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Article ; Online: COVID-19-Induced Aggression and Hypersexuality in an Adolescent Patient.

Parsa, Shyon / Pliszka, Andrew / Portley, Robert

Journal of the Academy of Consultation-Liaison Psychiatry

2022 Volume 63, Issue 4, Page(s) 406–407

MeSH term(s)	Adolescent ; Aggression ; COVID-19 ; Compulsive Behavior ; Humans ; Paraphilic Disorders
Language	English
Publishing date	2022-07-22
Publishing country	Netherlands
Document type	Letter
ISSN	2667-2960
ISSN (online)	2667-2960
DOI	10.1016/j.jaclp.2022.03.002
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Article: Risk-adjusted analysis of perioperative outcomes after the Sistrunk procedure.

Wynings, Erin M / Wang, Cynthia S / Parsa, Shyon / Johnson, Romaine F / Liu, Christopher C

Laryngoscope investigative otolaryngology

2023 Volume 8, Issue 6, Page(s) 1571–1578

Abstract: Objectives: Thyroglossal duct cyst (TGDC) is the most common pediatric congenital neck mass. The Sistrunk procedure is the standard method of excision and is associated with low rates of recurrence. This study aimed to review our institution's outcomes ... ...

Abstract	Objectives: Thyroglossal duct cyst (TGDC) is the most common pediatric congenital neck mass. The Sistrunk procedure is the standard method of excision and is associated with low rates of recurrence. This study aimed to review our institution's outcomes following the Sistrunk procedure, specifically the rates of wound complications and cyst recurrence. Methods: This was a retrospective case series of pediatric patients undergoing the Sistrunk procedure from June 2009 to April 2021. Results: A total of 273 patients were included. Of these, 139 (53%) patients were male and 181 (66%) were white. The average age at the time of surgery was 7.1 years. The overall cyst recurrence rate was 11%. The most common wound complications were seroma (14%) and surgical site infections (SSIs) (12%). Wound complications were associated with prior history of cyst infection (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.07-3.60, Conclusions: Prior cyst infection is associated with increased rates of postoperative wound complications. Postoperative antibiotics and drain placement did not significantly affect complication rates. Level of evidence: 4.
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1183
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Article ; Online: The Role of Fecal Microbiota Transplantation in the Induction of Remission in Ulcerative Colitis.

Saleh, Adam / Parsa, Shyon / Garza, Manuel / Quigley, Eamonn M M / Abraham, Bincy P

Digestive diseases (Basel, Switzerland)

2023 Volume 41, Issue 4, Page(s) 656–665

Abstract: Background: Considerable research supports an important role for the microbiome and/or microbiome-host immune system interactions in the pathogenesis of inflammatory bowel disease (IBD). Consequently, microbiota-modulating interventions, such as fecal ... ...

Abstract	Background: Considerable research supports an important role for the microbiome and/or microbiome-host immune system interactions in the pathogenesis of inflammatory bowel disease (IBD). Consequently, microbiota-modulating interventions, such as fecal microbiota transplantation (FMT), have attracted interest in the management of IBD, including ulcerative colitis (UC). Summary: While the clinical response to FMT in UC has varied between different studies, results to date may offer guidance toward optimal use of FMT. Thus, increased microbiome biodiversity, the presence of short-chain fatty acid-producing bacteria, Clostridium clusters IV and XIVa, Odoribacter splanchnicus, and reduced levels of Caudovirales bacteriophages have been identified as characteristics of the donor microbiome that predict a positive response. However, inconsistency in FMT protocol between studies confounds their interpretation, so it is currently difficult to predict response and premature to recommend FMT, in general, as a treatment for UC. Additional randomized controlled trials designed based on previous findings and employing a standardized protocol are needed to define the role of FMT in the management of UC. Key messages: There is a well-developed rationale for the use of microbiome-modulating interventions in UC. Despite variations in study protocol and limitations in study design that confound their interpretation, FMT seems to benefit patients with UC, overall. Available data identify factors predicting FMT response and should lead to the development of optimal FMT study protocols.
MeSH term(s)	Humans ; Fecal Microbiota Transplantation ; Colitis, Ulcerative/therapy ; Feces/microbiology ; Inflammatory Bowel Diseases ; Remission Induction ; Treatment Outcome
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000529591
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Zs.A 1853: Show issues

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Article ; Online: Use of Optical Coherence Tomography (OCT) in Assessment of Diabetic Skin Wound Characteristics and Blood Flow.

