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  1. Article ; Online: COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels.

    Szendrey, Mark / Guo, Jun / Li, Wentao / Yang, Tonghua / Zhang, Shetuan

    The Journal of pharmacology and experimental therapeutics

    2021  Volume 377, Issue 2, Page(s) 265–272

    Abstract: Drug-induced long QT syndrome (LQTS) is an established cardiac side effect of a wide range of medications and represents a significant concern for drug safety. The rapidly and slowly activating delayed rectifier ... ...

    Abstract Drug-induced long QT syndrome (LQTS) is an established cardiac side effect of a wide range of medications and represents a significant concern for drug safety. The rapidly and slowly activating delayed rectifier K
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Alanine/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Azithromycin/pharmacology ; Azithromycin/therapeutic use ; COVID-19/drug therapy ; COVID-19/metabolism ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Dose-Response Relationship, Drug ; ERG1 Potassium Channel/antagonists & inhibitors ; ERG1 Potassium Channel/metabolism ; HEK293 Cells ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Potassium Channel Blockers/pharmacology ; Potassium Channel Blockers/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Antimalarials ; Antiviral Agents ; ERG1 Potassium Channel ; KCNH2 protein, human ; Potassium Channel Blockers ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.120.000484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Kv1.5 channels are regulated by PKC-mediated endocytic degradation.

    Du, Yuan / Wang, Tingzhong / Guo, Jun / Li, Wentao / Yang, Tonghua / Szendrey, Mark / Zhang, Shetuan

    The Journal of biological chemistry

    2021  Volume 296, Page(s) 100514

    Abstract: The voltage-gated potassium channel Kv1.5 plays important roles in the repolarization of atrial action potentials and regulation of the vascular tone. While the modulation of Kv1.5 function has been well studied, less is known about how the protein ... ...

    Abstract The voltage-gated potassium channel Kv1.5 plays important roles in the repolarization of atrial action potentials and regulation of the vascular tone. While the modulation of Kv1.5 function has been well studied, less is known about how the protein levels of Kv1.5 on the cell membrane are regulated. Here, through electrophysiological and biochemical analyses of Kv1.5 channels heterologously expressed in HEK293 cells and neonatal rat ventricular myocytes, as well as native Kv1.5 in human induced pluripotent stem cell (iPSC)-derived atrial cardiomyocytes, we found that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA, 10 nM) diminished Kv1.5 current (I
    MeSH term(s) Animals ; Animals, Newborn ; Endocytosis ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Kv1.5 Potassium Channel/genetics ; Kv1.5 Potassium Channel/metabolism ; Phosphorylation ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Rats ; Signal Transduction ; Ubiquitination
    Chemical Substances Kv1.5 Potassium Channel ; Protein Kinase C (EC 2.7.11.13)
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2021.100514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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