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Article ; Online: PU-GAT

Xuan Deng / Cheng Zhang / Jian Shi / Zizhao Wu

Graphical Models, Vol 130, Iss , Pp 101201- (2023)

Point cloud upsampling with graph attention network

2023

Abstract: ... we propose PU-GAT, a novel 3D point cloud upsampling method that leverages graph attention networks to learn ...

Abstract	Point cloud upsampling has been extensively studied, however, the existing approaches suffer from the losing of structural information due to neglect of spatial dependencies between points. In this work, we propose PU-GAT, a novel 3D point cloud upsampling method that leverages graph attention networks to learn structural information over the baselines. Specifically, we first design a local–global feature extraction unit by combining spatial information and position encoding to mine the local spatial inter-dependencies across point features. Then, we construct an up-down-up feature expansion unit, which uses graph attention and GCN to enhance the ability of capturing local structure information. Extensive experiments on synthetic and real data have shown that our method achieves superior performance against previous methods quantitatively and qualitatively.
Keywords	Machine learning ; 3D vision ; Point cloud analysis ; Point cloud upsampling ; Science ; Q ; Technology (General) ; T1-995
Subject code	006
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rapid classification and identification of chemical compositions of Pu-zhi-hui-ling decoction by UHPLC-Q-Orbitrap HRMS.

Shao, Jia / Zheng, Yanxue / Wang, Yuanyuan / Li, Guohui / Wei, Jinxia / Cheng, Wenbo / Li, Yubo

Natural product research

2024 , Page(s) 1–10

Abstract: Pu-zhi-hui-ling decoction (PZHLD) is a traditional Chinese medicine (TCM) formula for the treatment ...

Abstract	Pu-zhi-hui-ling decoction (PZHLD) is a traditional Chinese medicine (TCM) formula for the treatment of Alzheimer's disease (AD), but its chemical composition has not been reported. In this study, we aimed to establish a mass spectrometry (MS) analysis method for rapid classification and identification of the chemical constituents in PZHLD. The sample was analysed by ultrahigh-performance liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). The chemical constituents of PZHLD were identified based on accurate MS data, fragmentation characteristics of MS/MS, and reference information described in the literature. A total of 123 chemical constituents were identified. In addition, we summarised the fragmentation pathways of the chemical constituents in PZHLD. Our finding might lay the foundation for the further pharmacodynamic study and clinical application of PZHLD.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2299302
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Article ; Online: Selective Separation of U(VI) from Pu(IV) by 2,9-Diamide-1,10-phenanthroline Ligands at High Acidity: Extraction and Coordination Chemistry.

Liu, Feng / Xiu, Tao-Yuan / Shehzad, Hamza / Jin, Wei / Huang, Zhi-Wei / Yang, Cheng-Chang / Fu, Xuan / Wang, Xin-Peng / Shi, Wei-Qun / Yuan, Li-Yong

Inorganic chemistry

2024 Volume 63, Issue 8, Page(s) 3859–3869

Abstract: During the PUREX process, the separation between U(VI) and Pu(IV) is achieved by reducing Pu(IV ... to Pu(III), which is complicated and energy-consuming. To address this issue, we report here the first ... case of separation of U(VI) from Pu(IV) by ...

Abstract	During the PUREX process, the separation between U(VI) and Pu(IV) is achieved by reducing Pu(IV) to Pu(III), which is complicated and energy-consuming. To address this issue, we report here the first case of separation of U(VI) from Pu(IV) by
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c04173
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Article ; Online: PU.1 Regulates Cathepsin S Expression in Large Yellow Croaker (

Zhang, Xiang-Yang / Zhuo, Xinyue / Cheng, Jie / Wang, Xiaohong / Liang, Kexin / Chen, Xinhua

Frontiers in immunology

2022 Volume 12, Page(s) 819029

Abstract: ... of reactive oxygen species (ROS) and nitric oxide (NO). The transcription factor PU.1, crucial for the development ... of macrophages in mammals, was found to exist in two transcripts, PU.1a and PU.1b, in large yellow croaker, and ... constitutively expressed in LYC-FM and LYC-RM cells. The expression levels of PU.1a and PU.1b could be ...