Parsa, Shyon / Wamsley, Christine / Kim, Paul / Kenkel, Jeffrey / Akgul, Yucel

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

2022 Volume 62, Issue 3, Page(s) 407–412

Abstract: Optical coherence tomography allows for various measurements of skin but the utility of the device in determining properties of normal and wounded skin in diabetic patients is unknown. This single-site, non-randomized, observational study used an optical ...

Abstract	Optical coherence tomography allows for various measurements of skin but the utility of the device in determining properties of normal and wounded skin in diabetic patients is unknown. This single-site, non-randomized, observational study used an optical coherence tomography device to acquire skin images at 1305 nm, creating real-time image of 17 patient's skin and wounds 1 to 2 mm under the skin surface. Vertical B-scan, en-face and 3-D images were produced to calculate surface and dermal-epidermal junction roughness, the optical attenuation coefficient, a measure of light absorption and scattering, and blood flow metrics. In subjects with diabetes there was an increase in both the Ra (p < .02) and Rz (p < .001) of the wounded versus the control skin. In subjects without diabetes, there was an increase in both the Ra (p < .001) and Rz (p < .03) values of the wounded versus the control skin. At a depth of 0.6 mm across all subjects, there was an average decrease in blood flow of 63% from control to wounded skin. In subjects with diabetes, this decrease was 76%. In subjects without diabetes the decrease was 55%. The change in vasculature between control and wounded skin was associated with a p < .005. There was an increase in the Ra and Rz values and a decrease in blood flow between the wounded skin and control. The device determined a difference in the Ra and Rz values of both diabetic and healthy subjects' skin and a more pronounced decrease in blood flow in the wounds of patients with diabetes as opposed to those without.
MeSH term(s)	Humans ; Tomography, Optical Coherence/methods ; Skin/diagnostic imaging ; Imaging, Three-Dimensional ; Soft Tissue Injuries ; Diabetes Mellitus
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	1146972-9
ISSN	1542-2224 ; 1067-2516
ISSN (online)	1542-2224
ISSN	1067-2516
DOI	10.1053/j.jfas.2022.10.001
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Zs.A 1468: Show issues

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Article ; Online: Measurement and Application of Incidentally Detected Coronary Calcium: JACC Review Topic of the Week.

Parsa, Shyon / Saleh, Adam / Raygor, Viraj / Hoeting, Natalie / Rao, Anjali / Navar, Ann Marie / Rohatgi, Anand / Kay, Fernando / Abbara, Suhny / Khera, Amit / Joshi, Parag H

Journal of the American College of Cardiology

2024 Volume 83, Issue 16, Page(s) 1557–1567

Abstract: Coronary artery calcium (CAC) scoring is a powerful tool for atherosclerotic cardiovascular disease risk stratification. The nongated, noncontrast chest computed tomography scan (NCCT) has emerged as a source of CAC characterization with tremendous ... ...

Abstract	Coronary artery calcium (CAC) scoring is a powerful tool for atherosclerotic cardiovascular disease risk stratification. The nongated, noncontrast chest computed tomography scan (NCCT) has emerged as a source of CAC characterization with tremendous potential due to the high volume of NCCT scans. Application of incidental CAC characterization from NCCT has raised questions around score accuracy, standardization of methodology including the possibility of deep learning to automate the process, and the risk stratification potential of an NCCT-derived score. In this review, the authors aim to summarize the role of NCCT-derived CAC in preventive cardiovascular health today as well as explore future avenues for eventual clinical applicability in specific patient populations and broader health systems.
MeSH term(s)	Humans ; Coronary Artery Disease ; Calcium ; Tomography, X-Ray Computed/methods ; Heart ; Atherosclerosis ; Coronary Vessels ; Risk Factors ; Coronary Angiography ; Vascular Calcification
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2024.01.039
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: The Efficacy of Intense Pulsed Light as a Treatment for Benign Pigmented Lesions on the Dorsal Hand.

