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Article: Strongyloides stercoralis Hyperinfection Syndrome in Pregnancy.

Akers, Allison N / Vest, Adriana / Schenone, Claudio V / Rodriguez, Alejandro

2023 Volume 15, Issue 8, Page(s) e43568

Abstract: Strongyloidiasis is a parasitic infection with a high global burden of disease. Hyperinfection syndrome is a life-threatening complication that predominantly affects immunosuppressed individuals, such as those receiving corticosteroid treatment. Despite ... ...

Abstract	Strongyloidiasis is a parasitic infection with a high global burden of disease. Hyperinfection syndrome is a life-threatening complication that predominantly affects immunosuppressed individuals, such as those receiving corticosteroid treatment. Despite its worldwide prevalence, little is known about the clinical effects of this condition on the feto-maternal dyad during pregnancy. We present a case of placental abruption leading to preterm delivery in a pregnancy complicated by
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43568
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast: A case report.

Akers, Allison / Read, Susan / Feldman, John / Gooden, Casey / English, Diana P

World journal of clinical cases

2024 Volume 12, Issue 2, Page(s) 412–417

Abstract: Background: Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature. Breast metastases are associated with poor prognosis. The following case highlights the diagnostic challenges associated ... ...

Abstract	Background: Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature. Breast metastases are associated with poor prognosis. The following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized treatment. Case summary: A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina, parametria and lymph node metastases. Cervical biopsies confirmed high grade adenocarcinoma with mucinous features. A positron emission tomography/computed tomography (PET/CT) did not show evidence of metastatic disease. She received concurrent cisplatin with external beam radiation therapy. Follow up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic disease. Patient was lost to follow up for six months. She was re-imaged on re-presentation and found to have widely metastatic disease including breast disease. Breast biopsy confirmed programmed death-ligand 1 positive metastatic cervical cancer. The patient received six cycles of carboplatin and paclitaxel with pembrolizumab. Restaging imaging demonstrated response. Patient continued on pembrolizumab with disease control. Conclusion: Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis challenging. Clinical history and immunohistochemical evaluation of breast lesion, and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the breast. Overall, the prognosis is poor, but immunotherapy can be considered in select patients and may result in good disease response.
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v12.i2.412
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Patient-Prosthesis Mismatch in Pregnancy: A Multidisciplinary Approach.

Akers, Allison / De Assis, Viviana / Scoma, Christopher / Cain, Mary Ashley / Crousillat, Daniela R

JACC. Case reports

2023 Volume 27, Page(s) 102073

Abstract: A 24-year-old gravida 3 para 1 woman with history of bioprosthetic aortic valve replacement complicated by patient-prosthesis mismatch presented for prenatal care. Her pregnancy was managed by a multidisciplinary cardio-obstetrics team, resulting in an ... ...

Abstract	A 24-year-old gravida 3 para 1 woman with history of bioprosthetic aortic valve replacement complicated by patient-prosthesis mismatch presented for prenatal care. Her pregnancy was managed by a multidisciplinary cardio-obstetrics team, resulting in an uncomplicated repeat cesarean section at term.
Language	English
Publishing date	2023-12-06
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2023.102073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Oocyte Retrieval in Asymptomatic Patients Positive for SARS-CoV-2.

Akers, Allison / New, Erika P / Plosker, Shayne / Silva, Celso P / Sprague, Rachel / Imudia, Anthony N

Case reports in obstetrics and gynecology

2022 Volume 2022, Page(s) 3107747

Abstract: Objective: To report two cases of oocyte retrieval performed in asymptomatic SARS-CoV-2-positive patients.: Design: Case report. : Results: Both patients underwent successful oocyte retrieval procedures without developing symptoms or complications ...

