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  1. Article ; Online: Update on the diagnosis and management of COVID-19 in pediatric patients.

    Carlotti, Ana Paula de Carvalho Panzeri / de Carvalho, Werther Brunow / Johnston, Cíntia / Gilio, Alfredo Elias / de Sousa Marques, Heloisa Helena / Ferranti, Juliana Ferreira / Rodriguez, Isadora Souza / Delgado, Artur Figueiredo

    Clinics (Sao Paulo, Brazil)

    2020  Volume 75, Page(s) e2353

    Abstract: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the ...

    Abstract Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SARS-CoV-2 infection. This review presents an update on the diagnostic methods for COVID-19, including reverse-transcriptase polymerase chain reaction (RT-PCR) tests, serology tests, and imaging, and summarizes the current recommendations for the management of the disease. Particular emphasis is placed on respiratory support, which includes noninvasive ventilation and invasive mechanical ventilation strategies according to lung compliance and pattern of lung injury. Pharmacological treatment, including pathogen-targeted drugs and host-directed therapies, has been addressed. The diagnostic criteria and management of MIS-C are also summarized.
    MeSH term(s) COVID-19/drug therapy ; COVID-19/therapy ; Child ; Humans ; Pandemics ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/therapy
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2020/e2353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytomegalovirus Active Infection in Critically Ill Children.

    Schwab, Sarah Cazella / Yamamoto, Aparecida Yulie / Aragon, Davi Casale / Carlotti, Ana Paula de Carvalho Panzeri

    The Pediatric infectious disease journal

    2023  Volume 42, Issue 10, Page(s) 875–882

    Abstract: Objective: To describe the epidemiology, clinical characteristics and outcomes of children with cytomegalovirus (CMV) active infection in the pediatric intensive care unit (PICU) and to investigate risk factors for mortality.: Methods: This was a ... ...

    Abstract Objective: To describe the epidemiology, clinical characteristics and outcomes of children with cytomegalovirus (CMV) active infection in the pediatric intensive care unit (PICU) and to investigate risk factors for mortality.
    Methods: This was a retrospective cohort study of patients who had CMV DNA detected in blood samples and/or tracheal aspirates by polymerase chain reaction (PCR) during stay at 2 PICUs of a university hospital. Suspected cases without etiological confirmation and patients with laboratory-confirmed CMV infection before PICU admission were excluded.
    Results: Demographic, clinical and outcome data were collected from medical records. From January 1, 2012, to December 31, 2019, 4748 children were admitted to the PICUs. Thirty-five (0.74%; 95% CI 0.51%-1.02%) had laboratory-confirmed CMV active infection; 71.4% were immunocompromised and 11 (31.4%) died. Patients who died were older than those who survived (median age 65 vs. 5.5 months, respectively; P = 0.048), and they received antiviral therapy for a shorter time (median 12 vs. 23 days, respectively; P = 0.001). The main causa mortis was septic shock (82%) and in most deceased patients (73%) the last CMV PCR before death was positive. PELOD score >6 was a risk factor for death (RR 2.96; 95% CI 1.07-8.21). Viral load in blood had a poor ability for the prediction of death (area under the receiver operating characteristic curve 0.62; 95% CI 0.37-0.84).
    Conclusions: The incidence of CMV active infection during PICU stay was 0.74% in an upper-middle income country with a high CMV seroprevalence. PELOD score higher than 6 was a risk factor for death. No association was observed between CMV viral load and mortality.
    MeSH term(s) Humans ; Child ; Aged ; Cytomegalovirus ; Retrospective Studies ; Critical Illness ; Seroepidemiologic Studies ; Cytomegalovirus Infections/epidemiology
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Update on the diagnosis and management of COVID-19 in pediatric patients

    Ana Paula de Carvalho Panzeri Carlotti / Werther Brunow de Carvalho / Cíntia Johnston / Alfredo Elias Gilio / Heloisa Helena de Sousa Marques / Juliana Ferreira Ferranti / Isadora Souza Rodriguez / Artur Figueiredo Delgado

    Clinics, Vol

    2020  Volume 75

    Abstract: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the ...