Wamsley, Christine E / Parsa, Shyon / Culver, Abby / Barillas, Jennifer / Kenkel, Jeffrey M

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2022 Volume 48, Issue 8, Page(s) 827–832

Abstract: Background: Intense pulsed light (IPL) is a noninvasive therapeutic option to treat benign pigmented lesions by targeting melanin.: Objective: The purpose of this study was to assess IPL as a treatment for benign pigmented dorsal hand lesions.: ... ...

Abstract	Background: Intense pulsed light (IPL) is a noninvasive therapeutic option to treat benign pigmented lesions by targeting melanin. Objective: The purpose of this study was to assess IPL as a treatment for benign pigmented dorsal hand lesions. Materials and methods: A total of fifteen subjects, 40 to 73 years old, received 3 monthly IPL treatments over the dorsal hands. Subjects followed up 1 and 3 months after treatment. At every visit, photographs were taken using the VISIA Complexion Analysis System (Canfield Scientific, Fairfield, NJ) and analyzed using the RBX Brown Spots Analysis algorithm. The Clinician Global Aesthetic Improvement Scale and Subject Global Aesthetic Improvement Scale were completed at both follow-up visits. Results: A total of fifteen subjects completed all six visits. The number of brown spots decreased 9.26% ( p = .0004) and 7.52% ( p = .0132) at each follow-up visit. The mean brown intensity decreased 6.15% ( p = .0183) and 7.67% ( p = .0178), whereas the mean contrast intensity decreased 8.88% ( p < .0001) and 6.60% ( p = .0007) 1 and 3 months after treatment, respectively. The mean Clinician Global Aesthetic Improvement Scale was 2.03 and 2.23, whereas the mean Subject Global Aesthetic Improvement Scale 1 and 3 months after treatment was 1.6 and 1.8, respectively. Conclusion: Objective analysis, along with clinician and subject assessments, showed an improvement in the appearance of benign pigmented lesions in the treated area after 3 IPL treatments.
MeSH term(s)	Adult ; Aged ; Hand ; Humans ; Intense Pulsed Light Therapy ; Middle Aged ; Phototherapy ; Treatment Outcome
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003494
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Zs.A 1212: Show issues

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Article ; Online: Temporal and Spatial Assessment of the Corneal Response to UV Cross-Linking Using 3-Dimensional In Vivo Confocal Microscopy.

Parsa, Shyon / Rodriguez, Alejandro / Robertson, Danielle M / Bowman, Robert Wayne / Petroll, Walter Matthew

Eye & contact lens

2022 Volume 48, Issue 7, Page(s) 308–312

Abstract: Abstract: The goal of this study was to evaluate the temporal and spatial pattern of wound healing following UV corneal cross-linking (CXL) using 3-dimensional (3-D) confocal imaging in vivo. Using a modified Heidelberg Retinal Tomograph with Rostock ... ...

