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  1. Article ; Online: Correction to: Investigation of pesticide residues level on commonly consumed leafy vegetables picked from the central market in Jeddah, Saudi Arabia.

    Almutiriy, Rawan S / Alnajeebi, Afnan M / Elhalwagy, Manal E A / Thabet, Omar A / Alenzi, Fahad K / Aljadani, Mona M

    Environmental science and pollution research international

    2024  Volume 31, Issue 10, Page(s) 16109

    Language English
    Publishing date 2024-02-05
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32306-0
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  2. Article ; Online: Investigation of pesticide residues level on commonly consumed leafy vegetables picked from the central market in Jeddah, Saudi Arabia.

    Almutiriy, Rawan S / Alnajeebi, Afnan M / Elhalwagy, Manal E A / Thabet, Omar A / Alenzi, Fahad K / Aljadani, Mona M

    Environmental science and pollution research international

    2023  Volume 31, Issue 4, Page(s) 6232–6242

    Abstract: This study aimed to investigate the presence of pesticide residues in a variety of commonly consumed leafy vegetables, including Grape leaves, Lettuce, Arugula, Spinach, Purslane, Ocimum, Parsley, Jew's mallow, Celery, Coriander, and Mint. A total of 100 ...

    Abstract This study aimed to investigate the presence of pesticide residues in a variety of commonly consumed leafy vegetables, including Grape leaves, Lettuce, Arugula, Spinach, Purslane, Ocimum, Parsley, Jew's mallow, Celery, Coriander, and Mint. A total of 100 samples were collected from the Central Market of Jeddah, Kingdom of Saudi Arabia. Our methodology involved employing the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction method in combination with Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) to analyze a comprehensive database of 237 distinct pesticides. The range for limit of detection (LOD) and limit of quantification (LOQ) of the method were 0.0001 to 0.0014 mg. Kg
    MeSH term(s) Pesticide Residues/analysis ; Vegetables/chemistry ; Chromatography, Liquid/methods ; Saudi Arabia ; Methomyl/analysis ; Triallate/analysis ; Tandem Mass Spectrometry/methods ; Food Contamination/analysis ; Pesticides/analysis ; Strobilurins ; Pyrimidines
    Chemical Substances Pesticide Residues ; azoxystrobin (NYH7Y08IPM) ; Methomyl (1NQ08HN02S) ; Triallate (A9S097HS99) ; Pesticides ; Strobilurins ; Pyrimidines
    Language English
    Publishing date 2023-12-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-31694-z
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  3. Article ; Online: Environmental epigenetics: Exploring phenotypic plasticity and transgenerational adaptation in fish.

    Abdelnour, Sameh A / Naiel, Mohammed A E / Said, Mourad Ben / Alnajeebi, Afnan M / Nasr, Fahd A / Al-Doaiss, Amin A / Mahasneh, Zeinab M H / Noreldin, Ahmed E

    Environmental research

    2024  Volume 252, Issue Pt 1, Page(s) 118799

    Abstract: Epigenetics plays a vital role in the interaction between living organisms and their environment by regulating biological functions and phenotypic plasticity. Considering that most aquaculture activities take place in open or natural habitats that are ... ...

    Abstract Epigenetics plays a vital role in the interaction between living organisms and their environment by regulating biological functions and phenotypic plasticity. Considering that most aquaculture activities take place in open or natural habitats that are vulnerable to environmental changes. Promising findings from recent research conducted on various aquaculture species have provided preliminary evidence suggesting a link between epigenetic mechanisms and economically valuable characteristics. Environmental stressors, including climate changes (thermal stress, hypoxia, and water salinity), anthropogenic impacts such as (pesticides, crude oil pollution, nutritional impacts, and heavy metal) and abiotic factors (infectious diseases), can directly trigger epigenetic modifications in fish. While experiments have confirmed that many epigenetic alterations caused by environmental factors have plastic responses, some can be permanently integrated into the genome through genetic integration and promoting rapid transgenerational adaptation in fish. These environmental factors might cause irregular DNA methylation patterns in genes related to many biological events leading to organs dysfunction by inducing alterations in genes related to oxidative stress or apoptosis. Moreover, these environmental issues alter DNA/histone methylation leading to decreased reproductive competence. This review emphasizes the importance of understanding the effects of environmentally relevant issues on the epigenetic regulation of phenotypic variations in fish. The goal is to expand our knowledge of how epigenetics can either facilitate or hinder species' adaptation to these adverse conditions. Furthermore, this review outlines the areas that warrant further investigation in understanding epigenetic reactions to various environmental issues.
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118799
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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  4. Article ; Online: Blockade of L-Type Ca