    Abstract Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SARS-CoV-2 infection. This review presents an update on the diagnostic methods for COVID-19, including reverse-transcriptase polymerase chain reaction (RT-PCR) tests, serology tests, and imaging, and summarizes the current recommendations for the management of the disease. Particular emphasis is placed on respiratory support, which includes noninvasive ventilation and invasive mechanical ventilation strategies according to lung compliance and pattern of lung injury. Pharmacological treatment, including pathogen-targeted drugs and host-directed therapies, has been addressed. The diagnostic criteria and management of MIS-C are also summarized.
    Keywords COVID-19 ; Diagnosis ; Respiratory Support ; Pharmacological Treatment ; Multisystem Inflammatory Syndrome in Children ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book: Manual de rotinas de terapia intensiva pediátrica

    Matsuno, Alessandra Kimie / Carvalho Panzeri Carlotti, Ana Paula de

    2005  

    Author's details Ana Paula de Carvalho Panzeri Carlotti, ed. cient. [Autores: Alessandra Kimie Matsuno ...]
    Language Portuguese
    Size 427 S. : Ill.
    Publisher Tecmedd Ed
    Publishing place São Paulo
    Publishing country Brazil
    Document type Book
    HBZ-ID HT014699058
    ISBN 85-8665338-1 ; 978-85-8665338-4
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Multiple Cerebral Infarcts in a Young Patient Associated With Marijuana Use.

    Volpon, Leila Costa / Sousa, Camila Lacerda Muniz de Melo / Moreira, Silvia Keiko Kavaguti / Teixeira, Sara Reis / Carlotti, Ana Paula de Carvalho Panzeri

    Journal of addiction medicine

    2017  Volume 11, Issue 5, Page(s) 405–407

    Abstract: Cerebrovascular events associated with marijuana use have been reported previously. This association is plausible, but not well-established yet. A 14-year-old girl, long-term heavy cannabis user, presented with generalized tonic-clonic seizures and ... ...

    Abstract : Cerebrovascular events associated with marijuana use have been reported previously. This association is plausible, but not well-established yet. A 14-year-old girl, long-term heavy cannabis user, presented with generalized tonic-clonic seizures and decreased level of consciousness a few hours after smoking cannabis. Brain magnetic resonance imaging showed multiple areas of acute, subacute and chronic ischemic lesions in the left frontal lobe, basal ganglia, and corpus callosum. History of other illicit drug use and other known causes of stroke were ruled out. Cannabis might cause stroke through direct effects on the cerebral blood circulation, orthostatic hypotension, vasculitis, vasospasm, and atrial fibrillation. Long-term daily use of marijuana in young people may cause serious damage to the cerebrovascular system.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000000326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 Diagnostic and Management Protocol for Pediatric Patients.

    Carlotti, Ana Paula de Carvalho Panzeri / Carvalho, Werther Brunow de / Johnston, Cíntia / Rodriguez, Isadora Souza / Delgado, Artur Figueiredo

    Clinics (Sao Paulo, Brazil)

    2020  Volume 75, Page(s) e1894

    Abstract: This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. An extensive review of the medical literature on COVID-19 was performed, ...

    Abstract This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. An extensive review of the medical literature on COVID-19 was performed, mainly focusing on the critical care of pediatric patients, considering expert opinions and recent reports related to this new disease. Experts from a large Brazilian public university analyzed all recently published material to produce a report aiming to standardize the care of critically ill children and adolescents. The report emphasizes on the clinical presentations of the disease and ventilatory support in pediatric patients with COVID-19. It establishes a flowchart to guide health practitioners on triaging critical cases. COVID-19 is essentially an unknown clinical condition for the majority of pediatric intensive care professionals. Guidelines developed by experts can help all practitioners standardize their attitudes and improve the treatment of COVID-19.
    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Child ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/metabolism ; Coronavirus Infections/therapy ; Critical Illness ; Diagnosis, Differential ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Positive-Pressure Respiration/methods ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/therapy ; Severity of Illness Index ; Time Factors
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2020/e1894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection.

