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  1. Article: Geography of Disparity: Connecting COVID-19 Vulnerability and Social Determinants of Health in Colorado.

    Lee, Jieun / Ramírez, Ivan J

    Behavioral medicine (Washington, D.C.)

    2022  Volume 48, Issue 2, Page(s) 72–84

    Abstract: The COVID-19 pandemic has drawn greater attention to social determinants of health and associated health inequities, which disproportionately affect vulnerable populations and places in the U.S. In this study, we explored geographic patterns of local- ... ...

    Abstract The COVID-19 pandemic has drawn greater attention to social determinants of health and associated health inequities, which disproportionately affect vulnerable populations and places in the U.S. In this study, we explored geographic patterns of local-level COVID-19 vulnerability and associations with social and health determinants across Colorado. To conceptualize social and health determinants and how together they generate risk and exposure, we integrated the concepts of social vulnerability and syndemic to situate COVID-19 vulnerability within a broader hazards of place framework. Using geospatial statistics and GIS, we estimated census tract-level rates of COVID-19, which are not yet available in Colorado, and mapped areas of high and low incidence risk. We also developed composite indices that characterized social and health vulnerabilities to measure multivariate associations with COVID-19 rates. The findings revealed hotspots of persistent risk in mountain communities since the pandemic emerged in Colorado, as well as clusters of risk in the Urban Front Range's central and southern counties, and across many parts of eastern Colorado. Vulnerability analyses indicate that COVID-19 rates were associated with mental health and chronic conditions along with social determinants that represent inequities in education, income, healthcare access, and race/ethnicity (minority percent of population), which may have disproportionately exposed some communities more than others to infection and severe health outcomes. Overall, the findings provide geographic health information about COVID-19 and vulnerability context, which may better inform local decision-making for interventions and policies that support equity of social determinants of health.Supplemental data for this article is available online at https://doi.org/10.1080/08964289.2021.2021382 .
    MeSH term(s) COVID-19/epidemiology ; Colorado/epidemiology ; Geography ; Humans ; Pandemics ; Social Determinants of Health
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 623101-9
    ISSN 0896-4289
    ISSN 0896-4289
    DOI 10.1080/08964289.2021.2021382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deconstructing the spatial effects of El Niño and vulnerability on cholera rates in Peru: Wavelet and GIS analyses.

    Ramírez, Ivan J / Lee, Jieun

    Spatial and spatio-temporal epidemiology

    2021  Volume 40, Page(s) 100474

    Abstract: This study examined the spatial effects of El Niño and vulnerability on cholera in Peru across the epidemic period of 1991 to 1998. Using Wavelet and GIS analyses, relationships between sea surface temperatures and department-level cholera rates were ... ...

    Abstract This study examined the spatial effects of El Niño and vulnerability on cholera in Peru across the epidemic period of 1991 to 1998. Using Wavelet and GIS analyses, relationships between sea surface temperatures and department-level cholera rates were estimated. In addition, we constructed composite indices to assess spatial vulnerability during the 1997-98 extreme El Niño. The findings demonstrated strong temporal connections in 1997-98, most evident in northern Peru, and less clear connections from 1991-93. Spatially, we found patterns of difference, greater cholera risk in northern coastal Peru in 1997-98, compared to greater risk in central and southern coastal Peru in 1991-92. Overall, the spatial vulnerability analysis suggested preexisting social conditions and disaster impacts increased cholera exposure and infection in 1998. Our study supports the notion that the spatial nature of El Niño's impacts on cholera rates exacerbated cholera vulnerability following the emergence, rather than triggered the epidemic's onset in 1991.
    MeSH term(s) Cholera/epidemiology ; El Nino-Southern Oscillation ; Epidemics ; Geographic Information Systems ; Humans ; Peru/epidemiology
    Language English
    Publishing date 2021-12-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2515896-X
    ISSN 1877-5853 ; 1877-5845
    ISSN (online) 1877-5853
    ISSN 1877-5845
    DOI 10.1016/j.sste.2021.100474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Removal of antimony by dissimilatory and sulfate‐reducing pathways in anaerobic packed bed bioreactors

