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  1. Article: A Case of Hepatotoxicity Induced by Therapeutic Ketamine Use for Sedation.

    Yoo, Noah / Thomas, Sarun / Bender, Michael / Cheng, Xian Jie Cindy

    Case reports in critical care

    2024  Volume 2024, Page(s) 8366034

    Abstract: Ketamine, initially developed as an anesthetic, has shown versatility in medical applications, including pain management, treatment-resistant depression, and sedation in the intensive care unit (ICU). While generally well-tolerated, long-term use at high ...

    Abstract Ketamine, initially developed as an anesthetic, has shown versatility in medical applications, including pain management, treatment-resistant depression, and sedation in the intensive care unit (ICU). While generally well-tolerated, long-term use at high doses raises concerns about potential toxicities, particularly in the liver. We present a case of a 27-year-old female with a complex medical history who received ketamine infusion for ICU sedation and experienced a sudden rise in liver function tests (LFTs), indicating possible ketamine-induced liver injury (KILI). The patient's liver function normalized after ketamine discontinuation. KILI is infrequent with short-term ketamine use, but emerging case reports suggest it may be associated with chronic or intermittent exposure. The underlying mechanisms for KILI are not fully understood but may involve the accumulation of ketamine metabolites, causing direct toxic effects on the liver. As ketamine's use expands, especially in critical care settings, clinicians should be vigilant for the potential development of KILI. Further research is needed to better understand its risk factors and mechanisms, as early detection and management of KILI are crucial to ensuring patient safety and optimizing ketamine's therapeutic benefits.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2927720-6
    ISSN 2090-6439 ; 2090-6420
    ISSN (online) 2090-6439
    ISSN 2090-6420
    DOI 10.1155/2024/8366034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A General Primer for Data Harmonization.

    Cheng, Cindy / Messerschmidt, Luca / Bravo, Isaac / Waldbauer, Marco / Bhavikatti, Rohan / Schenk, Caress / Grujic, Vanja / Model, Tim / Kubinec, Robert / Barceló, Joan

    Scientific data

    2024  Volume 11, Issue 1, Page(s) 152

    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-024-02956-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Direct Access to Bowl-Like Nanostructures with Block Copolymer Anisotropic Truncated Microspheres.

    Sun, Cheng-Hao / Septani, Cindy Mutiara / Sun, Ya-Sen

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 37, Issue 2, Page(s) 636–645

    Abstract: Bowl-like nanostructures have attracted significant scientific and technological interest due to their favorable characteristics, such as high specific surface area, interconnected porous channels, and conductivity. However, tailored synthesis of bowl- ... ...

    Abstract Bowl-like nanostructures have attracted significant scientific and technological interest due to their favorable characteristics, such as high specific surface area, interconnected porous channels, and conductivity. However, tailored synthesis of bowl-like nanostructures with well-defined and uniform morphology is still a challenge. Herein, we report a versatile microemulsion assembly approach to prepare bowl-like nanostructures of three different materials: polymer, carbon, and platinum. To this end, polystyrene-
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c02298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How Anti-Substance Abuse Campaigns Influence Substance Abusers' Psychological Health in Chinese Communities: The Mediating Role of Perceived Stigma.

    Zeng, Yonghui / Han, Li / Cheng, Yu / Jia, Cindy Xinshan

    International journal of environmental research and public health

    2022  Volume 19, Issue 11

    Abstract: The current study explored how anti-substance abuse campaigns influence substance abusers' psychological health through the perception of stigma. The study is based on a sample of substance abusers who received community-based treatments ( ...

    Abstract The current study explored how anti-substance abuse campaigns influence substance abusers' psychological health through the perception of stigma. The study is based on a sample of substance abusers who received community-based treatments (
    MeSH term(s) Anxiety ; China ; Humans ; Mental Health ; Social Stigma ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/psychology
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19116687
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  5. Article ; Online: Harmonizing government responses to the COVID-19 pandemic.

    Cheng, Cindy / Messerschmidt, Luca / Bravo, Isaac / Waldbauer, Marco / Bhavikatti, Rohan / Schenk, Caress / Grujic, Vanja / Model, Tim / Kubinec, Robert / Barceló, Joan

    Scientific data

    2024  Volume 11, Issue 1, Page(s) 204

    Abstract: Public health and safety measures (PHSM) made in response to the COVID-19 pandemic have been singular, rapid, and profuse compared to the content, speed, and volume of normal policy-making. Not only can they have a profound effect on the spread of the ... ...