    Al-Griw, Mohamed A / Alghazeer, Rabia / Ratemi, Haithm W / Ben-Othman, Mohamed E / Tabagah, Refaat / Shamlan, Ghalia / Habibullah, Mahmmoud M / Alnajeebi, Afnan M / Babteen, Nouf A / Eskandrani, Areej A / Al-Farga, Ammar / Alansari, Wafa S

    Current issues in molecular biology

    2023  Volume 45, Issue 5, Page(s) 3953–3964

    Abstract: A growing body of studies suggests that ... ...

    Abstract A growing body of studies suggests that Ca
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45050252
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    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: The prognostic value of microRNA-biogenesis genes

    Fawzy, Manal S / Toraih, Eman A / Alelwani, Walla / Kattan, Shahad W / Alnajeebi, Afnan M / Hassan, Ranya

    American journal of translational research

    2020  Volume 12, Issue 5, Page(s) 1994–2006

    Abstract: MicroRNA machinery genes Argonaute 1 ( ...

    Abstract MicroRNA machinery genes Argonaute 1 (
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  6. Article: Correction: Rashid et al. Natural Compounds of

    Rashid, Md Mamunur / Rahman, Md Atiar / Islam, Md Shahidul / Hossen, Md Amjad / Ahmed, A M Abu / Afroze, Mirola / Habib, Alaa H / Mansoury, Manal M S / Alharbi, Hend F / Algheshairy, Reham M / Alelwani, Walla / Alnajeebi, Afnan M / Tangpong, Jitbanjong / Saha, Srabonti / Qadhi, Alaa / Azhar, Wedad

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: In the published publication [ ... ]. ...

    Abstract In the published publication [...].
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020256
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  7. Article ; Online: The influence of polyatomic primary ion chemistry on matrix effects in secondary ion mass spectrometry analysis.

    Alnajeebi, Afnan M / Vickerman, John C / Lockyer, Nicholas P

    Rapid communications in mass spectrometry : RCM

    2018  Volume 32, Issue 22, Page(s) 1962–1970

    Abstract: Rationale: The application of mass spectrometry imaging techniques to determine two- (2D) and three- (3D) dimensional chemical distribution ideally provides uniform, high sensitivity to multiple components and reliable quantification. These criteria are ...

    Abstract Rationale: The application of mass spectrometry imaging techniques to determine two- (2D) and three- (3D) dimensional chemical distribution ideally provides uniform, high sensitivity to multiple components and reliable quantification. These criteria are typically not met due to variations in sensitivity due to the chemistry of the analyte and surrounding surface chemistry. Here we explore the influence of projectile beam chemistry and sample chemistry in time-of-flight secondary ion mass spectrometry (TOF-SIMS). To the authors' knowledge this is the first time the combined effects of projectile chemistry and sample environment on the quantitative determination of mixed samples have been systematically studied.
    Methods: Secondary ion yields of lipid and amino acid mixtures were measured under 20 keV C
    Results: The extent of the matrix effects and the secondary ion yield were found to depend on the chemistry of the primary ion beam and (for C
    Conclusions: Compared with C
    Language English
    Publishing date 2018-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.8265
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3461: Show issues Location:
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  8. Article ; Online: Exploring novel fluorine-rich fuberidazole derivatives as hypoxic cancer inhibitors: Design, synthesis, pharmacokinetics, molecular docking, and DFT evaluations.