    Ramírez‐Patiño, Jesús / Pérez‐Trevilla, Jaime / Cervantes, Francisco J. / Moreno‐Andrade, Iván

    Journal of Chemical Technology & Biotechnology. 2023 Apr., v. 98, no. 4 p.932-939

    2023  

    Abstract: BACKGROUND: Antimony is a toxic and potentially carcinogenic metalloid widely used in industry, whose untreated wastewater could lead to water body pollution. Antimony‐reduced species tend to precipitate in the form of minerals. The biological reduction ... ...

    Abstract BACKGROUND: Antimony is a toxic and potentially carcinogenic metalloid widely used in industry, whose untreated wastewater could lead to water body pollution. Antimony‐reduced species tend to precipitate in the form of minerals. The biological reduction of antimonate to antimonite occurs under anaerobic conditions by two extracellular pathways: dissimilatory biological reduction and reaction with dissolved H₂S in sulfate‐reducing systems. The objective of this study was to determine antimonate removal from synthetic wastewater by dissimilatory and sulfate‐reducing pathways in anaerobic packed bed reactors. RESULTS: The average antimony removal was 28.4% and 58.8% for the dissimilatory and sulfate‐reducing processes, respectively. At the end of the experiment, X‐ray diffraction analysis demonstrated the presence of valentinite in the dissimilatory reactor, and struvite, valentinite, and kermesite in the sulfate‐reducing reactor, being a crystal form resulting from stibnite oxidation by exposure to environmental conditions. Phylogenetic analysis showed the presence of genera Geobacter and Pseudomonas, associated with the dissimilatory reduction, and a high abundance of sulfate‐reducing bacteria in the sulfate‐reducing reactor. In the dissimilatory reactor, there was a dominance of the genus Dysgonomonas, which could play a key role in the redox transformation of the metalloid. CONCLUSION: Antimony removal has been obtained in dissimilatory and sulfate‐reducing processes. Valentinite was observed in the dissimilatory reactor, and struvite, valentinite, and kermesite in the sulfate‐reducing reactor. Phylogenetic analysis showed differences between both processes, with a possible key genus acting in the antimony transformation. © 2022 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
    Keywords Dysgonomonas ; Geobacter ; Pseudomonas ; X-ray diffraction ; antimony ; bioreactors ; carcinogenicity ; industry ; magnesium ammonium phosphate ; oxidation ; phylogeny ; pollution ; surface water ; wastewater
    Language English
    Dates of publication 2023-04
    Size p. 932-939.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1479465-2
    ISSN 1097-4660 ; 0268-2575
    ISSN (online) 1097-4660
    ISSN 0268-2575
    DOI 10.1002/jctb.7296
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Phylogeny and biogeography of the ancient spider family Filistatidae (Araneae) is consistent both with long-distance dispersal and vicariance following continental drift.

    Magalhaes, Ivan L F / Ramírez, Martín J

    Cladistics : the international journal of the Willi Hennig Society

    2022  Volume 38, Issue 5, Page(s) 538–562

    Abstract: Filistatids, the crevice weavers, are an ancient family of cribellate spiders without extant close relatives. As one of the first lineages of araneomorph spiders, they present a complicated mixture of primitive and derived characters that make them a key ...