Abstract	Different morphologies have been detected in teleost macrophages. In this study, two macrophage cell lines were sub-cloned from a large yellow croaker head kidney cell line, LYCK. One type of sub-cloned cells was fusiform but the other was round, named LYC-FM and LYC-RM cells respectively, based on their morphologies. Both types showed the characteristics of macrophages, including expression of macrophage-specific marker genes, possession of phagocytic and bactericidal activities, and production of reactive oxygen species (ROS) and nitric oxide (NO). The transcription factor PU.1, crucial for the development of macrophages in mammals, was found to exist in two transcripts, PU.1a and PU.1b, in large yellow croaker, and constitutively expressed in LYC-FM and LYC-RM cells. The expression levels of PU.1a and PU.1b could be upregulated by recombinant large yellow croaker IFN-γ protein (r
MeSH term(s)	Animals ; Cathepsins/genetics ; Cell Line ; Fish Diseases/genetics ; Fish Diseases/immunology ; Fish Diseases/microbiology ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Perciformes/physiology ; Phagocytosis ; Promoter Regions, Genetic ; Protein Binding ; Proto-Oncogene Proteins/metabolism ; Reactive Oxygen Species/metabolism ; Trans-Activators/metabolism
Chemical Substances	Proto-Oncogene Proteins ; Reactive Oxygen Species ; Trans-Activators ; proto-oncogene protein Spi-1 ; Cathepsins (EC 3.4.-) ; cathepsin S (EC 3.4.22.27)
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.819029
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Article: Flexible Temperature Sensor Utilizing MWCNT Doped PEG-PU Copolymer Nanocomposites.

Kumar, Amit / Hsieh, Pen-Yi / Shaikh, Muhammad Omar / Kumar, R K Rakesh / Chuang, Cheng-Hsin

Micromachines

2022 Volume 13, Issue 2

Abstract: In this study, polyethylene glycol (PEG) and polyurethane (PU)-based shape-stabilized copolymer ... nanocomposites were synthesized and utilized for developing low-cost and flexible temperature sensors. PU was ... MWCNT) as a conductive filler in the PEG-PU copolymer resulted in a nanocomposite with thermoresistive ...

Abstract	In this study, polyethylene glycol (PEG) and polyurethane (PU)-based shape-stabilized copolymer nanocomposites were synthesized and utilized for developing low-cost and flexible temperature sensors. PU was utilized as a flexible structural material for loading a thermosensitive phase change PEG polymer by means of physical mixing and chemical crosslinking. Furthermore, the introduction of multi-walled carbon nanotubes (MWCNT) as a conductive filler in the PEG-PU copolymer resulted in a nanocomposite with thermoresistive properties. MWCNT loading concentrations from 2 wt.% to 10 wt.% were investigated, to attain the optimum conductivity of the nanocomposite. Additionally, the effect of MWCNT loading concentration on the thermosensitive behavior of the nanocomposite was analyzed in the temperature range 25 °C to 50 °C. The thermosensitive properties of the physically mixed and crosslinked polymeric nanocomposites were compared by spin coating the respective nanocomposites on screen printed interdigitated (IDT) electrodes, to fabricate the temperature sensor. The chemically crosslinked MWCNT-PEG-PU polymeric nanocomposite showed an improved thermosensitive behavior in the range 25 °C to 50 °C, compared to the physically mixed nanocomposite. The detailed structural, morphological, thermal, and phase transition properties of the nanocomposites were investigated using XRD, FTIR, and DSC analysis. XRD and FTIR were used to analyze the crystallinity and PEG-PU bonding of the copolymer nanocomposite, respectively; while the dual phase (solid-liquid) transition of PEG was analyzed using DSC. The proposed nanocomposite-based flexible temperature sensor demonstrated excellent sensitivity, reliability and shows promise for a wide range of bio-robotic and healthcare applications.
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13020197
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Article ; Online: PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility.

Xu, Zihan / He, Libing / Wu, Yilin / Yang, Lu / Li, Cheng / Wu, Hong

Cell reports

2023 Volume 42, Issue 8, Page(s) 112967

Abstract: ... we find that PU.1 is an essential TF downstream of PTEN and that altering PU.1 levels can reprogram ...