Abstract	Objective: To report two cases of oocyte retrieval performed in asymptomatic SARS-CoV-2-positive patients. Design: Case report. Results: Both patients underwent successful oocyte retrieval procedures without developing symptoms or complications from COVID-19. No staff members that cared for these patients developed symptoms of COVID-19. Conclusion: Worsening fertility outcomes and potential for psychological and financial burdens to the patient must be balanced with risk of perioperative complications in patients testing positive for SARS-CoV-2. As we continue to provide fertility care in a world with COVID-19, appropriate risk mitigation strategies should be implemented to minimize exposure to SARS-CoV-2.
Language	English
Publishing date	2022-08-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627654-9
ISSN	2090-6692 ; 2090-6684
ISSN (online)	2090-6692
ISSN	2090-6684
DOI	10.1155/2022/3107747
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Updates and Advances in the Management of Lateral Meniscal Radial Tears: A Critical Analysis Review.

Lin, James S / Akers, Allison / Miller, Timothy L

JBJS reviews

2020 Volume 8, Issue 11, Page(s) e2000056

Abstract: Because of their increased mobility, lack of resistance to hoop stresses, and decreased blood supply, radial tears of the lateral meniscus are more troublesome to heal than vertical longitudinal tears. Given the success of meniscal root repairs, radial ... ...

Abstract	Because of their increased mobility, lack of resistance to hoop stresses, and decreased blood supply, radial tears of the lateral meniscus are more troublesome to heal than vertical longitudinal tears. Given the success of meniscal root repairs, radial tears of the lateral meniscal body should be given strong consideration for repair because of a more reproducible ability to heal such lesions in young, active patients. Technique options that should be considered for the less common anterior radial tears of the lateral meniscus include outside-in repair, self-capturing suture-passing devices, and orthobiologic treatments to stimulate healing. Although a variety of suture techniques, including the double horizontal mattress and horizontal butterfly patterns, have demonstrated improvements in patient outcomes, evidence is still limited with regard to the ideal suture pattern for radial tears.
MeSH term(s)	Animals ; Humans ; Menisci, Tibial/blood supply ; Menisci, Tibial/physiology ; Orthopedic Procedures/methods ; Tibial Meniscus Injuries/physiopathology ; Tibial Meniscus Injuries/surgery
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2329-9185
ISSN (online)	2329-9185
DOI	10.2106/JBJS.RVW.20.00056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 Implications on Clinical Clerkships and the Residency Application Process for Medical Students.

Akers, Allison / Blough, Christian / Iyer, Maya S

Cureus

2020 Volume 12, Issue 4, Page(s) e7800

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruption to undergraduate medical education (UME). Although the immediate scheduling challenges are being addressed, there has been less discourse regarding how this pandemic will ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruption to undergraduate medical education (UME). Although the immediate scheduling challenges are being addressed, there has been less discourse regarding how this pandemic will impact medical students in their preparation for and application to residency programs. While some historical disasters and pandemics provide a loose precedent for UME response during COVID-19, the impact of the current pandemic has surpassed any other events. COVID-19 will likely impact UME in the suspension of clinical rotations, alterations in grading, suspension or elimination of away rotations, changes in medical licensing exams, and ramifications on mental health. This review assesses governing medical bodies' recommendations regarding UME during the COVID-19 pandemic and how this may impact preparation for residency. In particular, residency programs will likely have to create new guidelines for assessing applicants during this unique cycle.
Keywords	covid19
Language	English
Publishing date	2020-04-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.7800
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets.

Meyerholz, David K / Leidinger, Mariah R / Adam Goeken, J / Businga, Thomas R / Vizuett, Sebastian / Akers, Allison / Evans, Idil / Zhang, Yan / Engelhardt, John F

BMC research notes

2023 Volume 16, Issue 1, Page(s) 111

Abstract: Objective: Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5AC and MUC5B ...

