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Article: COVID-19 Convalescent Plasma: from donation to treatment - A Systematic Review & Single Center Experience.

Fabricius, Michela M / Dandachi, Dima

2021 Volume 118, Issue 1, Page(s) 74–80

Abstract: Convalescent plasma is an old treatment for a new disease. The coronavirus disease 2019 (COVID-19) pandemic caused the analysis of convalescent plasma to reemerge as a possible treatment. First, a systematic review summarizes the available research ... ...

Abstract	Convalescent plasma is an old treatment for a new disease. The coronavirus disease 2019 (COVID-19) pandemic caused the analysis of convalescent plasma to reemerge as a possible treatment. First, a systematic review summarizes the available research examining the use of convalescent plasma for the treatment of patients with COVID-19. Second, we describe our experience in establishing a single-center convalescent plasma donation program.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Blood Donors/statistics & numerical data ; Blood Donors/supply & distribution ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; COVID-19/virology ; Donor Selection/methods ; Female ; Humans ; Immunization, Passive/methods ; Male ; Middle Aged ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Treatment Outcome
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	427362-x
ISSN	0026-6620
ISSN	0026-6620
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Article: Reverse Abdominoplasty for Reconstruction Following Oncologic Resection of Extensive Breast Disease.

Culbert, Matthew / Shock, Leslie / Fabricius, Michela M / Nelson, Nicole

Cureus

2022 Volume 14, Issue 9, Page(s) e28664

Abstract: We present two cases of patients with extensive breast disease who underwent a reverse abdominoplasty for closure following resection: one of Paget's disease extending beyond the breast borders and another of a locally recurrent triple-negative invasive ... ...

Abstract	We present two cases of patients with extensive breast disease who underwent a reverse abdominoplasty for closure following resection: one of Paget's disease extending beyond the breast borders and another of a locally recurrent triple-negative invasive ductal carcinoma following mastectomy in a patient who previously had an ipsilateral thoracotomy. The reverse abdominoplasty flap is a reconstructive option not readily considered for closure following mastectomy. However, we believe that the reverse abdominoplasty flap should be considered when evaluating patients for anterior chest wall reconstruction because it is a simple and versatile coverage option.
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.28664
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Article ; Online: Diabetes Control in a Student-Run Free Clinic During the COVID-19 Pandemic.

Simon, Madeline E / Reuter, Zachary C / Fabricius, Michela M / Hitchcock, Nicole M / Pierce, Robert P

Journal of community health

2022 Volume 47, Issue 5, Page(s) 835–840

Abstract: Student run free health clinics (SRFCs) provide medical care to vulnerable populations in communities throughout the United States. The COVID-19 pandemic had a significant impact on the delivery of healthcare services and demanded a rapid adjustment in ... ...

Abstract	Student run free health clinics (SRFCs) provide medical care to vulnerable populations in communities throughout the United States. The COVID-19 pandemic had a significant impact on the delivery of healthcare services and demanded a rapid adjustment in care delivery methods in both resource-rich and resource-poor settings. The aim of this study is to evaluate the impact of the pandemic on the management of chronic disease, specifically diabetes. Patients with diabetes who received care continuously throughout the pre-pandemic (face-to-face) and pandemic (telehealth) study periods at MedZou Community Health Center, a SRFC located in central Missouri, were evaluated. This sample of patients (n = 29) was evaluated on six quality measures including annual eye exams, blood pressure, hemoglobin A1c, chronic kidney disease monitoring, flu vaccination, and statin therapy. Overall diabetes care, as measured by the number of quality measures met per patient, decreased by 0.37 after the onset of the pandemic. The median COVID-era ranks were not statistically significantly different than the pre-pandemic ranks (z = 1.65, P = 0.099). Fewer patients received an influenza vaccination the year following the onset of the pandemic (10.3%) compared to the year before the pandemic (37.9%; difference in proportions 0.276, 95% CI 0.079, 0.473; p = 0.005). No other individual measures of diabetes care statistically differed significantly in the year after the pandemic began. Twenty-six (90%) patients received diabetes care using telehealth after the onset of the pandemic. Diabetes care using telehealth in a SRFC may be an acceptable alternative model when face-to-face visits are not feasible. Observed decreases in diabetes-related clinical quality measure performance warrant further study.
MeSH term(s)	COVID-19/epidemiology ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Glycated Hemoglobin A/analysis ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pandemics ; Student Run Clinic ; Students ; United States
Chemical Substances	Glycated Hemoglobin A ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2022-07-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	426631-6
ISSN	1573-3610 ; 0094-5145
ISSN (online)	1573-3610
ISSN	0094-5145
DOI	10.1007/s10900-022-01117-0
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Zs.A 1386: Show issues

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Article ; Online: Impact of the COVID-19 Pandemic & Telehealth Implementation in a Student Run Free Clinic.

Fabricius, Michela M / Hitchcock, Nicole M / Reuter, Zachary C / Simon, Madeline E / Pierce, Robert P

Journal of community health

2021 Volume 47, Issue 2, Page(s) 179–183

Abstract: Student run free clinics (SRFCs) fill a void in healthcare access for many communities and have been subject to unprecedented shifts in care delivery brought about by the coronavirus disease 2019 (COVID-19) pandemic. Our single-center institution serving ...