    Abstract Filistatids, the crevice weavers, are an ancient family of cribellate spiders without extant close relatives. As one of the first lineages of araneomorph spiders, they present a complicated mixture of primitive and derived characters that make them a key taxon to elucidate the phylogeny of spiders, as well as the evolution of phenotypic characters in this group. Their moderate diversity (187 species in 19 genera) is distributed mainly in arid and semi-arid subtropical zones of all continents, except Antarctica. The objective of this paper is to generate a comprehensive phylogenetic hypothesis for this family to advance the understanding of its morphological evolution and biogeography, as well as lay the basis for a natural classification scheme. By studying the morphology using optical and electronic microscopy techniques, we produced a matrix of 302 morphological characters coded for a sample of 103 species of filistatids chosen to represent the phylogenetic diversity of the family. In addition, we included sequences of four molecular markers (COI, 16S, H3 and 28S; 3787 aligned positions) of 70 filistatid species. The analysis of the data (morphological, molecular, and combined) consistently indicates the separation of the Filistatidae into two subfamilies, Prithinae and Filistatinae, in addition to supporting several groups of genera: Filistata, Zaitunia and an undescribed genus from Madagascar; Sahastata and Kukulcania; all Prithinae except Filistatinella and Microfilistata; Antilloides and Filistatoides; a large Old World group including Pritha, Tricalamus, Afrofilistata, Labahitha, Yardiella, Wandella and putative new genera; and a South American group formed by Lihuelistata, Pikelinia and Misionella. Pholcoides is transferred to Filistatinae and Microfilistata is transferred to Prithinae, and each represents the sister group to the remaining genera of its own subfamily. Most genera are valid, although Pikelinia is paraphyletic with respect to Misionella, so we consider the two genera as synonyms and propose a few new generic combinations. Considering the new phylogenetic hypothesis, we discuss the evolution of some morphological character systems and the biogeography of the family. The ages of divergence between clades were estimated using a total-evidence tip-dating approach by including fossils of Filistatidae and early spider clades; this approach resulted in younger age estimates than those obtained with traditional node-dating. Filistatidae is an ancient family that started diversifying in the Mesozoic and most genera date to the Cretaceous. Clades displaying transcontinental distributions were most likely affected by continental drift, but at least one clade shows unequivocal signs of transoceanic long-distance dispersal.
    MeSH term(s) Animals ; Antarctic Regions ; Fossils ; Madagascar ; Phylogeny ; Spiders/genetics
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1462608-1
    ISSN 1096-0031 ; 0748-3007
    ISSN (online) 1096-0031
    ISSN 0748-3007
    DOI 10.1111/cla.12505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 Emergence and Social and Health Determinants in Colorado: A Rapid Spatial Analysis.

    Ramírez, Ivan J / Lee, Jieun

    International journal of environmental research and public health

    2020  Volume 17, Issue 11

    Abstract: The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, ...

    Abstract The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, like other states, that communities of color and low-income persons are disproportionately affected by COVID-19. Using GIS and correlation analysis, this study explored COVID-19 incidence and deaths from March 14 to April 8, 2020, with social determinants and chronic conditions. Preliminary results demonstrate that COVID-19 incidence intensified in mountain communities west of Denver and along the Urban Front Range, and evolved into new centers of risk in eastern Colorado. Overall, the greatest increase in COVID-19 incidence was in northern Colorado, i.e., Weld County, which reported the highest rates in the Urban Front Range. Social and health determinants associated with higher COVID-19-related deaths were population density and asthma, indicative of urban areas, and poverty and unemployment, suggestive of rural areas. Furthermore, a spatial overlap of high rates of chronic diseases with high rates of COVID-19 may suggest a broader syndemic health burden, where comorbidities intersect with inequality of social determinants of health.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Chronic Disease ; Colorado/epidemiology ; Comorbidity ; Coronavirus Infections/epidemiology ; Humans ; Incidence ; Pandemics ; Pneumonia, Viral/epidemiology ; Population Density ; SARS-CoV-2 ; Spatial Analysis
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17113856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Opioid harm reduction and stigma: proposed methods to improve the perception of people with addiction.

    López-Ramírez, Enrique / Huber, Mary J / Matías-Pérez, Diana / Santos-López, Gonzalo / García-Montalvo, Iván Antonio

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1197305

    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1197305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: COVID-19 in a Time of El Niño and Ecosyndemic Vulnerability

    Ramírez, Ivan J / Lee, Jieun

    Insights from Latin America

    2020  

    Keywords covid19
    Publisher Wiley
    Publishing country us
    Document type Book ; Online
    DOI 10.1002/essoar.10503770.1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: COVID-19 Emergence and Social and Health Determinants in Colorado

    Ivan J. Ramírez / Jieun Lee

    International Journal of Environmental Research and Public Health ; Volume 17 ; Issue 11

    A Rapid Spatial Analysis

    2020  

    Abstract: The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, ...