    Portugal, Carolina Augusta Arantes / de Araújo Castro, Ítalo / Prates, Mirela Cristina Moreira / Gagliardi, Talita Bianca / Martins, Ronaldo Bragança / de Jesus, Bruna Laís Santos / de Souza Cardoso, Ricardo / da Silva, Marcus Vinícius Gomes / Aragon, Davi Casale / Arruda Neto, Eurico / Alves Filho, José Carlos Farias / Cunha, Fernando de Queiroz / Carlotti, Ana Paula de Carvalho Panzeri

    Cytokine

    2020  Volume 127, Page(s) 154965

    Abstract: Background: Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity.: Methods: Concentrations of ... ...

    Abstract Background: Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity.
    Methods: Concentrations of interleukin(IL)-33, soluble suppression of tumorigenicity (sST)2, IL-1ß, tumor necrosis factor α, IL-4, IL-6 and IL- 8 and types of respiratory viruses were evaluated in children at the first and fifth days after hospital admission. Disease severity was defined as need for mechanical ventilation.
    Results: Seventy-nine children <5 years-old were included; 33(41.8%) received mechanical ventilation. No associations between virus type, viral load or co-detections and severity of disease were observed. Detection of IL-33 and sST2 in nasopharyngeal aspirates (NPA) on admission were associated with higher risk for mechanical ventilation (RR = 2.89 and RR = 4.57, respectively). IL-6 and IL-8 concentrations were higher on Day 5 in mechanically ventilated children. IL-6 NPA concentrations decreased from Day 1 to Day 5 in children who did not receive mechanical ventilation. Increase in sST2 NPA concentrations from Day 1 to Day 5 was associated with longer hospital length of stay (p < 0.01).
    Conclusions: An exacerbated local activation of the IL-33/ST2 axis and persistently high sST2 concentrations over time were associated with severity of viral ALRI in children.
    MeSH term(s) Biomarkers/metabolism ; Child, Preschool ; Female ; Hospitalization ; Humans ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Interleukin-33/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Male ; Prospective Studies ; Respiratory Syncytial Virus Infections/metabolism ; Respiratory Syncytial Virus Infections/pathology ; Respiratory Tract Infections/metabolism ; Respiratory Tract Infections/pathology ; Severity of Illness Index
    Chemical Substances Biomarkers ; IL1RL1 protein, human ; IL33 protein, human ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; Interleukin-6 ; Interleukin-8
    Keywords covid19
    Language English
    Publishing date 2020-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2019.154965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of children with complex chronic conditions on costs in a tertiary referral hospital.

    Mattiello, Regina Maria Antunes / Pazin-Filho, Antonio / Aragon, Davi Casale / Cupo, Palmira / Carlotti, Ana Paula de Carvalho Panzeri

    Revista de saude publica

    2022  Volume 56, Page(s) 89

    Abstract: Objectives: To investigate the impact of complex chronic conditions on the use of healthcare resources and hospitalization costs in a pediatric ward of a public tertiary referral university hospital in Brazil.: Methods: This is a longitudinal study ... ...

    Abstract Objectives: To investigate the impact of complex chronic conditions on the use of healthcare resources and hospitalization costs in a pediatric ward of a public tertiary referral university hospital in Brazil.
    Methods: This is a longitudinal study with retrospective data collection. Overall, three one-year periods, separated by five-year intervals (2006, 2011, and 2016), were evaluated. Hospital costs were calculated in three systematic samples of 100 patients each, consisting of patients with and without complex chronic conditions in proportion to their participation in the studied year.
    Results: Over the studied period, the hospital received 2,372 admissions from 2,172 patients. The proportion of hospitalized patients with complex chronic conditions increased from 13.3% in 2006 to 16.9% in 2016 as a result of a greater proportion of neurologically impaired children, which rose from 6.6% to 11.6% of the total number of patients in the same period. Patients' complexity also progressively increased, which greatly impacted the use of healthcare resources and costs, increasing by 11.6% from 2006 (R$1,300,879.20) to 2011 (R$1,452,359.71) and 9.4% from 2011 to 2016 (R$1,589,457.95).
    Conclusions: Hospitalizations of pediatric patients with complex chronic conditions increased from 2006 to 2016 in a Brazilian tertiary referral university hospital, associated with an important impact on hospital costs. Policies to reduce these costs in Brazil are greatly needed.
    MeSH term(s) Child ; Humans ; Tertiary Care Centers ; Retrospective Studies ; Longitudinal Studies ; Brazil ; Hospital Costs ; Chronic Disease
    Language English
    Publishing date 2022-10-17
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 732179-x
    ISSN 1518-8787 ; 0034-8910
    ISSN (online) 1518-8787
    ISSN 0034-8910
    DOI 10.11606/s1518-8787.2022056004656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Increased nutrition risk at admission is associated with longer hospitalization in children and adolescents with COVID-19.