Abstract	Objective: Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5AC and MUC5B immunohistochemical techniques to provide a useful tool to identify, localize and interpret mucin expression in ferret tissues. Results: MUC5AC and MUC5B mucins were detected most commonly in large airways and least in small airways, consistent with reported goblet cell density in airway surface epithelia. We evaluated whether staining method affected the detection of goblet cell mucins in serial sections of bronchial surface epithelia. Significant differences between stains were not observed suggesting common co-expression MUC5AC and MUC5B proteins in goblet cells of airway surface epithelia. Gallbladder and stomach tissues are reported to have differential mucin enrichment, so we tested these tissues in wildtype ferrets. Stomach tissues were enriched in MUC5AC and gallbladder tissues enriched in MUC5B, mucin enrichment similar to human tissues. Mucin immunostaining techniques were further qualified for specificity using lung tissue from recently generated MUC5AC
MeSH term(s)	Animals ; Humans ; Ferrets ; Lung/metabolism ; Cystic Fibrosis ; Respiratory Mucosa/metabolism ; Thorax ; Mucin-5B/metabolism ; Mucin 5AC/metabolism
Chemical Substances	MUC5B protein, human ; Mucin-5B ; MUC5AC protein, human ; Mucin 5AC
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-023-06388-x
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Article: COVID-19 Implications on Clinical Clerkships and the Residency Application Process for Medical Students

Akers, Allison / Blough, Christian / Iyer, Maya S.

Cureus

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruption to undergraduate medical education (UME) Although the immediate scheduling challenges are being addressed, there has been less discourse regarding how this pandemic will ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruption to undergraduate medical education (UME) Although the immediate scheduling challenges are being addressed, there has been less discourse regarding how this pandemic will impact medical students in their preparation for and application to residency programs While some historical disasters and pandemics provide a loose precedent for UME response during COVID-19, the impact of the current pandemic has surpassed any other events COVID-19 will likely impact UME in the suspension of clinical rotations, alterations in grading, suspension or elimination of away rotations, changes in medical licensing exams, and ramifications on mental health This review assesses governing medical bodies' recommendations regarding UME during the COVID-19 pandemic and how this may impact preparation for residency In particular, residency programs will likely have to create new guidelines for assessing applicants during this unique cycle
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #422937
Database	COVID19

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Article ; Online: Understanding Barriers to COVID-19 Testing Among Rural and Urban Populations in Kansas.

Collie-Akers, Vicki L / Ablah, Elizabeth / Landry, Sarah / Honn, Allison / Mussulman, Laura / Ricketts, Mary / Carter, Tony / Wright, Ullyses / Watson, Christal / Liu, Bing / Crawford, Broderick / Greiner, K Allen / Ellerbeck, Edward F

American journal of public health

2022 Volume 112, Issue S9, Page(s) S874–S877

MeSH term(s)	Humans ; Urban Population ; COVID-19 Testing ; Kansas/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; Rural Population
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2022.306978
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Article ; Online: Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets

David K. Meyerholz / Mariah R. Leidinger / J. Adam Goeken / Thomas R. Businga / Sebastian Vizuett / Allison Akers / Idil Evans / Yan Zhang / John F. Engelhardt

BMC Research Notes, Vol 16, Iss 1, Pp 1-

2023 Volume 7

Abstract: Abstract Objective Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5AC ... ...

Abstract	Abstract Objective Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5AC and MUC5B immunohistochemical techniques to provide a useful tool to identify, localize and interpret mucin expression in ferret tissues. Results MUC5AC and MUC5B mucins were detected most commonly in large airways and least in small airways, consistent with reported goblet cell density in airway surface epithelia. We evaluated whether staining method affected the detection of goblet cell mucins in serial sections of bronchial surface epithelia. Significant differences between stains were not observed suggesting common co-expression MUC5AC and MUC5B proteins in goblet cells of airway surface epithelia. Gallbladder and stomach tissues are reported to have differential mucin enrichment, so we tested these tissues in wildtype ferrets. Stomach tissues were enriched in MUC5AC and gallbladder tissues enriched in MUC5B, mucin enrichment similar to human tissues. Mucin immunostaining techniques were further qualified for specificity using lung tissue from recently generated MUC5AC −/− and MUC5B −/− ferrets. Qualified techniques for MUC5AC and MUC5B immunohistochemistry will be useful tools for mucin tissue studies in CF and other ferret models.
Keywords	Cystic fibrosis ; Ferret ; Immunohistochemistry ; Lung ; Mucin ; Mucus ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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