Abstract	PTEN loss in fetal liver hematopoietic stem cells (HSCs) leads to alterations in myeloid, T-, and B-lineage potentials and T-lineage acute lymphoblastic leukemia (T-ALL) development. To explore the mechanism underlying PTEN-regulated hematopoietic lineage choices, we carry out integrated assay for transposase-accessible chromatin using sequencing (ATAC-seq), single-cell RNA-seq, and in vitro culture analyses using in vivo-isolated mouse pre-leukemic HSCs and progenitors. We find that PTEN loss alters chromatin accessibility of key lineage transcription factor (TF) binding sites at the prepro-B stage, corresponding to increased myeloid and T-lineage potentials and reduced B-lineage potential. Importantly, we find that PU.1 is an essential TF downstream of PTEN and that altering PU.1 levels can reprogram the chromatin accessibility landscape and myeloid, T-, and B-lineage potentials in Pten
MeSH term(s)	Animals ; Mice ; Cell Differentiation ; Cell Lineage ; Chromatin ; Hematopoietic Stem Cells/metabolism ; Protein Binding ; Trans-Activators/metabolism
Chemical Substances	Chromatin ; Trans-Activators ; Pten protein, mouse (EC 3.1.3.67)
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112967
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Article ; Online: Haemonchus contortus HcL6 promoted the Th9 immune response in goat PBMCs by activating the STAT6/PU.1/NF-κB pathway.

Liang, Meng / Zhang, Yang / Wang, Mingyue / Wen, Zhaohai / Chen, Cheng / Bu, Yongqian / Lu, Mingmin / Song, Xiaokai / Xu, Lixin / Li, Xiangrui / Yan, Ruofeng

Veterinary research

2023 Volume 54, Issue 1, Page(s) 80

Abstract: ... by several cytokines. Key transcription factors, such as STAT6, STAT5, and PU.1, are known to enhance IL-9 expression ... pathway. Moreover, silencing STAT6, PU.1, and NF-κB was found to attenuate the Th9 immune response ...

Abstract	Th9 cells play a crucial role in parasite immunity. The development of Th9 cells is facilitated by several cytokines. Key transcription factors, such as STAT6, STAT5, and PU.1, are known to enhance IL-9 expression during the Th9 immune response. NF-κB-mediated transduction pathways participate in the induction of IL-9. In a previous study, we unveiled a unique ribosomal protein derived from Haemonchus contortus excretory-secretory proteins (HcESPs) that interact with host Th9 cells. In the present study, the effects of the Haemonchus contortus ribosomal protein L6 domain DE-containing protein (HcL6) on IL-9 secretion, Th9 differentiation, and IL-9 transcription were assessed by employing ELISA, flow cytometry, and qPCR methodologies. The observations revealed the transcriptional upregulation of several key genes within the Th9 immune response pathway. Moreover, silencing STAT6, PU.1, and NF-κB was found to attenuate the Th9 immune response. In this study, we unveiled the Th9 immune response-inducing capabilities of HcL6 and elucidated some of its underlying mechanisms. These findings suggest that HcL6 is an immunostimulatory antigen capable of inducing the Th9 immune response. These insights could prove instrumental in identifying potential candidate antigens for the development of immunoprophylactic strategies against H. contortus infections.
MeSH term(s)	Animals ; NF-kappa B ; Haemonchus ; Goats ; Interleukin-9/genetics ; Immunity
Chemical Substances	NF-kappa B ; Interleukin-9
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1146298-x
ISSN	1297-9716 ; 0928-4249
ISSN (online)	1297-9716
ISSN	0928-4249
DOI	10.1186/s13567-023-01214-5
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Article ; Online: Highly Stretchable PU Ionogels with Self-Healing Capability for a Flexible Thermoelectric Generator.

Xu, Junhuai / Wang, Hui / Du, Xiaosheng / Cheng, Xu / Du, Zongliang / Wang, Haibo

ACS applied materials & interfaces

2021 Volume 13, Issue 17, Page(s) 20427–20434

Abstract: ... stretchable polyurethane (PU) ionogel, composed of polyurethane main chains with double bonds in the side ... cross-linkers (BDB) and nonconjugated ionic liquids (EMIM:DCA). The PU ionogels with 30 wt % ILs have ...