Abstract	Abstract: The goal of this study was to evaluate the temporal and spatial pattern of wound healing following UV corneal cross-linking (CXL) using 3-dimensional (3-D) confocal imaging in vivo. Using a modified Heidelberg Retinal Tomograph with Rostock Corneal Module confocal microscope, we performed 3-D scans on two patients at multiple time points after CXL. Patient 1 showed a normal post-CXL wound healing response, with initial subbasal nerve loss and keratocyte apoptosis in the anterior stroma, followed by partial restoration of both the nerve plexus and stromal keratocytes by 6 months. In patient 2, in addition to anterior corneal damage, pyknotic nuclei were observed in the posterior stroma 7 days after CXL. Acellular areas were present in the posterior stroma at 3 months, with only partial keratocyte repopulation at 6 months. Regeneration of the subbasal nerve plexus was also delayed. Three-dimensional confocal imaging allowed these unusual wound healing responses to be identified in the absence of any corresponding clinical observations.
MeSH term(s)	Collagen ; Cornea/innervation ; Corneal Stroma ; Cross-Linking Reagents ; Humans ; Keratoconus ; Microscopy, Confocal ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Riboflavin ; Ultraviolet Rays
Chemical Substances	Cross-Linking Reagents ; Photosensitizing Agents ; Collagen (9007-34-5) ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2103049-2
ISSN	1542-233X ; 1542-2321
ISSN (online)	1542-233X
ISSN	1542-2321
DOI	10.1097/ICL.0000000000000892
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Zs.B 1724: Show issues

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Article ; Online: Pediatric Tissue Expansion: Analysis of the National Surgical Quality Improvement Program-Pediatric.

Harrison, Lucas M / Rizvi, Imran / Parsa, Shyon / Hallac, Rami R / Kane, Alex A / Seaward, James R

The Journal of craniofacial surgery

2022

Abstract: Introduction: Tissue expansion (TE) in pediatric surgery provides vascularized tissue to attain functional and esthetic goals in a broad range of reconstructive procedures. Our study evaluates the demographic, operative, and short-term outcomes of TE in ...

Abstract	Introduction: Tissue expansion (TE) in pediatric surgery provides vascularized tissue to attain functional and esthetic goals in a broad range of reconstructive procedures. Our study evaluates the demographic, operative, and short-term outcomes of TE in pediatric patients utilizing the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (NSQIP-P) database and highlights factors associated with postoperative complications. Materials and methods: Retrospective review of a large multicenter database of 402 pediatric patients that underwent TE within the NSQIP-P database from 2013 to 2020 at freestanding general acute care children's hospitals, children's hospitals within a larger hospital, specialty children's hospitals, or general acute care hospitals with a pediatric wing. Patient demographics, clinical risk factors, operative information, and postoperative outcomes were collected with an odds ratio analysis of risk factors. Results: Patients were majority female (55.5%), White (63.2%), and non-Hispanic (67.4%). The minority were born prematurely (11.9%) and had congenital malformations (16.7%). Complications occurred in 5.7%, unplanned readmission in 4.5%, and unplanned operation in 6.5% of patients. Complications lead to readmission in 2.5% and return to the operating room in 3.2% of patients. American Society of Anesthesiology (ASA) score III-IV, congenital malformations, >1-day hospital stay, and pulmonary, neurologic, and hematologic comorbidities were associated with the greatest increase in odds of complication. Conclusion: This study utilizes the NSQIP-P to provide a comprehensive multicenter view of pediatric patients undergoing TE. Increased understanding of risk factors for complications allows for guidance in patient selection and helps in achieving favorable surgical outcomes.
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000008973
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Open Versus Minimally Invasive Approach for Craniosynostosis: Analysis of the National Surgical Quality Improvement Program-Pediatric.

Rizvi, Imran / Harrison, Lucas M / Parsa, Shyon / Hallac, Rami R / Seaward, James R / Kane, Alex A

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2022 Volume 60, Issue 7, Page(s) 804–809

Abstract: Objective: This multicenter study aimed to compare demographic, operative, and short-term outcomes data between open and minimally invasive surgical approaches for craniosynostosis repair utilizing the American College of Surgeon's National Surgical ... ...

