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Article ; Online: Determining the Need for Metastatic Staging in Patients with Bilateral Breast Cancers.

Alcantara, Veronica Siton / Chan, Sut Mo Zachary / Wong, Fuh Yong / Allen, John Carson / Lim, Geok Hoon

2024 Volume 31, Issue 4, Page(s) 1936–1946

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Neoplasm Staging ; Middle Aged ; Aged ; Retrospective Studies ; Neoplasm Metastasis ; Adult
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31040145
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Article ; Online: Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins.

Llobet, Mònica Ortega / Johansson, Åsa / Gyllensten, Ulf / Allen, Marie / Enroth, Stefan

Forensic science international. Genetics

2023 Volume 65, Page(s) 102871

Abstract: The prediction of human characteristics from blood using molecular markers would be very helpful in forensic science. Such information can be particularly important in providing investigative leads in police casework from, for example, blood found at ... ...

Abstract	The prediction of human characteristics from blood using molecular markers would be very helpful in forensic science. Such information can be particularly important in providing investigative leads in police casework from, for example, blood found at crime scenes in cases without a suspect. Here, we investigated the possibilities and limitations of predicting seven phenotypic traits (sex, age, height, body mass index [BMI], hip-to-waist [WTH] ratio, smoking status and lipid-lowering drug use) using either DNA methylation or plasma proteins separately or in combination. We developed a prediction pipeline starting with the prediction of sex followed by sex-specific, stepwise, individual age, sex-specific anthropometric traits and, finally, lifestyle-related traits. Our data revealed that age, sex and smoking status can be accurately predicted from DNA methylation alone, while the use of plasma proteins was highly accurate for prediction of the WTH ratio, and a combined analysis of the best predictions for BMI and lipid-lowering drug use. In unseen individuals, age was predicted with a standard error of 3.3 years for women and 6.5 years for men, while the accuracy in smoking prediction across both men and women was 0.86. In conclusion, we have developed a stepwise approach for the de-novo prediction of individual characteristics from plasma proteins and DNA methylation markers. These models are accurate and may provide valuable information and investigative leads in future forensic casework.
MeSH term(s)	Male ; Humans ; Female ; Child, Preschool ; Body Mass Index ; Smoking ; Genetic Markers ; Lipids ; Blood Proteins ; Epigenesis, Genetic
Chemical Substances	Genetic Markers ; Lipids ; Blood Proteins
Language	English
Publishing date	2023-04-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2493339-9
ISSN	1878-0326 ; 1872-4973
ISSN (online)	1878-0326
ISSN	1872-4973
DOI	10.1016/j.fsigen.2023.102871
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Zs.A 6764: Show issues

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Article ; Online: Palliative Care Across the Spectrum of Heart Failure.

Gelfman, Laura P / Blum, Moritz / Ogunniyi, Modele O / McIlvennan, Colleen K / Kavalieratos, Dio / Allen, Larry A

JACC. Heart failure

2024

Abstract: Persons with heart failure (HF) often suffer from poor symptom control, decreased quality of life, and poor communication with their health care providers. These needs are particularly acute in advanced HF, a leading cause of death in the United States. ... ...

Abstract	Persons with heart failure (HF) often suffer from poor symptom control, decreased quality of life, and poor communication with their health care providers. These needs are particularly acute in advanced HF, a leading cause of death in the United States. Palliative care, when offered alongside HF disease management, offers improved symptom control, quality of life, communication, and caregiver satisfaction as well as reduced caregiver anxiety. The dynamic nature of the clinical trajectory of HF presents distinct symptom patterns, changing functional status, and uncertainty, which requires an adaptive, dynamic model of palliative care delivery. Due to a limited specialty-trained palliative care workforce, patients and their caregivers often cannot access these benefits, especially in the community. To meet these needs, new models are required that are better informed by high-quality data, engage a range of health care providers in primary palliative care principles, and have clear triggers for specialty palliative care engagement, with specific palliative interventions tailored to patient's illness trajectory and changing needs.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2024.01.010
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Article: The use of nephrostomy tubes in optimizing surgical conditions for a patient with xanthogranulomatous pyelonephritis.

Allen, Jordan L / Erdman, Marcus O / Clark, Joseph Y

The Canadian journal of urology

2020 Volume 27, Issue 4, Page(s) 10342–10345

Abstract: Xanthogranulomatous pyelonephritis is a rare variant of pyelonephritis that often requires radical surgery. We report a case of a 51-year-old female patient who was managed with prolonged placement of nephrostomy tubes prior to surgery. This case ... ...