Abstract	Student run free clinics (SRFCs) fill a void in healthcare access for many communities and have been subject to unprecedented shifts in care delivery brought about by the coronavirus disease 2019 (COVID-19) pandemic. Our single-center institution serving uninsured patients in central Missouri switched from in-person visits to strictly telehealth visits with the onset of the pandemic. This study investigated the impact of the pandemic and the switch to telehealth on the clinic return rates by ethnicity, race, gender, rurality, and age. The pandemic led to a 47.4% reduction in the number of monthly patient encounters. Of the established SRFC population (N = 309), only 87 patients (28.2%) returned for a telehealth visit during the COVID-19 pandemic. Older patients (≥ 45 years old) were more likely to return (OR 1.71, 95% CI 1.02-2.85) for care via telehealth after the onset of the pandemic than younger patients (< 45 years old). No differences in the likelihood of returning for a telehealth visit were identified by race, ethnicity, gender, or rurality. Telehealth offers an effective solution to the complex problems faced by SRFCs during the COVID-19 pandemic and has not added barriers to care with regards to race, ethnicity, gender, or rurality at our SRFC.
MeSH term(s)	COVID-19/epidemiology ; Health Services Accessibility ; Humans ; Middle Aged ; Pandemics ; Student Run Clinic ; Telemedicine
Language	English
Publishing date	2021-09-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	426631-6
ISSN	1573-3610 ; 0094-5145
ISSN (online)	1573-3610
ISSN	0094-5145
DOI	10.1007/s10900-021-01034-8
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Article ; Online: Antiretrovirals for People with HIV on Dialysis.

Dandachi, Dima / Fabricius, Michela / Saad, Baraa / Sawkin, Mark T / Malhotra, Kunal

AIDS patient care and STDs

2022 Volume 36, Issue 3, Page(s) 86–96

Abstract: In the era of widespread use of antiretroviral therapy (ART), people with HIV (PWH) have a near-normal life expectancy. However, PWH have high rates of kidney diseases and progression to end-stage renal disease at a younger age. PWH have multiple risks ... ...

Abstract	In the era of widespread use of antiretroviral therapy (ART), people with HIV (PWH) have a near-normal life expectancy. However, PWH have high rates of kidney diseases and progression to end-stage renal disease at a younger age. PWH have multiple risks for developing acute and chronic kidney diseases, including traditional risk factors such as diabetes, hypertension, and HIV-related factors such as HIV-associated nephropathy and increased susceptibility to infections and exposure to nephrotoxic medications. Despite an improvement in access to kidney transplant among PWH, the number of PWH on dialysis continues to increase. The expansion of the number of antiretrovirals (ARVs) and kidney replacement modalities, the absence of pharmacokinetic data, and therapeutic drug monitoring make it very challenging for providers to dose ARVs appropriately leading to medication errors, adverse events, and higher mortality. Most of the recommendations are either based on small sample size studies or extrapolated based on physiochemical characteristics of ART. We aim to review the most available and most current literature on ART in PWH with renal insufficiency and ART dosing recommendations on dialysis to ensure that PWH are provided with the safest and most effective ART regimen.
MeSH term(s)	Anti-Retroviral Agents/therapeutic use ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Kidney Transplantation ; Male ; Renal Dialysis ; Renal Insufficiency
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1326868-5
ISSN	1557-7449 ; 0893-5068 ; 1087-2914
ISSN (online)	1557-7449
ISSN	0893-5068 ; 1087-2914
DOI	10.1089/apc.2021.0173
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Zs.A 2328: Show issues

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Article ; Online: Macroalgal cover on coral reefs: Spatial and environmental predictors, and decadal trends in the Great Barrier Reef.

Fabricius, Katharina E / Crossman, Kerryn / Jonker, Michelle / Mongin, Mathieu / Thompson, Angus

PloS one

2023 Volume 18, Issue 1, Page(s) e0279699

Abstract: ... 11-24°S, coastal to offshore, 0-18 m depth), while the temporal trends analysis was based on 26 years ... steeply towards the coast, with latitude away from the equator, and towards shallow (≤3 m) depth. Environmental conditions ...

Abstract	Macroalgae are an important component of coral reef ecosystems. We identified spatial patterns, environmental drivers and long-term trends of total cover of upright fleshy and calcareous coral reef inhabiting macroalgae in the Great Barrier Reef. The spatial study comprised of one-off surveys of 1257 sites (latitude 11-24°S, coastal to offshore, 0-18 m depth), while the temporal trends analysis was based on 26 years of long-term monitoring data from 93 reefs. Environmental predictors were obtained from in situ data and from the coupled hydrodynamic-biochemical model eReefs. Macroalgae dominated the benthos (≥50% cover) on at least one site of 40.4% of surveyed inshore reefs. Spatially, macroalgal cover increased steeply towards the coast, with latitude away from the equator, and towards shallow (≤3 m) depth. Environmental conditions associated with macroalgal dominance were: high tidal range, wave exposure and irradiance, and low aragonite saturation state, Secchi depth, total alkalinity and temperature. Evidence of space competition between macroalgal cover and hard coral cover was restricted to shallow inshore sites. Temporally, macroalgal cover on inshore and mid-shelf reefs showed some fluctuations, but unlike hard corals they showed no systematic trends. Our extensive empirical data may serve to parameterize ecosystem models, and to refine reef condition indices based on macroalgal data for Pacific coral reefs.
MeSH term(s)	Animals ; Coral Reefs ; Ecosystem ; Anthozoa ; Seaweed ; Temperature
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0279699
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Article ; Online: Aim for heterogeneous biodiversity restoration.