Abstract	With the development of thermoelectric (TE) generator, the flexible, stretchable, self-healable, and wearable TE devices have aroused great interest. Therefore, we designed a self-healable and stretchable polyurethane (PU) ionogel, composed of polyurethane main chains with double bonds in the side, cross-linkers (BDB) and nonconjugated ionic liquids (EMIM:DCA). The PU ionogels with 30 wt % ILs have a high mechanical stretchability (300%), good tensile strength (1.61 MPa), and suitable Young's modulus (0.79 MPa). The proposed materials also exhibited an excellent ionic figure of merit (
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c03328
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Article: Anti-Oxidative Effect of Pu-erh Tea in Animals Trails: A Systematic Review and Meta-Analysis.

Yang, Chiung-Ying / Hung, Kuang-Chen / Yen, Yea-Yin / Liao, Hung-En / Lan, Shou-Jen / Lin, Hsin-Cheng

Foods (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: ... anti-oxidative effect of pu-erh tea. Study authors have systemically searched seven databases up until 21 February 2020 ... In performing the literature search on the above-mentioned databases, the authors used keywords of pu-erh AND ... statistically significant effects of pu-erh tea on reducing serum MDA levels (SMD, −4.19; 95% CI, −5.22 to −3.15 ...

Abstract	This study adopted systematic literature review and meta-analysis methodology to explored anti-oxidative effect of pu-erh tea. Study authors have systemically searched seven databases up until 21 February 2020. In performing the literature search on the above-mentioned databases, the authors used keywords of pu-erh AND (superoxide dismutase OR glutathione peroxidase OR malondialdehyde). Results derived from meta-analyses showed statistically significant effects of pu-erh tea on reducing serum MDA levels (SMD, −4.19; 95% CI, −5.22 to −3.15; p < 0.001; I2 = 93.67%); increasing serum SOD levels (SMD, 2.41; 95% CI, 1.61 to 3.20; p < 0.001; I2 = 91.36%); and increasing serum GSH-Px levels (SMD, 4.23; 95% CI, 3.10 to 5.36; p < 0.001; I2 = 93.69%). Results from systematic review and meta-analyses validated that various ingredients found in pu-erh tea extracts had anti-oxidation effects, a long-held conventional wisdom with limited supporting evidence.
Language	English
Publishing date	2022-05-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11091333
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Article ; Online: Joint Determination of Reactor Antineutrino Spectra from ^{235}U and ^{239}Pu Fission by Daya Bay and PROSPECT.

An, F P / Andriamirado, M / Balantekin, A B / Band, H R / Bass, C D / Bergeron, D E / Berish, D / Bishai, M / Blyth, S / Bowden, N S / Bryan, C D / Cao, G F / Cao, J / Chang, J F / Chang, Y / Chen, H S / Chen, S M / Chen, Y / Chen, Y X /