    Taj, Muhammad Babar / Raheel, Ahmad / Ayub, Rabia / Alnajeebi, Afnan M / Abualnaja, Matokah / Habib, Alaa Hamed / Alelwani, Walla / Noor, Sadia / Ullah, Sami / Al-Sehemi, Abdullah G / Simsek, Rahime / Babteen, Nouf Abubakr / Alshater, Heba

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0262790

    Abstract: Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation ...

    Abstract Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation tests on chosen hypoxic cancer cells. Eight substances (Compound 5a, 5c, 5d, 5e, 5g, 5h, 5i, and 5m) showed promising cytotoxicity values compared to the standard control. The potential of compounds was also examined through in silico studies (against human serum albumin), including chem-informatics, to understand the structure-activity relationship (SAR), pharmacochemical strength, and the mode of interactions responsible for their action. The DFT calculations revealed that only the 5b compound showed the lowest ΔET (2.29 eV) while 5i showed relatively highest βtot (69.89 x 10-31 esu), highest αave (3.18 x 10-23 esu), and dipole moment (6.49 Debye). This study presents a novel class of fuberidazole derivatives with selectivity toward hypoxic cancer cells.
    MeSH term(s) Humans ; Molecular Docking Simulation ; Fluorine ; Structure-Activity Relationship ; Neoplasms/drug therapy ; Antineoplastic Agents/chemistry ; Molecular Structure ; Drug Screening Assays, Antitumor
    Chemical Substances fuberidazole (RXD450F6C7) ; Fluorine (284SYP0193) ; Antineoplastic Agents
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0262790
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  9. Article: Development of instant paneer type product from groundnut using microwave dehydration.

    Bal, Atreyee / Chauhan, Om Prakash / Pandey, Arun Kumar / Semwal, Anil Dutt / Mishra, Avinash / Almujaydil, Mona S / Alharbi, Hend F / Alnajeebi, Afnan M / Elansary, Hosam O / Mahmoud, Eman A

    Food science & nutrition

    2022  Volume 10, Issue 5, Page(s) 1520–1526

    Abstract: The present study aimed at the development of a groundnut-based dehydrated paneer type product which could serve as an instant vegan protein source. In the process of preparing groundnut paneer, a ratio of 1:5 of groundnut to water and 2.0% calcium ... ...

    Abstract The present study aimed at the development of a groundnut-based dehydrated paneer type product which could serve as an instant vegan protein source. In the process of preparing groundnut paneer, a ratio of 1:5 of groundnut to water and 2.0% calcium chloride (CaCl
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.2770
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  10. Article ; Online: Exploring novel fluorine-rich fuberidazole derivatives as hypoxic cancer inhibitors

    Muhammad Babar Taj / Ahmad Raheel / Rabia Ayub / Afnan M Alnajeebi / Matokah Abualnaja / Alaa Hamed Habib / Walla Alelwani / Sadia Noor / Sami Ullah / Abdullah G Al-Sehemi / Rahime Simsek / Nouf Abubakr Babteen / Heba Alshater

    PLoS ONE, Vol 18, Iss 2, p e

    Design, synthesis, pharmacokinetics, molecular docking, and DFT evaluations.

    2023  Volume 0262790

    Abstract: Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation ...

    Abstract Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation tests on chosen hypoxic cancer cells. Eight substances (Compound 5a, 5c, 5d, 5e, 5g, 5h, 5i, and 5m) showed promising cytotoxicity values compared to the standard control. The potential of compounds was also examined through in silico studies (against human serum albumin), including chem-informatics, to understand the structure-activity relationship (SAR), pharmacochemical strength, and the mode of interactions responsible for their action. The DFT calculations revealed that only the 5b compound showed the lowest ΔET (2.29 eV) while 5i showed relatively highest βtot (69.89 x 10-31 esu), highest αave (3.18 x 10-23 esu), and dipole moment (6.49 Debye). This study presents a novel class of fuberidazole derivatives with selectivity toward hypoxic cancer cells.
    Keywords Medicine ; R ; Science ; Q
    Subject code 540
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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