Toma, Tiago S P / Oliveira, Hernani F M / Overbeck, Gerhard E / Grelle, Carlos E V / Roque, Fabio O / Negreiros, Daniel / Rodrigues, Domingos J / Guimaraes, Aretha F / Streit, Helena / Dechoum, Michele S / Fonsêca, Nathan C / Rocha, Tainá C / Pereira, Cássio C / Garda, Adrian A / Bergallo, Helena G / Domingos, Fabricius M C B / Fernandes, Geraldo W

Science (New York, N.Y.)

2024 Volume 383, Issue 6681, Page(s) 376

MeSH term(s)	Biodiversity ; Environmental Restoration and Remediation ; Brazil
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Letter
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adn3767
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Article: Research priorities for the sustainability of coral-rich western Pacific seascapes.

Cumming, Graeme S / Adamska, Maja / Barnes, Michele L / Barnett, Jon / Bellwood, David R / Cinner, Joshua E / Cohen, Philippa J / Donelson, Jennifer M / Fabricius, Katharina / Grafton, R Quentin / Grech, Alana / Gurney, Georgina G / Hoegh-Guldberg, Ove / Hoey, Andrew S / Hoogenboom, Mia O / Lau, Jacqueline / Lovelock, Catherine E / Lowe, Ryan / Miller, David J /

Morrison, Tiffany H / Mumby, Peter J / Nakata, Martin / Pandolfi, John M / Peterson, Garry D / Pratchett, Morgan S / Ravasi, Timothy / Riginos, Cynthia / Rummer, Jodie L / Schaffelke, Britta / Wernberg, Thomas / Wilson, Shaun K

Regional environmental change

2023 Volume 23, Issue 2, Page(s) 66

Abstract: Nearly a billion people depend on tropical seascapes. The need to ensure sustainable use of these vital areas is recognised, as one of 17 policy commitments made by world leaders, in Sustainable Development Goal (SDG) 14 ('Life below Water') of the ... ...

Abstract	Nearly a billion people depend on tropical seascapes. The need to ensure sustainable use of these vital areas is recognised, as one of 17 policy commitments made by world leaders, in Sustainable Development Goal (SDG) 14 ('Life below Water') of the United Nations. SDG 14 seeks to secure marine sustainability by 2030. In a time of increasing social-ecological unpredictability and risk, scientists and policymakers working towards SDG 14 in the Asia-Pacific region need to know: (1) How are seascapes changing? (2) What can global society do about these changes? and (3) How can science and society together achieve sustainable seascape futures? Through a horizon scan, we identified nine emerging research priorities that clarify potential research contributions to marine sustainability in locations with high coral reef abundance. They include research on seascape geological and biological evolution and adaptation; elucidating drivers and mechanisms of change; understanding how seascape functions and services are produced, and how people depend on them; costs, benefits, and trade-offs to people in changing seascapes; improving seascape technologies and practices; learning to govern and manage seascapes for all; sustainable use, justice, and human well-being; bridging communities and epistemologies for innovative, equitable, and scale-crossing solutions; and informing resilient seascape futures through modelling and synthesis. Researchers can contribute to the sustainability of tropical seascapes by co-developing transdisciplinary understandings of people and ecosystems, emphasising the importance of equity and justice, and improving knowledge of key cross-scale and cross-level processes, feedbacks, and thresholds.
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1464515-4
ISSN	1436-3798
ISSN	1436-3798
DOI	10.1007/s10113-023-02051-0
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Article: Biomineralization control related to population density under ocean acidification.

Goffredo, Stefano / Prada, Fiorella / Caroselli, Erik / Capaccioni, Bruno / Zaccanti, Francesco / Pasquini, Luca / Fantazzini, Paola / Fermani, Simona / Reggi, Michela / Levy, Oren / Fabricius, Katharina E / Dubinsky, Zvy / Falini, Giuseppe

Nature climate change

2014 Volume 4, Issue 7, Page(s) 593–597

Abstract: Anthropogenic ... ...

Abstract	Anthropogenic CO
Language	English
Publishing date	2014-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2614383-5
ISSN	1758-6798 ; 1758-678X
ISSN (online)	1758-6798
ISSN	1758-678X
DOI	10.1038/nclimate2241
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Article: Biomineralization control related to population density under ocean acidification

Nature climate change

2014 Volume 4, Issue 7, Page(s) 593

Language	English
Document type	Article
ZDB-ID	2614383-5
ISSN	1758-678x
Database	Current Contents Nutrition, Environment, Agriculture

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