    Zamberlan, Patrícia / Carlotti, Ana Paula de Carvalho Panzeri / Viani, Karina Helena Canton / Rodriguez, Isadora Souza / Simas, Josiane de Carvalho / Silvério, Ariadne Beatriz / Volpon, Leila Costa / de Carvalho, Werther Brunow / Delgado, Artur Figueiredo

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2022  Volume 37, Issue 2, Page(s) 393–401

    Abstract: Background: We investigated the association of nutritional risk and inflammatory marker level with length of stay (LOS) in children and adolescents hospitalized for COVID-19 infection in two pediatric teaching hospitals in a developing country.: ... ...

    Abstract Background: We investigated the association of nutritional risk and inflammatory marker level with length of stay (LOS) in children and adolescents hospitalized for COVID-19 infection in two pediatric teaching hospitals in a developing country.
    Methods: This was a cross-sectional analytical retrospective study performed in two pediatric hospitals. We included the data from all children and adolescents who were hospitalized with a SARS-CoV-2 infection between March and December 2020. Demographic, anthropometric, clinical, and laboratory data were extracted from electronic medical records. Nutritional risk was assessed according to the STRONGkids tool within 24 hours of admission and was categorized into two levels: ≥4 (high risk) and <4 (moderate or low risk). Means or medians were compared between nutritional risk groups using the t test and Mann-Whitney U test, respectively. The association of nutritional risk and inflammatory markers with LOS was estimated using the Kaplan-Meier method and log-rank test. Cox proportional-hazard and linear regression models were performed, and adjusted for sex, age, and respiratory symptoms.
    Results: From a total of 73 patients, 20 (27.4%) had a STRONGkids score ≥4 at admission, which was associated with a longer LOS even after adjusting (β = 12.30; 1.74-22.9 95% CI; P = 0.023). The same association was observed between LOS and all laboratory markers except for D-dimer.
    Conclusion: Among children and adolescents with COVID-19, a STRONGkids score ≥4 at admission, lower values of albumin, lymphocytes, and hemoglobin, and higher CRP values were associated with longer LOS.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; Child ; Cross-Sectional Studies ; Hospitalization ; Humans ; Length of Stay ; Malnutrition/diagnosis ; Nutrition Assessment ; Nutritional Status ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: COVID-19 Diagnostic and Management Protocol for Pediatric Patients

    Carlotti, Ana Paula de Carvalho Panzeri / Carvalho, Werther Brunow de / Johnston, Cíntia / Rodriguez, Isadora Souza / Delgado, Artur Figueiredo

    Clinics v.75 2020

    2020  

    Abstract: This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. An extensive review of the medical literature on COVID-19 was performed, ...

    Abstract This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. An extensive review of the medical literature on COVID-19 was performed, mainly focusing on the critical care of pediatric patients, considering expert opinions and recent reports related to this new disease. Experts from a large Brazilian public university analyzed all recently published material to produce a report aiming to standardize the care of critically ill children and adolescents. The report emphasizes on the clinical presentations of the disease and ventilatory support in pediatric patients with COVID-19. It establishes a flowchart to guide health practitioners on triaging critical cases. COVID-19 is essentially an unknown clinical condition for the majority of pediatric intensive care professionals. Guidelines developed by experts can help all practitioners standardize their attitudes and improve the treatment of COVID-19.
    Keywords COVID-19 ; Pediatric Critical Care Medicine ; Infection ; Ventilatory Support ; Diagnostic Criteria ; covid19
    Subject code 610
    Language English
    Publishing date 2020-01-01
    Publisher Faculdade de Medicina / USP
    Publishing country br
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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