    Abstract Public health and safety measures (PHSM) made in response to the COVID-19 pandemic have been singular, rapid, and profuse compared to the content, speed, and volume of normal policy-making. Not only can they have a profound effect on the spread of the disease, but they may also have multitudinous secondary effects, in both the social and natural worlds. Unfortunately, despite the best efforts by numerous research groups, existing data on COVID-19 PHSM only partially captures their full geographical scale and policy scope for any significant duration of time. This paper introduces our effort to harmonize data from the eight largest such efforts for policies made before September 21, 2021 into the taxonomy developed by the CoronaNet Research Project in order to respond to the need for comprehensive, high quality COVID-19 data. In doing so, we present a comprehensive comparative analysis of existing data from different COVID-19 PHSM datasets, introduce our novel methodology for harmonizing COVID-19 PHSM data, and provide a clear-eyed assessment of the pros and cons of our efforts.
    MeSH term(s) Humans ; COVID-19 ; Government ; Pandemics ; Public Health ; Datasets as Topic ; Policy Making
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-02881-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Some Drugs Have Two Faces: Paradoxical Colitis in a Patient with Psoriatic Arthritis Previously Treated with Etanercept and IL-17 Inhibitors.

    Huynh, Sandy / Achalu, Sudharshan / Berry, Rani / Lin, Janice / Wang, Cindy X / Gubatan, John / Cheng, Alice G

    Digestive diseases and sciences

    2024  

    Abstract: Tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) inhibitors are among the most potent treatments for inflammatory arthropathies including rheumatoid arthritis, psoriasis, and spondyloarthropathies. The availability of these biologic agents ... ...

    Abstract Tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) inhibitors are among the most potent treatments for inflammatory arthropathies including rheumatoid arthritis, psoriasis, and spondyloarthropathies. The availability of these biologic agents have revolutionized the management of these conditions and improved patient outcomes. Though generally safe, these biologics may contribute to the induction or exacerbation of colitis. This paradoxical colitis has been observed in patients on TNF-α inhibitor etanercept and IL-17 inhibitors (secukinumab and ixekizumab). We report a case of a 46-year-old female with psoriasis and psoriatic arthritis who presented with gastrointestinal symptoms after treatment with etanercept and IL-17 inhibitors. She was later diagnosed with paradoxical indeterminate colitis that was masked and treated by subsequent biologics given for her RA and psoriatic arthritis. In this report, we will discuss the importance of considering paradoxical colitis in the differential diagnosis for patients even several years after TNF-α/IL-17 inhibitor initiation and explain why careful consideration must be made when initiating these colitis-inducing agents to treat patients with inflammatory disorders.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-024-08380-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.35: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: How Anti-Substance Abuse Campaigns Influence Substance Abusers’ Psychological Health in Chinese Communities

    Yonghui Zeng / Li Han / Yu Cheng / Cindy Xinshan Jia

    International Journal of Environmental Research and Public Health, Vol 19, Iss 6687, p

    The Mediating Role of Perceived Stigma

    2022  Volume 6687

    Abstract: The current study explored how anti-substance abuse campaigns influence substance abusers’ psychological health through the perception of stigma. The study is based on a sample of substance abusers who received community-based treatments ( n = 3457) and ... ...

    Abstract The current study explored how anti-substance abuse campaigns influence substance abusers’ psychological health through the perception of stigma. The study is based on a sample of substance abusers who received community-based treatments ( n = 3457) and used structural equation modeling to estimate the role of perceived stigma in mediating between perceptions of overstatement of harm conveyed in anti-substance abuse campaigns and psychological outcomes. The results revealed that substance abusers’ perception of overstatement of the harm caused by the substances and substance abusers enhanced their perceived stigma and impaired their psychological health in terms of anxiety, depression, and somatization, through both direct and indirect pathways. The results advocate for proper strategies in the design of anti-substance abuse campaigns. Possible initiatives to reduce substance abusers’ perceived stigma are recommended.
    Keywords substance abusers ; perceived stigma ; psychological health ; Medicine ; R
    Subject code 540
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A comparative analysis of the effects of containment policies on the epidemiological manifestation of the COVID-19 pandemic across nine European countries.

    Podrecca, Chiara / Parimbelli, Enea / Pala, Daniele / Cheng, Cindy / Messerschmidt, Luca / Büthe, Tim / Bellazzi, Riccardo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11631

    Abstract: The COVID-19 pandemic has been a catastrophic event that has seriously endangered the world's population. Governments have largely been unprepared to deal with such an unprecedented calamity, partially due to the lack of sufficient or adequately fine- ... ...