    Abstract The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, like other states, that communities of color and low-income persons are disproportionately affected by COVID-19. Using GIS and correlation analysis, this study explored COVID-19 incidence and deaths from March 14 to April 8, 2020, with social determinants and chronic conditions. Preliminary results demonstrate that COVID-19 incidence intensified in mountain communities west of Denver and along the Urban Front Range, and evolved into new centers of risk in eastern Colorado. Overall, the greatest increase in COVID-19 incidence was in northern Colorado, i.e., Weld County, which reported the highest rates in the Urban Front Range. Social and health determinants associated with higher COVID-19-related deaths were population density and asthma, indicative of urban areas, and poverty and unemployment, suggestive of rural areas. Furthermore, a spatial overlap of high rates of chronic diseases with high rates of COVID-19 may suggest a broader syndemic health burden, where comorbidities intersect with inequality of social determinants of health.
    Keywords coronavirus ; COVID-19 ; GIS ; social determinants of health ; multiple chronic conditions ; spatial analysis ; Colorado ; pandemic ; covid19
    Subject code 910
    Language English
    Publishing date 2020-05-29
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: COVID-19 Emergence and Social and Health Determinants in Colorado

    Ivan J. Ramírez / Jieun Lee

    International Journal of Environmental Research and Public Health, Vol 17, Iss 3856, p

    A Rapid Spatial Analysis

    2020  Volume 3856

    Abstract: The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, ...

    Abstract The aim of this rapid analysis was to investigate the spatial patterns of COVID-19 emergence across counties in Colorado. In the U.S. West, Colorado has the second highest number of cases and deaths, second only to California. Colorado is also reporting, like other states, that communities of color and low-income persons are disproportionately affected by COVID-19. Using GIS and correlation analysis, this study explored COVID-19 incidence and deaths from March 14 to April 8, 2020, with social determinants and chronic conditions. Preliminary results demonstrate that COVID-19 incidence intensified in mountain communities west of Denver and along the Urban Front Range, and evolved into new centers of risk in eastern Colorado. Overall, the greatest increase in COVID-19 incidence was in northern Colorado, i.e., Weld County, which reported the highest rates in the Urban Front Range. Social and health determinants associated with higher COVID-19-related deaths were population density and asthma, indicative of urban areas, and poverty and unemployment, suggestive of rural areas. Furthermore, a spatial overlap of high rates of chronic diseases with high rates of COVID-19 may suggest a broader syndemic health burden, where comorbidities intersect with inequality of social determinants of health.
    Keywords coronavirus ; COVID-19 ; GIS ; social determinants of health ; multiple chronic conditions ; spatial analysis ; Medicine ; R
    Subject code 910
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: JNK Activation in Alzheimer's Disease Is Driven by Amyloid β and Is Associated with Tau Pathology.

    Solas, Maite / Vela, Silvia / Smerdou, Cristian / Martisova, Eva / Martínez-Valbuena, Iván / Luquin, María-Rosario / Ramírez, María J

    ACS chemical neuroscience

    2023  

    Abstract: c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative disorders, especially in Alzheimer's disease (AD). However, it remains unclear whether JNK or amyloid β (Aβ) appears first in the disease onset. Postmortem brain ... ...

    Abstract c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative disorders, especially in Alzheimer's disease (AD). However, it remains unclear whether JNK or amyloid β (Aβ) appears first in the disease onset. Postmortem brain tissues from four dementia subtypes of patients (frontotemporal dementia, Lewy body dementia, vascular dementia, and AD) were used to measure activated JNK (pJNK) and Aβ levels. pJNK expression is significantly increased in AD; however, similar pJNK expression was found in other dementias. Furthermore, there was a significant correlation, co-localization, and direct interaction between pJNK expression and Aβ levels in AD. Significant increased levels of pJNK were also found in Tg2576 mice, a model of AD. In this line, Aβ
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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