Abstract	Xanthogranulomatous pyelonephritis is a rare variant of pyelonephritis that often requires radical surgery. We report a case of a 51-year-old female patient who was managed with prolonged placement of nephrostomy tubes prior to surgery. This case illustrates the importance of surgical optimization of a poor operative candidate and the use of nephrostomy tubes as a temporizing management strategy.
MeSH term(s)	Female ; Humans ; Middle Aged ; Nephrotomy/instrumentation ; Preoperative Period ; Pyelonephritis, Xanthogranulomatous/surgery ; Pyelonephritis, Xanthogranulomatous/therapy
Language	English
Publishing date	2020-08-26
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	2064475-9
ISSN	1195-9479
ISSN	1195-9479
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Zs.A 5607: Show issues

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Article: Canada's animal transport regulations and the veterinarian's role.

Allen, Anne / Rot, Corrie / Brown, Heather / Rozon, Marie-Odile / Johannson, Sarah

The Canadian veterinary journal = La revue veterinaire canadienne

2022 Volume 63, Issue 8, Page(s) 866–868

MeSH term(s)	Animal Welfare ; Animals ; Canada ; Humans ; Veterinarians ; Veterinary Medicine
Language	English
Publishing date	2022-08-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
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Article: Adult Mouse Leptomeninges Exhibit Regional and Age-related Cellular Heterogeneity Implicating Mental Disorders.

Allen, Christina A / Goderie, Susan K / Liu, Mo / Kiehl, Thomas R / Farjood, Farhad / Wang, Yue / Boles, Nathan C / Temple, Sally

bioRxiv : the preprint server for biology

2023

Abstract: The leptomeninges envelop the central nervous system (CNS) and contribute to cerebrospinal fluid (CSF) production and homeostasis. We analyzed the meninges overlying the anterior or posterior forebrain in the adult mouse by single nuclear RNA-sequencing ( ...

Abstract	The leptomeninges envelop the central nervous system (CNS) and contribute to cerebrospinal fluid (CSF) production and homeostasis. We analyzed the meninges overlying the anterior or posterior forebrain in the adult mouse by single nuclear RNA-sequencing (snucRNA-seq). This revealed regional differences in fibroblast and endothelial cell composition and gene expression. Surprisingly, these non-neuronal cells co-expressed genes implicated in neural functions. The regional differences changed with aging, from 3 to 18 months. Cytokine analysis revealed specific soluble factor production from anterior vs posterior meninges that also altered with age. Secreted factors from the leptomeninges from different regions and ages differentially impacted the survival of anterior or posterior cortical neuronal subsets, neuron morphology, and glia proliferation. These findings suggest that meningeal dysfunction in different brain regions could contribute to specific neural pathologies. The disease-associations of meningeal cell genes differentially expressed with region and age were significantly enriched for mental and substance abuse disorders.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.10.557097
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Article ; Online: The mevalonate suppressor δ-tocotrienol increases AMPA receptor-mediated neurotransmission.

Wei, Wei / Yount, Sophie T / Allen, Zachary D / Bechdol, Katherine F / Xia, Weiming / Mo, Huanbiao / Mabb, Angela M

Biochemical and biophysical research communications

2022 Volume 638, Page(s) 112–119

Abstract: Synaptic dysfunction is a hallmark of aging and is found in several neurological disorders such as Alzheimer's disease. A common mechanism related to synaptic dysfunction is dysregulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) ... ...

Abstract	Synaptic dysfunction is a hallmark of aging and is found in several neurological disorders such as Alzheimer's disease. A common mechanism related to synaptic dysfunction is dysregulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which mediate excitatory neurotransmission and synaptic plasticity. Accumulating evidence suggests that tocotrienols, vitamin E molecules that contain an isoprenoid side chain, may promote cognitive improvement in hippocampal-dependent learning tasks. Tocotrienols have also been shown to reduce the secretion of β-amyloid (Aβ) and cholesterol biosynthesis in part by downregulating 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme that controls flux of the mevalonate pathway and cholesterol biosynthesis. We hypothesized that tocotrienols might promote cognitive improvement by increasing AMPA receptor-mediated synaptic transmission. Here, we found that δ-tocotrienol increased surface levels of GluA1 but not the GluA2 AMPA receptor subunit in primary hippocampal neurons. Unexpectedly, δ-tocotrienol treatment caused a decrease in the phosphorylation of GluA1 at Serine 845 with no significant changes in GluA1 at Serine 831. Moreover, δ-tocotrienol increased spontaneous excitatory postsynaptic current (sEPSC) amplitude and reduced the secretion of Aβ
MeSH term(s)	Receptors, AMPA/metabolism ; Mevalonic Acid/metabolism ; Tocotrienols/metabolism ; Synaptic Transmission ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid ; Cholesterol/metabolism ; Serine/metabolism ; Hippocampus/metabolism
Chemical Substances	Receptors, AMPA ; tocotrienol, delta (1SRB74OWSI) ; Mevalonic Acid (S5UOB36OCZ) ; Tocotrienols ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0) ; Cholesterol (97C5T2UQ7J) ; Serine (452VLY9402)
Language	English
Publishing date	2022-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.11.052
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Zs.A 116: Show issues

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Article: The Use and Limitations of Exome Capture to Detect Novel Variation in the Hexaploid Wheat Genome.