    Abstract The COVID-19 pandemic has been a catastrophic event that has seriously endangered the world's population. Governments have largely been unprepared to deal with such an unprecedented calamity, partially due to the lack of sufficient or adequately fine-grained data necessary for forecasting the pandemic's evolution. To fill this gap, researchers worldwide have been collecting data about different aspects of COVID-19's evolution and government responses to them so as to provide the foundation for informative models and tools that can be used to mitigate the current pandemic and possibly prevent future ones. Indeed, since the early stages of the pandemic, a number of research initiatives were launched with this goal, including the PERISCOPE (Pan-European Response to the ImpactS of COVID-19 and future Pandemics and Epidemics) Project, funded by the European Commission. PERISCOPE aims to investigate the broad socio-economic and behavioral impacts of the COVID-19 pandemic, with the goal of making Europe more resilient and prepared for future large-scale risks. The purpose of this study, carried out as part of the PERISCOPE project, is to provide a first European-level analysis of the effect of government policies on the spread of the virus. To do so, we assessed the relationship between a novel index, the Policy Intensity Index, and four epidemiological variables collected by the European Centre for Disease Control and Prevention, and then applied a comprehensive Pan-European population model based on Multilevel Vector Autoregression. This model aims at identifying effects that are common to some European countries while treating country-specific policies as covariates, explaining the different evolution of the pandemic in nine selected countries due to data availability: Spain, France, Netherlands, Latvia, Slovenia, Greece, Ireland, Cyprus, Estonia. Results show that specific policies' effectiveness tend to vary consistently within the different countries, although in general policies related to Health Monitoring and Health Resources are the most effective for all countries.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; Policy ; France ; Cyprus
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37751-4
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  9. Article: Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

    Fang, Hanshu / Lee, Chung-Ho / Cao, Huiluo / Jiang, Shuo / So, Simon Yung-Chun / Tse, Cindy Wing-Sze / Cheng, Vincent Chi-Chung / Ho, Pak-Leung

    Microorganisms

    2023  Volume 11, Issue 1

    Abstract: Bacteremia caused by extended-spectrum β-lactamases- ... ...

    Abstract Bacteremia caused by extended-spectrum β-lactamases-producing
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11010128
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  10. Article: Non-Laboratory-Based Risk Prediction Tools for Undiagnosed Pre-Diabetes: A Systematic Review.

    Cheng, Will Ho-Gi / Mi, Yuqi / Dong, Weinan / Tse, Emily Tsui-Yee / Wong, Carlos King-Ho / Bedford, Laura Elizabeth / Lam, Cindy Lo-Kuen

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 7

    Abstract: Early detection of pre-diabetes (pre-DM) can prevent DM and related complications. This review examined studies on non-laboratory-based pre-DM risk prediction tools to identify important predictors and evaluate their performance. PubMed, Embase, MEDLINE, ...

    Abstract Early detection of pre-diabetes (pre-DM) can prevent DM and related complications. This review examined studies on non-laboratory-based pre-DM risk prediction tools to identify important predictors and evaluate their performance. PubMed, Embase, MEDLINE, CINAHL were searched in February 2023. Studies that developed tools with: (1) pre-DM as a prediction outcome, (2) fasting/post-prandial blood glucose/HbA1c as outcome measures, and (3) non-laboratory predictors only were included. The studies' quality was assessed using the CASP Clinical Prediction Rule Checklist. Data on pre-DM definitions, predictors, validation methods, performances of the tools were extracted for narrative synthesis. A total of 6398 titles were identified and screened. Twenty-four studies were included with satisfactory quality. Eight studies (33.3%) developed pre-DM risk tools and sixteen studies (66.7%) focused on pre-DM and DM risks. Age, family history of DM, diagnosed hypertension and obesity measured by BMI and/or WC were the most common non-laboratory predictors. Existing tools showed satisfactory internal discrimination (AUROC: 0.68-0.82), sensitivity (0.60-0.89), and specificity (0.50-0.74). Only twelve studies (50.0%) had validated their tools externally, with a variance in the external discrimination (AUROC: 0.31-0.79) and sensitivity (0.31-0.92). Most non-laboratory-based risk tools for pre-DM detection showed satisfactory performance in their study populations. The generalisability of these tools was unclear since most lacked external validation.
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13071294
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