sequences using water-dispersed ultrathin sulfur-doped g- ... ...

    Abstract In this work, a novel photo-chemiluminescence (PCL) array imaging technique was developed to detect HIV DNA sequences using water-dispersed ultrathin sulfur-doped g-C
    MeSH term(s) Humans ; Luminescence ; DNA/chemistry ; Graphite/chemistry ; Sulfur/chemistry ; HIV Infections/diagnosis
    Chemical Substances DNA (9007-49-2) ; Graphite (7782-42-5) ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay00312d
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  9. Article ; Online: Efficient Photoreduction of CO

    Chen, Cheng / Wu, Mingge / Xu, Yifan / Ma, Chunyan / Song, Maoyong / Jiang, Guibin

    Journal of the American Chemical Society

    2024  Volume 146, Issue 13, Page(s) 9163–9171

    Abstract: It remains challenging to obtain a single product in the gas-solid photocatalytic reduction of ... ...

    Abstract It remains challenging to obtain a single product in the gas-solid photocatalytic reduction of CO
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14590
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  10. Article ; Online: Corrigendum to "Neuroprotective effect of Vesatolimod in an experimental autoimmune encephalomyelitis mice model" [Int. Immunopharmacol. 116 (2023) 109717].

    Jiang, Xian / Song, Yifan / Fang, Jie / Yang, Xiaosheng / Mu, Shuhua / Zhang, Jian

    International immunopharmacology

    2024  Volume 128, Page(s) 111448

    Language English
    Publishing date 2024-01-07
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.111448
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