Abstract	Objective: This multicenter study aimed to compare demographic, operative, and short-term outcomes data between open and minimally invasive surgical approaches for craniosynostosis repair utilizing the American College of Surgeon's National Surgical Quality Improvement Program Pediatric (NSQIP-P) database and highlight surgical disparities among races and ethnicities. Design: Retrospective review of large multicenter database. Setting: Freestanding general acute care children's hospitals, children's hospitals within a larger hospital, specialty children's hospitals, or general acute care hospitals with a pediatric wing. Patients and participants: A total of 4931 pediatric patients underwent craniosynostosis correction within the NSQIP-P database from 2013 to 2019. Interventions: None. Main outcome measure(s): Demographic information included age at surgery, sex, race, and ethnicity. Operative and outcomes measures included operative time, anesthesia time, days until discharge, postoperative complications, blood transfusions, 30-day readmission, and 30-day unplanned return to operating room. Results: Patients who underwent minimally invasive surgery had significantly shorter operative and anesthesia times ( Conclusions: This study adds to a growing consensus that minimally invasive surgery has significantly decreased operative time, anesthesia time, transfusion rates, length of hospital stay, and postoperative complications compared to open surgery. Racial and ethnic surgical disparities showed larger proportions of Black and Hispanic populations undergoing open procedures.
MeSH term(s)	Humans ; Child ; United States ; Quality Improvement ; Craniosynostoses/surgery ; Craniosynostoses/complications ; Minimally Invasive Surgical Procedures/methods ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656221085478
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Zs.A 451: Show issues

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Article ; Online: Evaluation and characterization of facial skin aging using optical coherence tomography.

Vingan, Nicole R / Parsa, Shyon / Barillas, Jennifer / Culver, Abby / Kenkel, Jeffrey M

Lasers in surgery and medicine

2022 Volume 55, Issue 1, Page(s) 22–34

Abstract: Objectives: The skin aging exposome encompasses internal and external factors that contribute to clinical signs of facial aging. Aging skin can be characterized by distinctive features such as wrinkles, lentigines, elastosis, and roughness. Optical ... ...

Abstract	Objectives: The skin aging exposome encompasses internal and external factors that contribute to clinical signs of facial aging. Aging skin can be characterized by distinctive features such as wrinkles, lentigines, elastosis, and roughness. Optical coherence tomography (OCT) is capable of noninvasively measuring skin characteristics. This study aimed to assess bilateral features using OCT to explore temporal skin changes among decades and potential changes in facial skin aging based on laterality. Methods: A total of 97 subjects between 20 and 89 years old with Fitzpatrick skin types I to IV were enrolled. VivoSight, a Multi-Beam OCT system intended to gather topographical and histological images of skin, was used to scan the area inferolateral to the lateral canthus, bilaterally. Investigators compared characteristics of skin roughness, attenuation coefficient and blood flow across age groups and based on laterality to determine any differences. Results: Only data from successful OCT scans were used. Seventy subjects, 10 from each specified decade, had successful bilateral scans and were thus included in the analysis. Chronological aging was characterized by significantly decreased dermal attenuation coefficient with increased age. Skin roughness measurements showed trends of increased roughness with age; however, no statistically significant changes were seen between groups. Qualitative differences amongst scans taken on right and left sides of the face showed no significance regarding roughness, density or blood flow at depths ranging from 0.05 to 0.5 mm. Conclusions: OCT is an effective method for evaluating changes in aging skin. Our results illustrate a decline in skin density with chronological age. Additionally, it was illustrated that structural change in the epidermis and dermis does occur, however on a microscopic scale, there are no significant differences based on laterality. OCT holds promise as a noninvasive technique for characterization of aging skin. Its utility and application in the clinical management and treatment of aged skin requires further research; however, the technology has potential to personalize therapies based on objective findings.
MeSH term(s)	Humans ; Aged ; Young Adult ; Adult ; Middle Aged ; Aged, 80 and over ; Skin Aging ; Tomography, Optical Coherence/methods ; Skin ; Epidermis ; Lentigo
Language	English
Publishing date	2022-10-08
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	604493-1
ISSN	1096-9101 ; 0196-8092
ISSN (online)	1096-9101
ISSN	0196-8092
DOI	10.1002/lsm.23611
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