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  1. Article ; Online: Are health care policies for COVID-19 evidence-based?

    Bonini, Sergio / Fiorito, Silvana

    Allergy

    2022  Volume 77, Issue 8, Page(s) 2290–2291

    MeSH term(s) COVID-19 ; Delivery of Health Care ; Health Policy ; Humans ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-03-26
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15297
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  2. Article ; Online: Novel adaptive design for allergen immunotherapy clinical trials.

    Bonini, Sergio / Pfaar, Oliver

    Allergy

    2022  Volume 77, Issue 7, Page(s) 1950–1951

    MeSH term(s) Allergens/therapeutic use ; Clinical Trials as Topic ; Desensitization, Immunologic ; Humans ; Immunotherapy ; Research Design
    Chemical Substances Allergens
    Language English
    Publishing date 2022-01-28
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15231
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  3. Article ; Online: COVID-19 Clinical trials: Quality matters more than quantity.

    Bonini, Sergio / Maltese, Giuseppe

    Allergy

    2020  Volume 75, Issue 10, Page(s) 2542–2547

    Abstract: Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical ... ...

    Abstract Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical research is rapidly progressing, as shown by the hundreds of registered clinical trials on candidate drugs for COVID-19. Unfortunately, information on protocols of individual studies differs from registry to registry. Furthermore, study designs, criteria for stratification of patients and choice of outcomes are quite heterogeneous. All this makes data sharing and secondary analysis difficult. At last, small single centre studies and the use of drugs on a compassionate basis should be replaced by highly powered, multi-centre, multi-arm clinical trials, in order to provide the required evidence of safety and efficacy of novel or repurposed candidate drugs. Hopefully, the efforts of clinical researchers in the fight against the SARS Cov-2 will result into the identification of effective treatments. To make this possible, clinical research should be oriented by guidelines for more harmonized high-quality studies and by a united commitment of the scientific community to share personal knowledge and data. Allergists and clinical immunologists should have a leading role in this unprecedent challenge.
    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Research Design ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14409
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  4. Article ; Online: Allergy and the eye.

    Bonini, Sergio

    Chemical immunology and allergy

    2014  Volume 100, Page(s) 105–108

    Abstract: This review of the major milestones in the history of ocular allergy and immunology shows how significantly this subdiscipline has contributed to the tremendous progress in the understanding of mechanisms of allergic and immunologic diseases, as well as ... ...

    Abstract This review of the major milestones in the history of ocular allergy and immunology shows how significantly this subdiscipline has contributed to the tremendous progress in the understanding of mechanisms of allergic and immunologic diseases, as well as in their better management. It also indicates unmet needs and priority areas for future research.
    MeSH term(s) Conjunctivitis, Allergic/immunology ; Conjunctivitis, Allergic/metabolism ; Conjunctivitis, Allergic/pathology ; Eye Diseases/history ; Eye Diseases/immunology ; Eye Diseases/pathology ; History, 19th Century ; Humans ; Hypersensitivity/history ; Hypersensitivity/immunology ; Hypersensitivity/pathology ; Immunoglobulin E/metabolism
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Review
    ISSN 1662-2898 ; 1660-2242
    ISSN (online) 1662-2898
    ISSN 1660-2242
    DOI 10.1159/000358615
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  5. Article ; Online: Biosimilars and drug development in allergic and immunologic diseases.

    Bonini, Sergio / Bonini, Matteo

    The Journal of allergy and clinical immunology

    2017  Volume 139, Issue 5, Page(s) 1461–1464

    MeSH term(s) Animals ; Anti-Allergic Agents/therapeutic use ; Antirheumatic Agents/economics ; Antirheumatic Agents/therapeutic use ; Biological Products/economics ; Biological Products/therapeutic use ; Biosimilar Pharmaceuticals/economics ; Biosimilar Pharmaceuticals/therapeutic use ; Drug Development ; Drugs, Generic/economics ; Drugs, Generic/therapeutic use ; Europe/epidemiology ; Humans ; Hypersensitivity/drug therapy ; Hypersensitivity/epidemiology ; Immune System Diseases/drug therapy ; Immune System Diseases/epidemiology ; United States/epidemiology
    Chemical Substances Anti-Allergic Agents ; Antirheumatic Agents ; Biological Products ; Biosimilar Pharmaceuticals ; Drugs, Generic
    Language English
    Publishing date 2017-03-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2017.03.008
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  6. Article ; Online: Reply to: "COVID-19 pandemic and environment: Not only air pollution."

    Fiorito, Silvana / Soligo, Marzia / Gao, Yadong / Ogulur, Ismail / Akdis, Cezmi A / Bonini, Sergio

    Allergy

    2022  Volume 77, Issue 12, Page(s) 3702–3703

    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Air Pollution/adverse effects
    Language English
    Publishing date 2022-11-18
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15492
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  7. Article: Regulatory aspects of allergen-specific immunotherapy: europe sets the scene for a global approach.

    Bonini, Sergio

    The World Allergy Organization journal

    2012  Volume 5, Issue 10, Page(s) 120–123

    Language English
    Publishing date 2012-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1097/WOX.0b013e318272484e
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  8. Article ; Online: Annotated guidance to the European Medicines Agency (EMA) guidelines and regulatory documents. A new series of the BJCP.

    Cohen, Adam / Bonini, Sergio

    British journal of clinical pharmacology

    2018  Volume 84, Issue 7, Page(s) 1399–1400

    MeSH term(s) Drug Approval/organization & administration ; Europe ; European Union/organization & administration ; Practice Guidelines as Topic
    Language English
    Publishing date 2018-05-30
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.13599
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  9. Article ; Online: COVID‐19 Clinical trials

    Bonini, Sergio / Maltese, Giuseppe

    Allergy ; ISSN 0105-4538 1398-9995

    Quality matters more than quantity

    2020  

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/all.14409
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Inhibitor of Fatty Acid Amide Hydrolase — Learning from Tragic Failures

    Bonini, Sergio / Rasi, Guido

    The New England journal of medicine

    2017  Volume 376, Issue 4, Page(s) 394

    MeSH term(s) Amidohydrolases ; Enzyme Inhibitors/pharmacology ; Humans
    Chemical Substances Enzyme Inhibitors ; Amidohydrolases (EC 3.5.-)
    Language English
    Publishing date 2017--26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1615417
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