Cheng, J / Cheng, Z K / Cherwinka, J J / Chu, M C / Classen, T / Conant, A J / Cummings, J P / Dalager, O / Deichert, G / Delgado, A / Deng, F S / Ding, Y Y / Diwan, M V / Dohnal, T / Dolinski, M J / Dolzhikov, D / Dove, J / Dvořák, M / Dwyer, D A / Erickson, A / Foust, B T / Gaison, J K / Galindo-Uribarri, A / Gallo, J P / Gilbert, C E / Gonchar, M / Gong, G H / Gong, H / Grassi, M / Gu, W Q / Guo, J Y / Guo, L / Guo, X H / Guo, Y H / Guo, Z / Hackenburg, R W / Hans, S / Hansell, A B / He, M / Heeger, K M / Heffron, B / Heng, Y K / Hor, Y K / Hsiung, Y B / Hu, B Z / Hu, J R / Hu, T / Hu, Z J / Huang, H X / Huang, J H / Huang, X T / Huang, Y B / Huber, P / Koblanski, J / Jaffe, D E / Jayakumar, S / Jen, K L / Ji, X L / Ji, X P / Johnson, R A / Jones, D C / Kang, L / Kettell, S H / Kohn, S / Kramer, M / Kyzylova, O / Lane, C E / Langford, T J / LaRosa, J / Lee, J / Lee, J H C / Lei, R T / Leitner, R / Leung, J K C / Li, F / Li, H L / Li, J J / Li, Q J / Li, R H / Li, S / Li, S C / Li, W D / Li, X N / Li, X Q / Li, Y F / Li, Z B / Liang, H / Lin, C J / Lin, G L / Lin, S / Ling, J J / Link, J M / Littenberg, L / Littlejohn, B R / Liu, J C / Liu, J L / Liu, J X / Lu, C / Lu, H Q / Lu, X / Luk, K B / Ma, B Z / Ma, X B / Ma, X Y / Ma, Y Q / Mandujano, R C / Maricic, J / Marshall, C / McDonald, K T / McKeown, R D / Mendenhall, M P / Meng, Y / Meyer, A M / Milincic, R / Mueller, P E / Mumm, H P / Napolitano, J / Naumov, D / Naumova, E / Neilson, R / Nguyen, T M T / Nikkel, J A / Nour, S / Ochoa-Ricoux, J P / Olshevskiy, A / Palomino, J L / Pan, H-R / Park, J / Patton, S / Peng, J C / Pun, C S J / Pushin, D A / Qi, F Z / Qi, M / Qian, X / Raper, N / Ren, J / Morales Reveco, C / Rosero, R / Roskovec, B / Ruan, X C / Searles, M / Steiner, H / Sun, J L / Surukuchi, P T / Tmej, T / Treskov, K / Tse, W-H / Tull, C E / Tyra, M A / Varner, R L / Venegas-Vargas, D / Viren, B / Vorobel, V / Wang, C H / Wang, J / Wang, M / Wang, N Y / Wang, R G / Wang, W / Wang, X / Wang, Y / Wang, Y F / Wang, Z / Wang, Z M / Weatherly, P B / Wei, H Y / Wei, L H / Wen, L J / Whisnant, K / White, C / Wilhelmi, J / Wong, H L H / Woolverton, A / Worcester, E / Wu, D R / Wu, F L / Wu, Q / Wu, W J / Xia, D M / Xie, Z Q / Xing, Z Z / Xu, H K / Xu, J L / Xu, T / Xue, T / Yang, C G / Yang, L / Yang, Y Z / Yao, H F / Ye, M / Yeh, M / Young, B L / Yu, H Z / Yu, Z Y / Yue, B B / Zavadskyi, V / Zeng, S / Zeng, Y / Zhan, L / Zhang, C / Zhang, F Y / Zhang, H H / Zhang, J W / Zhang, Q M / Zhang, S Q / Zhang, X / Zhang, X T / Zhang, Y M / Zhang, Y X / Zhang, Y Y / Zhang, Z J / Zhang, Z P / Zhang, Z Y / Zhao, J / Zhao, R Z / Zhou, L / Zhuang, H L / Zou, J H

Physical review letters

2022 Volume 128, Issue 8, Page(s) 81801

Abstract: ... 239}Pu has been carried out by the Daya Bay and PROSPECT Collaborations. This Letter reports the level ... between the dominant ^{235}U and ^{239}Pu isotopes and improves the uncertainty of the ^{235}U spectral ... shape to about 3%. The ^{235}U and ^{239}Pu antineutrino energy spectra are unfolded from the jointly ...

Abstract	A joint determination of the reactor antineutrino spectra resulting from the fission of ^{235}U and ^{239}Pu has been carried out by the Daya Bay and PROSPECT Collaborations. This Letter reports the level of consistency of ^{235}U spectrum measurements from the two experiments and presents new results from a joint analysis of both data sets. The measurements are found to be consistent. The combined analysis reduces the degeneracy between the dominant ^{235}U and ^{239}Pu isotopes and improves the uncertainty of the ^{235}U spectral shape to about 3%. The ^{235}U and ^{239}Pu antineutrino energy spectra are unfolded from the jointly deconvolved reactor spectra using the Wiener-SVD unfolding method, providing a data-based reference for other reactor antineutrino experiments and other applications. This is the first measurement of the ^{235}U and ^{239}Pu spectra based on the combination of experiments at low- and highly enriched uranium reactors.
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.128.081801
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