Burridge, Amanda J / Winfield, Mark O / Wilkinson, Paul A / Przewieslik-Allen, Alexandra M / Edwards, Keith J / Barker, Gary L A

Frontiers in plant science

2022 Volume 13, Page(s) 841855

Abstract: The bread wheat ( ...

Abstract	The bread wheat (
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.841855
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Article: The association of prostatic lipids with progression, racial disparity and discovery of biomarkers in prostate cancer.

Zhou, Xinchun / Mao, Jinghe / Peng, Wanxin / Chen, Zhenbang / Mei, Hao / Kyle, Patrick / Mo, Yinyuan / Allen, Timothy C

Translational oncology

2021 Volume 14, Issue 12, Page(s) 101218

Abstract: Background: It remains under-investigated whether prostatic lipid profiles are associated with pathogenesis, progression, racial disparity, and discovery of biomarkers in prostate cancer (PCa).: Methods: The electrospray ionization-tandem mass ... ...

Abstract	Background: It remains under-investigated whether prostatic lipid profiles are associated with pathogenesis, progression, racial disparity, and discovery of biomarkers in prostate cancer (PCa). Methods: The electrospray ionization-tandem mass spectrometry was applied to quantitate prostatic lipids in human and mouse PCa and non-cancer prostatic tissues. Biostatistics and bioinformatics were used to compare the concentrations of prostatic lipids at levels of total lipid, group, class and individual species between PCa and benign prostatic tissues, between races, and among pathological conditions of PCa. Results: Prostatic concentrations of total lipids as well as neutral lipids were significantly higher in PCa than in benign prostatic tissues in all population and Caucasian American population, but not in African American population. The prostatic phospholipid were not statistically different between PCa and benign prostatic tissues in all study populations. Cholesteryl ester is the only lipid class significantly higher in PCa than in benign prostatic tissues in all study populations. A panel of prostatic lipid parameters in each study population was identified as diagnostic and prognostic biomarkers with >60% of sensitivity, specificity and accuracy simultaneously. Lipid profiling on mouse prostatic tissues further confirmed correlation of prostatic lipid profiles to the pathogenesis and progression of PCa. In addition, a few prostatic lipids in mouse can serve as prognostic biomarkers in differentiation of indolent from aggressive PCa. Conclusion: The prostatic lipids are widely associated with the pathogenesis, progression and racial disparity of PCa. A panel of prostatic lipids can serve as diagnostic, prognostic and race-specific biomarkers for PCa.
Language	English
Publishing date	2021-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2021.101218
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Article ; Online: Higher psychogeriatric admissions in COVID-19 than in severe acute respiratory syndrome.

Lee, Allen T C / Mo, Flora Y M / Lam, Linda C W

International journal of geriatric psychiatry

2020 Volume 35, Issue 12, Page(s) 1449–1457

Abstract: Objectives: To examine whether psychogeriatric admissions increased after COVID-19, independent of seasonal variation; whether the increase was comparable with that seen in severe acute respiratory syndrome (SARS); and which factors were associated with ...

Abstract	Objectives: To examine whether psychogeriatric admissions increased after COVID-19, independent of seasonal variation; whether the increase was comparable with that seen in severe acute respiratory syndrome (SARS); and which factors were associated with such increase. Methods: All psychiatric admissions aged 65 or older in the 3 months before and after COVID-19 (from November 2019 to April 2020), in the previous 2 years (from November 2017 to April 2018 and from November 2018 to April 2019), and in the year of SARS (from November 2002 to April 2003) in a major gazette inpatient psychiatric unit in Hong Kong, which serves a catchment population of 1.4 million, were anonymously reviewed. The number of psychogeriatric admissions between different timeframes was compared, and factors that might explain the increase in admissions following COVID-19 were examined. Results: Psychogeriatric admissions increased by 21.4% following the COVID-19 outbreak. This increase was not explained by seasonal variation and was greater and lasted longer than that in SARS. A rising trend in admissions for older adults living in residential care homes was observed. The increase in admissions was associated with fewer outpatient attendance, fewer home visits by nurses, and more older adults with dementia requiring inpatient care. Conclusions: Our findings highlight the impact of COVID-19 on older adults' mental health, greater demand for inpatient psychogeriatric services in COVID-19 than in SARS, and the importance of maintaining support for community-living older adults, in particular those with dementia, and their caregivers in reducing the needs for inpatient psychiatric treatment during the pandemic. Clinicaltrials.gov # ChiCTR2000033317.
MeSH term(s)	Aged ; COVID-19 ; Geriatric Psychiatry ; Hong Kong/epidemiology ; Humans ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Journal Article
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5422
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